IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. throughout this paper there are many instances when it is not clear if ERG or the TMPRSS-ERG fusion protein is used (as e.g -bait or prey) - I have entered the appropriate molecule when it IS obvious - but as TMPRSS2 exon 1 is non-coding, the 2 proteins are often, in effect, interchangeable... A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. This interaction is the same as Fig 1B - only ERG-V5 is over-expressed in this one.(+ tag on presumed Bait) Cells were infected with adenovirus encoding V5-ERG. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-pc3 Human PC3 Caucasian prostate adenocarcinoma pc3 Human Caucasian prostate adenocarcinoma ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. Formaldehyde was used as a cross-linking agent. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-pc3 Human PC3 Caucasian prostate adenocarcinoma pc3 Human Caucasian prostate adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-rwpe Human -RWPE rwpe RWPE Non-neoplastic adult human prostatic epithelial cells from a white male donor were immortalized with human papillomavirus 18 which resulted in the establishment of the RWPE-1 cell line. ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. It is not stated which of the RWPE cell lines were used. The benign immortalized prostate epithelial cell line RWPE was infected with lentivirus expressing ERG. (Tomlins et al,. 2008) Formaldehyde was used as a cross-linking agent. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-rwpe Human -RWPE rwpe RWPE Non-neoplastic adult human prostatic epithelial cells from a white male donor were immortalized with human papillomavirus 18 which resulted in the establishment of the RWPE-1 cell line. anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. It is not stated which of the RWPE cell lines were used. Cells were infected with adenovirus encoding V5-ERG. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. Serial ChIP reactions (ERG, then PARP1 or DNA-PKcs) demonstrated that an ERG:PARP1 complex and an ERG:DNA-PKcs complex are both present at ERG-regulated loci. Re-ChIP using an antibody to PRKDC and PARP1 after a first round IP using an anti-ERG antibody. Formaldehyde was used as a cross-linking agent. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. Formaldehyde was used as a cross-linking agent. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-prostate_carcinoma Homo sapiens prostate carcinoma prostate_carcinoma Prostate carcinoma (cancer) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. The antibody used to detect ERG is to "ERG 1/2/3" - I assume this means isoforms of ERG -UniProt P11308 (rather than e.g. any of the "Potassium voltage-gated channel subfamily XXX ")etc... P11308 added as a Prey - though it is a bait as well.(this cell line contains the fusion protein) A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. not sure what the aa nos for the ETS domain are meant to be from Fig 1F - so I blasted the aas for the ETS domain from Isoform 3 (canonical) -and took the aa nos for P11308-1 (entered here) - whixh has 462 aas - the only isoform that does...as shown in Fig 1F. I then found out that the mutation "Y373A" refers to the isoform P11308-4 - not the one in Fig 1F! So I have found the equivalent residue in P11308-1 and entered a caution. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. Cancer Cell (1535-6108) 2011 imex curation Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu 23-Sept-2011: Contacted by JYOTI. orchard Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Accepted 2011-AUG-08 by ORCHARD 23-Sept-2011: Contacted by JYOTI. Cancer Cell (1535-6108) 2011 orchard Only protein-protein interactions imex curation ets1_human Protein C-ets-1 p54 ETS1 EWSR2 protein protein human Homo sapiens Human MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGRTSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE DIP protein P14921 original sequence version: 175 3B66BCC464B393FB if2a_human Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 EIF2A Eukaryotic translation initiation factor 2 subunit alpha protein protein human Homo sapiens Human MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED DIP protein P05198 original sequence version: 149 FF3E75E3816E6B1E tbb5_human Tubulin beta chain TUBB Tubulin beta-5 chain TUBB5 OK/SW-cl.56 protein protein human Homo sapiens Human MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA DIP protein P07437 original sequence version: 170 1E6CD0A36773A103 parp1_human Poly [ADP-ribose] polymerase 1 PARP1 ADPRT PPOL NAD(+) ADP-ribosyltransferase 1 Poly[ADP-ribose] synthase 1 ADP-ribosyltransferase diphtheria toxin-like 1 DNA ADP-ribosyltransferase PARP1 Protein poly-ADP-ribosyltransferase PARP1 protein protein human Homo sapiens Human MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW DIP protein P09874 original sequence version: 189 DIP protein P09874 original sequence version: 183 DIP protein P09874 original sequence version: 166 DIP protein P09874 original sequence version: 117 DIP protein P09874 original sequence version: 143 DIP protein P09874 original sequence version: 136 DIP protein P09874 original sequence version: 137 DIP protein P09874 original sequence version: 147 DIP protein P09874 original sequence version: 193 DIP protein P09874 original sequence version: 202 DIP protein P09874 original sequence version: 171 DIP protein P09874 original sequence version: 153 DIP protein P09874 original sequence version: 175 6A5FC01EB91C046B xrcc5_human X-ray repair cross-complementing protein 5 XRCC5 