IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-fadu Homo sapiens fadu fadu ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. Sequential ChIP/Re-ChIP - the target/bait of the first antibody is a prey for the second round of IP. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-fadu Homo sapiens fadu fadu ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. Sequential ChIP/Re-ChIP - the target/bait of the first antibody is a prey for the second round of IP. ChIp and Sequential ChIp/Re-Chip The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-fadu Homo sapiens fadu fadu ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. ChIp and Sequential ChIp/Re-Chip The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-fadu Homo sapiens fadu fadu ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. ChIP results obtained using anti- H3 antibodies have not been included due to lack of antibody specificity. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-oecm-1 OECM-1 Human Head and Neck (oral) squamous cell carcinomar cell line oecm-1 OECM-1 Human Head and Neck oral squamous cell carcinoma cell line this cell line is also known as Meng-1 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-fadu Homo sapiens fadu fadu anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro deacetylase assay deacetylase assay western blot western blot Immuno blot Immuno blot Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. GST-Snail is stated to have been "purified from 293T cells cotransfected with pGST-Snail and pHA-CBP". However no details of purification are given. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell (1535-6108) 2014 imex curation Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Cancer - Interactions investigated in the context of cancer I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw 17-Sep-2015: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro acetylase assay acetylase assay antibody detection identification by antibody antibody detection Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. I had entered a Data-Proc statement:- "Constructs containing CBP have been determined to be of Human origin, based on mutation mapping."- until I got the reply from the authors stating they were murine- the mutants are not entered anywhere so IF they were human (?) this is not relevant. Filter Binding Assay/Dot Blot. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Accepted 2015-AUG-06 by PPORRAS Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation done; new Expt-12 created. tnfa_human_gene Tumor necrosis factor TNF TNFA TNFSF2 Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 gene gene human Homo sapiens Human hdac2_human Histone deacetylase 2 HDAC2 protein protein human Homo sapiens Human MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP DIP protein Q92769 original sequence version: 161 DIP protein Q92769 original sequence version: 154 DIP protein Q92769 original sequence version: 117 DIP protein Q92769 original sequence version: 113 DIP protein Q92769 original sequence version: 139 DIP protein Q92769 original sequence version: 163 DIP protein Q92769 original sequence version: 179 DIP protein Q92769 original sequence version: 153 DIP protein Q92769 original sequence version: 112 775419CCCDAE07FA ccl5_human_gene C-C motif chemokine 5 CCL5 D17S136E SCYA5 EoCP Eosinophil chemotactic cytokine SIS-delta Small-inducible cytokine A5 T cell-specific protein P228 T-cell-specific protein RANTES gene gene human Homo sapiens Human ercc1_human_gene DNA excision repair protein ERCC-1 ERCC1 gene gene human Homo sapiens Human h4_human Histone H4 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4 HIST2H4A HIST2H4B HIST4H4 protein protein human Homo sapiens Human MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG DIP protein P62805 original sequence version: 68 DIP protein P62805 original sequence version: 111 DIP protein P62805 original sequence version: 94 DIP protein P62805 original sequence version: 97 DIP protein P62805 original sequence version: 116 DIP protein P62805 original sequence version: 105 DIP protein P62805 original sequence version: 120 DIP protein P62805 original sequence version: 144 DIP protein P62805 original sequence version: 150 DIP protein P62805 original sequence version: 154 DIP protein P62805 original sequence version: 156 DIP protein P62805 original sequence version: 112 DIP protein P62805 original sequence version: 121 DIP protein P62805 original sequence version: 123 DIP protein P62805 original sequence version: 126 DIP protein P62805 original sequence version: 132 DIP protein P62805 original sequence version: 136 DIP protein P62805 original sequence version: 119 A9E5DFD3F8B97598 sin3a_human Paired amphipathic helix protein Sin3a SIN3A Transcriptional corepressor Sin3a Histone deacetylase complex subunit Sin3a protein protein human Homo sapiens Human MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP DIP protein Q96ST3 original sequence version: 128 DIP protein Q96ST3 original sequence version: 147 E6A329BE0EAD84CD hdac3_human Histone deacetylase 3 HDAC3 RPD3-2 SMAP45 protein protein human Homo sapiens Human MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI DIP protein O15379 original sequence version: 159 DIP protein O15379 original sequence version: 161 DIP protein O15379 original sequence version: 162 DIP protein O15379 original sequence version: 89 DIP protein O15379 original sequence version: 156 DIP protein O15379 original sequence version: 176 DIP protein O15379 original sequence version: 170 DIP protein O15379-1 original sequence version: 170 DIP protein O15379 original sequence version: 127 DIP protein O15379-1 original sequence version: 128 DIP protein O15379 original sequence version: 119 94485C1EBDCF5AD0 hdac1_human Histone deacetylase 1 HDAC1 RPD3L1 protein protein human Homo sapiens Human MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA DIP protein Q13547 original sequence version: 106 DIP protein Q13547 original sequence version: 173 DIP protein Q13547 original sequence version: 100 DIP protein Q13547 original sequence version: 166 DIP protein Q13547 original sequence version: 153 DIP protein Q13547 original sequence version: 164 DIP protein Q13547 original sequence version: 175 DIP protein Q13547 original sequence version: 191 DIP protein Q13547 original sequence version: 185 DIP protein Q13547 original sequence version: 165 DIP protein Q13547 original sequence version: 162 DIP protein Q13547 original sequence version: 189 DIP protein Q13547 original sequence version: 158 DIP protein Q13547 original sequence version: 134 DIP protein Q13547 original sequence version: 124 4D35B7C1ED7838D6 snai1_human Zinc finger protein SNAI1 Protein snail homolog 1 SNAI1 SNAH protein protein human Homo sapiens Human MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQPIAWASLRLQESPRVAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSVSSLEAEAYAAFPGLGQVPKQLAQLSEAKDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGCSGCPR DIP protein O95863 original sequence version: 109 DIP protein O95863 original sequence version: 141 70E298C9BB154115 ep300_human Histone acetyltransferase p300 Histone butyryltransferase p300 Histone crotonyltransferase p300 Protein propionyltransferase p300 EP300 P300 E1A-associated protein p300 Protein 2-hydroxyisobutyryltransferase p300 Protein lactyltransferas p300 protein protein human Homo sapiens Human MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH DIP protein Q09472 original sequence version: 193 DIP protein Q09472 original sequence version: 186 DIP protein Q09472 original sequence version: 107 DIP protein Q09472 original sequence version: 112 DIP protein Q09472 original sequence version: 181 DIP protein Q09472 original sequence version: 183 DIP protein Q09472 original sequence version: 136 DIP protein Q09472 original sequence version: 146 DIP protein Q09472 original sequence version: 165 DIP protein Q09472 original sequence version: 192 DIP protein Q09472 original sequence version: 200 DIP protein Q09472 original sequence version: 206 DIP protein Q09472 original sequence version: 194 DIP protein Q09472 original sequence version: 171 DIP protein Q09472 original sequence version: 142 DIP protein Q09472 original sequence version: 180 8E869E1F174A6FEB cbp_human CREB-binding protein CREBBP CBP Histone lysine acetyltransferase CREBBP Protein-lysine acetyltransferase CREBBP protein protein human Homo sapiens Human MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL DIP protein Q92793 original sequence version: 134 DIP protein Q92793-1 original sequence version: 171 DIP protein Q92793 original sequence version: 171 DIP protein Q92793 original sequence version: 185 DIP protein Q92793 original sequence version: 106 DIP protein Q92793 original sequence version: 104 DIP protein Q92793 original sequence version: 112 DIP protein Q92793 original sequence version: 135 DIP protein Q92793 original sequence version: 139 DIP protein Q92793 original sequence version: 157 DIP protein Q92793 original sequence version: 177 DIP protein Q92793 original sequence version: 168 DIP protein Q92793-1 original sequence version: 174 DIP protein Q92793 original sequence version: 146 DIP protein Q92793 original sequence version: 161 DIP protein Q92793 original sequence version: 172 3BEA9B8558BA1A5E p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD DIP protein P04637 original sequence version: 121 DIP protein P04637 original sequence version: 115 DIP protein P04637-1 original sequence version: 224 DIP protein P04637 original sequence version: 117 DIP protein P04637-1 original sequence version: 226 DIP protein P04637 original sequence version: 226 DIP protein P04637 original sequence version: 212 DIP protein P04637 original sequence version: 220 DIP protein P04637-1 original