IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. Cell (0092-8674) 2009 imex curation Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu 23-Feb-2010: Contacted by JYOTI. jyoti Only protein-protein interactions 2 pyrfu Pyrococcus furiosus chromatography chromatography technology column chromatography chromatography de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu Accepted 2009-Not a month!-30 by JYOTI. 23-Feb-2010: Contacted by JYOTI. Cell (0092-8674) 2009 jyoti Only protein-protein interactions 2 imex curation RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. Cell (0092-8674) 2009 imex curation Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu 23-Feb-2010: Contacted by JYOTI. jyoti Only protein-protein interactions 2 in vitro In vitro ribonuclease assay ribonuclease assay weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu Accepted 2009-Not a month!-30 by JYOTI. 23-Feb-2010: Contacted by JYOTI. Cell (0092-8674) 2009 jyoti Only protein-protein interactions 2 imex curation RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. Cell (0092-8674) 2009 imex curation Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu 23-Feb-2010: Contacted by JYOTI. jyoti Only protein-protein interactions 2 pyrfu Pyrococcus furiosus chromatography chromatography technology column chromatography chromatography de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu Accepted 2009-Not a month!-30 by JYOTI. 23-Feb-2010: Contacted by JYOTI. Cell (0092-8674) 2009 jyoti Only protein-protein interactions 2 imex curation lysy_pyrfu Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase lysY PF1683 protein protein pyrfu Pyrococcus furiosus MIKAAVVGASGYIGGELVRLLAMHPEVEITAITSRQYAGKKVHKVHPNLRGLDLRFTNDYNFDADVIFLAVPHGTSMKIIEEFLGSAKIIDMSADFRIKKELYEKYYGPHEKPELIDRFTYGLPELHRKEIKKAELVANPGCNATATILGLYPFKDLTQEAIVDLKVSSSAGGRRENIASIHPERSNVVRVYKPYHHRHEAEVLQETRVKAMFTVHSVDLVRGLLATIYFRYEGNERELLRKLLMYKDEPFVRIVTDKGGLQRYPDPKYVIGSNFIDIGFAYDSENSRVMVFSAIDNLIKGGAGQAVQNMNIMFGLKETTGLEYYPVYPV 054F3EA18E0874F0 syfb_pyrfu Phenylalanine--tRNA ligase beta subunit pheT Phenylalanyl-tRNA synthetase beta subunit PF0990 protein protein pyrfu Pyrococcus furiosus MPKFDVAKSDLERLVGREFSVEEWEDLVLYAKCELDDVWEEDGKIYFKLDSKDTNRPDLWSAEGVARQIRWALGLAKGLPKYEVEESDVVVYVDKKLRNIRPYGVYAVVEGLKLDEEALSQLIQLQEKVALTYGRRRREVAIGIFDFDKVKPPIYYRAAEKTEKFVPLGYSEEMTLEEILEKHEKGREYGHLIRDKPYYPLLVDSEGNVLSMPPIINSELTGRVTTETKNVFVDVTGWDLRKVMLALNVIVTALAERGGKIKRVKVIYPDFEITTPDLTPKEFEVSFEYIRKLSGLELSNEEIKELLERMMYEVEILSENKAKVKYPAFRDDIMHTRDVLEDVLIAYGYNNIDPEEPKLAVQGRGDPFKDFEDAIRDLMVGFGLQEVMTFNLTSKEVQFDKMNIPEEEIVEIANPISSRWSALRKWLLPSLMEFLSNNTHEEYPQRIFEVGLATLIDESRETKTVSEPKLAVALAGSGYTFTNAKEILDSLMRHLGIEYDIEETVHGSFIPGRVGKILVDGKEIGIIGEIHPQVLENWNIQVPVVAFEIFLKPLYR CFFB32F60D001432 otca_pyrfu Ornithine carbamoyltransferase, anabolic argF PF0594 protein protein pyrfu Pyrococcus furiosus MVVSLAGRDLLCLQDYTAEEIWTILETAKMFKIWQKIGKPHRLLEGKTLAMIFQKPSTRTRVSFEVAMAHLGGHALYLNAQDLQLRRGETIADTARVLSRYVDAIMARVYDHKDVEDLAKYATVPVINGLSDFSHPCQALADYMTIWEKKGTIKGVKVVYVGDGNNVAHSLMIAGTKLGADVVVATPEGYEPDEKVIKWAEQNAAESGGSFELLHDPVKAVKDADVIYTDVWASMGQEAEAEERRKIFRPFQVNKDLVKHAKPDYMFMHCLPAHRGEEVTDDVIDSPNSVVWDQAENRLHAQKAVLALVMGGIKF 14404FBDC2ECCB95 14404FBDC2ECCB95 top6b_pyrfu Type 2 DNA topoisomerase 6 subunit B top6B Type II DNA topoisomerase VI subunit B PF1579 protein protein pyrfu Pyrococcus furiosus MAEARDLFKEFKVQSVSEFFRRNAAMLGYTGSIRSLTTVIHEAVTNSLDACEEAGILPYVRVEIEELGKEHYKVIVEDNGPGIPEDYIPHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGDDEIVEAWVKIDVQKNEGKIVKKIKHPNPKRWRGTRIELEVKNVKYVRSKQGVYWYLKLTAIANPHAHIELVEPDGKLIVFPRSSEDIPEPPVEMKPHPKGVMTDDVYTMAHRSKRSTVRRFLVSEFSRISDKKVDELVLYIAALRLINREVTDQNLKSQLIERLANGEVEKVLKSFGRKWKKVVEEVEKIMEKPPEKLTWHEAEEIVEAFKLMKFLAPPTYGLRPIGEENIEKGLSSILRPEFVTAVTRPPKVYSGGIPFQVEVGIAYGGEITNSEILRYANRVPLLFDAGSCVITSAVRSIDWRRYRVESFDNAPLVVLVNVVSVHVPYTSTGKQSIASIDEIYNEIRLALMEAARRLAAYLGGKYRRLYQIRRKKIFEKYLPEIARSLHILTGEPEEKIKEYFLRLIESKITVAQEGVSEVEVEEGEA 6240A450DBAFE9FB q9hgz8_pyrfu PF1746 protein protein pyrfu Pyrococcus furiosus MSVILSYNGAFAVTRQNGDMKDGYDGFYIFDTRFLKGVKLKLDKNSVLIGSSQDGPRKAYSHFSIEDEVVLLRKREIKDNWAYREELQFYNTSKRKVHLRVEYSFKVPIEDIFEVRKFGGQKIRRRIKSSLGDENEYSYTGKDKIKRNLKIKTNMRTEKGLAFAEITLEPLEKETLYLEFIPKISKEGLEIFLTEKPLLLPNVVSTNLTWLDRVFERAIEDLTALTAYTNYGMVPFAGIPYYACPFGRDSIITSWFLLPYYPQYAEGTLKFFAKIQGKKFNPLNEEEPGKIPHEFRFGELSHSRKMPFAPYYGTVDATPLYVILAAEYLRWTGDRELIERLKPNLTAAVEWILRRLDEGGGYIRYKGGLLANQGWKDSKEGIPTEEGTPTKPPVALVEVQGYAYKALMDAASLGLTSLDPKMLKKEAEELKKRFNKDFWCDGFYALALDGDNVPSKVVSSNMGHLLFTGIAEHQEKIAERLFEEDMFSGWGIRTLSSKEKAYNPFSYHNGSIWPHDNAVIAIGLASIGEKEKARMLAEAIFKTAKFLPNSQLPELFSGLESEYPLLCPRANAPQAWSAASVFALLTALLGLKAEKELTVSPLLPKNFKVSALVRFRRKAYLIESQEKEVVRFEERDI EBFA42F42FB5A428 q9p9k5_9eury protein protein 9eury Pyrococcus furiosus MVRRIRRWDIWDPFDLIREIQEEIDAMFDEFFSRPRLWTYRRWSEPAMYEERVGEVWREPFVDIFDNGDEFVITAELPGVRKEDIKVRVTEDTVYIEATVKREKELEREGAVRIERYFTGYRRAIRLPEEVIPEKAKAKYNNGVLEIRVPKKHPTKKESEGFEVKVE 75D09C9389902AAC smc_pyrfu Chromosome partition protein Smc