G22P2 ATP-dependent DNA helicase II 80 kDa subunit Lupus Ku autoantigen protein p86 86 kDa subunit of Ku antigen Ku86 Ku80 Thyroid-lupus autoantigen CTC box-binding factor 85 kDa subunit Nuclear factor IV DNA repair protein XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) ATP-dependent DNA helicase 2 subunit 2 protein protein human Homo sapiens Human MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDMI DIP protein P13010 original sequence version: 128 DIP protein P13010 original sequence version: 127 DIP protein P13010 original sequence version: 122 DIP protein P13010 original sequence version: 174 DIP protein P13010 original sequence version: 153 DIP protein P13010 original sequence version: 155 DIP protein P13010 original sequence version: 142 2363CA84834E74A3 erg_human Transcriptional regulator ERG ERG Transforming protein ERG protein protein human Homo sapiens Human MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY DIP protein P11308 original sequence version: 138 A5069C393E409483 p11308-4 Transcriptional regulator ERG ERG Transforming protein ERG protein protein human Homo sapiens Human MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY A5069C393E409483 b7z722_human TPM1 hCG_33495 protein protein human Homo sapiens Human MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM A175BDD53107B563 rs18_human 40S ribosomal protein S18 RPS18 D6S218E Ke-3 Small ribosomal subunit protein uS13 protein protein human Homo sapiens Human MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK DIP protein P62269 original sequence version: 125 4DAF0662C3F37F22 ddx5_human Probable ATP-dependent RNA helicase DDX5 HLR1 DDX5 HELR G17P1 DEAD box protein 5 RNA helicase p68 protein protein human Homo sapiens Human MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ DIP protein P17844 original sequence version: 98 DIP protein P17844 original sequence version: 148 DIP protein P17844 original sequence version: 137 DIP protein P17844 original sequence version: 124 DIP protein P17844 original sequence version: 177 DIP protein P17844-1 original sequence version: 177 DIP protein P17844 original sequence version: 179 DIP protein P17844 original sequence version: 182 84DF684FD6871594 prkdc_human DNA-dependent protein kinase catalytic subunit PRKDC HYRC HYRC1 DNPK1 p460 protein protein human Homo sapiens Human MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM DIP protein P78527 original sequence version: 118 DIP protein P78527-1 original sequence version: 117 DIP protein P78527 original sequence version: 170 DIP protein P78527 original sequence version: 179 DIP protein P78527 original sequence version: 114 DIP protein P78527 original sequence version: 125 AC6E747FEB09F3E5 prp8_human Pre-mRNA-processing-splicing factor 8 Splicing factor Prp8 PRP8 homolog 220 kDa U5 snRNP-specific protein p220 PRPC8 PRPF8 protein protein human Homo sapiens Human MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPISHRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPGQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA DIP protein Q6P2Q9 original sequence version: 48 DIP protein Q6P2Q9 original sequence version: 129 DIP protein Q6P2Q9 original sequence version: 104 E823A15C60EA61C9 xrcc6_human X-ray repair cross-complementing protein 6 XRCC6 G22P1 ATP-dependent DNA helicase II 70 kDa subunit Lupus Ku autoantigen protein p70 70 kDa subunit of Ku antigen Thyroid-lupus autoantigen CTC box-binding factor 75 kDa subunit DNA repair protein XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 ATP-dependent DNA helicase 2 subunit 1 5'-deoxyribose-5-phosphate lyase Ku70 protein protein human Homo sapiens Human MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELLEALTKHFQD DIP protein P12956 original sequence version: 184 DIP protein P12956 original sequence version: 138 DIP protein P12956 original sequence version: 185 DIP protein P12956 original sequence version: 164 DIP protein P12956 original sequence version: 166 BBD3CD434526DFCB p78527-1 DNA-dependent protein kinase catalytic subunit PRKDC HYRC HYRC1 DNPK1 p460 protein protein human Homo sapiens Human MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM AC6E747FEB09F3E5 hnrpm_human Heterogeneous nuclear ribonucleoprotein M HNRNPM HNRPM NAGR1 protein protein human Homo sapiens Human MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA DIP protein P52272 original sequence version: 71 DIP protein P52272 original sequence version: 86 1A73DD35A3501861 b2y833_human ERG protein protein human Homo sapiens Human MTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPVSYR tmps2_human_gene Human TMPS2/TMPRSS2 gene gene gene human Homo sapiens Human etv1_human ETS translocation variant 1 ETV1 ER81 Ets-related protein 81 protein protein human Homo sapiens Human MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYVY DIP protein P50549 original sequence version: 102 BE95FA3F07196F06 roa2_human Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1 HNRPA2B1 protein protein human Homo sapiens Human MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY DIP protein P22626 original sequence version: 152 DIP protein P22626 original sequence version: 159 4C2560A3D8E99D62 p11308-1 Transcriptional regulator ERG ERG Transforming protein ERG ERG-2 protein protein human Homo sapiens Human MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY B29F14B0F5C2C697 hnrdl_human Heterogeneous nuclear ribonucleoprotein D-like HNRNPDL AU-rich element RNA-binding factor HNRPDL JKT41-binding protein JKTBP Protein laAUF1 protein protein human Homo sapiens Human