IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. J. Biol. Chem. (0021-9258) 2011 imex curation Griffiths G.S., Grundl M., Leychenko A., Reiter S., Young-Robbins S.S., Sulzmaier F.J., Caliva M.J., Ramos J.W., Matter M.L. Apoptosis - Interactions involving proteins with a function related to apoptosis matter@hawaii.edu 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions human-hcaec human coronary artery endothelial cells hcaec human cardiac artery endothelial cells anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Griffiths G.S., Grundl M., Leychenko A., Reiter S., Young-Robbins S.S., Sulzmaier F.J., Caliva M.J., Ramos J.W., Matter M.L. Apoptosis - Interactions involving proteins with a function related to apoptosis matter@hawaii.edu Accepted 2012-JUL-30 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. J. Biol. Chem. (0021-9258) 2011 Only protein-protein interactions imex curation Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. J. Biol. Chem. (0021-9258) 2011 imex curation Griffiths G.S., Grundl M., Leychenko A., Reiter S., Young-Robbins S.S., Sulzmaier F.J., Caliva M.J., Ramos J.W., Matter M.L. Apoptosis - Interactions involving proteins with a function related to apoptosis matter@hawaii.edu 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions rat-h9c2 h9c2 rat myoblasts h9c2 h9c2 rat myoblasts fluorescence imaging fluorescence microscopy fluorescence imaging immunostaining immunostaining Griffiths G.S., Grundl M., Leychenko A., Reiter S., Young-Robbins S.S., Sulzmaier F.J., Caliva M.J., Ramos J.W., Matter M.L. Apoptosis - Interactions involving proteins with a function related to apoptosis matter@hawaii.edu Accepted 2012-JUL-30 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. J. Biol. Chem. (0021-9258) 2011 Only protein-protein interactions imex curation Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. J. Biol. Chem. (0021-9258) 2011 imex curation Griffiths G.S., Grundl M., Leychenko A., Reiter S., Young-Robbins S.S., Sulzmaier F.J., Caliva M.J., Ramos J.W., Matter M.L. Apoptosis - Interactions involving proteins with a function related to apoptosis matter@hawaii.edu 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions rat-h9c2 h9c2 rat myoblasts h9c2 h9c2 rat myoblasts anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Griffiths G.S., Grundl M., Leychenko A., Reiter S., Young-Robbins S.S., Sulzmaier F.J., Caliva M.J., Ramos J.W., Matter M.L. Apoptosis - Interactions involving proteins with a function related to apoptosis matter@hawaii.edu Accepted 2012-JUL-30 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. J. Biol. Chem. (0021-9258) 2011 Only protein-protein interactions imex curation pth2_human Peptidyl-tRNA hydrolase 2, mitochondrial PTRH2 BIT1 PTH2 CGI-147 Bcl-2 inhibitor of transcription 1 protein protein human Homo sapiens Human MPSKSLVMEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCGQPKVVVKAPDEETLIALLAHAKMLGLTVSLIQDAGRTQIAPGSQTVLGIGPGPADLIDKVTGHLKLY 11A0BA9ECF6B5E46 q5xi86_rat Aminoacyl-tRNA hydrolase Ptrh2 RGD1306819 rCG_34306 protein protein rat Rattus norvegicus (Rat) Rat MLSKLLTMEYLVHPGTLSLAAGVACGMCLGWGLRSHLGIFPQNSTSETNRDTEMGTEASILGESGEYKMILVVRTDLKMGKGKVAAQCSHAAVSAYKQIQRRNPQVLKEWEYCGQPKVVVKAPDEDSLIQLLTHAKALGLTVSLIQDAGRTQIEPGSRTVLGIGPGPVELIDEVTGHLKLY 5CA250522F88FCF0 fak1_rat Focal adhesion kinase 1 Ptk2 Fak Fak1 Focal adhesion kinase-related nonkinase Protein-tyrosine kinase 2 p125FAK pp125FAK protein protein rat Rattus norvegicus (Rat) Rat MAAAYLDPNLNHTPSSSTKTHLGTGTERSPGAMERVLKVFHYFESSNEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQDIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANNEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQISGYPGSHGIPAMAGSIYPGQASLLDQTELWNHRPQEMSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPAESYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPILPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH DIP protein O35346 original sequence version: 101 DIP protein O35346 original sequence version: 124 3AFB4ED682D14A33 fak1_human Focal adhesion kinase 1 PTK2 FAK FAK1 pp125FAK Protein-tyrosine kinase 2 Focal adhesion kinase-related nonkinase Protein phosphatase 1 regulatory subunit 71 p125FAK protein protein human Homo sapiens Human MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH D8A4C15138AB0243 ptk2-ptrh2 2 5 unspecified role unspecified role neutral component neutral component 6 unspecified role unspecified role neutral component neutral component colocalization colocalization 8a ptrh2-ptk2 3 6 unspecified role unspecified role prey prey 5 unspecified role unspecified role bait bait physical association physical association 9a ptk2-ptrh2-1 3 5 unspecified role unspecified role prey prey 6 unspecified role unspecified role bait bait physical association physical association 9a ptrh2-ptk2-1 1 4 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 9b ptk2-ptrh2-2 1 4 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait physical association physical association 9b