IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Induction of BAFF expression by IFN-γ via JAK/STAT signaling pathways in human intestinal epithelial cells. Induction of BAFF expression by IFN-γ via JAK/STAT signaling pathways in human intestinal epithelial cells. Journal of leukocyte biology 2013 imex curation Woo SJ., Im J., Jeon JH., Kang SS., Lee MH., Yun CH., Moon EY., Song MK., Kim HH., Han SH. IBD - Inflammatory bowel disease shhan-mi@snu.ac.kr 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-ht_29 Homo sapiens HT-29 caucasian women with colon adenocarcinoma ht_29 HT-29 confirmed as human with IEF of AST, LDH established from the primary tumor of a 44-year-old Caucasian woman with colon adenocarcinoma in 1964; described to be heterotransplantable forming well-differentiated grade I tumors ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Woo SJ., Im J., Jeon JH., Kang SS., Lee MH., Yun CH., Moon EY., Song MK., Kim HH., Han SH. IBD - Inflammatory bowel disease shhan-mi@snu.ac.kr Accepted 2015-JUL-28 by ORCHARD Journal of leukocyte biology 2013 Only protein-protein interactions imex curation imex curation tn13b_human_gene Tumor necrosis factor ligand superfamily member 13B TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 gene gene human Homo sapiens Human stat1_human Signal transducer and activator of transcription 1-alpha/beta STAT1 Transcription factor ISGF-3 components p91/p84 protein protein human Homo sapiens Human MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV 054A813522364BA6 stat1-tnfsf13b-1 1 2 unspecified role unspecified role prey prey promoter_region_including_gas_element_and_IRF1_binding site sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 unspecified role unspecified role bait bait region phosres phosphorylated residue PhosRes Phospho Phosphorylation Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 4C P01579 increases binding of P42224 to ENSG00000102524. P01574 increases expression at RNA level of ENSG00000102524. IFNgamma increases RNA levels of IRF1 (not otherwise entered here) - but IFN-gamma also increases RNA level of P01574- IFNBeta- (which increases RNA levels of ENSG00000102524-see causality statement) -cannot think of a sensible casusality statement to include this, as gene for IFNbeta is not otherwise entered here. P01579 increases expression at protein level of ENSG00000102524. CHEBI:87103 decreases expression at RNA level of ENSG00000102524. CHEBI:87103 decreases expression at protein level of ENSG00000102524 JAK I inhibitor (CHEBI:87103) reduced IFN-gamma -induced soluble and membrane-bound BAFF at protein and mRNA levels. P42224 increases expression at protein level of ENSG00000102524. P42224 increases expression at RNA level of ENSG00000102524. regarding statement :-"P42224 increases expression at RNA level of ENSG00000102524." -I cannot find a figure showing a decrease in mRNA in to confirm this - but have left it in, as if P42224 causes an increase of protein levels of BAFF (Fig 3) (-well really the STAT1 siRNA decreases it) then there must have been increased mRNA..