PF1843 smc protein protein pyrfu Pyrococcus furiosus MPYIEKLELKGFKSYGNKKVVIPFSKGFTAIVGANGSGKSNIGDAILFVLGGLSAKAMRASRISDLIFAGSKNEPPAKYAEVAIYFNNEDRGFPIDEDEVVIRRRVYPDGRSSYWLNGRRATRSEILDILTAAMISPDGYNIVLQGDITKFIKMSPLERRLLIDDISGIAEYDSKKEKALEELKQAEENLARVDLLIKEVKKQLDKLEKERNDALRYLDLKDKLEKAKVSLLLGEIKILETQIKEGEKRRAEIEEEIQKIEKEIEKIGKEIVEKVKVLREIEERIEKESGEEAIQITKKIGEVTSKIELTKRNIEVAKEELEDAQRRLAKTKEELRKVLSEIEKSKGAITRWKKRRDALINEIKKKEEERNVLVVKLGEIDKTFGAAREEFDSVVKELEETTRKMYEIEGNIRRLQEEKEKLHSRILFLRAKLPGIKEKINEFKAVVEDKRAEISEIEGKLSTIQAKRIKVEKEIEAKSNELEKVSKELESSERELIAAEAQREVRGNRAAEELKRSGIGGIYGTLAELIKVKDEAYALAIEVALGNRADNVVVEDELVAEKAIKYLKEHKLGRLTFLPLNKIKPKHVDSSVGLPAVDVIEYDQKIENAVKFALGDTVIVNSMEEARPHIGKVRMVTIEGELYERSGAITGGHFRARGLAVDTTKLREKVESLRRRKEALEGELNSLKIELRSLENASFELRIKLSDEKKELELASKDLNRLLEEENAVKEEIEESERKIQEIEQKIENEKSELAKLRGRIQRLERKKEKLKKALENPEARELMEKIRIIDGEISSLKEELSRIESRIESLESRLNEELLPRKASLEEEIEGLVNKINALKNNISENEKALELLNKELEKLKSIEENIKGEIRTLREKRKKLEEDISKLREKKEVLQRKLQELEIEANTLKVRDAQLNAQLEEKKYQLTHYDKNLIKSIKEIPLDLEKVKKEIEKMEEEIRSLEPVNMKAIEDFEIVERRYLELKSKREKLEAEKESIIEFINEIEKEKKNVFMRTFEAISRNFSEIFAKLSPGGSARLILENPEDPFSGGLEIEAKPAGKDVKRIEAMSGGEKALTALAFVFAIQKFKPAPFYLFDEIDAHLDDANVKRVADLIKESSKESQFIVITLRDVMMANADKIIGVSMRDGVSKVVSLSLEKAMKILEEIRKKQGWEHGN DIP protein Q8TZY2 original sequence version: 70 EC12C4C060E5A1CB trm1_pyrfu tRNA (guanine(26)-N(2))-dimethyltransferase trm1 tRNA(guanine-26,N(2)-N(2)) methyltransferase tRNA 2,2-dimethylguanosine-26 methyltransferase tRNA(m(2,2)G26)dimethyltransferase PF1871 protein protein pyrfu Pyrococcus furiosus MSMELFEVHEGKAKVLVPKAKTIYDSPVFYNPRMAPNRDVVVLLLNVLKPKIVLDALSATGIRGIRFALETPAEEIWMNDINELAYELMKKNVLLNFKGTLKENAKRAIFEGEKTIVINNDDANRLMAEKHRYFHFIDLDPFGSPMEFLDTALRSVKRKGILGVTATDGAPLCGAHPKACLRKYLAVPLRGELCHEVGTRILVGVIARYAAKYDLGMEVLLAYYKDHYFRAFVKLKDGAKKGDETLENLGYVYFDEKTGRFEVEKSFLSTRPNAYGPLWLGPLKNEKVVGEMLELLVSGFEVANYREVLKLLHMLHEELDIPLFYDTHALGKRLKIEPKKLGEIIKELKSMGYEATRTHFSPTGIKTNAPYEVFVEVMRKN 36F2C5125C9CC6EC q8u310_pyrfu PF0666 protein protein pyrfu Pyrococcus furiosus MEAEKEKKLSIPPRGIRAIIEAVRLGEVIKPSQYAKREAFKKHDIKEAWLNRVLTMIFYDIMKKQGLIDKAIKDVVGVTPLILDPWLRAALRVAFDVVLFHDPNQNTLKNLKWKASDFISSKTHPYVGMYYWDIFERILEYKPNPKTELERLEWEYLAPAWLIERVRKLLGDETKAFFEAVNRKHEWISIRVNTLKTTPEEVIKEFEEEGVEVVQSKRIPVVLKIKGPYDFDSSYLFRKGKIIVQEEASAVASVILDPKPGEVVVDLAAAPGGKTTHMAELMKNRGKIFAFDIDKARMKRLKDFVSRMGIKIVKPIVKDARKAPEILGEEVADRVMLDAPCTSSGTIGKNPELRWRLREQKIEEMAQLQRELLESAAKLVKPGGRLLYTTCSIFIEEDEDNVSWFLETYKEFRLVKLSGPYDPGFLEGTMRAWPHRHETIGFFYALFEKVTQ 99FFDD7419D4583E q8u3c3_pyrfu cobW domain-containing protein PF0547 protein protein pyrfu Pyrococcus furiosus MAEKKRRRVVILGAAGRDFHNFNVFFRDNPDYEVVAFTATQIPDIEGRIYPPELAGELYPNGIPILPEDDLEKIIKEHDVDIVVFAYSDVSHEHVMHLASRAHSAGADFWLLGPKSTMLKSSKPVVAVTAVRTGCGKSQTSRKVAQILQEMGFKVVAVRHPMPYGDLRKQVVQRFATFEDLDRYECTIEEREEYEPYLERGMVVYAGVDYEKILREAEKEADIILWDGGNNDFPFFEPDLWIVVTDPHRPGHELTHHPGETNFRSADVIIINKIDTAPPENIQKIRENIEKINPNAIVIEAASPIFVDKPELIKGKRVLVVEDGPTLTHGGMSFGAGYIAAKKFGAKEIVDPRPYAVGSIIETYKKYPHLSNILPAMGYGKKQIKELEETINRADADVVVMGTPVDLRRFMNLNKPAVRVKYELEEIGKPKLRDVLEEWVKKCEKLKK FB154F1722F57C8F gapor_pyrfu Glyceraldehyde-3-phosphate:ferredoxin oxidoreductase gor Tungsten-containing glyceraldehyde-3-phosphate ferredoxin oxidoreductase PF0464 protein protein pyrfu Pyrococcus furiosus MKFSVLKLDVGKREVEAQEIEREDIFGVVDYGIMRHNELRTYEVDPYDPRNIVIFGIGPFAGSVLPGSHRLVFFFRSPLYGGLFPSTMGGAGYQFKNVGVDFVEIHGKAEKPTVIILKNDGEKLSVDFYEIELEKLLDVWKEYKGEEGVYALTQYLLDNLASVFEGMEFRIAVVGPAALNTNMGAIFSQALRNGKRAVGSEDWAARGGPGSVLLRAHNVVAIAFGGKKRKREFPGEDISDVKVAKRVVEGIHKKAQRDVINESTVKYRYNPKLNTGGTFGGNYPAEGDLVPVLNWQMPYIPKEERIKIHELIMKYYWEPFNKESIQPKNWTTCGEPCPVVCKKHRKGHHVEYEPYEANGPLSGSIYLYASDISVHAVDAMGFDAIEFGGTAAWVLELVHKGLLKPAEVGISDVPEFTKDDLITKPVEASEKNAKLVAELAHSIAFGKTEVARIIGMGKRKASKILDEKFKDRLSYGESFKDYGVYTPLGDDGEINPTMYWAIGNFIPLPIQGRYWTFYQFGVFLEPEELAQKIVSSALWEFWYDNVGWCRFHRGWMKKVLKALFMEAYGVSIDMEEHAKKQIRKLIDYLKKAGYEPVFWDSMRVIDLVAKGSEEFGNENWAKKFKEDKIGTAKEYLKRVLDAYSQLIGTEWTL 0ADAC8E59E8884AD top6a_pyrfu Type 2 DNA topoisomerase 6 subunit A top6A Type II DNA topoisomerase VI subunit A PF1578 protein protein pyrfu Pyrococcus furiosus MKLKRGKPKEKFSYDPQKVLKKLEDLAYKILEEVKAGKNPYFDVPTRGLSNVYFDEEARLIKLGDKLSRRYFLNVAHARKFMQTLILMAYVKRLVSEGKHASLREAYYANKHTIPGTHENTFEDQSESDPIIEDLERMLGVLREEMHITADRRGYVYGDIVIKDGEDEFNASKLGMGGWAVPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRERALIIATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYGLEHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP 4994F23656AC5F26 ndrz_pyrfu Vitamin B12-dependent ribonucleoside-diphosphate reductase rnr Ribonucleotide reductase PF0440 protein protein pyrfu Pyrococcus furiosus MAVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGIRDEKKLDEVVKSIVQRINELYDGKIPHIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINALRVLASRYLKKDENGNIVESPRELFERVAILAVIPDLLYDERVFDKNGNYSQDLKRVEYYLEHFEEFDRKYSIGKYKLNKYHFERMVNLYKELAEQGKMKVSIDEFLAMLEKGEFNEYEKEINEYFRLMTNQIFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGGGCIDGKAKIIFENEGEEHLTTMEEMYERYKHLGEFYDEEYNRWGIDVSNVPIYVKSFDPESKRVVKGKVNVIWKYELGKDVTKYEIITNKGTKILTSPWHPFFVLTPDFKIVEKRADELKEGDILIGGMPDGEDYKFIFDYWLAGFIAGDGCFDKYHSHVKGHEYIYDRLRIYDYRIETFEIINDYLEKTFGRKYSIQKDRNIYYIDIKARNITSHYLKLLEGIDNGIPPQILKEGKNAVLSFIAGLFDAEGHVSNKPGIELGMVNKRLIEDVTHYLNALGIKARIREKLRKDGIDYVLHVEEYSSLLRFYELIGKNLQNEEKREKLEKVLSNHKGGNFGLPLNFNAFKEWASEYGVEFKTNGSQTIAIINDERISLGQWHTRNRVSKAVLVKMLRKLYEATKDEEVKRMLHLIEGLEVVRHITTTNEPRTFYDLTVENYQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGKKYPLINPRTGEVVKEVDPKTLFEELAYMAWAKADPGVIFFDVINRRNVLKKAKGGPIRATNPCVVGDTRILTPEGYLKAEEIFSLAKERGKKEAVAVEGIAEEGEPYAYSVEILLPGEEKVEYETVHGKVLAVADPVAVPAYVWKVGRKKVARVKTKEGYEITATLDHKLMTPEGWKEVGKLKEGDKILLPRFEVEEEFGSESIGEDLAFVLGWFIGDGYLNVNDKRAWFYFNAEKEEEIAVRIRDILVKHFGIKAELHRYGNQIKLGVRGEAYRWLENIVKNNEKRIPEIVYRLKPREIAAFLRGLFSADGYVDKDMAIRLTSKSRELLREVQDLLLLFGILSKIYEKPYESEFHYTTKNGEERIYRSKGYYELVITNYSRKLFAEKIGLEGYKMEKLSLKKTKVDQPIVTVESVEVLGEEIVYDFTVPNYHMYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYDKTEYPEGKLPVEGFYHPEIWNLPWDKLVEEIKKYGLRNAMVTTCPPTGSVSMIADTSSGIEPVYALVYKKSVTVGEFYYVDPVFEEELKKRGLYSEELLKKISDNYGSVQGLEEIPEDMQRVFVTALDIHWLDHIIAQASIQMWLTDSASKTINMINEATVEDVKAAYLIARFLGCKGVTVYRDGSLSVQVYSVEGEKKKRRFKPKPSEYAKKILLEIVEKEPWIKNFINVDEILNGKKEQLLFSLRPANESKLKVPGREEEVRPGNIPEEKIRELLGVVYCPVCYEKEGKLVELKMESGCATCPVCGWSKCVIS 49B27D2C17C3913B cmr3_pyrfu CRISPR system Cmr subunit Cmr3 cmr3 CRISPR type III-B/RAMP module-associated protein Cmr3 PF1128 protein protein pyrfu Pyrococcus furiosus MIEVTFTPYDVLLFRESRPFDAGSESVARSIIPLPQTVAGAIRTLLFYKGLKNCVGVGEEEPEFTLVGIAIGTEKGRIYPLPFNIIKSEKFYKVVNPGRFLGKLILPPKGKYKSGYVTESILEKYLKGELKEVEENKVIRIEKEKRIGIKLSREKKVVEEGMLYTVEFLRIEKIYAWIEDPGCGIKDILSSYEFLTLGGESRVAFVEVDDKTPDIFNRELGSTKKALFYFSTPTIGKVGEIVQELEKRLNAKIDDYLLVSSRPTAISGWDMHEKKPKGTKFAIPPGSVLFVEFKEEVEVPPYIKLGKLKKLGYGLALGGIWE DIP protein Q8U1S7 original sequence version: 50 0097FC64CA296F03 sys_pyrfu Serine--tRNA ligase serS Seryl-tRNA(Ser/Sec) synthetase PF1204 Seryl-tRNA synthetase protein protein pyrfu Pyrococcus furiosus MLDINLIRNNPELVKNDLKKRGELDKIAWIDEILRLDEEWRKKLKEINRLRHERNKIAIEIGKRKKAGEPVEDLLAKSKEIVKRIEELEKEVEELRKRIDYYLWRLPNITHPSVPVGKDENDNVPIRFWGKAKVWKGHLESFLEQSQGKMEYEVLEWRPKLHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTTFEDFEDVIYKVEGEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVAFSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWHERLVRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGRFREVVSASNCTDWQARRLNIRFRDRTDEKPRYVHTLNSTAIATSRAIVAILENHQQEDGTVKIPRALWKYTGFKEIVPVEKKEGCCKA FF04FBBC03F8EA8A vora_pyrfu Ketoisovalerate oxidoreductase subunit VorA vorA 2-oxoisovalerate oxidoreductase alpha chain 2-oxoisovalerate ferredoxin reductase subunit alpha PF0969 protein protein pyrfu Pyrococcus furiosus MEYKPIRKVVSGNYAAAYAALHARVQVVAAYPITPQTSIIEKIAEFIANGEADIQYIPVESEHSAMAACIGASATGARTFTATSAQGLALMHEMLHWAAGARLPIVMVDVNRAMAPPWSVWDDQTDSLSQRDTGWMQFYAENNQEVYDGVLMAYKVAETVNVPAMVVESAFILSHTYDVVEMIPQELVDEFLPPRKPLYSLANFDEPIAVGALATPNDYYEFRYKLAKAHEEAKKVIKEVGKEFGERFGRDYSQMIETGYIDDADFVFMGMGSLMGTVKEAVDLLRKEGYKVGYAKVRWFRPFPKEELVEIAESVKGIAVLDRNFSFGQEGILFTESKGALYNSSAHPLMKNYIVGLGGRDVTVKDIKAIADDMKKVIESGKVDKEVVWYHLKR D8E580E790CEBB2B q8u4i5_pyrfu KaiC domain-containing protein PF0102 protein protein pyrfu Pyrococcus furiosus MPLQPIRRVKSGIPGFDELIEGGFPEGTTVLLTGGTGTGKTTFAAQFIYKGAEEYGEPGVFVTLEERAKDLRREMAAFGWDFEKYEKEGKIAIIDGVSSIAGIPSEEKFVLEDRFNVENFLRYVYRVVKAINAKRLVIDSIPSIAMRLEEENRIREVLLKLNTILLEMGVTTILTTEAPDPQHGRISRYGIEEFIARGVVILDLQERNIELKRYILIRKMRGTRHSMKKYPFEIGPNGIVVYPSGEIY 32A7EA92CF8044BD y1931_pyrfu UPF0273 protein PF1931 PF1931 protein protein pyrfu Pyrococcus furiosus MVRRVKTGIPGMDEILHGGIPERNVVLLSGGPGTGKSIFSQQFLWNGLQMGEPGIYVALEEHPVQVRQNMAQFGWDVRKYEEEGLFAMVDAFTAGVGKSKEYEKYIVHDLTDIREFIEVLRQAIRDINAKRVVVDSVTTLYINKPAMARSIILQLKRVLAGTGCTSIFVSQISVGERGFGGPGVEHGVDGIIRLDLDEIDGELKRSLIVWKMRGTSHSMKRHPFDITDKGIIVYPDKVLKRGRIYEL F8E34D8D215FD94B q8u472_pyrfu 3-hexulose-6-phosphate synthase PF0220 protein protein pyrfu Pyrococcus furiosus MASPVDGYYQILWSSKFFSLFSYLSPSDNTTNIKTLKEHPLKQKRVCVMILQVALDLTDIEQAISIAEKAARGGAHWLEVGTPLIKKEGMRAVELMKRRFPDRKIVADLKTMDTGALEVEMAARHGADVVSILGVADDKTIKDALAVARKYGIKVMVDLIGVKDKVKRAKELEEMGVHYILVHTGIDEQAQGKSPLEDLEKVVKAVKIPVAVAGGLNLETIPKVIELGATIIVVGSAITKAKDPEEVTRKIIDLFWDEYMRTIKKAMKDITEHINEVADKLKLEEVRGLVDAMIGANKIFIYGAGRSGLVGKAFAMRLMHLDFNVYVVGETITPAFEEGDLLIAISGSGETKTIVDAAEIAKQQGGKVVAITSYRDSTLGKLADVVVEIPGRTKTDVPTDYIARQMLTQYKWTAPMGTLFEDSTMVFLDGVIAC BACA57D926976F05 tmbl2_pyrfu Putative HTH-type transcriptional regulator TrmBL2 trmBL2 PF0496 protein protein pyrfu Pyrococcus furiosus MSKDRMVELLQEHFELNLYEARAYVALVAFGVLTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGKTNKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLIETEVPKYGVERVWVVRGIKNSTLKTKEMLEEAQNEILLADDGFIAVNLEDDIIKAVDRGVKTKILLTKNLLPRLKASKIIDYAKEGKLELRALDKFDLPMLICDEEVFFALEDLAARYFNYETQVWIKDHRVVALFKEKFNEYWEKAEKV B08D78D05CF1A254 if2a_pyrfu Translation initiation factor 2 subunit alpha eif2a eIF-2-alpha aIF2-alpha PF1140 protein protein pyrfu Pyrococcus furiosus