IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease. Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease. The Journal of experimental medicine 2011 imex curation Vanvalkenburgh J., Albu DI., Bapanpally C., Casanova S., Califano D., Jones DM., Ignatowicz L., Kawamoto S., Fagarasan S., Jenkins NA., Copeland NG., Liu P., Avram D. IBD - Inflammatory bowel disease avramd@mail.amc.edu 03-Dec-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-t-cell Mouse T cell t-cell Peripheral blood T-lymphocytes ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Vanvalkenburgh J., Albu DI., Bapanpally C., Casanova S., Califano D., Jones DM., Ignatowicz L., Kawamoto S., Fagarasan S., Jenkins NA., Copeland NG., Liu P., Avram D. IBD - Inflammatory bowel disease The IL10 regulatory region "6.5" (referred to on Figure 8) is assumed to be the region "6.45" referred to in the Methods section; no sequences are stated. T-Reg cells avramd@mail.amc.edu Accepted 2015-OCT-21 AT 09:05 BST AT 09:05 BST by ORCHARD The Journal of experimental medicine 2011 Only protein-protein interactions imex curation imex curation bc11b_mouse B-cell lymphoma/leukemia 11B Bcl11b Ctip2 Rit1 B-cell CLL/lymphoma 11B COUP-TF-interacting protein 2 Radiation-induced tumor suppressor gene 1 protein protein protein mouse Mus musculus Mouse MSRRKQGNPQHLSQRELITPEADHVEATILEEDEGLEIEEPSSLGLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKKKQCGGLGPCYDKVLDKSSPPPSSRSELRRVSEPVEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPSMAPIAASSSHPPTSVITSPLRALGVLPPCFPLPCCGARPISGDGTQGEGQMEAPFGCQCELSGKDEPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASTSLTPRLTIPPPLGPETVAQSPLMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPPPRHHLDPHRLSAEEMGLVAQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSPGRGNPMHRLLNPFQPSPKSPFLSTPPLPPMPAGTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELPGDLKAADGDFRHHESDPSLGPEPEDDEDEEEEEEELLLENESRPESSFSMDSELGRGRENGGGVPPGVAGAGAAAAALADEKALALGKVMEDAGLGALPQYGEKRGAFLKRAGDTGDAGAVGCGDAGAPGAVNGRGGAFAPGAEPFPALFPRKPAPLPSPGLGGPALHAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAERS 9A86B7E34450B2F2 foxp3_mouse_gene Forkhead box protein P3 Foxp3 gene gene mouse Mus musculus Mouse il10_mouse_gene Interleukin-10 gene gene gene mouse Mus musculus Mouse bcl11b-foxp3-1 1 3 unspecified role unspecified role prey prey promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined cns1_and cns2_intronic_enhancer_regions sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 2 unspecified role unspecified role bait bait association association 7E Q99PV8 increases the expression at protein level of ENSMUSG00000039521 Q99PV8 increases the expression at RNA level of ENSMUSG00000039521 bcl11b-il10_mouse_gene-1 1 4 unspecified role unspecified role unspecified role unspecified role promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined CNS+(6.45)6.5_downstream_enhancer_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 2 unspecified role unspecified role unspecified role unspecified role association association 8C Q99PV8 increases expression at the protein level of ENSMUSG00000016529 Q99PV8 increases expression at the RNA level of ENSMUSG00000016529