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    <source releaseDate="2022-02-04">
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        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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        <names>
          <fullName>Raf-1 activation disrupts its binding to keratins during cell stress.</fullName>
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            <attribute name="publication title" nameAc="MI:1091">Raf-1 activation disrupts its binding to keratins during cell stress.</attribute>
            <attribute name="journal" nameAc="MI:0885">J. Cell Biol. (0021-9525)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2004</attribute>
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            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
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        <interactionDetectionMethod>
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            <shortLabel>experimental interac</shortLabel>
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        <participantIdentificationMethod>
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        <names>
          <shortLabel>raf1_human</shortLabel>
          <fullName>RAF proto-oncogene serine/threonine-protein kinase</fullName>
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          <alias type="gene name synonym" typeAc="MI:0302">Proto-oncogene c-RAF</alias>
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            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
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        <organism ncbiTaxId="9606">
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            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
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        <sequence>MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF</sequence>
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          <attribute name="remark-internal">DIP protein P04049 original sequence version: 117</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 106</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 114</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 141</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 142</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 147</attribute>
          <attribute name="remark-internal">DIP protein P04049-1 original sequence version: 136</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 136</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 153</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 150</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 164</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 172</attribute>
          <attribute name="remark-internal">DIP protein P04049-1 original sequence version: 172</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 184</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 188</attribute>
          <attribute name="remark-internal">DIP protein P04049 original sequence version: 195</attribute>
          <attribute name="crc64">EF821B5349711BC3</attribute>
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      </interactor>
      <interactor id="3">
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          <shortLabel>k1c18_human</shortLabel>
          <fullName>Keratin, type I cytoskeletal 18</fullName>
          <alias type="gene name" typeAc="MI:0301">KRT18</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CYK18</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Keratin-18</alias>
          <alias type="orf name" typeAc="MI:0306">PIG46</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cytokeratin-18</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cell proliferation-inducing gene 46 protein</alias>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005882" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005912" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007049" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009653" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009750" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031667" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033209" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034451" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043000" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045095" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045104" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070365" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072497" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097110" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097191" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097284" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098641" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902488" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002957" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018039" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR027695" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR039008" version="SP_231"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P05783" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6805567" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6809371" version="SP_231"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000111057" version="SP_231" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000388835" version="SP_231" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000388837" version="SP_231" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003723" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005198" version="SP_231"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000215.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_954657.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-633N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P05783 original sequence version: 186</attribute>
          <attribute name="remark-internal">DIP protein P05783 original sequence version: 175</attribute>
          <attribute name="crc64">1E5604C6BCC7A17A</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>krt18-raf1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-51055" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7291077" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1204765" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>monoclonal western</shortLabel>
                  <fullName>monoclonal antibody western blot</fullName>
                  <alias type="synonym" typeAc="MI:1041">monoclonal western</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0072" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-955" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>over-expressed</shortLabel>
                  <fullName>over expressed level</fullName>
                  <alias type="synonym" typeAc="MI:1041">over-expressed</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1204769" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>nucleotide sequence</shortLabel>
                  <fullName>nucleotide sequence identification</fullName>
                  <alias type="go synonym" typeAc="MI:0303">sequence cloning</alias>
                  <alias type="synonym" typeAc="MI:1041">sequence cloning</alias>
                  <alias type="synonym" typeAc="MI:1041">nucleotide sequence</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0078" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-958" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>over-expressed</shortLabel>
                  <fullName>over expressed level</fullName>
                  <alias type="synonym" typeAc="MI:1041">over-expressed</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <negative>true</negative>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">F1C</attribute>
          <attribute name="comment" nameAc="MI:0612">experimental=overlay assay</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>