IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner. Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner. Journal of hepatology 2015 imex curation Wang X., Lu Y., Wang E., Zhang Z., Xiong X., Zhang H., Lu J., Zheng S., Yang J., Xia X., Yang S., Li X. IBD - Inflammatory bowel disease in IBD dataset as FXR is on a "list" as being relevant. xmyangshuyu@126.com, lixy@sibs.ac.cn 21-10-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-liver Mus musculus liver liver ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Wang X., Lu Y., Wang E., Zhang Z., Xiong X., Zhang H., Lu J., Zheng S., Yang J., Xia X., Yang S., Li X. IBD - Inflammatory bowel disease in IBD dataset as FXR is on a "list" as being relevant. xmyangshuyu@126.com, lixy@sibs.ac.cn Accepted 2015-SEP-21 AT 14:26 BST AT 14:26 BST by ORCHARD Journal of hepatology 2015 Only protein-protein interactions imex curation imex curation Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner. Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner. Journal of hepatology 2015 imex curation Wang X., Lu Y., Wang E., Zhang Z., Xiong X., Zhang H., Lu J., Zheng S., Yang J., Xia X., Yang S., Li X. IBD - Inflammatory bowel disease in IBD dataset as FXR is on a "list" as being relevant. xmyangshuyu@126.com, lixy@sibs.ac.cn 21-10-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-hepatocyte Mouse hepatocyte hepatocyte Liver primary cell A hepatocyte is a cell of the main tissue of the liver. ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Wang X., Lu Y., Wang E., Zhang Z., Xiong X., Zhang H., Lu J., Zheng S., Yang J., Xia X., Yang S., Li X. IBD - Inflammatory bowel disease in IBD dataset as FXR is on a "list" as being relevant. xmyangshuyu@126.com, lixy@sibs.ac.cn Accepted 2015-SEP-21 AT 14:26 BST AT 14:26 BST by ORCHARD Journal of hepatology 2015 Only protein-protein interactions imex curation imex curation ncoa1_mouse Nuclear receptor coactivator 1 Ncoa1 Src1 Nuclear receptor coactivator protein 1 Steroid receptor coactivator 1 protein protein mouse Mus musculus Mouse MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPEDPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDSNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARVNRQQSSDLNSSSSHTNSSNNQGNFGCSPGNQIVANVALNQGQAGSQSSNPSLNLNNSPMEGTGIALSQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDSKEIASILNEMIQSDNSDNSANEGKPLDSGLLHNNDRLSEGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSVPASTAVSVSGQSQGSASIKLELDAAKKKESKDHQLLRYLLDKDEKDLRSTPNLCLDDVKVKVEKKEQMDPCNTNPTPMTKPAPEEVKLESQSQFTADLDQFDQLLPTLEKAAQLPSLCETDRMDGAVTGVSIKAEVLPASLQPTTARAAPRLSRLPELELEAIDNQFGQPGAGDQIPWANNTLTTINQNKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEDRPTLYSQPYSSPSPTAGLSGPFQGMVRQKPSLGAMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGTPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGAGISPQMQQNVFQYPGPGLVPQGEATFAPSLSPGSSMVPMPVPPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANIQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTDADGNQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE 65C08AFFCF14241D esr1_mouse Estrogen receptor Esr1 Esr Estr Estra Nr3a1 Estradiol receptor ER-alpha Nuclear receptor subfamily 3 group A member 1 protein protein mouse Mus musculus Mouse MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAYEFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI 05F5E2FC21CC0A8B nr0b2_mouse_gene Nuclear receptor subfamily 0 group B member 2 Nr0b2 Shp gene gene mouse Mus musculus Mouse esr1-nr0b2-1 2 5 unspecified role unspecified role prey prey promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 4 unspecified role unspecified role bait bait association association 4E CHEBI:23965 -estradiol CHEBI:23965 increases binding of P19785 to ENSMUSG00000037583 CHEBI:23965 increases expression at RNA level of ENSMUSG00000037583 Q60641 increases expression at RNA level of ENSMUSG00000037583 causality from Supp Fig 7;also also from Figs 2,4 CHEBI:87729 decreases expression at RNA level of ENSMUSG00000037583 CHEBI:87729 -ICI 182780 a steroidal estrogen receptor antagonist P19785 increases expression at RNA level of ENSMUSG00000037583 esr1-nr0b2-2 1 5 unspecified role unspecified role prey prey promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 4 unspecified role unspecified role bait bait association association 4F CHEBI:23965 -estradiol CHEBI:23965 increases binding of P19785 to ENSMUSG00000037583 ncoa1-nr0b2-1 1 5 unspecified role unspecified role prey prey promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 unspecified role unspecified role bait bait association association 4F-2 CHEBI:23965 -estradiol CHEBI:23965 increases binding of P70365 to ENSMUSG00000037583.