HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html Hepatitis C virus core protein interacts with fibrinogen-beta and attenuates cytokine stimulated acute-phase response. Hepatitis C virus core protein interacts with fibrinogen-beta and attenuates cytokine stimulated acute-phase response. Hepatology (0270-9139) 2010 imex curation Ait-Goughoulte M., Banerjee A., Meyer K., Mazumdar B., Saito K., Ray R.B., Ray R. Virus - Publications including interactions involving viral proteins rayr@slu.edu 30-Sept-2013: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Ait-Goughoulte M., Banerjee A., Meyer K., Mazumdar B., Saito K., Ray R.B., Ray R. Virus - Publications including interactions involving viral proteins rayr@slu.edu Accepted 2013-SEP-03 by ORCHARD 30-Sept-2013: Contacted by IntAct-Help. Hepatology (0270-9139) 2010 imex curation Hepatitis C virus core protein interacts with fibrinogen-beta and attenuates cytokine stimulated acute-phase response. Hepatitis C virus core protein interacts with fibrinogen-beta and attenuates cytokine stimulated acute-phase response. Hepatology (0270-9139) 2010 imex curation Ait-Goughoulte M., Banerjee A., Meyer K., Mazumdar B., Saito K., Ray R.B., Ray R. Virus - Publications including interactions involving viral proteins rayr@slu.edu 30-Sept-2013: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Ait-Goughoulte M., Banerjee A., Meyer K., Mazumdar B., Saito K., Ray R.B., Ray R. Virus - Publications including interactions involving viral proteins rayr@slu.edu Accepted 2013-SEP-03 by ORCHARD 30-Sept-2013: Contacted by IntAct-Help. Hepatology (0270-9139) 2010 imex curation Hepatitis C virus core protein interacts with fibrinogen-beta and attenuates cytokine stimulated acute-phase response. Hepatitis C virus core protein interacts with fibrinogen-beta and attenuates cytokine stimulated acute-phase response. Hepatology (0270-9139) 2010 imex curation Ait-Goughoulte M., Banerjee A., Meyer K., Mazumdar B., Saito K., Ray R.B., Ray R. Virus - Publications including interactions involving viral proteins rayr@slu.edu 30-Sept-2013: Contacted by IntAct-Help. Only protein-protein interactions imex curation chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 bifc bimolecular fluorescence complementation bifc tag fluorescence tag visualisation by fluorescence tag fluorescence Ait-Goughoulte M., Banerjee A., Meyer K., Mazumdar B., Saito K., Ray R.B., Ray R. Virus - Publications including interactions involving viral proteins rayr@slu.edu Accepted 2013-SEP-03 by ORCHARD 30-Sept-2013: Contacted by IntAct-Help. Hepatology (0270-9139) 2010 imex curation p27958-pro_0000037566 Core protein precursor protein protein HCV77 Hepatitis C virus genotype 1a (isolate H77) STNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRPEGRTWAQPGYPWPLYGNEGCGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLALLSCLTVPASA 2 191 7C9059C0D1D2732E fibb_human Fibrinogen beta chain FGB protein protein human Homo sapiens Human MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ DIP protein P02675 original sequence version: 111 DIP protein P02675 original sequence version: 153 DIP protein P02675 original sequence version: 149 DIP protein P02675 original sequence version: 147 B92FFB9976AB53C5 core-fbg-b-1 3 Core 4 unspecified role unspecified role bait bait cyfp tag cyfp cYFP undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Fibrinogen-B 5 unspecified role unspecified role prey prey nyfp tag nyfp nYFP undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Fig. 1 core-fbg-b-2 1 Fibrinogen-B 5 unspecified role unspecified role neutral component neutral component Core 4 unspecified role unspecified role neutral component neutral component colocalization colocalization Fig. 2A core-fbg-b-3 2 Fibrinogen-B 5 unspecified role unspecified role prey prey ha tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Core 4 unspecified role unspecified role bait bait flag tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Fig. 2B fgb-b-core-1 2 Core 4 unspecified role unspecified role prey prey flag tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Fibrinogen-B 5 unspecified role unspecified role bait bait ha tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Fig. 2B