IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development (0950-1991) 2008 imex curation Osterfield M., Egelund R., Young LM., Flanagan JG. Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. Apoptosis - Interactions involving proteins with a function related to apoptosis Alzheimers - Interactions investigated in the context of Alzheimers disease Chick brain tecta were surface biotinylated, then incubated with bait protein, washed, incubated in DTSSP (a cleavable, membrane impermeable crosslinker) then lysed and immunoprecipitated for the AP tag. flanagan@hms.harvard.edu 16-Dec-2008: Contacted by JYOTI. davet Only protein-protein interactions chick-embryonic_brain Chick embryonic brain embryonic_brain crosslink cross-linking study crosslink de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Osterfield M., Egelund R., Young LM., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Chick brain tecta were surface biotinylated, then incubated with bait protein, washed, incubated in DTSSP (a cleavable, membrane impermeable crosslinker) then lysed and immunoprecipitated for the AP tag. flanagan@hms.harvard.edu Accepted 2008-Not a month!-3 by DAVET. 16-Dec-2008: Contacted by JYOTI. Development (0950-1991) 2008 davet Only protein-protein interactions imex curation Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development (0950-1991) 2008 imex curation Osterfield M., Egelund R., Young LM., Flanagan JG. Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. Apoptosis - Interactions involving proteins with a function related to apoptosis Alzheimers - Interactions investigated in the context of Alzheimers disease Chick brain tecta were surface biotinylated, then incubated with bait protein, washed, incubated in DTSSP (a cleavable, membrane impermeable crosslinker) then lysed and immunoprecipitated for the AP tag. flanagan@hms.harvard.edu 16-Dec-2008: Contacted by JYOTI. davet Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Osterfield M., Egelund R., Young LM., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Chick brain tecta were surface biotinylated, then incubated with bait protein, washed, incubated in DTSSP (a cleavable, membrane impermeable crosslinker) then lysed and immunoprecipitated for the AP tag. flanagan@hms.harvard.edu Accepted 2008-Not a month!-3 by DAVET. 16-Dec-2008: Contacted by JYOTI. Development (0950-1991) 2008 davet Only protein-protein interactions imex curation Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development (0950-1991) 2008 imex curation Osterfield M., Egelund R., Young LM., Flanagan JG. Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. Apoptosis - Interactions involving proteins with a function related to apoptosis Alzheimers - Interactions investigated in the context of Alzheimers disease Chick brain tecta were surface biotinylated, then incubated with bait protein, washed, incubated in DTSSP (a cleavable, membrane impermeable crosslinker) then lysed and immunoprecipitated for the AP tag. flanagan@hms.harvard.edu 16-Dec-2008: Contacted by JYOTI. davet Only protein-protein interactions chick-embryonic_brain Chick embryonic brain embryonic_brain crosslink cross-linking study crosslink western blot western blot Immuno blot Immuno blot Osterfield M., Egelund R., Young LM., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Chick brain tecta were surface biotinylated, then incubated with bait protein, washed, incubated in DTSSP (a cleavable, membrane impermeable crosslinker) then lysed and immunoprecipitated for the AP tag. flanagan@hms.harvard.edu Accepted 2008-Not a month!-3 by DAVET. 16-Dec-2008: Contacted by JYOTI. Development (0950-1991) 2008 davet Only protein-protein interactions imex curation p12023-2 Amyloid-beta precursor protein App ABPP Alzheimer disease amyloid A4 protein homolog Amyloidogenic glycoprotein Amyloid precursor protein A4 AD1 Alzheimer disease amyloid protein Amyloid-beta (A4) precursor protein Amyloid-beta A4 protein protein protein mouse Mus musculus Mouse MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSVDSADAEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEEEADDDEDVEDGDEVEEEAEEPYEEATERTTSTATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 0DE93FA56FB20F3A f1nn99_chick protein protein chick Gallus gallus (Chicken) Chicken MDGGTAEAVSGPGRASFPFPYTPYRIQEQFMAALYAALEAGRIGIFESPTGTGKSLSLICGALSWLQDFEKKKQQEEARLLAPEGSGQEEKQPLASGGPACPNSRDASGEPDWVTAFVQKKEEQDLVHRLKVEKYLCVDKGENSKV The sequence has been withdrawn from uniprot. 1CB1ECEEABC427CB ncam1_chick Neural cell adhesion molecule 1 NCAM1 protein protein chick Gallus gallus (Chicken) Chicken MLPAAALPWTLFFLGAAASLQVDIVPSQGEISVGESKFFLCQVAGEAKYKDISWFSPNGEKLTPNQQRISVVRNDDFSSTLTIYNANIDDAGIYKCVVSSVEEGDSEATVNVKIFQKLMFKNAPTPQEFKEGDDAVIVCDVVSSLPPTIIWKHKGRDVMLKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPSVRARQSTMNATANLSQSVTLACDADGFPEPTMTWTKDGEPIEQEDNEEKYSFNYDGSELIIKKVDKSDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENKTAMELEDQITLTCEASGDPIPSITWKTSTRNISNEEKTLDGRIVVRSHARVSSLTLKEIQYTDAGEYVCTASNTIGQDSQAMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAVISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESSEFILVQADTPSSPSIDRVEPYSSTARVEFDEPEATGGVPILKYKAEWRALGEGEWHSRLYDAKEANVEGTITISGLKPETTYSVRLSAVNGKGVGEISLPSDFKTQPVREPSAPKLEGQMGEDGNSIKVNVIKQDDGGSPIRHYLIKYKAKHSSEWKPEIRLPSGIDHVMLKSLDWNAEYEVYVIAENQQGKSKPAHYAFRTSAQPTVIPASTSPTSGLGTAAIVGILIVIFVLLLVAVDVTCYFLNKCGLLMCIAVNLCGKSGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEHTADTAATVEDMLPSVTTGTTNSDTITETFATAQNSPTSETTTLTSSIAPPATAIPDSNAMSPGQATPAKAGASPVSPPPPSSTPKVAPLVDLSDTPSSAPATNNLSSSVLSNQGAVLSPSTVANMAETSKAAAGNKSAAPTPANLTSPPAPSEPKQEVSSTKSPEKEAAQPSTVKSPTETAKNPSNPKSEAASGGTTNPSQNEDFKMDEGTFKTPDIDLAKDVFAALGTTTPASVASGQARELASSTADSSVPAAPAKTEKTPVEDKSEVQATEIRHLQQK B151367002DF88E0 aplp1_human Amyloid beta precursor like protein 1 APLP1 Amyloid beta (A4) precursor-like protein 1 Amyloid-like protein 1 protein protein human Homo sapiens Human MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP DIP protein P51693 original sequence version: 82 DIP protein P51693-1 original sequence version: 124 B95F0F4D1C5CBAC7 q90842_chick FAR-1 protein protein chick Gallus gallus (Chicken) Chicken TISWRRADGKQIPRKARRHRSNGLLEIPNFQQEDAGLYECVAENVRGKNVARGQLTFYAQPNWIQKISDVHAAIEENVFWECHASGRPKPSYRWLKDGEPLLPQGRVQIEQGSLTIRNVSLSDA D7ED3D5D016280E3 nfasc_chick Neurofascin NFASC protein protein chick Gallus gallus (Chicken) Chicken MVLHSHQLTYAGIAFALCLHHLISAIEVPLDSNIQSELPQPPTITKQSVKDYIVDPRDNIFIECEAKGNPVPTFSWTRNGKFFNVAKDPKVSMRRRSGTLVIDFHGGGRPDDYEGEYQCFARNDYGTALSSKIHLQVSRSPLWPKEKVDVIEVDEGAPLSLQCNPPPGLPPPVIFWMSSSMEPIHQDKRVSQGQNGDLYFSNVMLQDAQTDYSCNARFHFTHTIQQKNPYTLKVKTKKPHNETSLRNHTDMYSARGVTETTPSFMYPYGTSSSQMVLRGVDLLLECIASGVPAPDIMWYKKGGELPAGKTKLENFNKALRISNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPQNLILAPGEDGRLVCRANGNPKPSIQWLVNGEPIEGSPPNPSREVAGDTIVFRDTQIGSSAVYQCNASNEHGYLLANAFVSVLDVPPRILAPRNQLIKVIQYNRTRLDCPFFGSPIPTLRWFKNGQGNMLDGGNYKAHENGSLEMSMARKEDQGIYTCVATNILGKVEAQVRLEVKDPTRIVRGPEDQVVKRGSMPRLHCRVKHDPTLKLTVTWLKDDAPLYIGNRMKKEDDGLTIYGVAEKDQGDYTCVASTELDKDSAKAYLTVLAIPANRLRDLPKERPDRPRDLELSDLAERSVKLTWIPGDDNNSPITDYIVQFEEDRFQPGTWHNHSRYPGNVNSALLSLSPYVNYQFRVIAVNDVGSSLPSMPSERYQTSGARPEINPTGVQGAGTQKNNMEITWTPLNATQAYGPNLRYIVRWRRRDPRGSWYNETVKAPRHVVWNTPIYVPYEIKVQAENDFGRAPEPETYIGYSGEDYPKAAPTDVRIRVLNSTAIALTWTRVHLDTIQGQLKEYRAYFWRDSSLLKNLWVSKKRQYVSFPGDRNRGIVSRLFPYSNYKLEMVVTNGRGDGPRSEVKEFPTPEGVPSSPRYLRIRQPNLESINLEWDHPEHPNGVLTGYNLRYQASCLSSPVNGSKTGRTLVENFSPNQTRFTVQRTDPISRYRFFLRARTQVGDGEVIVEESPALLNEATPTPASTWLPPPTTELTPAATIATTTTTATPTTETPPTEIPTTAIPTTTTTTTTTAASTVASTTTTAERAAAATTKQELATNGSSIWDIRAWANSNWANITWSHNYSAGTDFVVKYITSNKTEKSIPVKAQTPSSVQLANLTPGMVYKLWVFPIWSSPSEHSYITFTTSSAYTKNHVDIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVRDNKDEHLNPEDKNVEDGSFDYRSLESDEDNKPLPNSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 835F27D086B2BFF6 q90xc6_chick protein protein chick Gallus gallus (Chicken) Chicken PRVRRESALPTQRSCLSNTGGNFFMAGVGFSFIFSWLLMLLVLLTFFLGGNIYMLVCDSWRSQQLFQLVDTPGLIPGFNLSEVLGDESGTVTFSQIYRQCQQDAALWQTLHLDQRVSLDELLNISQYTGEISAAFQKLNVTLTPISVLNESQREQLLNVCRDAQPPSFTHTLQQLDQGITVGSLQELAVELEQLVDNTGADVQVDLKAHAAELRKLDRELESSFSGPLKTLKENIQLVQSRADQLEALTNSTLDKASATQEFLQREMKNIIKNETWAFLEELLGFFETYITWAKSALRTDVARCKPIAQSLDNVEAIACDHILDSMNAFWFSLGWCTVFLLPSIILAVRLAKFYRHMDIDDDYRDEAVEIGPAFNLYKIPRPATRH A80EF5077ACB60F2 neo1_chick Neogenin protein protein chick Gallus gallus (Chicken) Chicken RSGPRSPLTGSVVRTFTPFYFLVEPMDILSVRGASVIMNCSSYCETPPKIEWKKDGTLLNLVSDDRRQLLPDGSLLINSVVHSKHNKPDEGYYQCVATVESLGSIVSRTAKLTVAGLPRFTSQPELSSVYKGNSAILNCEVNVDLAPFVRWEQDRQPLSLDDRVFKLPSGALLIGNATDTDGGFYRCVIESGGTPKYSEEAELKILPDPEEPQSLVFVRQPSSLTKVTGQNAVFPCVAGGFPTPYVRWTKNGEELITEDSERFALRAGGSLLISDVTEEDVGTYTCIADNENETIEAQAELAVQVPPEFLKRPANIYAHESMDIVFECEVTGKPTPTVKWVKNGDVVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILDLDVAIPTLPPTSLTSATNDHLAPATTGPLPTAPRDVVATLVSTRFIRLTWRTPVSDPQGDNLTYSIFYTKEGINRERVENTSRPGETQVMIQNLMPETVYVFRVVAQNKHGHGESSAPLKVATQPEVQLPGPAPNIRAYAGSPTSVTVTWETPLSGNGEIQNYKLYYMEKGQDSEQDVDVAGLSYTITGLKKYTEYSFRVVAYNKHGPGVSTQDVVVRTLSDVPSAAPQNLTLEARNSKSIMLHWQPPPAGTHSGQITGYKIRYRKVSRKSDVTESVGGTQLFQLIEGLERGTEYNFRIAAMTVNGTGPATDWVSAETFESDLDESRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHSDTSEVDLFVINAPYTPVPDPSPMMPPVGVQASILSHDTIRITWADNSLPKNQKITDARYYTVRWKTNIPANTKYKTANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKAESSDKMPNDQASGSAGKGSRPVDVGPDYKPPLSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVIVVIVAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSGSLASPTRSYLHHQVSPWPVGTSMSHSDRANSTESVRNTPSSDTMPASSSQPCADHQDPDSSSGAYLGSAQEEDAAQSLPTAHVRPSHPLKSFAVPAVPAAGSAYDPTLPSTPLLTQQAPSHPVHSVKTASIGTLGRTRPPMPVVVPSAPDVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA 558C6795579C0E26 nrcam_chick Neuronal cell adhesion molecule NgCAM-related cell adhesion molecule Neuronal surface protein Bravo protein protein chick Gallus gallus (Chicken) Chicken MMKEKSISASKASLVFFLCQMISALDVPLDSKLLEELSQPPTITQQSPKDYIVDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDAQVTMKPNSGTLVVNIMNGVKAEAYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPNHVREGDSLVLNCRPPVGLPPPIIFWMDNAFQRLPQSERVSQGLNGDLYFSNVQPEDTRVDYICYARFNHTQTIQQKQPISVKVFSTKPVTERPPVLLTPMGSTSNKVELRGNVLLLECIAAGLPTPVIRWIKEGGELPANRTFFENFKKTLKIIDVSEADSGNYKCTARNTLGSTHHVISVTVKAAPYWITAPRNLVLSPGEDGTLICRANGNPKPSISWLTNGVPIAIAPEDPSRKVDGDTIIFSAVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANKLYQVIADSPALIDCAYFGSPKPEIEWFRGVKGSILRGNEYVFHDNGTLEIPVAQKDSTGTYTCVARNKLGKTQNEVQLEVKDPTMIIKQPQYKVIQRSAQASFECVIKHDPTLIPTVIWLKDNNELPDDERFLVGKDNLTIMNVTDKDDGTYTCIVNTTLDSVSASAVLTVVAAPPTPAIIYARPNPPLDLELTGQLERSIELSWVPGEENNSPITNFVIEYEDGLHEPGVWHYQTEVPGSHTTVQLKLSPYVNYSFRVIAVNEIGRSQPSEPSEQYLTKSANPDENPSNVQGIGSEPDNLVITWESLKGFQSNGPGLQYKVSWRQKDVDDEWTSVVVANVSKYIVSGTPTFVPYEIKVQALNDLGYAPEPSEVIGHSGEDLPMVAPGNVQVHVINSTLAKVHWDPVPLKSVRGHLQGYKVYYWKVQSLSRRSKRHVEKKILTFRGNKTFGMLPGLEPYSSYKLNVRVVNGKGEGPASPDKVFKTPEGVPSPPSFLKITNPTLDSLTLEWGSPTHPNGVLTSYILKFQPINNTHELGPLVEIRIPANESSLILKNLNYSTRYKFYFNAQTSVGSGSQITEEAVTIMDEAGILRPAVGAGKVQPLYPRIRNVTTAAAETYANISWEYEGPDHANFYVEYGVAGSKEDWKKEIVNGSRSFFVLKGLTPGTAYKVRVGAEGLSGFRSSEDLFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYRSLESDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV A3570BF9C3D47A0F cntn5_human Contactin-5 CNTN5 Neural recognition molecule NB-2 protein protein human Homo sapiens Human MASSWKLMLFLSVTMCLSEYSKSLPGLSTSYAALLRIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW 5883575D84AD030E cntn1_chick Contactin-1 CNTN1 Neural cell recognition molecule F11 protein protein chick Gallus gallus (Chicken) Chicken