sequence version: 220 DIP protein P04637-1 original sequence version: 145 DIP protein P04637 original sequence version: 146 DIP protein P04637 original sequence version: 145 DIP protein P04637 original sequence version: 166 DIP protein P04637-1 original sequence version: 166 DIP protein P04637 original sequence version: 169 DIP protein P04637 original sequence version: 177 DIP protein P04637 original sequence version: 175 DIP protein P04637-1 original sequence version: 175 DIP protein P04637-1 original sequence version: 172 DIP protein P04637-1 original sequence version: 169 DIP protein P04637 original sequence version: 170 DIP protein P04637 original sequence version: 172 DIP protein P04637-1 original sequence version: 194 DIP protein P04637 original sequence version: 196 DIP protein P04637 original sequence version: 185 DIP protein P04637-1 original sequence version: 191 DIP protein P04637 original sequence version: 191 DIP protein P04637 original sequence version: 180 DIP protein P04637-1 original sequence version: 197 DIP protein P04637 original sequence version: 183 DIP protein P04637-1 original sequence version: 183 DIP protein P04637-1 original sequence version: 185 DIP protein P04637 original sequence version: 199 DIP protein P04637 original sequence version: 201 DIP protein P04637 original sequence version: 189 DIP protein P04637 original sequence version: 235 DIP protein P04637 original sequence version: 230 DIP protein P04637 original sequence version: 234 DIP protein P04637-1 original sequence version: 234 DIP protein P04637-1 original sequence version: 235 DIP protein P04637 original sequence version: 239 DIP protein P04637-1 original sequence version: 212 DIP protein P04637-1 original sequence version: 213 DIP protein P04637 original sequence version: 213 DIP protein P04637 original sequence version: 206 DIP protein P04637-1 original sequence version: 188 DIP protein P04637-1 original sequence version: 228 DIP protein P04637 original sequence version: 208 DIP protein P04637 original sequence version: 240 DIP protein P04637-1 original sequence version: 240 DIP protein P04637 original sequence version: 204 DIP protein P04637-1 original sequence version: 204 DIP protein P04637-1 original sequence version: 209 DIP protein P04637-1 original sequence version: 203 DIP protein P04637 original sequence version: 221 DIP protein P04637-1 original sequence version: 152 DIP protein P04637 original sequence version: 217 DIP protein P04637-1 original sequence version: 140 DIP protein P04637 original sequence version: 215 DIP protein P04637 original sequence version: 214 DIP protein P04637-1 original sequence version: 182 DIP protein P04637 original sequence version: 182 DIP protein P04637 original sequence version: 188 DIP protein P04637 original sequence version: 192 DIP protein P04637-1 original sequence version: 192 DIP protein P04637 original sequence version: 218 DIP protein P04637-1 original sequence version: 218 AD5C149FD8106131 cbp_mouse Histone lysine acetyltransferase CREBBP Crebbp Cbp Protein-lysine acetyltransferase CREBBP protein protein mouse Mus musculus Mouse MAENLLDGPPNPKRAKLSSPGFSANDNTDFGSLFDLENDLPDELIPNGELSLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSTNMASLGAMGKSPLNQGDSSTPNLPKQAASTSGPTPPASQALNPQAQKQVGLVTSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLMNQAQQGQAQVMNGSLGAAGRGRGAGMPYPAPAMQGATSSVLAETLTQVSPQMAGHAGLNTAQAGGMTKMGMTGTTSPFGQPFSQTGGQQMGATGVNPQLASKQSMVNSLPAFPTDIKNTSVTTVPNMSQLQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGAGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPPAHQQMRTLNALGNNPMSIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPASGAQPPVIPPAQSVRPPNGPLPLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQNQFPSSSGAMSVNSVGMGQPAAQAGVSQGQVPGAALPNPLNMLAPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHPTAPGMTPPQPAAPTQPSTPVSSGQTPTPTPGSVPSAAQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGTPLSQAAASIDNRVPTPSSVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPEPTESKGEPRSEMMEEDLQGSSQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSSNDTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQNTALIAPHQIQGRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVNMSPAGFPNVARTQPPTIVSAGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRANINNGMPPGRAGMGTPGSQMTPVGLNVPRPNQVSGPVMSSMPPGQWQQAPIPQQQPMPGMPRPVMSMQAQAAVAGPRMPNVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPPQPAMGGLNPQGQALNIMNPGHNPNMTNMNPQYREMVRRQLLQHQQQQQQQQQQQQQQQNSASLAGGMAGHSQFQQPQGPGGYAPAMQQQRMQQHLPIQGSSMGQMAAPMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSMDQGHLGNPEQSAMLPQLNTPNRSALSSELSLVGDTTGDTLEKFVEGL DIP protein P45481 original sequence version: 148 DIP protein P45481 original sequence version: 126 DIP protein P45481 original sequence version: 152 DIP protein P45481 original sequence version: 115 DIP protein P45481 original sequence version: 127 DIP protein P45481 original sequence version: 123 DIP protein P45481 original sequence version: 149 DIP protein P45481 original sequence version: 156 DIP protein P45481 original sequence version: 169 DIP protein P45481 original sequence version: 175 DIP protein P45481 original sequence version: 135 D89AF52B7BD33347 il8_human_gene Human IL-8 gene gene gene human Homo sapiens Human cadh1_human_gene Human CDH1gene:Epithelial cadherin gene gene human Homo sapiens Human ajuba_human LIM domain-containing protein ajuba AJUBA JUB protein protein human Homo sapiens Human MERLGEKASRLLEKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPRGATGGPGDEPLEPAREQGSLDAERNQRGSFEAPRYEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGAGGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGPPLAGAPAGYSPGGVPSAYPELHAALDRLYAQRPAGFGCQESRHSYPPALGSPGALAGAGVGAAGPLERRGAQPGRHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPSGIEPSGLEEPPGPFVPEAARARMREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLNARQPPANYI 1E0DFA0336976A3C tf65_human Transcription factor p65 Nuclear factor NF-kappa-B p65 subunit RELA NFKB3 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 protein protein human Homo sapiens Human MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS DIP protein Q04206 original sequence version: 170 DIP protein Q04206 original sequence version: 173 DIP protein Q04206 original sequence version: 99 DIP protein Q04206-1 original sequence version: 99 DIP protein Q04206 original sequence version: 168 DIP protein Q04206 original sequence version: 128 DIP protein Q04206 original sequence version: 131 DIP protein Q04206 original sequence version: 153 DIP protein Q04206 original sequence version: 185 DIP protein Q04206 original sequence version: 181 DIP protein Q04206 original sequence version: 183 8147A6AF9F2445C6 finc_human_gene Fibronectin precursor gene gene gene human Homo sapiens Human ccl2_human_gene C-C motif chemokine 2 CCL2 MCP1 SCYA2 HC11 Monocyte chemoattractant protein 1 Monocyte chemotactic and activating factor Monocyte chemotactic protein 1 Monocyte secretory protein JE Small-inducible cytokine A2 gene gene human Homo sapiens Human snai1-cadh1 4 17 unspecified role unspecified role bait bait arg4 nonome2arg asymmetric dimethyl-L-arginine (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid MOD_RES Asymmetric dimethylarginine MOD_RES Omega-N-methylated arginine N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine asymmetric dimethylarginine omega-N,omega-N-dimethlyated L-arginine omega-N,omega-N-dimethyl-L-arginine Dimethyl NoNoMe2Arg di-Methylation certain certain sequence position certain certain certain sequence position certain 27 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 1A, Supp 1B H4R3(4)Me2 is a repressive mark on CDH1 promoter associated with Snail expression. P01137 increases binding of P62805 to ENSG00000039068 TGF-beta1 -P01137 snai1-crebbp 5 21 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey 23 unspecified role unspecified role prey prey association association 1C crebbp-snai1-7 6 25 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 1D snai1-crebbp-1 6 21 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 25 unspecified role unspecified role prey prey region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 1D-2 crebbp-ercc1-1 1 23 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 1Ei O95863 and Q92793 increases expression at RNA level of ENSG00000012061 snai1-crebbp-3 1 21 unspecified role unspecified role bait bait 23 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 1Eii O95863 and Q92793 increases expression at RNA level of ENSG00000012061 crebbp-ercc1-2 1 23 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 1Eiii O95863 and Q92793 increases expression at RNA level of ENSG00000169429 snai1-crebbp-4 1 21 unspecified role unspecified role bait bait 23 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 1Eiv O95863 and Q92793 increases expression at RNA level of ENSG00000169429 crebbp-il8-1 1 23 unspecified role unspecified role bait bait 21 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 1Ev Snail and CBP are stated to "less frequently occupy the CDH1 promoter". snai1-cadh1-1 1 27 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role bait bait 23 unspecified role unspecified role prey prey association association 1Evi Snail and CBP are stated to "less frequently occupy the CDH1 promoter". ep300-snai1 12 21 enzyme target enzyme target substrate substrate neutral component neutral component region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain O95863:p.Lys146Arg mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain K R Wed May 02 18:55:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys146arg' Tue Jun 30 18:53:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys146Arg' chemical synthesis Chemical synthesis (Chemical synthesis) 22 enzyme enzyme neutral component neutral component