IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. J. Proteome Res. (1535-3893) 2007 imex curation Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Only protein-protein interactions human-a_549 Homo sapiens Caucasian lung carcinoma cell line a_549 Human Caucasian lung carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. This experiment relates to a negative interaction. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Accepted 2007-APR-7 by JYOTI. J. Proteome Res. (1535-3893) 2007 Only protein-protein interactions imex curation A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. J. Proteome Res. (1535-3893) 2007 imex curation Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Only protein-protein interactions mouse-flec Mus musculus fetal lung epithelial cells from murine lungs at E16 foetal_lung_epithelium fetal lung epithelial cells (FLECs) antibody array antibody array sandwich immunoassay antigen capture assay antibody detection identification by antibody antibody detection Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Accepted 2007-APR-7 by JYOTI. J. Proteome Res. (1535-3893) 2007 Only protein-protein interactions imex curation A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. J. Proteome Res. (1535-3893) 2007 imex curation Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Only protein-protein interactions human-a_549 Homo sapiens Caucasian lung carcinoma cell line a_549 Human Caucasian lung carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Accepted 2007-APR-7 by JYOTI. J. Proteome Res. (1535-3893) 2007 Only protein-protein interactions imex curation A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. J. Proteome Res. (1535-3893) 2007 imex curation Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Only protein-protein interactions mouse-flec Mus musculus fetal lung epithelial cells from murine lungs at E16 foetal_lung_epithelium fetal lung epithelial cells (FLECs) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Accepted 2007-APR-7 by JYOTI. J. Proteome Res. (1535-3893) 2007 Only protein-protein interactions imex curation A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. J. Proteome Res. (1535-3893) 2007 imex curation Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis Cancer - Interactions investigated in the context of cancer The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Only protein-protein interactions human-a_549 Homo sapiens Caucasian lung carcinoma cell line a_549 Human Caucasian lung carcinoma antibody array antibody array sandwich immunoassay antigen capture assay antibody detection identification by antibody antibody detection Flores-Delgado G., Liu CW., Sposto R., Berndt N. Apoptosis - Interactions involving proteins with a function related to apoptosis The (+) signs indicate the strength of the signal obtained from exposure of arrays to film: +, weak signal; ++, moderate signal; +++, strong signal. For the arrays antibodies to 100 proteins of known function were used. Extracts, prepared under mild conditions to preserve protein complexes, from murine FLECs or human A549 cells were separated into thre aliquots and incubated with arrays, followed by probing with biotinylated antibodies to the three different forms of the PP1 catalytic subunit. A unique UniProtKb entry could not be associated with FAK, Lamin B, cyclin B, HSP-70, Syntaxin 1, cyclin A, PP2A, Bax, EGFR and PP2B since the subtype of these interactors cannot be ascertained. norbert.berndt@moffitt.org Accepted 2007-APR-7 by JYOTI. J. Proteome Res. (1535-3893) 2007 Only protein-protein interactions imex curation hdac1_mouse Histone deacetylase 1 Hdac1 protein protein mouse Mus musculus Mouse MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA DIP protein O09106 original sequence version: 147 DIP protein O09106 original sequence version: 87 DIP protein O09106 original sequence version: 131 DIP protein O09106 original sequence version: 119 DIP protein O09106 original sequence version: 106 DIP protein O09106 original sequence version: 144 DIP protein O09106 original sequence version: 146 DIP protein O09106 original sequence version: 161 DIP protein O09106 original sequence version: 167 DIP protein O09106 original sequence version: 169 DIP protein O09106 original sequence version: 124 DIP protein O09106 original sequence version: 134 DIP protein O09106 original sequence version: 103 DIP protein O09106 original sequence version: 122 7F64D3C17F5E4844 if2a_human Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 EIF2A Eukaryotic translation initiation factor 2 subunit alpha protein protein human Homo sapiens Human MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED DIP protein P05198 original sequence version: 149 FF3E75E3816E6B1E rb_human Retinoblastoma-associated protein pRb pp110 p105-Rb RB1 p110-RB1 protein protein human Homo sapiens Human MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK DIP protein P06400 original sequence version: 102 DIP protein P06400 original sequence version: 195 DIP protein P06400 original sequence version: 204 DIP protein P06400 original sequence version: 126 DIP protein P06400 original sequence version: 151 DIP protein P06400 original sequence version: 153 DIP protein P06400 original sequence version: 181 DIP protein P06400 original sequence version: 184 DIP protein P06400 original sequence version: 213 DIP protein P06400 original sequence version: 208 DIP protein P06400 original sequence version: 174 DIP protein P06400 original sequence version: 212 DIP protein P06400 original sequence version: 179 DIP protein P06400 original sequence version: 146 C8E746111E19CC32 b2cl1_mouse Bcl-2-like protein 1 Apoptosis regulator Bcl-X Bcl2l1 Bcl2l Bclx protein protein mouse Mus musculus Mouse MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEAERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK 24D2AC79887E072E gsk3a_mouse Glycogen synthase kinase-3 alpha Gsk3a Serine/threonine-protein kinase GSK3A protein protein mouse Mus musculus Mouse MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPAGPASPLTTSYNPSSQALTEAQTGQDWQPSDATTATLASSS 739CDD86BBFB497B pp1b_human Serine/threonine-protein phosphatase PP1-beta catalytic subunit PPP1CB protein protein human Homo sapiens Human MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR DIP protein P62140 original sequence version: 130 E8356022E9B94ECD pcna_mouse Proliferating cell nuclear