MPRRAREYPEEGELVVATVKRVHNYGAFLDLDEYPGKEGFMHISEVASTWVKNIRDYLREGQKVVAKVIRVDPKKGHIDLSLRRVTQQQRKAKLQEFKRAQKAENLLKLAAEKLGKDFEEAWREVWVPLENEWGEVYAAFEDAARNGIEVLKGYVPDEWLPVLKEIIDSYVEVPTVTIDAEFEITVPKPNGIEIIKEALIKARDRANQEKDIEVKFTYLGAPRYRIDITAPDYYKAEEVLEDIAEEILRVIKEAGGEATLLRKEKRIRKVKKRKK 1AEE323D1DC5F8FF if2g_pyrfu Translation initiation factor 2 subunit gamma eif2g eIF-2-gamma aIF2-gamma PF1717 protein protein pyrfu Pyrococcus furiosus MGEKRKTRQAEVNIGMVGHVDHGKTTLTKALTGVWTDTHSEELRRGITIKIGFADAEIRRCSNCGRYSTSPICPYCGHETEFIRRVSFIDSPGHEALMTTMLAGASLMDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEKALENYRQIKEFIKGTVAENAPIIPISALHGANIDVLVKAIEEFIPTPKRDSNKPPKMLVLRSFDVNKPGTPPEKLVGGVLGGSIVQGKLKVGDEIEIRPGVPYEEHGRIKYEPITTEIVSLQAGGQFVEEAYPGGLVGIGTKLDPYLTKGDLMAGNVVGKPGKLPPVWTDLRLEVHLLERVVGTEQELNVEPIKRKEVLLLNVGTARTMGLVTALGKDEIELKLQIPVCAEPGERVAISRQIGSRWRLIGYGIIKE DIP protein Q8U082 original sequence version: 79 377B25EC26B2D88C psirna701 P. furiosus psiRNA 7.01 rna ribonucleic acid RNA rna pyrfu Pyrococcus furiosus CUGAAGGUGCUCUCAGCCGCAAGGACCGCAUACUACAA 72FA9B02A267B6E5 q8u0n8_pyrfu PF1548 protein protein pyrfu Pyrococcus furiosus MSESINNITKPKERRDFVVMAGMRKDGTIDFIKVYALNEKLAIEVLEAFLKENNIHPSDFIVIQRGYEDVKDKKAITTRSEEELSAMLGRLGLRLVSNGVLYTDGIDKLYQITAISRELFESLQKEKREIFEDVQEKITFNFSKVDLPEKYVKKLRLLELMEDTIIFNMAELEIPNLLKAIVEGTVLIPRFLEKEDLIIRIFDEELHEYRGSYFDKVLIKPPIIHWDFYLDSLEDFSFKKVEESIYIAPLFLRATGGFLILTEPPEDLVKTLLKLKKRGEVRTILEGKRITIPINFTLIVDTRHPERYAGLKFPIRINLPPLDDETFLKVLETNLGITPPTEIVRIFPPDYKTFLGVELIKNLFEKLKLTEKGKDEVSLLKEAATIITGGTP 6FD19348069D73D0 pora_pyrfu Pyruvate synthase subunit PorA porA Pyruvate oxidoreductase alpha chain Pyruvic-ferredoxin oxidoreductase subunit alpha PF0966 protein protein pyrfu Pyrococcus furiosus MPIRKVMKANEAAAWAAKLAKPKVIAAFPITPSTLIPEKISEFVANGELDAEFIKVESEHSAISACVGAAAAGVRTFTATASQGLALMHEILFIAAGMRLPIVMAIGNRALSAPINIWNDWQDTISQRDTGWMQFYAENNQEALDLILIAYKVAEDERVLLPAMVGFDAFILTHTVEPVEIPDQEVVDEFLGEYEPKHAYIDPARPITQGSLAFPAHYMESRYTVWEAMERAKKVIDEAFAEFEKKFGRKYQKIEEYKTEDADIIFVTMGSLAGTLKEWIDKKREEGYKVGAAKITVYRPFPVEEIRELAKKAKVLAFLEKNITIGLYGAVFTDASAALINESEKPLMVDFIVGLGGRDVTFNQLDEALEIAEKALKEGKVENPINWIGLRWELVK 16204779F27B9BC3 if2b_pyrfu Translation initiation factor 2 subunit beta eif2b eIF-2-beta aIF2-beta PF0481 protein protein pyrfu Pyrococcus furiosus MEIDYYDYEKLLEKAYQELPENVKHHKSRFEVPGALVTIEGNKTIIENFKDIADALNRDPQHLLKFLLREIATAGTLEGRRVVLQGRFTPYLIANKLKKYIKEYVICPVCGSPDTKIIKRDRFHFLKCEACGAETPIQHL DIP protein Q8U3I5 original sequence version: 69 771153C98A871359 cmr2_pyrfu CRISPR system Cmr subunit Cmr2 cmr2 CRISPR-associated protein Cas10/Cmr2, subtype III-B PF1129 protein protein pyrfu Pyrococcus furiosus MVNIKEKLFVYLHDPPDKALKIENHEERSKKILSSGNIQYSRTDKVKQADALSSKTQRFIIRTKENKEPVIDFLGRSSGKYFHVGYPVFIHPISTEIKRYETLEKYIDLGRSNRGERFVNEFLERVSKLEGDVLKEVFEDASNKFKGEESKQWAYIWQFYPVKLKEGVKEFAKSELKLKEEEAEKFAEEFVNLPADTRFPDHAIWTHLDLTSALSVKDPTLLRIKIVPVQPFIANSRKQLDLWASSHLLSMLMYKALEVIVDKFGPEHVIYPSLRDQPFFLKFYLGENIGDEILVANLPNKALAIVSGKEAEKIEEEIKKRIRDFLLQLYREAVDWAVENGVVKVDRSEKDSMLKEAYLKIVREYFTVSITWVSLSEKEDIYQVTENAGLSDEDVKKWLKFAEKKENSRVLERIAIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYDHDNLKSLWLDEEPLCPMCLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNWRKIFDEKYGKDLVSKAREVSEDFVKDNMLVDSDLYYSSTWESGLSKKLKNKKEIDEEKVKEVVDFLNAAYKEIGNPPKYYAILVMDGDDMGKVISGEVLGEISTRIHPNIRDYVEIPEAKYYSTPQVHVAISQALANFSIREVRSVVKDEGLLIYAGGDDVLAILPVDKALEVAYKIRKEFGKSFENGSLLPGWKLSAGILIVHYKHPLYDALEKARDLLNNKAKNVPGKDTLAIGLLKRSGSYYISLVGWELIRVFYNSELRKKLLEEKGGVGKRFIYHVLREVDTWPKVGIDEMLKFEVIRHIRGRNKEETKELREKIYGEIKDLLEHVRGNNEVEKVRGLFTFLKIITDAEVFP DIP protein Q8U1S6 original sequence version: 50 859C2A9DA4490A2B syfa_pyrfu Phenylalanine--tRNA ligase alpha subunit pheS Phenylalanyl-tRNA synthetase alpha subunit PF0989 protein protein pyrfu Pyrococcus furiosus MLGYNEKLVLLKLNEVKKARIEELVKLTGLEQVAIMRALLTLEKEGLAKISERKERIIRLTDLGRKYIQMGLPEIRALNVLKSKKKVKLDELRGVLTEDELKPIVGILRKEGWVKVEKTPEGLVLEITERGENPEERPIDKALKILSEKEYATSEEISKIVPINELKRRKVAQEEEVVERIAEITEKGVELVKKGIELKREVTSLTPELIASGKWREVEFKPFNIKAPVKKIYPGKKQPYRVFLDKIRRKLIEMGFIEITVDSLIETQFWNFDALFQPQNHPAREWTDTYQLKYPEKGYLPNRELVERVKEAHERGLAGSRGWGYVWSPERAMFLMPRAHATALSARQLAKGIEIPGKYFTIQRVFRPDVLDRTHLIEFNQIDGFVAAEDLTFRHLLGILKKFAIEIAGAKKVKFFPDYYPFTEPSVQLSAYHPELGWVEFGGAGVFREEMTKALGIDVPVIAWGIGIDRLAMFRLGIDDIRYLFSYDLKWLREAKLIW 8D6E02185A571B2A cmr5_pyrfu CRISPR system Cmr subunit Cmr5 cmr5 CRISPR type III-B/RAMP module-associated protein Cmr5 PF1125 protein protein pyrfu Pyrococcus furiosus MEVHMLSKDNKKSIRKTLEQRRGEYAYYVIKEVADLNDKQLEEKYASLVKKAPVMILSNGLLQTLAFLLAKAETSPEKANQILSRVNEYPPRFIEKLGNDKDEHLLLYLHIVYWLRENVDRNIDVKTLLSQDYSKVLWATKEAIALLNWMRRFAVAMLKEEGKENEGSS DIP protein Q8U1T0 original sequence version: 51 22AF2EA37ABA2249 lysj_pyrfu Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase lysJ PF1685 protein protein pyrfu Pyrococcus furiosus MSLYRKRLRLVKGEGIYVWDSQGKKYIDLIAGIGVNVLGHNHPEWVSELQEQLEKLVVAGPMFDHEEKYEMLEELEKFVTYEYVYIGNSGTEAVEAALKFARLYTGRKEIIAMTNAFHGRTMGALSATWKPKYREDFKPLVPGFKHIPFNDVEAAKEAITTETAAVIFEPIQGEGGVVPANEEFVKTLRDLTEDKGALLIADEVQSGLRTGKFLAIEHYKVEPDIVTMGKGIGNGVPVSLTLTNFDVERGKHGSTFGGNPLACKAVAVTLRILRREKLIEKAAEKFIEIKGENVVLTRGKGLMIGIVMKKPVAKVVEELQNRGYLVHTAGQRVIRLLPPLIISKDEINQAKSAIEGVINDIYGRKN 