IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (0950-1991) 2003 imex curation Erhardt S., Su IH., Schneider R., Barton S., Bannister AJ., Perez-Burgos L., Jenuwein T., Kouzarides T., Tarakhovsky A., Surani MA. Chromatin - Epigenetic interactions resulting in chromatin modulation 7C and 7B as10021@mole.bio.cam.ac.uk Only protein-protein interactions mouse-embryonic_stem cell Mus musculus embryonic stem cell es cells embryonic stem cells anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Erhardt S., Su IH., Schneider R., Barton S., Bannister AJ., Perez-Burgos L., Jenuwein T., Kouzarides T., Tarakhovsky A., Surani MA. Chromatin - Epigenetic interactions resulting in chromatin modulation 7C and 7B as10021@mole.bio.cam.ac.uk Accepted 2006-MAR-16 by DAVET. Development (0950-1991) 2003 Only protein-protein interactions imex curation Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (0950-1991) 2003 imex curation Erhardt S., Su IH., Schneider R., Barton S., Bannister AJ., Perez-Burgos L., Jenuwein T., Kouzarides T., Tarakhovsky A., Surani MA. Chromatin - Epigenetic interactions resulting in chromatin modulation 7C and 7B as10021@mole.bio.cam.ac.uk Only protein-protein interactions mouse-embryo Mus musculus embryo embryo Embryo Defined as the development stage prior to the initiation of tissue differentiation. fluorescence imaging fluorescence microscopy fluorescence imaging predetermined predetermined participant predetermined Erhardt S., Su IH., Schneider R., Barton S., Bannister AJ., Perez-Burgos L., Jenuwein T., Kouzarides T., Tarakhovsky A., Surani MA. Chromatin - Epigenetic interactions resulting in chromatin modulation Revisit when term paternal X chromosome in GO. Ezh2 and Eed were shown to co-localise in trophectoderm cells at the blastocyst stage. 7C and 7B as10021@mole.bio.cam.ac.uk Accepted 2006-MAR-16 by DAVET. Development (0950-1991) 2003 Only protein-protein interactions imex curation eed_mouse Polycomb protein EED Eed protein protein mouse Mus musculus Mouse MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR DIP protein Q921E6 original sequence version: 48 DIP protein Q921E6 original sequence version: 73 DIP protein Q921E6 original sequence version: 98 D2E0A5BA27C0499A hdac1_mouse Histone deacetylase 1 Hdac1 protein protein mouse Mus musculus Mouse MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA DIP protein O09106 original sequence version: 147 DIP protein O09106 original sequence version: 87 DIP protein O09106 original sequence version: 131 DIP protein O09106 original sequence version: 119 DIP protein O09106 original sequence version: 106 DIP protein O09106 original sequence version: 144 DIP protein O09106 original sequence version: 146 DIP protein O09106 original sequence version: 161 DIP protein O09106 original sequence version: 167 DIP protein O09106 original sequence version: 169 DIP protein O09106 original sequence version: 124 DIP protein O09106 original sequence version: 134 DIP protein O09106 original sequence version: 103 DIP protein O09106 original sequence version: 122 7F64D3C17F5E4844 ezh2_mouse Histone-lysine N-methyltransferase EZH2 Ezh2 Enx1h Enhancer of zeste homolog 2 ENX-1 protein protein mouse Mus musculus Mouse MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP 7442C751E13EA24B hdac1-eed 1 5 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey 4 unspecified role unspecified role prey prey association association This complex showed methyl transferase activity when tested with the peptides ARTKQTARKSTGGKAPGGC and AARKSAPATGGC ezh2-eed 2 5 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component colocalization colocalization The Proteins appear to colocalize to the paternal X chromosome.