antigen Pcna Cyclin protein protein mouse Mus musculus Mouse MFEARLIQGSILKKVLEALKDLINEACWDVSSGGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVIKMPSGEFARICRDLSHIGDAVVISCAKNGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVHLTFALRYLNFFTKATPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEAS DIP protein P17918 original sequence version: 136 DIP protein P17918 original sequence version: 111 DIP protein P17918 original sequence version: 129 F705CCBDD3205986 arf_mouse Tumor suppressor ARF Cdkn2a p19ARF Alternative reading frame Cyclin-dependent kinase inhibitor 2A protein protein mouse Mus musculus Mouse MGRRFLVTVRIQRAGRPLQERVFLVKFVRSRRPRTASCALAFVNMLLRLERILRRGPHRNPGPGDDDGQRSRSSSSAQLRCRFELRGPHYLLPPGARRSAGRLPGHAGGAARVRGSAGCARCLGSPAARLGPRAGTSRHRAIFAFRWVLFVFRWVVFVYRWERRPDRRA DIP protein Q64364 original sequence version: 97 DIP protein Q64364 original sequence version: 110 644505EFE1CBF478 if2a_mouse Eukaryotic translation initiation factor 2 subunit 1 Eif2s1 Eif2a Eukaryotic translation initiation factor 2 subunit alpha protein protein mouse Mus musculus Mouse MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED 018480B89175D118 cdk2_human Cyclin-dependent kinase 2 CDK2 p33 protein kinase Cell division protein kinase 2 CDKN2 protein protein human Homo sapiens Human MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL DIP protein P24941 original sequence version: 142 DIP protein P24941 original sequence version: 118 DIP protein P24941 original sequence version: 143 DIP protein P24941 original sequence version: 144 DIP protein P24941 original sequence version: 152 DIP protein P24941 original sequence version: 182 DIP protein P24941-1 original sequence version: 204 DIP protein P24941 original sequence version: 90 DIP protein P24941 original sequence version: 190 DIP protein P24941 original sequence version: 168 F90A0F4E70910B51 nek2_mouse Serine/threonine-protein kinase Nek2 Nek2 Never in mitosis A-related kinase 2 protein protein mouse Mus musculus Mouse MPSRVEDYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGTKDRQYLEEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMSCLSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRPSVEEILESPLIADLVAEEQRRNLERRGRRSGEPSKLPDSSPVLSELKLKERQLQDREQALRAREDILEQKERELCIRERLAEDKLARAESLMKNYSLLKEHRLLCLAGGPELDLPSSAMKKKVHFHGESKENTARSENSESYLAKSKCRDLKKRLHAAQLRAQALADIEKNYQLKSRQILGMR 1EF2CA320F60FB5C esr1_human Estrogen receptor ESR1 ESR NR3A1 Estradiol receptor ER-alpha Nuclear receptor subfamily 3 group A member 1 protein protein human Homo sapiens Human MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV DIP protein P03372 original sequence version: 214 DIP protein P03372 original sequence version: 139 DIP protein P03372 original sequence version: 167 5455C57AB0CCCAA7 ccnd1_mouse G1/S-specific cyclin-D1 Ccnd1 Cyl-1 protein protein mouse Mus musculus Mouse MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI DIP protein P25322 original sequence version: 139 DIP protein P25322 original sequence version: 123 DIP protein P25322 original sequence version: 75 3A79736B4163251B max_human Protein max MAX BHLHD4 Class D basic helix-loop-helix protein 4 Myc-associated factor X protein protein human Homo sapiens Human MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS DIP protein P61244 original sequence version: 132 DIP protein P61244 original sequence version: 128 DIP protein P61244 original sequence version: 150 DIP protein P61244 original sequence version: 120 EB10F3137727A56F cul1_human Cullin-1 CUL1 protein protein human Homo sapiens Human MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA DIP protein Q13616 original sequence version: 144 DIP protein Q13616 original sequence version: 133 DIP protein Q13616 original sequence version: null DIP protein Q13616 original sequence version: 135 DIP protein Q13616 original sequence version: 98 DIP protein Q13616 original sequence version: 110 DIP protein Q13616 original sequence version: 146 DIP protein Q13616 original sequence version: 148 DIP protein Q13616 original sequence version: 100 DIP protein Q13616 original sequence version: 85 DIP protein Q13616 original sequence version: 114 DIP protein Q13616 original sequence version: 119 DIP protein Q13616 original sequence version: 136 DIP protein Q13616 original sequence version: 117 DIP protein Q13616 original sequence version: 99 DIP protein Q13616 original sequence version: 108 6625A1FFA7799BBA max_mouse Protein max Myc-associated factor X Protein myn Myc-binding novel HLH/LZ protein Max Myn protein protein mouse Mus musculus Mouse MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGGTISAFDGGSDSSSESEPEEPQSRKKLRMEAS 86D133137727A57A rb_mouse Retinoblastoma-associated protein Rb1 Rb-1 pRb pp105 p110-RB1 protein protein mouse Mus musculus Mouse MPPKAPRRAAAAEPPPPPPPPPREDDPAQDSGPEELPLARLEFEEIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFIAAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDTSTKVDNAMSRLLKKYNVLCALYSKLERTCELIYLTQPSSALSTEINSMLVLKISWITFLLAKGEVLQMEDDLVISFQLMLCVVDYFIKFSPPALLREPYKTAAIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFINSLGIVSSNGLPEVESLSKRYEEVYLKNKDLDARLFLDHDKTLQTDPIDSFETERTPRKNNPDEEANVVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFNNCTVNPKENILKRVKDVGHIFKEKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTLQHLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKVEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGPDNLEPACPLSLPLQGNHTAADMYLSPLRSPKKRTSTTRVNSAANTETQAASAFHTQKPLKSTSLALFYKKVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFSSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGADEADGSKHLPAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEEK DIP protein P13405 original sequence version: 115 DIP protein P13405 original sequence version: 114 DIP protein P13405 original sequence version: 110 AE81D35A07ADB493 atr_mouse Serine/threonine-protein kinase ATR Atr Ataxia telangiectasia and Rad3-related protein Kiaa4069 protein protein mouse Mus musculus Mouse MGDHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVALELVKKTDAQPTSVMLLDFIQHIMKSSPLMFVNVNGSQGQNEAKDSCIEFSHWIITRLLRIAATPSCHMLHKKICEVICSLLFLFKSKNPAIFGVLTRELLYLFEDLIYLHKRNAVGEVMEWPVVVSRFLSRLDEHMGCLQPAPLQFMNVQNVEFIEVTLLMVLIHIVPTVFFRRQELLLWQIGCALLEHGSPKIRSLAISLLTELFELGGLPAQPASTFFSLFLELLQHLVGMDADQLKLYEEPLSKLLKTLFPFEAEAYRNIEPVYLNVLLEKLSVMFEDRVLMRLKSDLLKAALCHLLQYFLTFVPAGYESALQVRKVYVTNICRALVDALGVQKHVGYLLGPFYAALKMESKEIIERIQCQAQQENLSGNNDEVSPKRRKLSSSLSSYKKPSRQPEEIIHVDMDKKSILWNVLKQKAESLQISLECGTLKNSVAEALEGITVVLQLTALCTVHCSHQDMDGHNVKDHQHKYKKKPPVVVTWMSLDFYTKVLKSCRSLLESVQKLELELVIDSMVRICDALMYMQVKSSFKDHVLEELCGMLSLPWIYSYSDDNSLKMTTFATNLLPLSQRVWDSYSPQAQSKCVFLLTLFPRRIFLEWRTAVYNWALKSSHEVIRASCVKGFFILLHQQNSCNQIPKMLVDRVKDDSDMVKKEFASVLGQLVCTLHGMFYLSSSVEPCFEHMDLFSKNLKATSQHECSSSQVKASTCKPFLFLLTKNTPSPVKLAFIDNLHHLCKHLDFQEDEREVKAVLGTLLNLMEDPDKDVRIAFSGNIKYILESLNSEDGFVKELFVLRMKEAYTHAQIARNNELKDTLILTTGDIGRAAKGDLIPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPSAPCQSSEIRKQDVAHHREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVSRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDITSPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLIHMQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELEKIKAVLQEYRKETSETTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPVISQLVTVILKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMQSNGPGYQLWKRFPEHVREILEPHLNTRYKSSQKSTDWSGVTKPIYLSKLGNNFAEWSSSWAGYLITKVRDNLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDEQHAISTQDSASDLCQLSTQTVFSVLDHLTQWARHKFQALNAEKLAQNKPKGVSNVNFEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQKHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESIGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDTTTFYDTLKLVRAEQIVPLSAASFERGSYQRGYEFIVRLHMLCELEHSLKPLFRKSPGDSCNEDSLNWGARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENKSPSESKHMLIHGRATLLVGRFMEETANFESNAVMKKYKDVTLFLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNRLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILTKAIHMKKSLEKFVGDATRLTDKLLELCNKSVDGSNSTLSMSTHFKMLKRLVEDPTFSEILIPLQSVMIPTLPSVLGAHANHDPFPGHWAYLAGFDDVVEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKIYKEKGVYMTGKELRQCMLPKSAALSEKLKVFQELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEGSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM C126413D15ACB8DC bcl2_mouse Apoptosis regulator Bcl-2 Bcl2 Bcl-2 protein protein mouse Mus musculus Mouse MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK DIP protein P10417 original sequence version: 71 DIP protein P10417 original sequence version: 126 80FDCFE78C735092 tau_mouse Microtubule-associated protein tau Neurofibrillary tangle protein Paired helical filament-tau Mapt Mtapt Tau protein protein mouse Mus musculus Mouse MADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKESPPQPPADDGAEEPGSETSDAKSTPTAEDVTAPLVDERAPDKQAAAQPHTEIPEGITAEEAGIGDTPNQEDQAAGHVTQGRREGQAPDLGTSDWTRQQVSSMSGAPLLPQGLREATCQPSGTRPEDIEKSHPASELLRRGPPQKEGWGQDRLGSEEEVDEDLTVDESSQDSPPSQASLTPGRAAPQAGSGSVCGETASVPGLPTEGSVPLPADFFSKVSAETQASQPEGPGTGPMEEGHEAAPEFTFHVEIKASTPKEQDLEGATVVGVPGEEQKAQTQGPSVGKGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKARVASKDRTGNDEKKAKTSTPSCAKAPSHRPCLSPTRPTLGSSDPLIKPSSPAVSPEPATSPKHVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 80C0D50AC5F64E6F skp1_human S-phase kinase-associated protein 1 SKP1 EMC19 OCP2 SKP1A TCEB1L Cyclin-A/CDK2-associated protein p19 p19skp1 RNA polymerase II elongation factor-like protein Organ of Corti protein 2 Organ of Corti protein II SIII Transcription elongation factor B polypeptide 1-like protein protein human Homo sapiens Human MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK C794D62AFB75528A cdk1_human Cyclin-dependent kinase 1 p34 protein kinase Cell division protein kinase 1 CDK1 CDC2 Cell division control protein 2 homolog CDC28A CDKN1 P34CDC2 protein protein human Homo sapiens Human MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM DIP protein P06493 original sequence version: 185 DIP protein P06493 original sequence version: 162 DIP protein P06493 original sequence version: 184 DIP protein P06493 original sequence version: 97 DIP protein P06493 original sequence version: 192 942D79448EFE490A ub2r1_human Ubiquitin-conjugating enzyme E2 R1 Ubiquitin-protein ligase R1 Ubiquitin-conjugating enzyme E2-32 kDa complementing Ubiquitin-conjugating enzyme E2-CDC34 CDC34 UBE2R1 UBCH3 (E3-independent) E2 ubiquitin-conjugating enzyme R1 E2 ubiquitin-conjugating enzyme R1 protein protein human Homo sapiens Human MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEEEADSCFGDDEDDSGTEES DIP protein P49427 original sequence version: 101 DIP protein P49427 original sequence version: 134 258960666B589DB3 pcna_human Proliferating cell nuclear antigen PCNA Cyclin protein protein human Homo sapiens Human MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS DIP protein P12004 original sequence version: 200 DIP protein P12004 original sequence version: 128 DIP protein P12004 original sequence version: 139 DIP protein P12004 original sequence version: 185 DIP protein P12004 original sequence version: 102 DIP protein P12004 original sequence version: 105 DIP protein P12004 original sequence version: 158 E6F08E7EDBC48B00 p36873-1 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit PPP1CC Protein phosphatase 1C catalytic subunit Gamma-1 PPPCC1 protein protein human Homo sapiens Human MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK 0EEEF0E842188536 pp1g_mouse Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Ppp1cc Protein phosphatase 1C catalytic subunit protein protein mouse Mus musculus Mouse MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK 4E28412C16898615 cdk4_mouse Cyclin-dependent kinase 4 Cell division protein kinase 4 PSK-J3 CRK3 Cdk4 Crk3 protein protein mouse Mus musculus Mouse MAATRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKEESDAE DIP protein P30285 original sequence version: 145 DIP protein P30285 original sequence version: 129 DIP protein P30285 original sequence version: 82 DIP protein P30285 original sequence version: 102 CB4F42A8AA13634A bad_human Bcl2-associated agonist of cell death Bcl-2-binding component 6 Bcl-2-like protein 8 BAD BBC6 BCL2L8 Bcl-xL/Bcl-2-associated death promoter Bcl2 antagonist of cell death protein protein human Homo sapiens Human MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ DIP protein Q92934 original sequence version: 66 DIP protein Q92934 original sequence version: 121 69FD8D27DDEE3241 skp1_mouse S-phase kinase-associated protein 1 Skp1 Skp1a S-phase kinase-associated protein 1A Cyclin-A/CDK2-associated protein p19 p19skp1 p19A protein protein mouse Mus musculus Mouse MPTIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK DIP protein Q9WTX5 original sequence version: 100 DIP protein Q9WTX5 original sequence version: 108 AE184C00BE6556DB apaf_human Apoptotic protease-activating factor 1 APAF1 