3E8AAF15CDF30B92 q8u1k3_pyrfu Aldehyde ferredoxin oxidoreductase PF1203 protein protein pyrfu Pyrococcus furiosus MNVKMVDSMYGWWGRILRVNLTTGEVKVQEYPEEVAKKFIGGRGLAAWILWNEARGVEPLSPENKLIFAAGPFNGLPTPSGGKLVVAAKSPLTGGYGDGNLGTMASVHLRRAGYDALVVEGKAKKPVYIYIEDDNVSILSAEGLWGKTTFETERELKEIHGKNVGVLTIGPAGENLVKYAVVISQEGRAAGRPGMGAVMGSKKLKAVVIRGTKEIPVADKEELKKLSQEAYNEILNSPGYPFWKRQGTMAAVEWCNTNYALPTRNFSDGYFEFARSIDGYTMEGMKVQQRGCPYCNMPCGNVVLDAEGQESELDYENVALLGSNLGIGKLNEVSVLNRIADEMGMDTISLGVSIAHVMEAVERGILKEGPTFGDFKGAKQLALDIAYRKGELGNLAAEGVKAMAEKLGTHDFAMHVKGLEVSGYNCYIYPAMALAYGTSAIGAHHKEAWVIAWEIGTAPIEGEKAEKVEYKISYDPIKAQKVVELQRLRGGLFEMLTACRLPWVEVGLSLDYYPKLLKAITGVTYTWDDLYKAADRVYSLIRAYWVREFNGKWDRKMDYPPKRWFTEGLKSGPHKGEHLDEKKYDELLSEYYRIRGWDERGIPKKETLKELDLDFVIPELEKVTNLE A3FD207AC9F23DF5 cmr6_pyrfu CRISPR system Cmr subunit Cmr6 cmr6 CRISPR type III-B/RAMP module RAMP protein Cmr6 PF1124 protein protein pyrfu Pyrococcus furiosus MKEVVKLVLLGERQNSLNLSLYFNKYPPTIIYPEVLEDRNKKLASPSGSQRKISLLVLNQGVLQFNKIKETIEKSLPIETKVKLPQKAYELYKKYYQDYTDMLNSLHAITGKFKTQSRLVVGLGDESVYETSIRLLRNYGVPYIPGSAIKGVTRHLTYYVLAEFINEGNDFYKRAKTVQDAFMKGDPKEILSNAKVPERCSRLCKEFLRIFGEKKVPEIIDELIRIFGTQKKEGEVVFFDAIPIAEEIADKPILELDIMNPHYGPYYQSGEKNVPPPGDWYDPIPIFFLTVPKDVPFLVAVGGRDRELTEKAFSLVKLALRDLGVGAKTSLGYGRLVEYV DIP protein Q8U1T1 original sequence version: 50 3E7578E79510FB32 cmr4_pyrfu CRISPR system Cmr endoribonuclease Cmr4 cmr4 CRISPR type III-B/RAMP module RAMP protein Cmr4 Target RNase Cmr4 PF1126 protein protein pyrfu Pyrococcus furiosus MKAYLVGLYTLTPTHPGSGTELGVVDQPIQRERHTGFPVIWGQSLKGVLRSYLKLVEKVDEEKINKIFGPPTEKAHEQAGLISVGDAKILFFPVRSLKGVYAYVTSPLVLNRFKRDLELAGVKNFQTEIPELTDTAIASEEITVDNKVILEEFAILIQKDDKGILESVVKAIEQAFGNEMAEKIKGRIAIIPDDVFRDLVELSTEIVARIRINAETGTVETGGLWYEEYIPSDTLFYSLILVTPRAKDNDMALIKEVLGKINGKYLQIGGNETVGKGFVKVTLKEVTNNGGTHAK DIP protein Q8U1S9 original sequence version: 54 FFF22879BB86CECE ef1a_pyrfu Elongation factor 1-alpha tuf Elongation factor Tu PF1375 protein protein pyrfu Pyrococcus furiosus MPKDKPHVNIVFIGHVDHGKSTTIGRLLYDTGNIPEQIIKKFEEMGEKGKSFKFAWVMDRLKEERERGITIDVAHTKFETPHRYITIIDAPGHRDFVKNMITGASQADAAVLVVAATDGVMPQTKEHAFLARTLGIKHIIVAINKMDMVNYNQKRFEEVKAQVEKLLKMLGYKDFPVIPISAWEGENVVKKSDKMPWYNGPTLIEALDQIPEPEKPVDKPLRIPIQDVYSIKGVGTVPVGRVETGKLRVGEVVIFEPASTIFHKPIQGEVKSIEMHHEPLEEALPGDNIGFNVRGVSKNDIKRGDVAGHTTNPPTVVRTKDTFKAQIIVLNHPTAITVGYSPVLHAHTAQVPVRFEQLLAKLDPKTGNIVEENPQFIKTGDAAIVILRPMKPVVLEPVKEIPQLGRFAIRDMGMTIAAGMVISIQRGE BDB7A52BEC528366 cmr1b_pyrfu CRISPR system Cmr subunit Cmr1-2 cmr1-2 CRISPR type III-B/RAMP module RAMP protein Cmr1-2 PF0352 protein protein pyrfu Pyrococcus furiosus MYEAIFDLEAITPLFMRGADARSPEFSSASVKGVMRWWFRALAGGYFGNNIEALKEVEEKIFGSTRNKSRVFVRAEVEDVKKGNIYRQASSWADKTIIVWSEYVDYFFFSVLDKRRNRKTKKIDIKTRFEYFDVGSKFSISLSSTDERYFRLAEASLWMTINLGGFGFRARRGAGSLKVQMLREMLL B0D3699E70C929E3 rtcb_pyrfu RNA-splicing ligase RtcB 3'-phosphate/5'-hydroxy nucleic acid ligase PF1615 rtcB protein protein pyrfu Pyrococcus furiosus MIILRVVNVAVPLKRIDKIRWEIPKFDKRMKVPGRVYADDVLIEKMRQDRTLEQAANVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDIKEGVISPGGIGYDINCLAPGTKVLTEHGYWLKIEEMPEKFKLQRLRLYNIEEGHNDFSRVAFVAERNIEKDETAIRIVTETGTLIEGSEDHPVLTPQGYVYLKNIKEGDYVIVYPFEGVPYEEKKGIIIDESAFEGEDPQVIKFLKERNLLPLRWEDPKIGTLARILGFALGDGHLGEMGGRLVLAFYGREETLRELKKDLESLGIKANLYVREKNYRIKTESGEYSGKTVLAELRVSSRSFALLLEKLGMPRGEKTKKAYRIPVWIMEAPLWVKRNFLAGFFGADGSIVEFKGTTPLPIHLTQAKDVALEENLKEFLYDISRILEEFGVKTTIYKVNSKKSVTYRLSIVGEENIRNFLGKINYEYDPKKKAKGLIAYAYLKFKESVKKERRKAMEISKKIYEETGNIDRAYKAVKDIVNRRFVERTIYEGERNPRVPKNFLTFEEFAKERGYEGGFVAEKVVKVERIKPEYDRFYDIGVYHEAHNFIANGIVVHNCGVRLIRTNLTEKDVRPKIKQLVDTLFKNVPSGVGSQGKVRLHWTQIDDVLVDGAKWAVDQGYGWERDLERLEEGGRMEGADPDAVSQRAKQRGAPQLGSLGSGNHFLEVQVVDKIFDEEIAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMERAIRKYGIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRESFQEVFRQDPEGDLGMEIVYDVAHNIGKVEEHEVDGKKVKVIVHRKGATRAFPPGHEAIPKIYRDVGQPVLIPGSMGTASYVLAGTEGAMAETFGSTCHGAGRVLSRAAATRQYRGDRIRDELLRRGIYVRAASMRVVAEEAPGAYKNVDNVVKVVSEAGIAKLVARMRPIGVAKG CC0AEE4573CFE7C2 q8u444_pyrfu PUA domain-containing protein PF0251 protein protein pyrfu Pyrococcus furiosus MVARVIVDAQAARAIGKGAMIVFKKGVVRTEGEIKPGDIVEVYTRGGKFLGKGFANPNSNIMVRIVTRDKDVEINKELFKERIRKANEYRKKVLKYTNVYRMVYGESDYLPGLIVDRFNDIASLQISSAGMERFKLEVAEAIMEVEPEIETVFEKNTGRSRRREGLPEIERVLLGKEKYRTIIQEGRAKFIVDMRGQKTGFFLDQRENRLALEKWVEPGDRVLDVFTYTGGFAIHAAIAGAEEVIAIDKSPRAIETAKENAKLNGVEDRIKFIVGSAFEEMEKLQKKGEKFDIVILDPPAFVQHEKDLQAGMRAYFNVNFAGLNLVKDGGILVTCSCSQHVDLQMFKDMIIAAGAKAGKFLKMLEPYRTQAPDHPILMASKDTEYLKCLFLYVEDMKH 6A72652175E26103 nadb_pyrfu L-aspartate oxidase nadB Quinolinate synthase B PF1976 protein protein pyrfu Pyrococcus furiosus MKVAVVGSGLAGLTAAMSLAKKGIEVTVFGPKPKESNSYLAQAGIAFPISDGDSIISHVTDTIRGGKYLNDVTVVWNVISKSTEAYHFLTSLGIEFTSRELEGGHSFPRIFTIKNETGKYIIPVLEKHAKEMGVNFIRKFAEEVAIHNKKIVGVFVEGELLYFDAVIIASGGFSGLYKFTAGNPWNLGIPIGDLALKGVPLRDIEFIQFHPTGFIGKRTYLISEAVRGAGAKLVTGEGERFVNELETRDVVAREIYRKMLEGKGVFLDATGIEDFKRRFPYIYSFLRREGINPKRDLIPVTPVAHYTIGGISVDIFYRTPIKGLYAIGEAACNGFHGANRLASNSLLECIVSGIEVSRTVIREKPRGERKEAKYHGYEPGNVDEVRDIMWNHAGIIRREESLRLGLKKLEKVEADPRVKILAEAVLKCALAREESRGAHYREDYPYSREEFRRPSIFRVENCML 