<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="17135203" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0471" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-80017" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579228" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="17135203" refType="primary-reference" refTypeAc="MI:0358"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Co-operative interactions between NFI and the adenovirus DNA binding protein at the adenovirus origin of replication.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="2767055" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="mint" dbAc="MI:0471" id="MINT-6547146" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="mint" dbAc="MI:0471" id="MINT-6628946" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8547807" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Co-operative interactions between NFI and the adenovirus DNA binding protein at the adenovirus origin of replication.</attribute>
            <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1989</attribute>
            <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
            <attribute name="rapid curation" nameAc="MI:0961"/>
            <attribute name="author-list" nameAc="MI:0636">Cleat PH., Hay RT.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
            <attribute name="remark-internal">suggested by asmolyard</attribute>
            <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628946" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="2767055" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-3">
            <names>
              <shortLabel>unknown</shortLabel>
              <fullName>Unknown</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>footprinting</shortLabel>
            <fullName>footprinting</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0417" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608495" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Cleat PH., Hay RT.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
          <attribute name="remark-internal">suggested by asmolyard</attribute>
          <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
          <attribute name="publication year" nameAc="MI:0886">1989</attribute>
          <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
          <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>dnb2_ade02</shortLabel>
          <fullName>DNA-binding protein</fullName>
          <alias type="gene name" typeAc="MI:0301">DBP</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Early 2A protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Early E2A DNA-binding protein</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P03264" version="SP_49" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="MINT-216033" refType="intact-secondary"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8547830" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_040527.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="AP_000177.1"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037540"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P03264"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036362"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036367"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036368"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003697" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006260" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006268" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006351" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019028" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0039687" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0039715" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045740" version="SP_116"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003176" version="SP_116"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005376" version="SP_116"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10515">
          <names>
            <shortLabel>ade02</shortLabel>
            <fullName>Human adenovirus C serotype 2 (HAdV-2)</fullName>
            <alias type="synonym" typeAc="MI:1041">Human adenovirus 2</alias>
            <alias type="synonym" typeAc="MI:1041">HAdV-2</alias>
          </names>
        </organism>
        <sequence>MASREEEQRETTPERGRGAARRPPTMEDVSSPSPSPPPPRAPPKKRLRRRLESEDEEDSSQDALVPRTPSPRPSTSTADLAIASKKKKKRPSPKPERPPSPEVIVDSEEEREDVALQMVGFSNPPVLIKHGKGGKRTVRRLNEDDPVARGMRTQEEKEESSEAESESTVINPLSLPIVSAWEKGMEAARALMDKYHVDNDLKANFKLLPDQVEALAAVCKTWLNEEHRGLQLTFTSNKTFVTMMGRFLQAYLQSFAEVTYKHHEPTGCALWLHRCAEIEGELKCLHGSIMINKEHVIEMDVTSENGQRALKEQSSKAKIVKNRWGRNVVQISNTDARCCVHDAACPANQFSGKSCGMFFSEGAKAQVAFKQIKAFMQALYPNAQTGHGHLLMPLRCECNSKPGHAPFLGRQLPKLTPFALSNAEDLDADLISDKSVLASVHHPALIVFQCCNPVYRNSRAQGGGPNCDFKISAPDLLNALVMVRSLWSENFTELPRMVVPEFKWSTKHQYRNVSLPVAHSDARQNPFDF</sequence>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
          <attribute name="function" nameAc="MI:0613">Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding</attribute>
          <attribute name="crc64">114F8F02A77B28F1</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>nfia_human</shortLabel>
          <fullName>Nuclear factor 1 A-type</fullName>
          <alias type="gene name" typeAc="MI:0301">NFIA</alias>
          <alias type="gene name synonym" typeAc="MI:0302">KIAA1439</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Nuclear factor I/A</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CCAAT-box-binding transcription factor</alias>
          <alias type="gene name synonym" typeAc="MI:0302">TGGCA-binding protein</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q12857" version="SP_98" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8TA97" version="SP_98" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H3X9" version="SP_98" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9P2A9" version="SP_98" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4DRJ3" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4DS53" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="F5H0R0" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="F8W8W3" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000384523" version="SP_192" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2795262" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001128145.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001138983.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001138984.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_005586.1"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006260" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006355" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008134" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019079" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030054" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060074" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072189" version="SP_192"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000647" version="SP_192"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003619" version="SP_192"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019548" version="SP_192"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019739" version="SP_192"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020604" version="SP_192"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q12857" version="SP_192"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-73980" version="SP_192"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-749476" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_192"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000162599" version="SP_192" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000403491" version="SP_192" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000785" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000978" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000981" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001228" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003682" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003700" version="SP_192"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_192"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG</sequence>
        <attributeList>
          <attribute name="crc64">42090C6B8B229F87</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>dnb2-nfia</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628948" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8547823" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628951" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P03264"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628949" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q12857"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">F2 F3 F4</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>