KIAA0413 protein protein human Homo sapiens Human MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE DIP protein O14727 original sequence version: 177 DIP protein O14727 original sequence version: 127 0750D05817AC9B3B pten_human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatase and tensin homolog Mutated in multiple advanced cancers 1 PTEN MMAC1 TEP1 protein protein human Homo sapiens Human MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV 75F97C3DD6802BA9 id2_mouse DNA-binding protein inhibitor ID-2 Id2 Id-2 Idb2 Inhibitor of DNA binding 2 Inhibitor of differentiation 2 protein protein mouse Mus musculus Mouse MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVTKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKVLCG DIP protein P41136 original sequence version: 92 A0D98D54F2686CC5 pp1b_mouse Serine/threonine-protein phosphatase PP1-beta catalytic subunit Ppp1cb protein protein mouse Mus musculus Mouse MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR E8356022E9B94ECD tsc1_mouse Hamartin Tsc1 Tuberous sclerosis 1 protein homolog Kiaa0243 protein protein mouse Mus musculus Mouse MAQLANIGELLSMLDSSTLGVRDDVTAIFKESLNSERGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKHLLDKINEYVGKAATRLSILSLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENVETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKTLETHDVVIECAKISLDPTEASYEDGYSVSHQLSACFPYRSADVTTSPYVDTQNSYGGSTSTPSSSSRLMLFSPPGQLPQSLSSPSTRLLPEPLQASLWSPSAVCGMTTPPTSPGNVPADLSHPYSKAFGTTAGGKGTPSGTPATSPPPAPPCPQDDCVHGSAAQASATAPRKEERADSSRPYLHRQSNDRGLEDPPGSKGSVTLRNLPDFLGDLASEEDSIEKDKEEAAISKELSEITTAEADPVVPRGGFDSPFYRDSLSGSQRKTHSAASGTQGSSVNPEPLHSSLDKHGPDTPKQAFTPIDPPSGSADVSPAGDRDRQTSLETSILTPSPCKIPPQRGVSFGSGQLPPYDHLFEVALPKTACHFVSKKTEELLKKVKGNPEEDCVPSTSPMEVLDRLIEQGAGAHSKELSRLSLPSKSVDWTHFGGSPPSDELRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYSQLQEQRDTMVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRVELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQSKHPDTTKEVEMMKTAYRKELEKNRSHLLQQNQRLDASQRRVLELESLLAKKDHLLLEQKKYLEDVKSQASGQLLAAESRYEAQRKITRVLELEILDLYGRLEKDGRLRKLEEDRAEAAEAAEERLDCCSDGCTDSLVGHNEEASGHNGETRTSRPGGTRASCGGRVTGGSSSSSSELSTPEKPPSQRFSSRWEPALGEPSSSIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDSVTMSSSSLSETLKTELGKDSGTENKTSLSLDAPHPSSPNSDNVGQLHIMDYNETHPEHS F80ACF8492007801 b2cl1_human Bcl-2-like protein 1 BCL2L1 BCL2L BCLX Apoptosis regulator Bcl-X protein protein human Homo sapiens Human MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK E09D3CDD851AE9BE cdk4_human Cyclin-dependent kinase 4 CDK4 Cell division protein kinase 4 PSK-J3 protein protein human Homo sapiens Human MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE DIP protein P11802 original sequence version: 177 DIP protein P11802 original sequence version: 135 DIP protein P11802 original sequence version: 136 DIP protein P11802 original sequence version: 200 DIP protein P11802 original sequence version: 86 0916A0C07403A33A ccnd3_human G1/S-specific cyclin-D3 CCND3 protein protein human Homo sapiens Human MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL DIP protein P30281 original sequence version: 150 DIP protein P30281 original sequence version: 111 16E7B1604FEB0029 bcl2_human Apoptosis regulator Bcl-2 BCL2 protein protein human Homo sapiens Human MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK DIP protein P10415 original sequence version: 148 DIP protein P10415 original sequence version: 125 DIP protein P10415 original sequence version: 151 DIP protein P10415 original sequence version: 204 DIP protein P10415 original sequence version: 149 3C49F2B714DC9CCB pp1a_mouse Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Ppp1ca Ppp1a protein protein mouse Mus musculus Mouse MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIRYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK 8FBFD158A52282E0 aurkb_human Aurora kinase B AIRK2 Aurora- and IPL1-like midbody-associated protein 1 Aurora/IPL1-related kinase 2 STK-1 Serine/threonine-protein kinase 12 Serine/threonine-protein kinase 5 STK1 STK5 Aurora 1 AURKB AIK2 AIM1 ARK2 STK12 Serine/threonine-protein kinase aurora-B protein protein human Homo sapiens Human MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA DIP protein Q96GD4 original sequence version: 88 DIP protein Q96GD4 original sequence version: 113 DIP protein Q96GD4 original sequence version: 116 DIP protein Q96GD4 original sequence version: 122 DIP protein Q96GD4 original sequence version: 177 DIP protein Q96GD4-1 original sequence version: 177 A5ED13EF5A1FAFBF atm_mouse Serine-protein kinase ATM Atm Ataxia telangiectasia mutated homolog protein protein mouse Mus musculus Mouse MSLALNDLLICCRQLEHDRATERRKEVDKFKRLIQDPETVQHLDRHSDSKQGKYLNWDAVFRFLQKYIQKEMESLRTAKSNVSATTQSSRQKKMQEISSLVRYFIKCANKRAPRLKCQDLLNYVMDTVKDSSNGLTYGADCSNILLKDILSVRKYWCEVSQQQWLELFSLYFRLYLKPSQDINRVLVARIIHAVTRGCCSQTDGLPSKFLDLFSKAIQYARQEKSSPGLSHILAALNIFLKSLAVNFRKRVCEAGDEILPTLLYIWTQHRLNDSLKEVIIELIQLQIYIHHPQGARAPEEGAYESMKWKSILYNLYDLLVNEISHIGSRGKYSSGSRNIAVKENLIDLMADICYQLFDADTRSVEISQSYVTQRESTDYSVPCKRRKIDVGWEVIKDYLQKSQSDFDLVPWLQITTRLISKYPSSLPNCELSPLILILYQLLPQQRRGERIPYVLRCLKEVALCQGKKSNLESSQKSDLLKLWIKIWSITFRGISSGQTQTENFGLLEAIIQGSLVELDREFWKLFTGSACKPSSPSVCCLTLALSICVVPDAIKMGTEQSVCEANRSFSVKESIMRWLLFYQLEDDLEDSTELPPILQSNFPHLVVEKILVSLTMKNSKAAMKFFQSVPECEQHCEDKEEPSFSEVEELFLQTTFDKMDFLTTVKEYAVEKFQSSVGFSVQQNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGIITEDEAHKSELFQKAKSLMQCAGESISLFKNKTNEESRIGSLRNVMHLCTSCLCIHTKHTPNKIASGFFLRLLTSKLMNDIADICKSLASCTKKPLDHGVHPGEDDEDGGGCDSLMEAEGPSSTGLSTAYPASSVSDANDYGENQNAVGAMSPLAADYLSKQDHLLLDMLRFLGRSVTASQSHTVSFRGADIRRKLLLLLDSSILDLMKPLHLHMYLVLLKDLPGNEHSLPMEDVVELLQPLSLVCSLHRRDQDVCKTILSNVLHIVTNLGQGSVDMESTRIAQGHFLTVMGAFWHLTKEKKCVFSVRMALVKCLQTLLEADPYSEWAILNVKGQDFPVNEAFSQFLADDHHQVRMLAAGSVNRLFQDMRQGDFSRSLKALPLKFQQTSFNNAYTTAEAGIRGLLCDSQNPDLLDEIYNRKSVLLMMIAVVLHCSPVCEKQALFALCKSVKENRLEPHLVKKVLEKVSESFGCRSLEDFMISHLDYLVLEWLNLQDTEYSLSSFPFMLLNYTSIEDFYRSCYKILIPHLVIRSHFDEVKSIANQIQKCWKSLLVDCFPKILVHILPYFAYEGTRDSYVSQKRETATKVYDTLKGEDFLGKQIDQVFISNLPEIVVELLMTLHETADSADSDASQSATALCDFSGDLDPAPNPPYFPSHVIQATFAYISNCHKTKFKSILEILSKIPDSYQKILLAICEQAAETNNVFKKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINKRSSHFTDVSLRSFSLCCDLLSRVCHTAVTQCKDALESHLHVIVGTLIPLVDYQEVQEQVLDLLKYLVIDNKDNKNLSVTIKLLDPFPDHVIFKDLRLTQQKIKYSGGPFSLLEEINHFLSVSAYNPLPLTRLEGLKDLRRQLEQHKDQMLDLLRASQDNPQDGIVVKLVVSLLQLSKMAVNQTGEREVLEAVGRCLGEIGPLDFSTIAVQHNKDVSYTKAYGLPEDRELQWTLIMLTALNNTLVEDSVKIRSAAATCLKNILATKIGHIFWENYKTSADPMLTYLQPFRTSRKKFLEVPRSVKEDVLEGLDAVNLWVPQSESHDIWIKTLTCAFLDSGGINSEILQLLKPMCEVKTDFCQMLLPYLIHDVLLQDTHESWRTLLSAHVRGFFTSCFKHSSQASRSATPANSDSESENFLRCCLDKKSQRTMLAVVDYLRRQKRPSSGTAFDDAFWLDLNYLEVAKVAQSCSAHFTALLYAEIYSDKKSTDEQEKRSPTFEEGSQGTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPLTRIRTYEHEATWEKALVTYDLETSISSSTRQSGIIQALQNLGLSHILSVYLKGLDYERREWCAELQELRYQAAWRNMQWGLCASAGQEVEGTSYHESLYNALQCLRNREFSTFYESLRYASLFRVKEVEELSKGSLESVYSLYPTLSRLQAIGELENSGELFSRSVTDRERSEAYWKWQKHSQLLKDSDFSFQEPLMALRTVILETLVQKEMERSQGACSKDILTKHLVEFSVLARTFKNTQLPERAIFKIKQYNSAICGISEWHLEEAQVFWAKKEQSLALSILKQMIKKLDSSFKDKENDAGLKVIYAECLRVCGSWLAETCLENPAVIMQTYLEKAVKVAGSYDGNSRELRNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQTLLKRAKEEVGLLREHKIQTNRYTVKVQRELELDECALRALREDRKRFLCKAVENYINCLLSGEEHDLWVFRLCSLWLENSGVSEVNGMMKKDGMKISSYKFLPLMYQLAARMGTKMTGGLGFHEVLNNLISRISLDHPHHTLFIILALANANKDEFLSKPETTRRSRITKSTSKENSHLDEDRTEAATRIIHSIRSKRCKMVKDMEALCDAYIILANMDASQWRAQRKGINIPANQPITKLKNLEDVVVPTMEIKVDPTGEYENLVTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSEDGAHRRYRPNDFSANQCQKKMMEVQKKSFEEKYDTFMTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESDLHSTPNADDQECKQSLSDTDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAMDPKNLSRLFPGWKAWV 7AE54BF9801C6336 p63087-1 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Ppp1cc Protein phosphatase 1C catalytic subunit Gamma-1 Pppcc1 protein protein mouse Mus musculus Mouse MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK 4E28412C16898615 birc5_human Baculoviral IAP repeat-containing protein 5 Apoptosis inhibitor survivin Apoptosis inhibitor 4 BIRC5 API4 IAP4 protein protein human Homo sapiens Human MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD DIP protein O15392 original sequence version: 129 DIP protein O15392 original sequence version: 132 DIP protein O15392-1 original sequence version: 141 DIP protein O15392-1 original sequence version: 143 9E7CADCDF2822286 cdk1_mouse Cyclin-dependent kinase 1 p34 protein kinase Cell division protein kinase 1 Cdk1 Cdc2a Cdc2 Cell division control protein 2 homolog Cdkn1 protein protein mouse Mus musculus Mouse MEDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYFDDLDNQIKKM DIP protein P11440 original sequence version: 149 DIP protein P11440 original sequence version: 164 9C399FCC41BA7F31 atm_human Serine-protein kinase ATM ATM Ataxia telangiectasia mutated protein protein human Homo sapiens Human MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV DIP protein Q13315 original sequence version: 122 DIP protein Q13315 original sequence version: 189 DIP protein Q13315 original sequence version: 195 DIP protein Q13315 original sequence version: 166 DIP protein Q13315 original sequence version: 196 C0B4866E1E3199E2 pp1a_human Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PPP1CA PPP1A protein protein human Homo sapiens Human MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK DIP protein P62136 original sequence version: 72 DIP protein P62136 original sequence version: 76 DIP protein P62136 original sequence version: 123 DIP protein P62136 original sequence version: 126 DIP protein P62136-1 original sequence version: 98 60C37E1AD9831DAC p53_mouse Cellular tumor antigen p53 Tp53 P53 Trp53 Tumor suppressor p53 protein protein mouse Mus musculus Mouse MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD DIP protein P02340 original sequence version: 117 DIP protein P02340 original sequence version: 165 DIP protein P02340 original sequence version: 187 DIP protein P02340 original sequence version: 201 DIP protein P02340 original sequence version: 111 DIP protein P02340 original sequence version: 141 DIP protein P02340 original sequence version: 180 DIP protein P02340 original sequence version: 163 DIP protein P02340 original sequence version: 152 ED5A607378D921D7 ts101_mouse Tumor susceptibility gene 101 protein Tsg101 ESCRT-I complex subunit TSG101 protein protein mouse Mus musculus Mouse MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTATGPPNTSYMPGMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY 79558EC535093492 cadh1_human Cadherin-1 Epithelial cadherin Uvomorulin CAM 120/80 CDH1 CDHE UVO protein protein human Homo sapiens Human MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD DIP protein P12830 original sequence version: 191 DIP protein P12830 original sequence version: 185 DIP protein P12830 original sequence version: 108 DIP protein P12830 original sequence version: null DIP protein P12830 original sequence version: 134 DIP protein P12830 original sequence version: 147 DIP protein P12830 original sequence version: 174 DIP protein P12830 original sequence version: 189 DIP protein P12830 original sequence version: 156 DIP protein P12830 original sequence version: 201 DIP protein P12830 original sequence version: 117 E427118043A13C67 ccnd3_mouse G1/S-specific cyclin-D3 Ccnd3 Cyl-3 protein protein mouse Mus musculus Mouse MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLAAVIAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGTEVDCLRACQEQIEAALRESLREAAQTAPSPVPKAPRGSSSQGPSQTSTPTDVTAIHL 5441639A9B1B1475 ub2r1_mouse Ubiquitin-conjugating enzyme E2 R1 Cdc34 Ubch3 Ube2r1 Ubiquitin-protein ligase R1 Ubiquitin-conjugating enzyme E2-32 kDa complementing Ubiquitin-conjugating enzyme E2-CDC34 (E3-independent) E2 ubiquitin-conjugating enzyme R1 E2 ubiquitin-conjugating enzyme R1 protein protein mouse Mus musculus Mouse MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEEADSCFGDEEDDSGTEES 3259FA0CD407E1E3 p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD DIP protein P04637 original sequence version: 121 DIP protein P04637 original sequence version: 115 DIP protein P04637-1 original sequence version: 224 DIP protein P04637 original sequence version: 117 DIP protein P04637-1 original sequence version: 226 DIP protein P04637 original sequence version: 226 DIP protein P04637 original sequence version: 212 DIP protein P04637 original sequence version: 220 DIP protein P04637-1 original sequence version: 220 DIP protein P04637-1 original sequence version: 145 DIP protein P04637 original sequence version: 146 DIP protein P04637 original sequence version: 145 DIP protein P04637 original sequence version: 166 DIP protein P04637-1 original sequence version: 166 DIP protein P04637 original sequence version: 169 DIP protein P04637 original sequence version: 177 DIP protein P04637 original sequence version: 175 DIP protein P04637-1 