MEVPPRLSHVPPPLFPSAPATLASRSLSHWRPRPPRQLAPLLPSLAPSSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY 00F631863859D0CA pyr1_human CAD protein CAD protein protein human Homo sapiens Human MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF DIP protein P27708 original sequence version: 163 2AB8E8413E825A8F pla1a_human_gene PLA1A-Phospholipase A1 member A gene gene human Homo sapiens Human atpa_human ATP synthase subunit alpha, mitochondrial ATP5F1A ATP synthase F1 subunit alpha ATP5A ATP5A1 ATP5AL2 ATPM protein protein human Homo sapiens Human MLSVRVAAAVVRALPRRAGLVSRNALGSSFIAARNFHASNTHLQKTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQHQALLGTIRADGKISEQSDAKLKEIVTNFLAGFEA DIP protein P25705 original sequence version: null DIP protein P25705 original sequence version: 136 AA47BBB8EDA77EAC hnrpu_human Heterogeneous nuclear ribonucleoprotein U HNRNPU SAFA U21.1 HNRPU p120 pp120 C1orf199 GRIP120 Nuclear p120 ribonucleoprotein Scaffold-attachment factor A protein protein human Homo sapiens Human MSSSPVNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALDDEEAGGRPAMEPGNGSLDLGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGDQMELGEENGAAGAADSGPMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAAKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEGGGGGGRPGAPAAGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGQFWGQKPWSQHYHQGYY DIP protein Q00839 original sequence version: 122 5D4EC4188436831F rla0_human 60S acidic ribosomal protein P0 RPLP0 60S ribosomal protein L10E Large ribosomal subunit protein uL10 protein protein human Homo sapiens Human MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD 255AD25571C51199 sptn1_human Spectrin alpha chain, non-erythrocytic 1 SPTAN1 SPTA2 Alpha-II spectrin Fodrin alpha chain NEAS Spectrin, non-erythroid alpha subunit protein protein human Homo sapiens Human MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN 4433BF74EFCEFC8A klk3_human_gene Human kallikrein-related peptidase 3 (KLK3) (PSA) gene gene human Homo sapiens Human fkbp5_human_gene Human FKBP5 gene gene gene human Homo sapiens Human p19474-1 E3 ubiquitin-protein ligase TRIM21 TRIM21 RNF81 52 kDa ribonucleoprotein autoantigen Ro/SS-A RING finger protein 81 Ro(SS-A) Sjoegren syndrome type A antigen Tripartite motif-containing protein 21 52 kDa Ro protein RO52 SSA1 52alpha Ro52alpha RING-type E3 ubiquitin transferase TRIM21 protein protein human Homo sapiens Human MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY DDFF2944AFC629FB spi1_human Transcription factor PU.1 SPI1 31 kDa-transforming protein protein protein human Homo sapiens Human MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHSEFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRHPPH DIP protein P17947 original sequence version: 88 9592DAA1D85053ED pcbp1_human Poly(rC)-binding protein 1 PCBP1 Alpha-CP1 Nucleic acid-binding protein SUB2.3 Heterogeneous nuclear ribonucleoprotein E1 protein protein human Homo sapiens Human MDAGVTESGLNVTLTIRLLMHGKEVGSIIGKKGESVKRIREESGARINISEGNCPERIITLTGPTNAIFKAFAMIIDKLEEDINSSMTNSTAASRPPVTLRLVVPATQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGVPQSVTECVKQICLVMLETLSQSPQGRVMTIPYQPMPASSPVICAGGQDRCSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVARQQSHFAMMHGGTGFAGIDSSSPEVKGYWASLDASTQTTHELTIPNNLIGCIIGRQGANINEIRQMSGAQIKIANPVEGSSGRQVTITGSAASISLAQYLINARLSSEKGMGCS DIP protein Q15365 original sequence version: 141 DIP protein Q15365 original sequence version: 116 6D1A261276CA206D ddx3x_human ATP-dependent RNA helicase DDX3X DDX3X DBX DDX3 DEAD box protein 3, X-chromosomal Helicase-like protein 2 DEAD box, X isoform CAP-Rf protein protein human Homo sapiens Human MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN DIP protein O00571 original sequence version: 116 DIP protein O00571 original sequence version: 123 7074D2B8A6EBBF09 rl7a_human 60S ribosomal protein L7a RPL7A SURF-3 SURF3 Surfeit locus protein 3 PLA-X polypeptide Large ribosomal subunit protein eL8 protein protein human Homo sapiens Human MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG DIP protein P62424 original sequence version: 106 54EF43F221D9F704 b2y833-erg 1 26 unspecified role unspecified role prey prey 47 unspecified role unspecified role prey prey 46 unspecified role unspecified role prey prey 33 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 44 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 40 unspecified role unspecified role prey prey 35 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 48 unspecified role unspecified role prey prey 36 unspecified role unspecified role prey prey 38 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey 39 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 41 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 30 unspecified role unspecified role bait bait region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 1A/S1A/TABLE S1 b2y833-erg-1 7 26 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 36 unspecified role unspecified role prey prey 47 unspecified role unspecified role prey prey 48 unspecified role unspecified role prey prey 35 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 41 unspecified role unspecified role prey prey 40 unspecified role unspecified role prey prey 39 unspecified role unspecified role prey prey 44 unspecified role unspecified role prey prey 46 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey 38 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 33 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 30 unspecified role unspecified role bait bait v5_or_flag_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 28 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey association association Fig 1A/S1A/TABLE S1 b2y833-erg-3 12 25 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 30 unspecified role unspecified role bait bait association association Fig 1B, S1C. Ethidium bromide treatment disrupted the interaction between ERG, Ku70, and Ku80, but not the interaction between ERG and either PARP1 or DNA-PKcs. b2y833-erg-4 11 27 unspecified role unspecified role prey prey 30 unspecified role unspecified role bait bait 18 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey association association Fig 1C, S1F, S1H. ERG-IP showed enrichment for DNA-PKcs, Ku70, Ku80, and PARP1 in ERG gene fusion-positive, but not in ETS gene fusion-negative, prostate cancer tissues. The interaction between ERG and PAPRP1 occurred in the absence of DNA (in the presence of ethidium bromide) in all three independent human (prostate cancer) tissues (Figure S1H). erg 14 21 unspecified role unspecified role bait bait c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged certain certain sequence position certain certain certain sequence position certain region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 18 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey association association Fig 1E erg-prkdc 13 34 unspecified role unspecified role bait bait halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined partial_ets_domain required to bind necessary binding region required to bind range range range range P11308-1:p.Tyr356Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain Y A Wed May 02 16:37:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr356ala' Tue Jun 30 17:15:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr356Ala' in vitro In vitro 25 unspecified role unspecified role prey prey human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 direct interaction direct interaction Fig 1F, S1M, S1N, S1P. The interaction was localised to the final 28 amino acids of the ETS domain. The mutation stated to be Y373A (as can be found in P11308-4) has been entered as Y356A - which corresponds to the same amino acid in isoform P11308-1 (as shown in Fig 1). erg-fkbp5-1 10 43 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait association association Fig 2A,S2A. ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-klk3-2 10 42 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait association association Fig 2A, S2A. ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-tmps2-1 10 20 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey association association Fig 2A, S2A. ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-pla1a 10 20 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association Fig 2A, S2A. ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-pla1a 10 37 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-fkbp5 10 43 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-klk3 10 42 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-tmps2 10 31 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-klk3 10 42 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-fkbp5 10 25 unspecified role unspecified role bait bait 43 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-tmps2 10 25 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-pla1a 10 25 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-tmps2 10 27 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-fkbp5 10 43 unspecified role unspecified role prey prey 27 unspecified role unspecified role bait bait association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-klk3 10 27 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-pla1a 10 27 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-pla1a 10 19 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-fkbp5 10 43 unspecified role unspecified role prey prey 19 unspecified role unspecified role bait bait association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-klk3 10 19 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-tmps2 10 19 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey association association Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-fkbp5-1 5 25 unspecified role unspecified role bait bait 43 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-pla1a-1 5 27 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-tmps2-2 5 20 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey association association Fig 2A ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-tmps2-1 5 25 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-tmps2-1 5 27 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-tmps2-1 5 31 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-pla1a-1 5 20 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association Fig 2A ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-pla1a-1 5 19 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-fkbp5-1 5 27 unspecified role unspecified role bait bait 43 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-klk3-3 5 20 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association Fig 2A ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-pla1a-1 5 37 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-klk3-1 5 42 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-fkbp5-1 5 18 unspecified role unspecified role bait bait 43 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-tmps2-1 5 19 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-pla1a-1 5 37 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-klk3-1 5 19 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-klk3-1 5 27 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-fkbp5-2 