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        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
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          <fullName>Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation.</fullName>
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            <attribute name="publication year" nameAc="MI:0886">2014</attribute>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-191650" version="SP_219"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-196025" version="SP_219"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9013406" version="SP_219"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905867" version="SP_219"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_034418.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29207N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDSQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P23242 original sequence version: 72</attribute>
          <attribute name="remark-internal">DIP protein P23242 original sequence version: 132</attribute>
          <attribute name="remark-internal">DIP protein P23242 original sequence version: 153</attribute>
          <attribute name="crc64">018DCB461FA69490</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>ita5_mouse</shortLabel>
          <fullName>Integrin alpha-5</fullName>
          <alias type="gene name" typeAc="MI:0301">Itga5</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CD49 antigen-like family member E</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Fibronectin receptor subunit alpha</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Integrin alpha-F</alias>
          <alias type="gene name synonym" typeAc="MI:0302">VLA-5</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P11688" version="SP_123" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E9QN40" version="SP_123" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000023128" version="SP_197" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6477055" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000000555" version="SP_197" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000023128" version="SP_197" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005154" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005178" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005783" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007044" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007155" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007157" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007159" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007229" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007565" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007613" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008305" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010811" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0023035" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030335" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031410" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031589" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033627" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033631" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034113" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034674" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035987" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045202" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045765" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050839" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903672" version="SP_197"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000811" version="SP_197"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000413" version="SP_197"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013517" version="SP_197"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013519" version="SP_197"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013649" version="SP_197"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018184" version="SP_197"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028994" version="SP_197"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032695" version="SP_197"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P11688" version="SP_197"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1566948" version="SP_197"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1566977" version="SP_197"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-202733" version="SP_197"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-216083" version="SP_197"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-445144" version="SP_197"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_034707.5"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MGSWTPRSPRSPLHAVLLRWGPRRLPPLLPLLLLLWPPPLQVGGFNLDAEAPAVLSGPPGSLFGFSVEFYRPGRDGVSVLVGAPKANTSQPGVLQGGAVYVCPWGTSPIQCTTIQFDSKGSRILESSLYSAKGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKDPQNDPVGTCYLSTENFTRILEYAPCRSDFGSAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQISESYYPEYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQRPAGIDPTPTLTLTGQDEFSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLSTKPSQVLQPLWAAGRTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPNSIGFEVELQLDWQKQKGGVRRALFLTSKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLDVYGEKKHVYLGDKNALNLTFHAQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSRQLVCDLGNPMKAGTSLWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNVVSFPLSVEAQAQVSLNGVSKPEAVIFPVSDWNPQDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTKVTGLSNCTSNYTPNSQGLELDPETSPHHLQKREAPGRSSTASGTQVLKCPEAKCFRLRCEFGPLHRQESRSLQLHFRVWAKTFLQREYQPFSLQCEAVYEALKMPYQILPRQLPQKKLQVATAVQWTKAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFFKRSLPYGTAMEKAQLKPPATSDA</sequence>
        <attributeList>
          <attribute name="crc64">8624AEF83E4A9C07</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-24058-1">
        <names>
          <shortLabel>245rwt-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-10765511" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-24058-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">2C</attribute>
          <attribute name="antagonist" nameAc="MI:0626">"AKTi"   AKT inhibitor VIII, Isozyme-Selective inhibitor  for Akti-1/2</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>