original sequence version: 175 DIP protein P04637-1 original sequence version: 172 DIP protein P04637-1 original sequence version: 169 DIP protein P04637 original sequence version: 170 DIP protein P04637 original sequence version: 172 DIP protein P04637-1 original sequence version: 194 DIP protein P04637 original sequence version: 196 DIP protein P04637 original sequence version: 185 DIP protein P04637-1 original sequence version: 191 DIP protein P04637 original sequence version: 191 DIP protein P04637 original sequence version: 180 DIP protein P04637-1 original sequence version: 197 DIP protein P04637 original sequence version: 183 DIP protein P04637-1 original sequence version: 183 DIP protein P04637-1 original sequence version: 185 DIP protein P04637 original sequence version: 199 DIP protein P04637 original sequence version: 201 DIP protein P04637 original sequence version: 189 DIP protein P04637 original sequence version: 235 DIP protein P04637 original sequence version: 230 DIP protein P04637 original sequence version: 234 DIP protein P04637-1 original sequence version: 234 DIP protein P04637-1 original sequence version: 235 DIP protein P04637 original sequence version: 239 DIP protein P04637-1 original sequence version: 212 DIP protein P04637-1 original sequence version: 213 DIP protein P04637 original sequence version: 213 DIP protein P04637 original sequence version: 206 DIP protein P04637-1 original sequence version: 188 DIP protein P04637-1 original sequence version: 228 DIP protein P04637 original sequence version: 208 DIP protein P04637 original sequence version: 240 DIP protein P04637-1 original sequence version: 240 DIP protein P04637 original sequence version: 204 DIP protein P04637-1 original sequence version: 204 DIP protein P04637-1 original sequence version: 209 DIP protein P04637-1 original sequence version: 203 DIP protein P04637 original sequence version: 221 DIP protein P04637-1 original sequence version: 152 DIP protein P04637 original sequence version: 217 DIP protein P04637-1 original sequence version: 140 DIP protein P04637 original sequence version: 215 DIP protein P04637 original sequence version: 214 DIP protein P04637-1 original sequence version: 182 DIP protein P04637 original sequence version: 182 DIP protein P04637 original sequence version: 188 DIP protein P04637 original sequence version: 192 DIP protein P04637-1 original sequence version: 192 DIP protein P04637 original sequence version: 218 DIP protein P04637-1 original sequence version: 218 AD5C149FD8106131 esr1_mouse Estrogen receptor Esr1 Esr Estr Estra Nr3a1 Estradiol receptor ER-alpha Nuclear receptor subfamily 3 group A member 1 protein protein mouse Mus musculus Mouse MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAYEFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI 05F5E2FC21CC0A8B apaf_mouse Apoptotic protease-activating factor 1 Apaf1 protein protein mouse Mus musculus Mouse MDAKARNCLLQHREALEKDIKTSYIMDHMISNGVLSVIEEEKVKSQATQYQRAAALIKMILNKDNCAYISFYNALLHEGYKDLAALLQSGLPLVSSSSGKDTDGGITSFVRTVLCEGGVPQRPVIFVTRKKLVHAIQQKLWKLNGEPGWVTIYGMAGCGKSVLAAEAVRDHSLLEGCFSGGVHWVSIGKQDKSGLLMKLQNLCMRLDQEESFSQRLPLNIEEAKDRLRVLMLRKHPRSLLILDDVWDPWVLKAFDNQCQILLTTRDKSVTDSVMGPKHVVPVESGLGREKGLEILSLFVNMKKEDLPAEAHSIIKECKGSPLVVSLIGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCVLWDLETEEVEDILQEFVNKSLLFCNRNGKSFCYYLHDLQVDFLTEKNRSQLQDLHRKMVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLDWIKAKTELVGPAHLIHEFVAYRHILDEKDCAVCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYRQAKLQAKQEGDTGRLYLEWINKKTIKNLSRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQVNCCHFTNKSNHLLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDKIIVAAKNKVLLFDIHTSGLLAEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETKKVCKNSAIVLKQEIDVVFQENETMVLAVDNIRGLQLIAGKTGQIDYLPEAQVSCCCLSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYVFLQAHQETVKDFRLLQDSRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSCAPISVEEGTATHGGWVTDVCFSPDSKTLVSAGGYLKWWNVATGDSSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGILYILQVLE AA639E407F9ABC24 arf_human Tumor suppressor ARF p14ARF CDKN2A CDKN2 MLM Alternative reading frame Cyclin-dependent kinase inhibitor 2A protein protein human Homo sapiens Human MVRRFLVTLRIRRACGPPRVRVFVVHIPRLTGEWAAPGAPAAVALVLMLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGRGAAGRARCLGPSARGPG DIP protein Q8N726 original sequence version: 97 DIP protein Q8N726 original sequence version: 113 DIP protein Q8N726 original sequence version: 72 7739A9050C21BC96 ccnd1_human G1/S-specific cyclin-D1 CCND1 BCL1 PRAD1 PRAD1 oncogene BCL-1 oncogene B-cell lymphoma 1 protein protein protein human Homo sapiens Human MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI DIP protein P24385 original sequence version: 163 DIP protein P24385 original sequence version: 165 DIP protein P24385 original sequence version: 160 DIP protein P24385 original sequence version: 121 DIP protein P24385 original sequence version: 122 DIP protein P24385 original sequence version: 143 DIP protein P24385 original sequence version: 127 3CC00C9905F58D3A pp1g_human Serine/threonine-protein phosphatase PP1-gamma catalytic subunit PPP1CC Protein phosphatase 1C catalytic subunit protein protein human Homo sapiens Human MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK DIP protein P36873 original sequence version: 169 DIP protein P36873 original sequence version: 177 0EEEF0E842188536 atm-ppp1ca 2 44 unspecified role unspecified role prey prey 46 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. bcl2-ppp1ca 2 24 unspecified role unspecified role bait bait 44 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins eif2s1-ppp1ca 2 44 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. hdac1-ppp1ca 2 44 unspecified role unspecified role prey prey 6 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins mapt-ppp1ca 2 25 unspecified role unspecified role bait bait 44 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins nek2-ppp1ca 2 44 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins cdkn2a-ppp1ca 2 44 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins cdc34-ppp1ca 2 44 unspecified role unspecified role prey prey 56 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins ccnd3-ppp1ca 2 44 unspecified role unspecified role prey prey 55 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins max-ppp1ca 2 44 unspecified role unspecified role prey