5 20 unspecified role unspecified role bait bait 43 unspecified role unspecified role prey prey association association Fig 2A ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-klk3-1 5 42 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-fkbp5-1 5 43 unspecified role unspecified role prey prey 19 unspecified role unspecified role bait bait association association Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. b2y833-erg-5 2 19 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 27 unspecified role unspecified role prey prey 30 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey association association Supp. Fig 1B Ethidium bromide treatment disrupted the interaction between ERG, Ku70, and Ku80, but not the interaction between ERG and either PARP1 or DNA-PKcs. prkdc-erg 8 25 unspecified role unspecified role bait bait 18 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig S1D parp1-erg 8 20 unspecified role unspecified role prey prey region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 18 unspecified role unspecified role bait bait physical association physical association Fig S1D xrcc5-erg 8 19 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 18 unspecified role unspecified role prey prey association association Fig S1D parp1-lots 12 20 unspecified role unspecified role prey prey 30 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait 25 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey association association Fig S1E. erg-parp1 6 20 unspecified role unspecified role bait bait 25 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey association association Fig S1G ets1-parp1 14 15 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 18 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey association association Fig S1J spi1-parp1 14 25 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 45 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig S1K etv1-parp1 14 27 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 32 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig S1L ets1-prkdc 13 15 unspecified role unspecified role bait bait halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined in vitro In vitro 25 unspecified role unspecified role prey prey human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 direct interaction direct interaction Fig S1M etv1-prkdc 13 25 unspecified role unspecified role prey prey human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 32 unspecified role unspecified role bait bait halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined in vitro In vitro direct interaction direct interaction Fig S1M spi1-prkdc 13 25 unspecified role unspecified role prey prey human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 45 unspecified role unspecified role bait bait halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined in vitro In vitro direct interaction direct interaction Fig S1M erg-parp1 13 18 unspecified role unspecified role prey prey ecoli Escherichia coli (strain K12) 34 unspecified role unspecified role bait bait partial_ets_domain required to bind necessary binding region required to bind range range range range halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined in vitro In vitro direct interaction direct interaction Fig S1O. The interaction was localised to the final 28 amino acids of the ETS domain. Ethidium bromide -purified ERG was only able to interact with purified PARP1 in the absence of ethidium bromide. parp1-klk3 9 20 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association Fig S2C. parp1-pla1a 9 20 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey association association Fig S2C parp1-fkbp5 9 43 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig S2C. parp1-tmps2 9 31 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait association association Fig S2C prkdc-tmps2 9 25 unspecified role unspecified role bait bait 31 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey association association Fig S2C prkdc-pla1a 9 37 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey association association Fig S2C prkdc-klk3 9 42 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait association association Fig S2C prkdc-fkbp5 9 25 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey 43 unspecified role unspecified role prey prey association association Fig S2C prkdc-parp1 12 27 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait association association Fig S2D. PARP1 and DNA-PKcs interact in a DNA-independent manner in VCaP cells. (in the presence of Ethidium bromide there was no interaction observed between DNA-PKcs and Ku70.) b2y833-erg-6 4 25 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 30 unspecified role unspecified role bait bait 18 unspecified role unspecified role prey prey association association Fig S5D IP-western confirmed the ERG:DNA-PKcs and ERG:PARP1 interactions. erg-tmps2-3 3 31 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait association association Fig S5E ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-fkbp5-3 3 43 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait association association Fig S5E ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-klk3-4 3 20 unspecified role unspecified role bait bait 42 unspecified role unspecified role prey prey association association Fig S5E ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-pla1a-2 3 37 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait association association Fig S5E ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers.