IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-bd215 Homo sapiens Fanconi anaemia cell lines BD215 (FA-C) bd215 Human Fanconi anaemia cell lines BD215 (FA-C) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-hcs72 Homo sapiens Fanconi anaemia cell line HCS72 (FA-A) hcs72 Human Fanconi anaemia cell line HCS72 (FA-A) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions crigr-v79 Cricetulus griseus lung fibroblast V79 cell line v79 Chinese hamster lung fibroblast V79 cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-326v Homo sapiens Fanconi anaemia fibroblast cell line 326V (FA-G) 326v Human Fanconi anaemia fibroblast cell line 326V (FA-G) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-3a_tpa_30_1 Homo sapiens 3A(tPA-30-1) cell line 3a_tpa_30_1 Human placental cell line 3A(tPA-30-1) ( transformed by SV40 ts30) This is a hypodiploid human cell line with the modal chromosome number of 42 occurring in 34% of cells. However, cells with 44 chromosomes also occurred at a high frequency (26%). Most cells contained 41-45 chromosomes. Cells having a higher ploidy occurred at 20.7%, which is very high. Most cells averaged five or six marker chromosomes, none of which appeared twice in the cells examined. No chromosomes were paired consistently. (The cells are sometimes referred by the ATCC catalogue no. CRL-1583. However, these catalogue nos are not stable identifiers). anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-eufa121 Homo sapiens Fanconi anaemia cell lines EUFA121 (FA-F) eufa121 Human Fanconi anaemia cell line EUFA121 (FA-F) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions crigr-40bp6 Cricetulus griseus ovary derived cells (FANCG-corrected) 40bp6 Chinese hamster ovary cell derived cell line 40BP6 (FANCG-corrected) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-bd180 Homo sapiens BD180 cell line bd180 Human cell line BD180 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions crigr-aa8 Cricetulus griseus AA8 cell line (derived from CHO-K1) aa8 Chinese hamster cell line (derived from CHO-K1) This line is a derivative of the CHO-K1 cell line. The AA8 line has 21 chromosomes and is heterozygous at the aprt locus. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions crigr-nm3 Cricetulus griseus - CHO derived cell line NM3 harbouring a mutation in FANCG nm3 Chinese hamster ovary cell derived cell line NM3 harbouring mutated FANCG This is a FA-like cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-pd20 Homo sapiens Fanconi anaemia cell line PD20 (FA-D2) pd20 Human Fanconi anaemia cell line PD20 (FA-D2) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-eufa409 Homo sapiens Fanconi anaemia cell lines EUFA409 (FA-E) eufa409 Human Fanconi anaemia cell lines EUFA409 (FA-E) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-bd220 Homo sapiens Fanconi anaemia cell line BD220 (FA-A) bd220 Fanconi anaemia cell line BD220 (FA-A) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene (0950-9232) 2008 imex curation Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk 14-May-2008: Contacted by JYOTI. davet Only protein-protein interactions human-eufa143 Homo sapiens Fanconi anaemia lymphoblast cell line EUFA143 (FA-G) eufa143 Human Fanconi anaemia lymphoblast cell line EUFA143 (FA-G) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Accepted 2008-MAR-27 by DAVET. 14-May-2008: Contacted by JYOTI. Oncogene (0950-9232) 2008 davet Only protein-protein interactions imex curation q8r4x4_crigr BRCA2 protein protein crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster KNCSHIQPWETDCLSCLPERQCEYDPKGPKVSDGKEEVLVSACHPAGQHTAAAQPSSISFELQEDPVNGHNSTSPKETPSLKVLLSKPVVLSRGKVSCKMPEKLQCESYKDNTELSKSIPLGGNKIHILSENSKPPELLPPGKYVTEASPTVKSQFNQNTNLAVKKNDQEETPFISEVTVNVSSGELFPDNENNFAFQVTHENNKTALGSTVELQEEDLRHAKGPNLNNSPTAVDGDIGDEQAAHALIMEDSDSSALVHECAKKSRNTIEQHLKGTTDKDFNSSLDVKSDGNNDYTDKWPGFLDPVFKHKFGGSFRTASNKEIKLSEHNVKKSKMFFKDIEEEYPTSLTCIDIVNASPLANQEILSGPYTFDLQSVTTMSAHPQSQASVSCEDTHTSLQVLPSKQDFHSNHNLTPSQKAEITELSTILEESGSQFEFTQFKKPSHVAQNNIPEVPGKQTVAINTTSEGWKRIGLHLTVDPASVAQTDDSKKFEGSAGFRQSFPCLLKSSCNKNTSSFLANVNEMEFRGFRSALGTKLSVSSEALQKAVKLFSDIESGSEETSTKVDPRALSSGARHDSGASVFKIRKQNSGKSFDEKTSKCQVTLQNNTEVTTGIFVDRNPENYARNTKCEDNNSTGFQRSPYKLKNSEDSESSTSGTVSVHQDDGDLPCAADHCSKYPESCSQYVREENTQIKECVSDLTCLEVMKAEETCYIQPSDKEQLPSGKMEQNRKDFNISFQTASGKNVRVSEESLSKSMNILNQVTDESIISSDSLNSKFHCGTNNNKMGISHHKETTSTKKVFEERFPVGTVSQLPTLQQHPRCEIESIKEPALLGFHTASGKKVKIMQKSLDKVKNLFDETQYVSHQGSKPLKDRENCKEGLALGCETIEIPASKCEEMQKSFLSKESEVLSKQSDRLYRSTENLRTSNGTSSKANVHGNIESEIEKSPTTCCISHLSYSVTEDSALTCDTGHGRKTCVSESSLSKDRKWLRDRLGDKLQKRDAAEIECVKEHTEGYAGDASCEHSLDSIRNEVDINCVSENQTSALFSDPSMCHSCPSHFGCHCDNKHNDSGYFSKNKIYSDTQPDTKNEDTANFSSVYATKEVNIYPPTVNEDICVQKLETNSSPHTNKNVAIDLAIADSRNCKVCPSKFITDHSQETVKTVKAIFTHNSDKTIKQNTKSKPDTCRTSCQKALDNSEDFICPSSLEDDYMNSHKTSVYTHDEQILQHNLSVSGLEKAQIPPVHLETWDKCKSTRELAQAACSSHMPGIFSTASGKAVQVSDASLEKARQVFSEMDGGAKQLLSTLSLESHEQSDHSGRRENSVTHNPEDVLSLPKTFASNANSSVFSGFSTAGGKRVTVSESALHKVKGMLEEFDLIGTEHTLQCPPTSEGVSKILPQYCVEKRTPEYPINSKLQKTYDDKFSLPNNYKESASLGNTHSLEASPQLSQFKQDTRLVLGTKVSLLEKEQTFPQNIKTESGVMET 0D240808BD234BE4 q9bxw9-2 Fanconi anemia group D2 protein FANCD2 FACD protein protein human Homo sapiens Human MVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESPSLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVTPDYVPPLGNFDVETLDITPHTVTAISAKIRKKGKIERKQKTDGSKTSSSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEKTSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWPSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQNSQESTADESEDDMSSQASKSKATEDGEEDEVSAGEKEQDSDESYDDSD Contains a phosphoserine at position 1423. Contains a phosphothreonine at position 1426. Contains a phosphoserine at position 1435. BF931980ADA67405 fancg_human Fanconi anemia group G protein FANCG XRCC9 DNA repair protein XRCC9 protein protein human Homo sapiens Human MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL 4BC7475472AC3C84 brca2_human Breast cancer type 2 susceptibility protein BRCA2 FANCD1 FACD Fanconi anemia group D1 protein protein protein human Homo sapiens Human MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVVDTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCENDPKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLSNLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYMRVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNNLALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVKQHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLSEHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSDCKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKSTFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDCNKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQIKEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAKESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTGNQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFSHQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNLCRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTSVSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYLSNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAYPQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLISQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQNVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQDKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKERQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKNNSNQAAAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLIAASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSVSTPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI DIP protein P51587 original sequence version: 162 DIP protein P51587 original sequence version: 83 DIP protein P51587 original sequence version: 145 DIP protein P51587 original sequence version: 122 DIP protein P51587 original sequence version: 120 DIP protein P51587 original sequence version: 138 DIP protein P51587 original sequence version: 125 DIP protein P51587 original sequence version: 123 DIP protein P51587 original sequence version: 155 DIP protein P51587 original sequence version: 168 DIP protein P51587 original sequence version: 156 DIP protein P51587 original sequence version: 180 6A0B3B7B332153EB facd2_human Fanconi anemia group D2 protein FANCD2 FACD protein protein human Homo sapiens Human MVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESPSLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVTPDYVPPLGNFDVETLDITPHTVTAISAKIRKKGKIERKQKTDGSKTSSSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEKTSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWPSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQNSQESTADESEDDMSSQASKSKATEDGEEDEVSAGEKEQDSDESYDDSD DIP protein Q9BXW9 original sequence version: 96 DIP protein Q9BXW9 original sequence version: 111 DIP protein Q9BXW9-2 original sequence version: 44 DIP protein Q9BXW9 original sequence version: 93 BF931980ADA67405 g3gx36_crigr I79_002348 protein protein crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster MLLIIYSTSTQTKKGSEKVLRNKIQSGCIQEQLLEGTFSTHYMVLKDICPSILLLAQTLFHSQDQRIILFGSLLYKYAFKFFDTYCQQEVVGALVTHVCSGNEAEVDTALDVLLELIALNPSAMRLNAVFVKGILDYLETMSPQQIRKIFCILSTLAFSQQPGTSNHIQDEMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRSVPSNSTQRRADLSSEWCTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVGQTIFNDFQDAFVVDFCAIPEGDFPFPVKALYGLEESSTQDGIVINLLPLFFQEFAGVSQMTSQESSQKSMSSLCLASHFRLLRLCVARQHNGNLDEIDGLLDCPLFLPDLEPGEKLESMSAKERSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVIPDYVPPFANVDMDTLDMIPKSSSAVSTKNRNKGKMGGRKQKADISKASSTETLLTEDTSECDTVTSGRSPVEKESAGKEGKTFVSLQNYHAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENVLTPSFAKRLCFLKNKGNRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNYFQSLGAEHLSVDDKPRVKAQEQHTMSSCYQKLLQIFYTLFAWKGFTHHSNLHLLHSALEVLTSRLKQTEQEQPLEELISQSFNYLQNFHHCIPNFQCGLYLLRLLMTLLEKSAAPTQKKEKLATLAKQLLCRAWPHGEKEKNTNFNDHLHDLLCIYLEHTDNVLKAIEEIAGVGVPELVNAPKDASSSTFPMLTRHTFVIFFRVMMAELEKTVKSLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRHFVEAFLKQCMPLLDFCFRKHREDVLSLLETLQRNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIVSQHLSSPESTSEDSESGMTSHVSRDRATQDGEDEASDGQKDQDNDESDDSSD fancd2-brca2 7 20 unspecified role unspecified role bait bait 19 unspecified role unspecified role prey prey physical association physical association 1 A, 2B BRCA2 co-immunoprecipitated using FANCD2 antisera in bothwi ld-type cells(HeLa and CRL-1583) and cells from groups FA-A/C/E/F fancd2-brca2-3 5 20 unspecified role unspecified role bait bait 19 unspecified role unspecified role prey prey physical association physical association 1 A BRCA2 co-immunoprecipitated using FANCD2 antisera in bothwi ld-type cells(HeLa and CRL-1583) and cells from groups FA-A/C/E/F fancd2-brca2-4 14 20 unspecified role unspecified role bait bait 19 unspecified role unspecified role prey prey physical association physical association 1 A BRCA2 co-immunoprecipitated using FANCD2 antisera in bothwi ld-type cells(HeLa and CRL-1583) and cells from groups FA-A/C/E/F fancd2-brca2-5 1 20 unspecified role unspecified role bait bait 19 unspecified role unspecified role prey prey physical association physical association 1 A BRCA2 co-immunoprecipitated using FANCD2 antisera in bothwi ld-type cells(HeLa and CRL-1583) and cells from groups FA-A/C/E/F fancd2-brca2-6 13 19 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait physical association physical association 1 A BRCA2 co-immunoprecipitated using FANCD2 antisera in bothwi ld-type cells(HeLa and CRL-1583) and cells from groups FA-A/C/E/F fancd2-brca2-7 6 19 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait physical association physical association 1 A BRCA2 co-immunoprecipitated using FANCD2 antisera in bothwi ld-type cells(HeLa and CRL-1583) and cells from groups FA-A/C/E/F fancd2-brca2-8 4 18 unspecified role unspecified role ancillary ancillary 19 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait association association 1 B Introduction of wild-type FANCG (either human cDNA or genomic hamster for 40BP6), and expression of FANCG protein in the four cell lines restored the interaction of FANCD2-BRCA2. Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2. fancd2-brca2-9 15 18 unspecified role unspecified role ancillary ancillary O15287:p.Ser7Ala mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain S A Wed May 02 19:35:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser7ala' Tue Jun 30 15:37:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser7Ala' 19 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait association association 1 B, 2 B, 3 B Introduction of wild-type FANCG (either human cDNA or genomic hamster for 40BP6), and expression of FANCG protein in the four cell lines restored the interaction of FANCD2-BRCA2. Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2. fancd2-brca2-10 11 18 unspecified role unspecified role ancillary ancillary O15287:p.Ser7Ala mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain S A Wed May 02 16:40:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser7ala' Tue Jun 30 16:00:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser7Ala' 21 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey association association 1 B, 3 A Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2. Introduction of wild-type FANCG (either human cDNA or genomic hamster for 40BP6), and expression of FANCG protein in the four cell lines restored the interaction of FANCD2-BRCA2. fancd2-brca2-11 8 21 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey physical association physical association 1 B, 3 A Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2. Introduction of wild-type FANCG (either human cDNA or genomic hamster for 40BP6), and expression of FANCG protein in the four