413C23A61594A7B3 q8u1h0_pyrfu PF1238 protein protein pyrfu Pyrococcus furiosus MLIRGKVKESKIPKFKHRWFGVLEVEANGETYRLYMSGIAQWFLEGDEVEIKILRPPREKEGIKILEFNDYELYKFYNGEKIKVWPVWEKIYKTKRFSPLTAELLYEYEIRAREATYESDFEAIAELEQYHYASQKEKVALWRCEKCGIIIEANTKPICPKCKTDKHVHILEIKGSTPASRFLLLELVKREEYEPRVLAYVRVDPPIPLMHRKLPNGEIDKNIREKVFPKDCLSLASGRKRLMYELFVELRKKYPKKIARSLLWEKAKERALRESNTAGARIARVVVHPDYRSDGLGQLSVKAALEWIAERRIPEMRKKKHFVETIAQMARYNPFFEKVGFRYVWETASGRPVLIYPLTEEAKEYLENYFKNDPYAPKEPLWKPSYGKVEPLNGPIVFKNVSKVFESELDIKGLPEEIQDLLKAFGVRHRVIQRPVLRNLNFEIKPGEVIVVVGASGAGKTTLLRLILGAIMKYWEEKYRPTNGEIKVPDNAKVSVLIPGEFEPEFGSESILEHVYRKIRDLNAAVEVLNRAGLSDAVLYRAKFSELSTGQKERAKIASLLAEKPNLILIDEFAAHLDTLTAMRVARKVAEIIREAGITAVIITHRPEVVKALDPDRILFVGYGTAIMKDKL AA639C2D68B23B83 tmbl1_pyrfu HTH-type sugar sensing transcriptional regulator TrmBL1 trmBL1 PF0124 protein protein pyrfu Pyrococcus furiosus MLEEEILQKLQKFGLTKYESLAYLTLLKLGPSKATDVTKESGIPHTRIYDVLSSLARKGFVDIVHGTPRLYAPVNPEIVLEKIREDLISDIERLKKAFQELYREVHGEELPEIWTVHGFENTIDRAQHIIRSAKHDILINTPYEFLEYLRGVLEKRNDVLIIVISNFSEIPLWLRNKNNVILARSGQAPWLLGTWVIGDINYALFFGTLPEDKGKERFYSFWVKSTRLIQNYVHWFYTMYFDNSEIVKPLNYERMEKPLTLSHIRTVITVLKQAGLPRNIEVIGRSLADKKQVTIKGKVIDYEYTPLTANITVKTDNKKIKVGGLGSYLEDIEGESFILLD 6D94DC1D059EBB26 q8u3v4_pyrfu PF0351 protein protein pyrfu Pyrococcus furiosus MDDNKPRRFWFSSKTRGRKFESTNAEGDVTLNFTKFDSLKKFSQELSNVVSQFNKAIRELDIKFEQSGREKEHYPNYPTFDQENSLVFTNEEWAASGKKETWIKALDNFGRWYLGRRRGRKFIDGFRFKFADYTLSHALEKVKEDSIIKTVNSEPLKEKRYYLGLPIRYANYGTTVSGWSGDLPLENKKLKKDNIVHRRASGYWLSLIDINGTIYPTVTVFAYQFYPNYRGAFYFEKQDNKTKARGLIYIYEDNYSAYLFYKRWIENIVQNSDKGKFVVLWPKKS 36042301CFE5E57A q8tzz6_pyrfu PF1827 protein protein pyrfu Pyrococcus furiosus MKVKTIMTPNPVTITLPATRNYALELFRKHKVRSFPVVNKEGKLVGIISIKRVLTNVDEEQLAMLVKRDVPTVKPDDTLKKAAKLMLEYDYRRVVVIDEEGKPVGILTVGDIIRRYLAKSEKYKDVEIEPYYQRYVSVVWRGTPLMAALKALLLSNAMALPVIDDDGKLIGIVDETDLLRDSEIVRIMKSTELAASSEEEWILESHPTLLFEKFELKLPNKPVEDIMTRDVIVATPHMTVHEVARKMVKYKIEQLPVIRGDGDLVGLIRDFDLLKVLVK B7707133D185A96D atgt_pyrfu tRNA-guanine(15) transglycosylase tgtA Archaeal tRNA-guanine transglycosylase PF1046 7-cyano-7-deazaguanine tRNA-ribosyltransferase protein protein pyrfu Pyrococcus furiosus MSRGDSMLRFEIKDRDAAGRIGKLEVNGKKIETPAIMPVVNPKQLIVEPKELKRMGFDIIITNSYIIYKDKKLREKALEKGIHRLLDYDGIIEVDSGSFQLMRYGKVEVTNREIVEFQHKIGVDIGTFLDIPTPPDAPREKAEQDLKITLERAKEAESIKQIPMNATVQGSTYLDLRKLAARKLSEMNFEIHPIGAVVPLLESYRFKDVVDIVIASKMGLRPDRPVHLFGAGHPMVFALAVAMGVDLFDSASYALYAKDDRYLTPQGTKRLEELEYFSCSCPVCSKYTPQELREMPKEEREKLLALHNLWVIREEINRVKQAIKEGELWRLVDERARAHPKLYAAYKRLLEYYHYLEEYEPITKKSAFFKISEESLKWPIARRAKERAEKVKAKFPESIPHPIFGEIPKYLSLTYPFAQSESEEDFQIEKPTRENAILYIMAIAEYQFGEGAGEAFRDAEVEIAKTGMPRQVKKNGKRLATVRAEDGLLTLGIEGAKRLHELLPYPVMRVVVNKEAEPFARKGKDVFAKFVEFADPKIRPYDEVLIVNENDELLATGQALLSGREMVLFSSGRAVKTRRGVEEKK 747CDCB3E147CC0A if5a_pyrfu Translation initiation factor 5A eif5a eIF-5A Hypusine-containing protein PF1264 protein protein pyrfu Pyrococcus furiosus MGDKTKVQVSKLKPGRYIIIDDEPCRIVNITVSSPGKHGSAKARIEAVGIFDGKVRSIVKPTSAEVDVPIIDKRTAQVIAVTPDTVQIMDMETYEMFEVPLDTGVEEEIKDKIKEGINVEYWETLGRIKIMRIKGEEE FCBEE47EC4B5A7C1 rgyr_pyrfu Reverse gyrase rgy PF0495 protein protein pyrfu Pyrococcus furiosus MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS 7B854F084C254EE6 alba_pyrfu DNA/RNA-binding protein Alba albA PF1881 protein protein pyrfu Pyrococcus furiosus MAEEHVVYIGKKPVMNYVLAVITQFNEGAKEVSIKARGRAISRAVDVAEIVRNRFLKDTVDIKEIKIGTEELPTADGRTTNTSTIEIVLERKV B9ADBD0587A13243 q8u1g3_pyrfu PF1245 protein protein pyrfu Pyrococcus furiosus MRNLRPLDLTEKKKKKVRIYFEGKELEAYEGEKLPVALLANGIYWLTTSLEGRKRGAFTFGPVPMIINGVKGVDARKTKVKDGMKVQRQTYGDFHEEPLPQDGEVKQVVVDVLVIGGGPAGLGAVLEMQEHLNVALVEEKGWLGGDMFLKTSTAEGFEESSRKVVDKLAKEVKANVYLGTVALGVFDKGEYFLVPATKGNNLIEFLAKRVVLATGAVDNIMLFENNDMPGVFRRDFALEVMNVWEVAPGWNVAVTGSKAEEVIYELERWGIDYVEVPSVKRVEGKEKVEKVIDFNGNEYKVDAIIFADGKRPDINPITQAGGKLHFRRGYYRPVVNEYNQIREGVYVAGSAVTIKPHYTNYLEGRLVGAYILREFGIDSEPCIYKEKLKEFEPEALPVPKIPINKLNLDDVQICGCDVSLRKVYDVVEKGITDLQIIKRLTHLAMGFCQGRFCLFNGAAVVSQVTGIKLGEIDLPVARPPIKTVKLGILSRR B16BCACD91B42642 acda1_pyrfu Acetate--CoA ligase [ADP-forming] I subunit alpha acdAI ADP-forming acetyl coenzyme A synthetase I subunit alpha PF1540 protein protein pyrfu Pyrococcus furiosus MSLEALFNPKSVAVIGASAKPGKIGYAIMKNLIEYGYEGKIYPVNIKGGEIEINGRKFKVYKSVLEIPDEVDMAVIVVPAKFVPQVLEECGQKGVKVVPIISSGFGELGEEGKKVEQQLVETARKYGMRILGPNIFGVVYTPAKLNATFGPTDVLPGPLALISQSGALGIALMGWTILEKIGLSAVVSVGNKADIDDADLLEFFKDDENTRAILIYMEGVKDGRRFMEVAKEVSKKKPIIVIKAGRSERGAKAAASHTGSLAGSDKVYSAAFKQSGVLRAYTIGEAFDWARALSNLPEPQGDNVVIITNGGGIGVMATDAAEEEGLHLYDNLEELKIFANHMPPFGSYKNPVDLTGMADGKSYEGAIRDALAHPEMHSIAVLYCQTAVLDPRELAEIVIREYNESGRKKPLVVAIVGGIEAKEAIDMLNENGIPAYPEPERAIKALSALYKWSKWKAKHKEK 756BB577C8112504 rad50_pyrfu DNA double-strand break repair Rad50 ATPase rad50 pfRad50 PF1167 protein protein pyrfu Pyrococcus furiosus MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREVLNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLEETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEKELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLEELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDRKSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLEKAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIALGLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS DIP protein P58301 original sequence version: 78 3ADCBD250382A99E q8u4c6_pyrfu PF0162 protein protein pyrfu Pyrococcus furiosus MEINEFISQLKLGETVLVEHSSYSKPELLFYGIIKESRMPVVIDDILDTLFEYYNKLKVWGYDLTVFDKVYVIKAGGNEVIGNLLGKLEVGKYVIEAREYTKIIKEVNPPIINPVLGVHKLILLGNLLENLRLLKEISTYVGNENRVAIYFVNRDVVESHSPAALKLLEEISTSVFQLNEENKIKRMK 6EF5FDAF98D02FF1 q8u049_pyrfu PF1768 protein protein pyrfu Pyrococcus furiosus MIIRGDEPEQKALLRKLYRAGNYFMMGDEAIAYGAIFAGCRFYAGYPITPSSEIAETMARELPKVGGYYLQMEDEIASIAAIIGASWTGLKAMTATSGPGFSLMQENIGYAVMTETPVVIVDVQRSGPSTGQATKGAQGDFFQARWGTHGDHPIIAVSPISVEDAFWETIRAFNIAEQLRTPVIVLFDGILGHTREQIRIPDPDEVEISYRKLPRNEEEAKLPFGDPHGDGVPPMPIFGKGYFTHVTGSTHKENGLRDVYTPEVHDRLVRRLHKKIEKNRHIYEKYNEYFTDDAEILVVSWGVSARPSLGAVKKAREEGIKAGLFVPKTVHPFPGEKMRELGKKVRAILVPEMNLGQLILEVQRFVNDDVILKGVNKIGGVPITVEEILREIRGVA 703B88ED29204FED q8u124_pyrfu PF1405 protein protein pyrfu Pyrococcus furiosus MTILIKRETMVEEILKEIREKVAQKIPKEAKITEIEFEGPELVIYVKNPEVVMKDGELIKELAKILKKRISIRPDPDVLLPPEEAEKLILEIVPKEAEITNISFDPSVGEVLIEAKKPGLVIGKNGETLRLITEKVRWAPKVVRTPPLQSQTIYLIRQILQTESKDRRKFLRQVGRNIYRKPEYKSRWIRITGLGGFREVGRSALLVQTDESFVLVDFGINVAALNDPYKAFPHFDAPEFQYVLKEGLLDAIVITHAHLDHSGMLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFVEIQQSNGQEPLYKPKDIKEVIKHTITLDYGEVRDISPDVRLTLHNAGHILGSAIVHLHIGNGLHNIAVTGDFKFIPTRLLEPASYRFPRLETLVMESTYGGANDIQMPREEAEKRLIEVIHQTIRRGGKVLIPAMAVGRAQEIMMVLEEYARVGGIDVPIYLDGMIWEATAIHTAYPEYLSKTLREQIFKEDYNPFLSEIFHPVANSKERQDIIDSNEPAIIIASSGMLVGGPSVEYFKQLASDKRNSIIFVSYQAEGTLGRQVQSGVREIPMIGESGRTEVIKVNMEVHTIDGFSGHADRKELMNYVAKVRPRPERVITVHGEPQKCLDLATSIHKKFGLSTRAPNNLDTIRLR 9F3E9789A06F6027 q8u3d5_pyrfu Indolepyruvate oxidoreductase subunit IorA Indolepyruvate ferredoxin oxidoreductase subunit alpha PF0533 protein protein pyrfu Pyrococcus furiosus MVKVTDIVLWDKPGERVLLLGNQAIVRGALEGNIAVFAAYPGTPSSEVTDTMAAVAKRAGVYMEYSTNEKVAFETALSASWAGLRAMTAMKHVGLNVAMDSFMTVSYMGVNGGFIVMVADDPSMWSSQNEQDTRAIGKFANIPVLEPSSVQEAKDIVKYGFEISEKYGQMVILRTTTRSSHMRGDVVLGELPEEIKQGKRKFGEFKKNPERYVDIPAFQRKKHLWLLETIEKYRKEFESSPFNWIEGDGKVGIIAPGLSYAYVKEALAWLGMENIRILKLGTPFPVPYALLEKFFDGLEKVLIVEELEPVVEEQVKLWAYDNDVRIPIHGKDLVPRVYEMTTRRAVEAIAKFLGVSTPIKFEEIDEKYKKVQEIVPPRPPSLCPACPHRNTFFAIRKAAGPKAIYPSDIGCYTLGVLPPLKTVDTTIAMGGSIGIAHGLSIALNGALSEEQRKTGKEKKVIVATIGDSTFFHTGLPALANAIYNRSNVLIVVMDNLVTAMTGDQPNPGTGETPHGEGRRILIEEVAAAMGADFVAVVDPYDIKATYETIKKALEVEGVSVVVSRRACALYRIGQLRREGKQWPIYQVNEEKCTGCKVCINAYGCPAIYWDAEKKKARVDPLMCWGCGGCAQVCPFGAFEKVREGEL 99A962164656E17E cmr1a_pyrfu CRISPR system Cmr subunit Cmr1-1 cmr1-1 CRISPR type III-B/RAMP module RAMP protein Cmr1-1 PF1130 protein protein pyrfu Pyrococcus furiosus MFIEEFEIESITSTHLLEVLTREYPEVRSPSIKGAMRWWFRALAGSYFGDDAQKLKEIENQVFGSTKERSRVKISVTPLSSPKRLNLKEFKDKNVGYIWFSINLLGKRGTITHYYPPGSRFRVVLESPSERVIKLATLSLWALVSLGSVGFRSRRGTGSMKIVRASSEVLEDLGLTTEFNSIDEFKDSLKRVLDVTGEILGVKNSETNKSLPSYATLKFSDVEVFGPGKNTWEVLAQFNNSYKEYLRRRIKKYQRIIFGLPRFKLRGVRKDLRRASPLWFGVVEIGGKPYGRIIKFFQSTFHPEVRSKHIVDWNVLSNFDWFISSRLPVTKVWGGWSG DIP protein Q8U1S5 original sequence version: 49 65EF194EF9A9851C q8u487_pyrfu Glutamine amidotransferase type-2 domain-containing protein PF0204 protein protein pyrfu Pyrococcus furiosus MLKYRDEKDISACGIFGIMDRKGRRFNGKLVIEAMSQMKVRGNGLGAGFAVYGLYKKFKEYYAFHVMIYDKDGREKLEKFLSTNFDIVYVDEIPVNDKAKVIDPPKFMRYFVAPRKKGTEKVLNDDDFVVKKVMYINRAIPGVYVISSGKNMGVFKGVGFPEDIADYFMIEEYKGYIWTAHTRFPTNTPGWWGGAHPFSILDWSVVHNGEISSYGTNKRYLEMYGYYSTLQTDTEVITYIFDLLVRRQGLPIEVVSKILAPPMWEEIDRMPEKEKKFYKALRMVYSPILLNGPWAIIVARHGEMIGLTDRIRLRPLTVAEKKSFLIISSEEAPIRYLFRDVDRIYTPYGGELVVGKLEEDIKKFVGESQ ACC7975C101F7243 cca_pyrfu CCA-adding enzyme cca tRNA nucleotidyltransferase tRNA adenylyl-/cytidylyl- transferase tRNA CCA-pyrophosphorylase tRNA-NT PF0026 CCA tRNA nucleotidyltransferase protein protein pyrfu Pyrococcus furiosus MDIEEVIEEALQKIVPKEEEERFVKTLMSEIEEKARETIEELNLNAKPYFVGSLAKNTYLAGDHDLDLFIAFPLDTSLEKLREKGLEAGKVLGKKLGRYELAYAEHPYVRAEYKGVKVDIVPCYDVKSWKDVRTAVDRSILHTKWVIENLKGKNNEVRLFKRFLKGIKAYGSEIYVRGFSGYLAEILVIEFGSFLSVLEKADFMLKKKIIDTGKWMKKESEITMKTIKREAEEDKPLIVIDPVDPRRNVAANLSWERFGLFYFSSMQFLEKPSLEFFFPGEKRGNYREELKRKGTHLVTLLFTPPKLVDDLLLPQVEKTAKGLAKALEIEGFKVFGIDYGRNFIFLEVDRVEKPRIEIKRGPLYFTSHGRRFYEKNEKVWIEGKDLMAEKKVGGFIVEVLEEIFKKGQFSAGKNVKEVIKSSDILIDFVPKPLANEAYLFLSREKFNVKRSTS 858955F2683F05F3 cmr2-syfa-1 1 19 unspecified role unspecified role neutral component neutral component 51 unspecified role unspecified role neutral component neutral component 6 unspecified role unspecified role neutral component neutral component 47 unspecified role unspecified role neutral component neutral component 55 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component 