MRFFISHLVTLCFIFCVADSTHFSEEGNKGYGPVFEEQPIDTIYPEESSDGQVSMNCRARAVPFPTYKWKLNNWDIDLTKDRYSMVGGRLVISNPEKSRDAGKYVCVVSNIFGTVRSSEATLSFGYLDPFPPEEHYEVKVREGVGAVLLCEPPYHYPDDLSYRWLLNEFPVFIALDRRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPQADRAKVYPADIKVKFKDTYALLGQNVTLECFALGNPVPELRWSKYLEPMPATAEISMSGAVLKIFNIQYEDEGLYECEAENYKGKDKHQARVYVQASPEWVEHINDTEKDIGSDLYWPCVATGKPIPTIRWLKNGVSFRKGELRIQGLTFEDAGMYQCIAENAHGIIYANAELKIVASPPTFELNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTELLVNGSRIHIWDDGSLEIINVTKLDEGRYTCFAENNRGKANSTGVLEMTEATRITLAPLNVDVTVGENATMQCIASHDPTLDLTFIWSLNGFVIDFEKEHEHYERNVMIKSNGELLIKNVQLRHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGIRIEEIRDTAVALTWSRGTDNHSPISKYTIQSKTFLSEEWKDAKTEPSDIEGNMESARVIDLIPWMEYEFRIIATNTLGTGEPSMPSQRIRTEGAPPNVAPSDVGGGGGSNRELTITWMPLSREYHYGNNFGYIVAFKPFGEKEWRRVTVTNPEIGRYVHKDESMPPSTQYQVKVKAFNSKGDGPFSLTAVIYSAQDAPTEVPTDVSVKVLSSSEISVSWHHVTEKSVEGYQIRYWAAHDKEAAAQRVQVSNQEYSTKLENLKPNTRYHIDVSAFNSAGYGPPSRTIDIITRKAPPSQRPRIISSVRSGSRYIITWDHVKAMSNESAVEGYKVLYRPDGQHEGKLFSTGKHTIEVPVPSDGEYVVEVRAHSEGGDGEVAQIKISGATAGVPTLLLGLVLPALGVLAYSGF 2E38F071AF423AE1 cntn4_human Contactin-4 CNTN4 Brain-derived immunoglobulin superfamily protein 2 protein protein human Homo sapiens Human MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 2B53D15665B4287B cntn3_human Contactin-3 CNTN3 KIAA1496 PANG Brain-derived immunoglobulin superfamily protein 1 Plasmacytoma-associated neuronal glycoprotein protein protein human Homo sapiens Human MMFPWKQLILLSFIGCLGGELLLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKEDYIIEVKATTDGGDGTSSEQIRIPRITSMDARGSTSAISNVHPMSSYMPIVLFLIVYVLW 575945CD75D21844 tena_chick Tenascin TNC Tenascin-C Hexabrachion Cytotactin Neuronectin GMEM JI Myotendinous antigen Glioma-associated-extracellular matrix antigen GP 150-225 protein protein chick Gallus gallus (Chicken) Chicken MGLPSQVLACAILGLLYQHASGGLIKRIIRQKRETGLNVTLPEDNQPVVFNHVYNIKLPVGSLCSVDLDTASGDADLKAEIEPVKNYEEHTVNEGNQIVFTHRINIPRRACGCAAAPDIKDLLSRLEELEGLVSSLREQCASGAGCCPNSQTAEGRLDTAPYCSGHGNYSTEICGCVCEPGWKGPNCSEPACPRNCLNRGLCVRGKCICEEGFTGEDCSQAACPSDCNDQGKCVDGVCVCFEGYTGPDCGEELCPHGCGIHGRCVGGRCVCHEGFTGEDCNEPLCPNNCHNRGRCVDNECVCDEGYTGEDCGELICPNDCFDRGRCINGTCFCEEGYTGEDCGELTCPNNCNGNGRCENGLCVCHEGFVGDDCSQKRCPKDCNNRGHCVDGRCVCHEGYLGEDCGELRCPNDCHNRGRCINGQCVCDEGFIGEDCGELRCPNDCHNRGRCVNGQCECHEGFIGEDCGELRCPNDCNSHGRCVNGQCVCDEGYTGEDCGELRCPNDCHNRGRCVEGRCVCDNGFMGEDCGELSCPNDCHQHGRCVDGRCVCHEGFTGEDCRERSCPNDCNNVGRCVEGRCVCEEGYMGIDCSDVSPPTELTVTNVTDKTVNLEWKHENLVNEYLVTYVPTSSGGLDLQFTVPGNQTSATIHELEPGVEYFIRVFAILKNKKSIPVSARVATYLPAPEGLKFKSVRETSVQVEWDPLSISFDGWELVFRNMQKKDDNGDITSSLKRPETSYMQPGLAPGQQYNVSLHIVKNNTRGPGLSRVITTKLDAPSQIEAKDVTDTTALITWSKPLAEIEGIELTYGPKDVPGDRTTIDLSEDENQYSIGNLRPHTEYEVTLISRRGDMESDPAKEVFVTDLDAPRNLKRVSQTDNSITLEWKNSHANIDNYRIKFAPISGGDHTELTVPKGNQATTRATLTGLRPGTEYGIGVTAVRQDRESAPATINAGTDLDNPKDLEVSDPTETTLSLRWRRPVAKFDRYRLTYVSPSGKKNEMEIPVDSTSFILRGLDAGTEYTISLVAEKGRHKSKPTTIKGSTEEEPELGNLSVSETGWDGFQLTWTAADGAYENFVIQVQQSDNPEETWNITVPGGQHSVNVTGLKANTPYNVTLYGVIRGYRTKPLYVETTTGAHPEVGELTVSDITPESFNLSWTTTNGDFDAFTIEIIDSNRLLEPMEFNISGNSRTAHISGLSPSTDFIVYLYGISHGFRTQAISAAATTEAEPEVDNLLVSDATPDGFRLSWTADDGVFDSFVLKIRDTKRKSDPLELIVPGHERTHDITGLKEGTEYEIELYGVSSGRRSQPINSVATTVVGSPKGISFSDITENSATVSWTPPRSRVDSYRVSYVPITGGTPNVVTVDGSKTRTKLVKLVPGVDYNVNIISVKGFEESEPISGILKTALDSPSGLVVMNITDSEALATWQPAIAAVDNYIVSYSSEDEPEVTQMVSGNTVEYDLNGLRPATEYTLRVHAVKDAQKSETLSTQFTTGLDAPKDLSATEVQSETAVITWRPPRAPVTDYLLTYESIDGRVKEVILDPETTSYTLTELSPSTQYTVKLQALSRSMRSKMIQTVFTTTGLLYPYPKDCSQALLNGEVTSGLYTIYLNGDRTQPLQVFCDMAEDGGGWIVFLRRQNGKEDFYRNWKNYVAGFGDPKDEFWIGLENLHKISSQGQYELRVDLRDRGETAYAVYDKFSVGDAKTRYRLRVDGYSGTAGDSMTYHNGRSFSTFDKDNDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSSFRNLEGRRKRA B924A06CF9EFD6DE ngca_chick Neuronal-glial cell adhesion molecule protein protein chick Gallus gallus (Chicken) Chicken MALPMVGLLLLLLLGGPGAAITIPPEYGAHDFLQPPELTEEPPEQLVVFPSDDIVLKCVATGNPPVQYRWSREDQPFVPEEHGGVSVVPGSGTLVINATLAARLQGRFRCFATNALGTAVSPEANVIAENTPQWPKEKVTPVEVEEGDPVVLPCDPPESAVPPKIYWLNSDIVHIAQDERVSMGQDGNLYFSNAMVGDSHPDYICHAHFLGPRTIIQKEPLDLRVAPSNAVRSRRPRLLLPRDPQTTTIALRGGSVVLECIAEGLPTPWVRWRRLNGPLLPGGVGNFNKTLRLWGVTESDDGEYECVAENGRGTARGTHSVTVEAAPYWVRRPQSGVFGPGETARLDCEVGGKPRPQIQWSINGVPIEAAGAERRWLRGGALVLPELRPNDSAVLQCEARNRHGPLLANAFLHVVELPLRMLTADEQRYEVVENQTVFLHCRTFGAPAPNVEWLTPTLEPALQDDRSFVFTNGSLRVSAVRGGDGGVYTCMAQNAHSNGSLTALLEVRAPTRISAPPRSATAKKGETVTFHCGATFDPAVTPGELRWLRGGQPLPDDPRYSVAAEMTVSNVDYGDEGTIQCRASTPLDSAEAEAQLRVVGRPPSRDLQVMEVDEHRVRLSWTPGDDHNSPIEKFVVEEEEEREDLQRGFGAADVPGQPWTPPLPLSPYGRFPFRVVAVNAYGRGEHHAPSAPIETPPAAPERNPGGVHGEGNETGNLVITWEPLPPQAWNAPWARYRVQWRPLEEPGGGGPSGGFPWAESTVDAPPVVVGGLPPFSPFQIRVQAVNGAGKGPEATPGVGHSGEDLPLVYPENVGVELLNSSTVRVRWTLGGGPKELRGRLRGFRVLYWRLGWVGERSRRQAPPDPPQIPQSPAEDPPPFPPVALTVGGDARGALLGGLRPWSRYQLRVLVFNGRGDGPPSEPIAFETPEGVPGPPEELRVERLDDTALSVVERRTFKRSITGYVLRYQQVEPGSALPGGSVLRDPQCDLRGLNARSRYRLALPSTPRERPALQTVGSTKPEPPSPLWSRFGVGGRGGFHGAAVEFGAAQEDDVEFEVQFMNKSTDEPWRTSGRANSSLRRYRLEGLRPGTAYRVQFVGRNRSGENVAFWESEVQTNGTVVPQPGGGVCTKGWFIGFVSSVVLLLLILLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESEAEKGSASGSGAGSGVGSPGRGPCAAGSEDSLAGYGGSGDVQFNEDGSFIGQYRGPGAGPGSSGPASPCAGPPLD 32E17912014D5DF1 p05067-4 Amyloid-beta precursor protein APP A4 AD1 ABPP Alzheimer disease amyloid protein Cerebral vascular amyloid peptide PreA4 Protease nexin-II APPI PreA4 695 Amyloid precursor protein Amyloid-beta A4 protein Alzheimer disease amyloid A4 protein homolog Amyloid-beta (A4) precursor protein protein protein human Homo sapiens Human MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN DIP protein P05067-4 original sequence version: 183 DIP protein P05067-4 original sequence version: 198 DIP protein P05067-4 original sequence version: 224 A major isoform. 4F6EA0139F969D56 app-cntn4-1 1 17 unspecified role unspecified role prey prey 14 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey 9 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 5 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 4 unspecified role unspecified role bait bait n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 8 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey association association Fig. 3 The participant EBI-2028081(P35331) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later. app-cntn4-2 2 15 unspecified role unspecified role bait bait c-terminal fc fusion fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 19 unspecified role unspecified role prey prey n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. direct