prey 21 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins skp1a-ppp1ca 2 44 unspecified role unspecified role prey prey 34 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins pcna-ppp1ca 2 44 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins apaf1-ppp1ca 2 59 unspecified role unspecified role bait bait 44 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins atr-ppp1ca 2 23 unspecified role unspecified role bait bait 44 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins tsc1-ppp1ca 2 44 unspecified role unspecified role prey prey 39 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins id2-ppp1ca 2 44 unspecified role unspecified role prey prey 37 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins tsg101-ppp1cc 2 47 unspecified role unspecified role prey prey 53 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 tp53-ppp1cc 2 47 unspecified role unspecified role prey prey 52 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 esr1-ppp1cc 2 58 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins PREY gene BC014073 The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. pcna-ppp1cc 2 12 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 skp1a-ppp1cc 2 34 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 max-ppp1cc 2 21 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 ccnd3-ppp1cc 2 55 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins PREY gene BC014073 The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. ccnd1-ppp1cc 2 18 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 cdk4-ppp1cc 2 32 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins PREY gene BC014073 The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. cdk2-ppp1cc 2 31 unspecified role unspecified role prey prey 47 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 cdc2-ppp1cc 2 47 unspecified role unspecified role prey prey 49 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins PREY gene BC014073 The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. cdc34-ppp1cc 2 47 unspecified role unspecified role prey prey 56 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 bcl2l1-ppp1cc 2 47 unspecified role unspecified role prey prey 9 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 rb1-ppp1cc 2 47 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins PREY gene BC014073 The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. cdkn2a-ppp1cc 2 47 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 eif2s1-ppp1cc 2 14 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 bcl2-ppp1cc 2 24 unspecified role unspecified role bait bait 47 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 gsk3a-ppp1cc 2 47 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins The sequence referenced by the authors for PP1 gamma1 is BC014073 and as compared to P63087 it has L not I at position 4. PREY gene BC014073 Q2NL51 is the only mouse sequence corresponding to GSK-3alpha but it is only a fragment. ccnd3-ppp1cb 2 55 unspecified role unspecified role bait bait 38 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins max-ppp1cb 2 38 unspecified role unspecified role prey prey 21 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 In murine FLECs, 10 of the 14 remaining PIPs were recognized, including ATM and eIF-2R, two proteins that so far have not been demonstrated to interact stably with PP1. In addition, this assay identified 27 novel potential PIPs. Remarkably, individual PP1 isoforms were apparently interacting with overlapping but distinct subsets of proteins atm-ppp1ca-1 5 50 unspecified role unspecified role bait bait 51 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types aurkb-ppp1ca 5 51 unspecified role unspecified role prey prey 45 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types bcl2-ppp1ca-1 5 43 unspecified role unspecified role bait bait 51 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types rb1-ppp1ca 5 8 unspecified role unspecified role bait bait 51 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types bcl2l1-ppp1ca 5 51 unspecified role unspecified role prey prey 40 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdc2-ppp1ca 5 51 unspecified role unspecified role prey prey 27 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdk2-ppp1ca 5 51 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdk4-ppp1ca 5 51 unspecified role unspecified role prey prey 41 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types max-ppp1ca-2 5 19 unspecified role unspecified role bait bait 51 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types skp1a-ppp1ca-1 5 51 unspecified role unspecified role prey prey 26 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types apaf1-ppp1ca-1 5 35 unspecified role unspecified role bait bait 51 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdh1-ppp1ca 5 51 unspecified role unspecified role prey prey 54 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types pten-ppp1ca 5 36 unspecified role unspecified role bait bait 51 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types atm-ppp1cc 5 50 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types bcl2-ppp1cc-1 5 30 unspecified role unspecified role prey prey 43 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types eif2s1-ppp1cc-1 5 30 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdkn2a-ppp1cc-1 5 60 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types bcl2l1-ppp1cc-1 5 40 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdc34-ppp1cc-1 5 28 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdc2-ppp1cc-1 5 27 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdk2-ppp1cc-2 5 15 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types ccnd1-ppp1cc-1 5 61 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types ccnd3-ppp1cc-2 5 42 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types max-ppp1cc-1 5 19 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types skp1a-ppp1cc-1 5 30 unspecified role unspecified role prey prey 26 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types pcna-ppp1cc-1 5 30 unspecified role unspecified role prey prey 29 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types esr1-ppp1cc-1 5 17 unspecified role unspecified role bait bait 62 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types tp53-ppp1cc-1 5 57 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types