I2D I2D Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene (0950-9232) 2012 imex curation Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr 15-Nov-2012: Contacted by pporras. Only protein-protein interactions Curated by: I2D - Interologous Interaction Database human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr Accepted 2012-OCT-31 by MGT 15-Nov-2012: Contacted by pporras. Oncogene (0950-9232) 2012 Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene (0950-9232) 2012 imex curation Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr 15-Nov-2012: Contacted by pporras. Only protein-protein interactions Curated by: I2D - Interologous Interaction Database human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma pla proximity ligation assay pELISA pELISA PLA tag visualisation tag visualisation Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr Accepted 2012-OCT-31 by MGT 15-Nov-2012: Contacted by pporras. Oncogene (0950-9232) 2012 Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene (0950-9232) 2012 imex curation Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr 15-Nov-2012: Contacted by pporras. Only protein-protein interactions Curated by: I2D - Interologous Interaction Database human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr Accepted 2012-OCT-31 by MGT 15-Nov-2012: Contacted by pporras. Oncogene (0950-9232) 2012 Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene (0950-9232) 2012 imex curation Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr 15-Nov-2012: Contacted by pporras. Only protein-protein interactions Curated by: I2D - Interologous Interaction Database human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr Accepted 2012-OCT-31 by MGT 15-Nov-2012: Contacted by pporras. Oncogene (0950-9232) 2012 Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene (0950-9232) 2012 imex curation Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr 15-Nov-2012: Contacted by pporras. Only protein-protein interactions Curated by: I2D - Interologous Interaction Database human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Germann S., Gratadou L., Zonta E., Dardenne E., Gaudineau B., Fougere M., Samaan S., Dutertre M., Jauliac S., Auboeuf D. Cancer - Interactions investigated in the context of cancer Author confirms that HA-ddx5, MYC-NFAT5 and FLAG-ddx17 are human. didier.auboeuf@inserm.fr Accepted 2012-OCT-31 by MGT 15-Nov-2012: Contacted by pporras. Oncogene (0950-9232) 2012 Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database lcn2_human_gene Human lipocalin 2 gene gene human Homo sapiens Human nfat5_human Nuclear factor of activated T-cells 5 NFAT5 KIAA0827 TONEBP T-cell transcription factor NFAT5 Tonicity-responsive enhancer-binding protein protein protein human Homo sapiens Human MPSDFISLLSADLDLESPKSLYSRESVYDLLPKELQLPPSRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLENQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNLDKVNIIPNALMTPLIPSSMIKSEDVTPMEVTAEKRSSTIFKTTKSVGSTQQTLENISNIAGNGSFSSPSSSHLPSENEKQQQIQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPNSDALLQQATQFQTRETQSREILQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQQQISSNIFPSPNSVSQLQNTIQQLQAGSFTGSTASGSSGSVDLVQQVLEAQQQLSSVLFSAPDGNENVQEQLSADIFQQVSQIQSGVSPGMFSSTEPTVHTRPDNLLPGRAESVHPQSENTLSNQQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSTASANGNLQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTSSSGDGEETGTQAKQIQNSVFQTMVQMQHSGDNQPQVNLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSLFHSPNPIVHSQTSTTSSEQMQPPMFHSQSTIAVLQGSSVPQDQQSTNIFLSQSPMNNLQTNTVAQEAFFAAPNSISPLQSTSNSEQQAAFQQQAPISHIQTPMLSQEQAQPPQQGLFQPQVALGSLPPNPMPQSQQGTMFQSQHSIVAMQSNSPSQEQQQQQQQQQQQQQQQQQSILFSNQNTMATMASPKQPPPNMIFNPNQNPMANQEQQNQSIFHQQSNMAPMNQEQQPMQFQSQSTVSSLQNPGPTQSESSQTPLFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSINQQDMQQSPLYSPQNNMPGIQGATSSPQPQATLFHNTAGGTMNQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAISQPGQPQNEGQPPVTTLLSQQMPENSPLASSINTNQNIEKIDLLVSLQNQGNNLTGSF A68C68088DABF69E ddx5_human Probable ATP-dependent RNA helicase DDX5 HLR1 DDX5 HELR G17P1 DEAD box protein 5 RNA helicase p68 protein protein human Homo sapiens Human MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ DIP protein P17844 original sequence version: 98 DIP protein P17844 original sequence version: 148 DIP protein P17844 original sequence version: 137 DIP protein P17844 original sequence version: 124 DIP protein P17844 original sequence version: 177 DIP protein P17844-1 original sequence version: 177 DIP protein P17844 original sequence version: 179 DIP protein P17844 original sequence version: 182 84DF684FD6871594 s100a4_human_gene Human S100 calcium binding protein A4 gene gene human Homo sapiens Human ddx17_human Probable ATP-dependent RNA helicase DDX17 DEAD box protein 17 RNA-dependent helicase p72 DEAD box protein p72 DDX17 DEAD box protein p82 protein protein human Homo sapiens Human MPTGFVAPILCVLLPSPTREAATVASATGDSASERESAAPAAAPTAEAPPPSVVTRPEPQALPSPAIRAPLPDLYPFGTMRGGGFGDRDRDRDRGGFGARGGGGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNSAFGAQAGQYTYGQGTYGAAAYGTSSYTAQEYGAGTYGASSTTSTGRSSQSSSQQFSGIGRSGQQPQPLMSQQFAQPPGATNMIGYMGQTAYQYPPPPPPPPPSRK DIP protein Q92841 original sequence version: 89 DIP protein Q92841 original sequence version: 125 DIP protein Q92841 original sequence version: 112 DIP protein Q92841 original sequence version: 134 DIP protein Q92841 original sequence version: 145 DIP protein Q92841 original sequence version: 129 C819F53515B1BC39 nfat5-ddx17 1 10 unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 7 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 1a ddx17-nfat5 1 7 unspecified role unspecified role prey prey region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 10 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 1a ddx5-nfat5 5 7 unspecified role unspecified role prey prey region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 8 unspecified role unspecified role bait bait physical association physical association 1b ddx5-nfat5-1 1 7 unspecified role unspecified role prey prey region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 8 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 1b ddx5-nfat5-2 2 8 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 1d ddx17-nfat5-1 2 10 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 1d nfat5-s100a4 3 7 unspecified role unspecified role bait bait 9 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 3b, S3 nfat5-lcn2 3 7 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 3b, S3 ddx5-s100a4 3 8 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 9 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 3e/f, S3 NFAT5 depletion reduced the recruitment of HA-ddx5 and FLAG-ddx17. ddx5-lcn2 3 8 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 3e/f, S3 NFAT5 depletion reduced the recruitment of HA-ddx5 and FLAG-ddx17. ddx17-lcn2 3 10 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 3e/f, S3 NFAT5 depletion reduced the recruitment of HA-ddx5 and FLAG-ddx17. ddx17-s100a4 3 10 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 9 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 3e/f, S3 NFAT5 depletion reduced the recruitment of HA-ddx5 and FLAG-ddx17. nfat5-ddx5 4 7 unspecified role unspecified role bait bait 8 unspecified role unspecified role prey prey physical association physical association 1c