Molecular Connections Molecular Connections Pvt. Ltd. 2/2, Kariappa Road, Basavanagudi, Bangalore -560 004 www.molecularconnections.com MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab. MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab. Mol. Cancer 2014 imex curation Zhang K.L., Zhou X., Han L., Chen L.Y., Chen L.C., Shi Z.D., Yang M., Ren Y., Yang J.X., Frank T.S., Zhang C.B., Zhang J.X., Pu P.Y., Zhang J.N., Jiang T., Wagner E.J., Li M., Kang C.S., Zhang K.L., Zhou X., Han L., Chen L.Y., Chen L.C., Shi Z.D., Yang M., Ren Y., Yang J.X., Frank T.S., Zhang C.B., Zhang J.X., Pu P.Y., Zhang J.N., Jiang T., Wagner E.J., Li M., Kang C.S. Cancer - Interactions investigated in the context of cancer Eric.J.Wagner@uth.tmc.edu 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions Molecular Connections Pvt Ltd. human-u87 Human U-87 MG glioblastoma cell line u87 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang K.L., Zhou X., Han L., Chen L.Y., Chen L.C., Shi Z.D., Yang M., Ren Y., Yang J.X., Frank T.S., Zhang C.B., Zhang J.X., Pu P.Y., Zhang J.N., Jiang T., Wagner E.J., Li M., Kang C.S., Zhang K.L., Zhou X., Han L., Chen L.Y., Chen L.C., Shi Z.D., Yang M., Ren Y., Yang J.X., Frank T.S., Zhang C.B., Zhang J.X., Pu P.Y., Zhang J.N., Jiang T., Wagner E.J., Li M., Kang C.S. Cancer - Interactions investigated in the context of cancer Eric.J.Wa gner@uth.tmc.edu Eric.J.Wagner@uth.tmc.edu Accepted 2018-MAY-09 AT 10:41 BST AT 10:41 BST by ORCHARD Mol. Cancer 2014 Only protein-protein interactions imex curation Molecular Connections Pvt Ltd. MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab. MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab. Mol. Cancer 2014 imex curation Zhang K.L., Zhou X., Han L., Chen L.Y., Chen L.C., Shi Z.D., Yang M., Ren Y., Yang J.X., Frank T.S., Zhang C.B., Zhang J.X., Pu P.Y., Zhang J.N., Jiang T., Wagner E.J., Li M., Kang C.S., Zhang K.L., Zhou X., Han L., Chen L.Y., Chen L.C., Shi Z.D., Yang M., Ren Y., Yang J.X., Frank T.S., Zhang C.B., Zhang J.X., Pu P.Y., Zhang J.N., Jiang T., Wagner E.J., Li M., Kang C.S. Cancer - Interactions investigated in the context of cancer Eric.J.Wagner@uth.tmc.edu 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions Molecular Connections Pvt Ltd. human-ln_229 Homo sapiens malignant glioma cell line LN-229 ln_229 Human malignant glioma cell line LN-229 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang K.L., Zhou X., Han L., Chen L.Y., Chen L.C., Shi Z.D., Yang M., Ren Y., Yang J.X., Frank T.S., Zhang C.B., Zhang J.X., Pu P.Y., Zhang J.N., Jiang T., Wagner E.J., Li M., Kang C.S., Zhang K.L., Zhou X., Han L., Chen L.Y., Chen L.C., Shi Z.D., Yang M., Ren Y., Yang J.X., Frank T.S., Zhang C.B., Zhang J.X., Pu P.Y., Zhang J.N., Jiang T., Wagner E.J., Li M., Kang C.S. Cancer - Interactions investigated in the context of cancer Eric.J.Wa gner@uth.tmc.edu Eric.J.Wagner@uth.tmc.edu Accepted 2018-MAY-09 AT 10:41 BST AT 10:41 BST by ORCHARD Mol. Cancer 2014 Only protein-protein interactions imex curation Molecular Connections Pvt Ltd. ctnb1_human Catenin beta-1 Beta-catenin OK/SW-cl.35 PRO2286 CTNNB1 CTNNB protein protein human Homo sapiens Human MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL DIP protein P35222 original sequence version: 187 DIP protein P35222 original sequence version: 188 DIP protein P35222 original sequence version: 180 DIP protein P35222-1 original sequence version: 181 DIP protein P35222 original sequence version: 181 DIP protein P35222 original sequence version: 107 DIP protein P35222-1 original sequence version: 107 DIP protein P35222 original sequence version: 103 DIP protein P35222-1 original sequence version: 103 DIP protein P35222 original sequence version: 175 DIP protein P35222 original sequence version: 136 DIP protein P35222 original sequence version: 135 DIP protein P35222 original sequence version: 131 DIP protein P35222-1 original sequence version: 133 DIP protein P35222 original sequence version: 133 DIP protein P35222 original sequence version: 148 DIP protein P35222-1 original sequence version: 139 DIP protein P35222 original sequence version: 139 DIP protein P35222 original sequence version: 146 DIP protein P35222 original sequence version: 196 DIP protein P35222 original sequence version: 192 DIP protein P35222 original sequence version: 185 DIP protein P35222 original sequence version: 151 DIP protein P35222-1 original sequence version: 151 DIP protein P35222-1 original sequence version: 171 DIP protein P35222-1 original sequence version: 148 DIP protein P35222 original sequence version: 177 DIP protein P35222 original sequence version: 178 DIP protein P35222-1 original sequence version: 178 CB78F165A3EEF86E hif1a_human Hypoxia-inducible factor 1-alpha ARNT-interacting protein Member of PAS protein 1 Basic-helix-loop-helix-PAS protein MOP1 HIF1A MOP1 BHLHE78 PASD8 PAS domain-containing protein 8 Class E basic helix-loop-helix protein 78 protein protein human Homo sapiens Human MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN DIP protein Q16665 original sequence version: 94 DIP protein Q16665 original sequence version: 98 DIP protein Q16665-1 original sequence version: 102 DIP protein Q16665 original sequence version: 102 DIP protein Q16665 original sequence version: 127 DIP protein Q16665 original sequence version: 120 DIP protein Q16665 original sequence version: 169 DIP protein Q16665 original sequence version: 174 DIP protein Q16665-1 original sequence version: 174 DIP protein Q16665-1 original sequence version: 191 DIP protein Q16665 original sequence version: 191 DIP protein Q16665 original sequence version: 179 DIP protein Q16665 original sequence version: 150 DIP protein Q16665 original sequence version: 156 DIP protein Q16665 original sequence version: 177 ABD4F7DAA135BE2D ctnnb1-hif1a-3 1 3 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level 4 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association 5a lenti-AS-566 (a miR-566 inhibitor) ctnnb1-hif1a-1 1 4 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level 3 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association 5a lenti-AS-566 (a miR-566 inhibitor) ctnnb1-hif1a-4 2 3 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level 4 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association 5a lenti-AS-566 (a miR-566 inhibitor) ctnnb1-hif1a-5 2 4 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level 3 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association 5a lenti-AS-566 (a miR-566 inhibitor)