region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined hat_domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) acetylation acetylation reaction acetylation 2E ep300-snai1-1 12 22 enzyme enzyme neutral component neutral component region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined hat_domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 21 enzyme target enzyme target substrate substrate neutral component neutral component zinc finger c2h2-type/integrase dna-binding domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined O95863:p.Lys187Arg mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain K R Wed May 02 20:17:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys187arg' Tue Jun 30 17:31:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys187Arg' chemical synthesis Chemical synthesis (Chemical synthesis) acetylation acetylation reaction acetylation 2E-2 crebbp-snai1-1 10 25 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role prey prey physical association physical association 3A CBP and the corepressor Ajuba were not present in the same complex crebbp-snai1-2 10 28 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role prey prey physical association physical association 3A-2 CBP and the corepressor Ajuba were not present in the same complex crebbp-ep300-1 9 23 unspecified role unspecified role bait bait 22 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain association association 3B acetylated Snail was only present in the CBP-associated complex. the anti-Ac Snail antibodies do NOT react with unacetylated forms (Fig S2C) - but have added Mod as "possible" as we dont know if the unphosph-ed form reacts also. sin3a-hdac1-3 9 18 unspecified role unspecified role bait bait 14 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey association association 3B-2 snai1-ajuba 10 21 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 28 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 14 unspecified role unspecified role prey prey association association 3C Ectopic CBP inhibited the interaction between WT Snail and the corepressors (Ajuba, HDAC1, and HDAC2) but had no effect on the interaction between the nonacetylatable Snail mutant (Snail2R) and corepressors -Ajuba and Sin3A. snai1-cadh1-2 3 27 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 28 unspecified role unspecified role bait bait association association 3D sin3a-snai1-1 3 18 unspecified role unspecified role bait bait 27 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association 3D-3 snai1-ercc1 4 16 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role bait bait possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain association association 3E A greater enrichment of acetylated Snail was shown on the promoters of Snail-activated genes than on CDH1. Transfecting cells with non-acetylatable Snail (Snail2R) lowered gene expression.. P01375 indirectly increases expression at RNA level of ENSG00000012061 human tumor necrosis factor alpha (TNF-alpha) (P01375) CHEBI:4875 indirectly decreases expression at RNA level of ENSG00000012061 O95863 increases expression at RNA level of ENSG00000012061 crebbp-snai1-3 4 26 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role bait bait possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain association association 3E A greater enrichment of acetylated Snail was shown on the promoters of Snail-activated genes than on CDH1. Transfecting cells with non-acetylatable Snail (Snail2R) lowered gene expression. human tumor necrosis factor alpha (TNF-alpha) (P01375) P01375 indirectly increases expression at RNA level of ENSG00000169429 O95863 increases expression at RNA level of ENSG00000169429 CHEBI:4875 indirectly decreases expression at RNA level of ENSG00000169429 CHEBI:7939 indirectly decreases expression at RNA level of ENSG00000169429 crebbp-snai1-4 4 27 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role bait bait possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain association association 3E hdac1-snai1 11 20 enzyme enzyme neutral component neutral component c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range c_terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range 21 enzyme target enzyme target substrate substrate neutral component neutral component n_terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. deacetylation deacetylation reaction deacetylation 3H hdac1-snai1-1 11 14 enzyme enzyme neutral component neutral component c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 21 enzyme target enzyme target substrate substrate neutral component neutral component lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain n_terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. deacetylation deacetylation reaction deacetylation 3H hdac1-snai1-2 11 19 enzyme enzyme neutral component neutral component c_terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range 