UniProt UniProt http://www.uniprot.org hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (0092-8674) 2001 imex curation Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. Apoptosis - Interactions involving proteins with a function related to apoptosis please delete here (exp-1) the interactions EBI-4478176 sirt1-tp53-2 EBI-4478181 sirt1-tp53-3 have been duplicated by the program cannot get rid of them!! sent already an error report about this weinberg@wi.mit.edu 21-Dec-2011: Contacted by JYOTI. Only protein-protein interactions human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. Apoptosis - Interactions involving proteins with a function related to apoptosis please delete here (exp-1) the interactions EBI-4478176 sirt1-tp53-2 EBI-4478181 sirt1-tp53-3 have been duplicated by the program cannot get rid of them!! sent already an error report about this weinberg@wi.mit.edu Accepted 2011-OCT-18 by JYOTI 21-Dec-2011: Contacted by JYOTI. Cell (0092-8674) 2001 Only protein-protein interactions imex curation hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (0092-8674) 2001 imex curation Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. Apoptosis - Interactions involving proteins with a function related to apoptosis please delete here (exp-1) the interactions EBI-4478176 sirt1-tp53-2 EBI-4478181 sirt1-tp53-3 have been duplicated by the program cannot get rid of them!! sent already an error report about this weinberg@wi.mit.edu 21-Dec-2011: Contacted by JYOTI. Only protein-protein interactions in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. Apoptosis - Interactions involving proteins with a function related to apoptosis please delete here (exp-1) the interactions EBI-4478176 sirt1-tp53-2 EBI-4478181 sirt1-tp53-3 have been duplicated by the program cannot get rid of them!! sent already an error report about this weinberg@wi.mit.edu Accepted 2011-OCT-18 by JYOTI 21-Dec-2011: Contacted by JYOTI. Cell (0092-8674) 2001 Only protein-protein interactions imex curation hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (0092-8674) 2001 imex curation Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. Apoptosis - Interactions involving proteins with a function related to apoptosis please delete here (exp-1) the interactions EBI-4478176 sirt1-tp53-2 EBI-4478181 sirt1-tp53-3 have been duplicated by the program cannot get rid of them!! sent already an error report about this weinberg@wi.mit.edu 21-Dec-2011: Contacted by JYOTI. Only protein-protein interactions human-bj Homo sapiens BJ normal foreskin fibroblasts bj Human normal foreskin fibroblasts The ATCC rference number is CRL-2522. The ATCC reference number is CRL-2522. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. Apoptosis - Interactions involving proteins with a function related to apoptosis please delete here (exp-1) the interactions EBI-4478176 sirt1-tp53-2 EBI-4478181 sirt1-tp53-3 have been duplicated by the program cannot get rid of them!! sent already an error report about this weinberg@wi.mit.edu Accepted 2011-OCT-18 by JYOTI Cell (0092-8674) 2001 Only protein-protein interactions imex curation hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (0092-8674) 2001 imex curation Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. Apoptosis - Interactions involving proteins with a function related to apoptosis please delete here (exp-1) the interactions EBI-4478176 sirt1-tp53-2 EBI-4478181 sirt1-tp53-3 have been duplicated by the program cannot get rid of them!! sent already an error report about this weinberg@wi.mit.edu 21-Dec-2011: Contacted by JYOTI. Only protein-protein interactions human-h1299 Homo sapiens lung lymph node carcinoma h1299 Human lung lymph node carcinoma p53 null. These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP). Also known as NCI H1299 or CRL-5803. http://www.lgcpromochem.com/atcc/ ATCC number: CRL-5803. ATCC number of the cell line is CRL-5803. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. Apoptosis - Interactions involving proteins with a function related to apoptosis please delete here (exp-1) the interactions EBI-4478176 sirt1-tp53-2 EBI-4478181 sirt1-tp53-3 have been duplicated by the program cannot get rid of them!! sent already an error report about this weinberg@wi.mit.edu Accepted 2011-OCT-18 by JYOTI 21-Dec-2011: Contacted by JYOTI. Cell (0092-8674) 2001 Only protein-protein interactions imex curation sir1_human NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacylase sirtuin-1 SIRT1 SIR2L1 SIR2-like protein 1 Regulatory protein SIR2 homolog 1 protein protein human Homo sapiens Human MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS DIP protein Q96EB6 original sequence version: 140 DIP protein Q96EB6 original sequence version: 71 DIP protein Q96EB6 original sequence version: 125 DIP protein Q96EB6 original sequence version: 115 DIP protein Q96EB6 original sequence version: 63 DIP protein Q96EB6-1 original sequence version: 102 DIP protein Q96EB6 original sequence version: 102 DIP protein Q96EB6 original sequence version: 98 DIP protein Q96EB6 original sequence version: 144 DIP protein Q96EB6 original sequence version: 120 DIP protein Q96EB6-1 original sequence version: 120 DIP protein Q96EB6 original sequence version: 113 DIP protein Q96EB6-1 original sequence version: 117 2D3BEA6D73DA229F p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD DIP protein P04637 original sequence version: 121 DIP protein P04637 original sequence version: 115 DIP protein P04637-1 original sequence version: 224 DIP protein P04637 original sequence version: 117 DIP protein P04637-1 original sequence version: 226 DIP protein P04637 original sequence version: 226 DIP protein P04637 original sequence version: 212 DIP protein P04637 original sequence version: 220 DIP protein P04637-1 original sequence version: 220 DIP protein P04637-1 original sequence version: 145 DIP protein P04637 original sequence version: 146 DIP protein P04637 original sequence version: 145 DIP protein P04637 original sequence version: 166 DIP protein P04637-1 original sequence version: 166 DIP protein P04637 original sequence version: 169 DIP protein P04637 original sequence version: 177 DIP protein P04637 original sequence version: 175 DIP protein P04637-1 original sequence version: 175 DIP protein P04637-1 original sequence version: 172 DIP protein P04637-1 original sequence version: 169 DIP protein P04637 original sequence version: 170 DIP protein P04637 original sequence version: 172 DIP protein P04637-1 original sequence version: 194 DIP protein P04637 original sequence version: 196 DIP protein P04637 original sequence version: 185 DIP protein P04637-1 original sequence version: 191 DIP protein P04637 original sequence version: 191 DIP protein P04637 original sequence version: 180 DIP protein P04637-1 original sequence version: 197 DIP protein P04637 original sequence version: 183 DIP protein P04637-1 original sequence version: 183 DIP protein P04637-1 original sequence version: 185 DIP protein P04637 original sequence version: 199 DIP protein P04637 original sequence version: 201 DIP protein P04637 original sequence version: 189 DIP protein P04637 original sequence version: 235 DIP protein P04637 original sequence version: 230 DIP protein P04637 original sequence version: 234 DIP protein P04637-1 original sequence version: 234 DIP protein P04637-1 original sequence version: 235 DIP protein P04637 original sequence version: 239 DIP protein P04637-1 original sequence version: 212 DIP protein P04637-1 original sequence version: 213 DIP protein P04637 original sequence version: 213 DIP protein P04637 original sequence version: 206 DIP protein P04637-1 original sequence version: 188 DIP protein P04637-1 original sequence version: 228 DIP protein P04637 original sequence version: 208 DIP protein P04637 original sequence version: 240 DIP protein P04637-1 original sequence version: 240 DIP protein P04637 original sequence version: 204 DIP protein P04637-1 original sequence version: 204 DIP protein P04637-1 original sequence version: 209 DIP protein P04637-1 original sequence version: 203 DIP protein P04637 original sequence version: 221 DIP protein P04637-1 original sequence version: 152 DIP protein P04637 original sequence version: 217 DIP protein P04637-1 original sequence version: 140 DIP protein P04637 original sequence version: 215 DIP protein P04637 original sequence version: 214 DIP protein P04637-1 original sequence version: 182 DIP protein P04637 original sequence version: 182 DIP protein P04637 original sequence version: 188 DIP protein P04637 original sequence version: 192 DIP protein P04637-1 original sequence version: 192 DIP protein P04637 original sequence version: 218 DIP protein P04637-1 original sequence version: 218 AD5C149FD8106131 sir1_mouse NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacylase sirtuin-1 Sirt1 Sir2l1 SIR2alpha SIR2-like protein 1 Regulatory protein SIR2 homolog 1 protein protein mouse Mus musculus Mouse MADEVALALQAAGSPSAAAAMEAASQPADEPLRKRPRRDGPGLGRSPGEPSAAVAPAAAGCEAASAAAPAALWREAAGAAASAEREAPATAVAGDGDNGSGLRREPRAADDFDDDEGEEEDEAAAAAAAAAIGYRDNLLLTDGLLTNGFHSCESDDDDRTSHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRILQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRPQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQATNNNVNDLEVSESSCVEEKPQEVQTSRNVENINVENPDFKAVGSSTADKNERTSVAETVRKCWPNRLAKEQISKRLEGNQYLFVPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDTERPECAGGSGFGADGGDQEVVNEAIATRQELTDVNYPSDKS DIP protein Q923E4 original sequence version: 83 DIP protein Q923E4 original sequence version: 135 7F15625E29433119 tp53-sirt1-2 3 6 unspecified role unspecified role bait bait 5 unspecified role unspecified role prey prey physical association physical association 1C tp53-sirt1-3 1 5 unspecified role unspecified role prey prey 6 unspecified role unspecified role bait bait physical association physical association 1C tp53-sirt1-4 4 5 unspecified role unspecified role prey prey 6 unspecified role unspecified role bait bait physical association physical association 1C sirt1-tp53-1 3 5 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association 1C sirt1-tp53-2 1 5 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association 1C sirt1-tp53-3 4 5 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association 1C sirt1-tp53-4 2 6 enzyme target enzyme target substrate substrate neutral component neutral component region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lys373 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain lys382 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain 7 enzyme enzyme neutral component neutral component direct interaction direct interaction 2 TP53 preferentially deacetylated at lys382