56 unspecified role unspecified role neutral component neutral component 48 unspecified role unspecified role neutral component neutral component 16 unspecified role unspecified role neutral component neutral component 34 unspecified role unspecified role neutral component neutral component 46 unspecified role unspecified role neutral component neutral component 54 unspecified role unspecified role neutral component neutral component 14 unspecified role unspecified role neutral component neutral component 39 unspecified role unspecified role neutral component neutral component 8 unspecified role unspecified role neutral component neutral component 59 unspecified role unspecified role neutral component neutral component 42 unspecified role unspecified role neutral component neutral component 40 unspecified role unspecified role neutral component neutral component 44 unspecified role unspecified role neutral component neutral component 23 unspecified role unspecified role neutral component neutral component 15 unspecified role unspecified role neutral component neutral component 12 unspecified role unspecified role neutral component neutral component 24 unspecified role unspecified role neutral component neutral component 41 unspecified role unspecified role neutral component neutral component 37 unspecified role unspecified role neutral component neutral component 18 unspecified role unspecified role neutral component neutral component 13 unspecified role unspecified role neutral component neutral component 38 unspecified role unspecified role neutral component neutral component 57 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component 17 unspecified role unspecified role neutral component neutral component 30 unspecified role unspecified role neutral component neutral component 32 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component 28 unspecified role unspecified role neutral component neutral component 10 unspecified role unspecified role neutral component neutral component 33 unspecified role unspecified role neutral component neutral component 49 unspecified role unspecified role neutral component neutral component 5 unspecified role unspecified role neutral component neutral component 4 unspecified role unspecified role neutral component neutral component 45 unspecified role unspecified role neutral component neutral component 43 unspecified role unspecified role neutral component neutral component 25 unspecified role unspecified role neutral component neutral component 29 unspecified role unspecified role neutral component neutral component 31 unspecified role unspecified role neutral component neutral component physical association physical association Fig. 1E, Supp. Table 1 A number of prokaryotic silencing (psi)RNAs were purified with this complex pf1130-pf1128-1 2 26 enzyme target enzyme target substrate substrate neutral component neutral component 32 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) 35 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) 36 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) 30 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) 17 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) 57 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) rna cleavage rna cleavage It is unclear which of the subunits has catalytic activity so the biological role 'enzyme' could not be assigned. 5A psiRNA cleaved at 2 sites to generate 14- and 20-nucleotide 5′ end-labeled products. A reconstituted set of six P. furiosus Cmr proteins (Cmr1-1, Cmr2 - Cmr6) and two mature psiRNA species (45- and 39-nucleotide psiRNA 7.01, found in the native complex based on Northern analysis [Figure 1] and activity of the native complex against the 7.01 target [Figure 3]) cleaved the target RNA at 2 sites generating the same size products as those observed with the isolated native complex (Figure 5A). pf1130-pf1128-2 3 20 unspecified role unspecified role neutral component neutral component 21 unspecified role unspecified role neutral component neutral component 50 unspecified role unspecified role neutral component neutral component 11 unspecified role unspecified role neutral component neutral component 58 unspecified role unspecified role neutral component neutral component 27 unspecified role unspecified role neutral component neutral component 10 unspecified role unspecified role neutral component neutral component 52 unspecified role unspecified role neutral component neutral component 9 unspecified role unspecified role neutral component neutral component 45 unspecified role unspecified role neutral component neutral component 53 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component 30 unspecified role unspecified role neutral component neutral component 17 unspecified role unspecified role neutral component neutral component association association Supp. Table 1