IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Cancer cell 2015 imex curation Hill RM., Kuijper S., Lindsey JC., Petrie K., Schwalbe EC., Barker K., Boult JK., Williamson D., Ahmad Z., Hallsworth A., Ryan SL., Poon E., Robinson SP., Ruddle R., Raynaud FI., Howell L., Kwok C., Joshi A., Nicholson SL., Crosier S., Ellison DW., Wharton SB., Robson K., Michalski A., Hargrave D., Jacques TS., Pizer B., Bailey S., Swartling FJ., Weiss WA., Chesler L., Clifford SC. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer steve.clifford@ncl.ac.uk,louis.chesler@icr.ac.uk Only protein-protein interactions imex curation mouse-medulloblastoma Mouse medulloblastoma medulloblastoma Medulloblastoma pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Hill RM., Kuijper S., Lindsey JC., Petrie K., Schwalbe EC., Barker K., Boult JK., Williamson D., Ahmad Z., Hallsworth A., Ryan SL., Poon E., Robinson SP., Ruddle R., Raynaud FI., Howell L., Kwok C., Joshi A., Nicholson SL., Crosier S., Ellison DW., Wharton SB., Robson K., Michalski A., Hargrave D., Jacques TS., Pizer B., Bailey S., Swartling FJ., Weiss WA., Chesler L., Clifford SC. Affinomics - Interactions curated for the Affinomics consortium. Neurospheres derived from GTML/Trp53KI/KI tumors;GTML mice are doubly transgenic for Glt1-tTA (glutamate transporter 1-tetracycline transactivator) and tetracycline response element (TRE)-MYCN/luciferase (Luc). The MYCN cDNA is of Human origin and these mice produce no p53. steve.clifford@ncl.ac.uk,louis.chesler@icr.ac.uk Accepted 2015-MAY-26 by ORCHARD Cancer cell 2015 Only protein-protein interactions imex curation imex curation mycn_human N-myc proto-oncogene protein MYCN NMYC BHLHE37 Class E basic helix-loop-helix protein 37 protein protein human Homo sapiens Human MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC DIP protein P04198 original sequence version: 157 560E885602E30DAD aurka_mouse Aurora kinase A Serine/threonine-protein kinase Ayk1 Aurka Aik Airk Ark1 Aura Ayk1 Btak Iak1 Stk15 Stk6 Aurora 2 Aurora family kinase 1 Aurora/IPL1-related kinase 1 Ipl1- and aurora-related kinase 1 Serine/threonine-protein kinase 6 Serine/threonine-protein kinase aurora-A protein protein mouse Mus musculus Mouse MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQKLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS 26B6B65105A1A812 324132rwer-1 1 3 unspecified role unspecified role neutral component neutral component 2 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 4A MLN8237 (Alisertib)- a small molecule specific Aurora A kinase inhibitor.