birc5-ppp1cc 5 48 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types bcl2-ppp1cb 5 11 unspecified role unspecified role prey prey 43 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdkn2a-ppp1cb 5 60 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdc34-ppp1cb 5 28 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types ccnd1-ppp1cb 5 11 unspecified role unspecified role prey prey 61 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +, weak signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types ccnd3-ppp1cb-1 5 11 unspecified role unspecified role prey prey 42 unspecified role unspecified role bait bait physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types max-ppp1cb-1 5 19 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score +++, strong signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types cdk4-ppp1cc-1 5 41 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey physical association physical association author score author-based confidence author score ++, moderate signal 2, Table 2 PP1R interactions were markedly different in A549 lung cancer cells. First, the PP1R antibody reacted only with 6 known PIPs including Aurora, while 22 novel PIPs were recognized. It is noteworthy that, in A549 cells, some interactions (protein kinase B or Akt, E-cadherin, PTEN, and survivin) were uniquely present, while others (e.g., ATR, Bax, cyclin E, EGFR, GSK-3R, hamartin, histone deacetylase 1, Id2, MAP �, Nek2, PP2B, and TSG101) were absent. Altogether, 5 of the tentatively identified novel PIPs bound to only one PP1 isozyme, whereas 13 other novel PIPs appeared to be specific for one isozyme and one of the two cell types rb1-ppp1ca-1 4 44 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait physical association physical association Although all three isoforms were physically associated with pRb during the G1 phase of the cell cycle 3 A All three isoforms of PP1 associate with pRb in G1 FLECs but the gamma isoform was the most abundant, followed by beta and then alpha. rb1-ppp1cb 4 38 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait physical association physical association Although all three isoforms were physically associated with pRb during the G1 phase of the cell cycle 3 A All three isoforms of PP1 associate with pRb in G1 FLECs but the gamma isoform was the most abundant, followed by beta and then alpha. rb1-ppp1cc-1 4 31 unspecified role unspecified role prey prey 22 unspecified role unspecified role bait bait physical association physical association Although all three isoforms were physically associated with pRb during the G1 phase of the cell cycle 3 A All three isoforms of PP1 associate with pRb in G1 FLECs but the gamma isoform was the most abundant, followed by beta and then alpha. ppp1ca-id2 4 44 unspecified role unspecified role bait bait 37 unspecified role unspecified role prey prey physical association physical association Seven previously unknown PIPs, that is, APAF-1, E-cadherin, HSP-70, Id2, p19Skp1, PCNA, and PTEN, could be precipitated with the PP1alpha antibody, 3 B ppp1ca-skp1a 4 34 unspecified role unspecified role prey prey 44 unspecified role unspecified role bait bait physical association physical association Seven previously unknown PIPs, that is, APAF-1, E-cadherin, HSP-70, Id2, p19Skp1, PCNA, and PTEN, could be precipitated with the PP1alpha antibody, 3 B ppp1ca-pcna 4 44 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey physical association physical association Seven previously unknown PIPs, that is, APAF-1, E-cadherin, HSP-70, Id2, p19Skp1, PCNA, and PTEN, could be precipitated with the PP1alpha antibody, 3 B ppp1ca-apaf1 3 35 unspecified role unspecified role prey prey 51 unspecified role unspecified role bait bait physical association physical association 3 B Seven previously unknown PIPs, that is, APAF-1, E-cadherin, HSP-70, Id2, p19Skp1, PCNA, and PTEN, could be precipitated with the PP1alpha antibody, ppp1ca-cdh1 3 51 unspecified role unspecified role bait bait 54 unspecified role unspecified role prey prey physical association physical association 3 B Seven previously unknown PIPs, that is, APAF-1, E-cadherin, HSP-70, Id2, p19Skp1, PCNA, and PTEN, could be precipitated with the PP1alpha antibody, ppp1ca-pten 3 51 unspecified role unspecified role bait bait 36 unspecified role unspecified role prey prey physical association physical association 3 B Seven previously unknown PIPs, that is, APAF-1, E-cadherin, HSP-70, Id2, p19Skp1, PCNA, and PTEN, could be precipitated with the PP1alpha antibody, ppp1cc-tp53 3 57 unspecified role unspecified role prey prey 30 unspecified role unspecified role bait bait physical association physical association 3 B Seven previously unknown PIPs, that is, APAF-1, E-cadherin, HSP-70, Id2, p19Skp1, PCNA, and PTEN, could be precipitated with the PP1alpha antibody, whereas one more, p53, could be precipitated with the PP1gamma antibody ppp1ca-bad 3 33 unspecified role unspecified role bait bait 51 unspecified role unspecified role prey prey physical association physical association 4 A exposure of A549 cells to nicotine appeared to induce binding between PP1R and Bad This interaction occurred when cells were exposed to nicotine. ppp1ca-cul1 3 51 unspecified role unspecified role bait bait 20 unspecified role unspecified role prey prey physical association physical association 5 A Figure 5A shows that PP1R also associated with cullin 1 ppp1ca-skp1a-1 3 26 unspecified role unspecified role prey prey 51 unspecified role unspecified role bait bait physical association physical association 5 B The association between p19Skp1 and PP1R was readily detectable at the G1/S transition and during S phase, but barely in G2/M and not at all during G1 This interaction was cell-cycle dependent, occurring at the G1/S phase transition and during S phase but not during G1 and only slightly in G2/M. skp1a-ppp1ca-2 1 51 unspecified role unspecified role prey prey 26 unspecified role unspecified role bait bait physical association physical association 5 C PP1 overlay experiments indicated that purified PP1R was unable to bind directly to p19Skp1, suggesting that there is another protein in the SCF complex that directly binds to PP1R This negative interaction indicates that PP1alpha and p19Skp1 do not interact directly but that another protein in the SCF complex binds directly to PP1alpha.