cell lines restored the interaction of FANCD2-BRCA2. fancd2-brca2-12 12 17 unspecified role unspecified role bait bait Q9BXW9-2:p.Lys561Arg mutation mutation certain certain sequence position certain certain certain sequence position certain K R Wed May 02 16:22:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys561arg' Tue Jun 30 17:05:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys561Arg' 19 unspecified role unspecified role prey prey physical association physical association 2 B Coprecipitation of BRCA2 withFANCD2 was observed in wild-type cell lines and PD20-3-15 (functionally complemented withh uman chromosome 3p) and also in PD20K561R-FANCD2 Q9BXW9 transfection fancd2-brca2-13 12 19 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait physical association physical association 2 B Coprecipitation of BRCA2 withFANCD2 was observed in wild-type cell lines and PD20-3-15 (functionally complemented withh uman chromosome 3p) and also in PD20K561R-FANCD2 This interaction occurred in cells functionally complemented with human chromosome 3p. fancd2-brca2-14 2 19 unspecified role unspecified role prey prey 17 unspecified role unspecified role bait bait physical association physical association 2 B Coprecipitation of BRCA2 withFANCD2 was observed in wild-type cell lines and PD20-3-15 (functionally complemented withh uman chromosome 3p) and also in PD20K561R-FANCD2 and an additional FA-A cell line (HCS72). brca2-fancd2-4 10 21 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait physical association physical association 2 C, 3 A The two isoforms of FANCD2 can be distinguished in the wild-type cells, but only FANCD2-S co-precipitated with BRCA2 in human cells of complementation groups FA-A/C/E/F as expected The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2. brca2-fancd2-1 3 21 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait physical association physical association 2 C The two isoforms of FANCD2 can be distinguished in the wild-type cells, but only FANCD2-S co-precipitated with BRCA2 in human cells of complementation groups FA-A/C/E/F as expected The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2. brca2-fancd2-2 8 16 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey physical association physical association 2 C The two isoforms of FANCD2 can be distinguished in the wild-type cells, but only FANCD2-S co-precipitated with BRCA2 in human cells of complementation groups FA-A/C/E/F as expected The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2. The reintroduction of FANCG restores this interacton. fancd2-brca2-15 14 19 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey physical association physical association 2 C The two isoforms of FANCD2 can be distinguished in the wild-type cells, but only FANCD2-S co-precipitated withBRC A2 in human cells of complementation groups FA-A/C/E/F as expected Only the FANCD2-S isoform coimmunoprecipitates with BRCA2 in this FA-A cell line. fancd2-brca2-16 2 19 unspecified role unspecified role bait bait 17 unspecified role unspecified role prey prey physical association physical association 2 C Only the FANCD2-S isoform coimmunoprecipitates with BRCA2 in this FA-A cell line. fancd2-brca2-17 1 19 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey physical association physical association 2 C The two isoforms of FANCD2 can be distinguished in the wild-type cells, but only FANCD2-S co-precipitated withBRC A2 in human cells of complementation groups FA-A/C/E/F as expected fancd2-brca2-18 13 20 unspecified role unspecified role prey prey 19 unspecified role unspecified role bait bait physical association physical association 2 C The two isoforms of FANCD2 can be distinguished in the wild-type cells, but only FANCD2-S co-precipitated withBRC A2 in human cells of complementation groups FA-A/C/E/F as expected Only the FANCD2-S isoform coimmunoprecipitated with BRCA2 in the FA-E cell line. fancd2-brca2-19 6 19 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey physical association physical association 2 C The two isoforms of FANCD2 can be distinguished in the wild-type cells, but only FANCD2-S co-precipitated withBRC A2 in human cells of complementation groups FA-A/C/E/F as expected Only the FANCD2-S isoform coimmunoprecipitated with BRCA2 in theis FA-F cell line. fancd2-brca2-20 9 19 unspecified role unspecified role prey prey 20 unspecified role unspecified role bait bait physical association physical association 2 B, 3 B Coprecipitation of BRCA2 withFANCD2 was observed in wild-type cell lines