interaction direct interaction APP bound prominently to contactins 3 and 4. Fig. 4C app-cntn3-1 2 19 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 16 unspecified role unspecified role bait bait c-terminal fc fusion fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 47 43 direct interaction direct interaction APP bound prominently to contactins 3 and 4. Fig. 4B aplp1-cntn3-1 2 7 unspecified role unspecified role prey prey n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 16 unspecified role unspecified role bait bait c-terminal fc fusion fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. direct interaction direct interaction APLP1 bound to contactins 3, 4 and 5. Fig. 4D aplp1-cntn4-1 2 15 unspecified role unspecified role bait bait c-terminal fc fusion fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 7 unspecified role unspecified role prey prey n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. direct interaction direct interaction APLP1 bound to contactins 3, 4 and 5. Fig. 4E aplp1-cntn5-1 2 13 unspecified role unspecified role bait bait c-terminal fc fusion fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 7 unspecified role unspecified role prey prey n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 65 68 direct interaction direct interaction APLP1 bound to contactins 3, 4 and 5. Fig. 4F app-cntn3-2 2 16 unspecified role unspecified role bait bait c-terminal fc fusion fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range fn region sufficient to bind sufficient binding region sufficient to bind range range range range human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 4 unspecified role unspecified role prey prey n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 75 72 direct interaction direct interaction AP-fused APP domains were tested for binding to Fc-fused contactin 3 or 4 domains Fig. 5A Exact coordinates of FN domain of Q9P232 could not be traced so inferred from UniProtKB record. app-cntn4-3 2 15 unspecified role unspecified role bait bait c-terminal fc fusion fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range fn region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis range range range range human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 4 unspecified role unspecified role prey prey n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. direct interaction direct interaction AP-fused APP domains were tested for binding to Fc-fused contactin 3 or 4 domains Fig. 5A Exact coordinates of FN domain of Q8IWV2 could not be traced so inferred from UniProtKB record. app-nrcam-1 3 4 unspecified role unspecified role bait bait n-terminal alk phosphatase tag alkaline phosphatase tag alk phosphatase tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 12 unspecified role unspecified role prey prey association association APP association with NgCAM. Western blots with antibodies against NgCAM after immunoprecipitating for AP tag. Fig. 5B