21 enzyme target enzyme target substrate substrate neutral component neutral component lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain n_terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. deacetylation deacetylation reaction deacetylation 3Hi positive control. Human NcoR2 (amino acids 395-489) with an N-terminal GST tag is also present. I am not sure what this is meant to be a positive control of - it is not a very good one, whatever. crebbp-snai1-5 10 25 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 4A Both phosphomimetic CBP (EE-CBP) and unphosphorylatable CBP (AA-CBP) interacted with Snail. snai1-crebbp-5 6 21 unspecified role unspecified role bait bait region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 25 unspecified role unspecified role prey prey region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp 1C crebbp-snai1-6 6 25 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region_including_bromodomain_and_hat sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 21 unspecified role unspecified role prey prey region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp 1D crebbp-tp53-4 7 23 unspecified role unspecified role neutral component neutral component 24 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction Supp Fig 2A crebbp-tp53-5 7 21 unspecified role unspecified role neutral component neutral component possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain O95863:p.[Lys146Arg;Lys187Arg] mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R Wed May 02 14:24:43 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys146arg,lys187arg' Tue Jun 30 20:06:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys146Arg;Lys187Arg]' undefined mutation mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain Wed Jul 06 17:43:54 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'possible_acetyl_lys146' 23 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction Supp Fig 2B rela-snail 5 21 unspecified role unspecified role prey prey possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain 29 unspecified role unspecified role bait bait physical association physical association Supp 3C snai1-rela-1 10 21 unspecified role unspecified role bait bait O95863:p.[Lys146Arg;Lys187Arg] mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R Wed May 02 20:31:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys146arg,lys187arg' Tue Jun 30 15:50:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys146Arg;Lys187Arg]' region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 29 unspecified role unspecified role prey prey physical association physical association Supp 3D HA-tagged CBP was present in the experimental setup. crebbp-rela-1 10 25 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 anti tag western anti tag western blot anti tag western western blot western blot Immuno blot Immuno blot unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 29 unspecified role unspecified role prey prey association association Supp 3E rela-crebbp-2 8 21 unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 29 unspecified role unspecified role bait bait 25 unspecified role unspecified role prey prey region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Supp 3E-2 ajuba-cadh1-1 3 29 unspecified role unspecified role bait bait 30 unspecified role unspecified role prey prey nfkb_binding_site_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Supp 3F rela-finc-1 3 21 unspecified role unspecified role bait bait lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain 30 unspecified role unspecified role prey prey nfkb_binding_site_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Supp 3F-2 snai1-il8 4 21 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey ebox3_and_4_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Supp 4J O95863 increases expression at RNA level of ENSG00000204490 CHEBI:4875 indirectly decreases expression at RNA level of ENSG00000204490 Transfecting cells with non-acetylatable Snail (Snail2R) lowered gene expression. snai1-tnf 4 31 unspecified role unspecified role prey prey ebox1-4_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role bait bait association association Supp 4J-2 CHEBI:4875 indirectly decreases expression at RNA level of ENSG00000108691 O95863 increases expression at RNA level of ENSG00000108691 Transfecting cells with non-acetylatable Snail (Snail2R) lowered gene expression. CHEBI:7939 indirectly decreases expression at RNA level of ENSG00000108691 snai1-ccl2 4 15 unspecified role unspecified role prey prey ebox1-4_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 21 unspecified role unspecified role bait bait association association Supp 4J-3 A greater enrichment of acetylated Snail was shown on the promoters of Snail-activated genes than on CDH1 human tumor necrosis factor alpha (TNF-alpha) (P01375) P01375 indirectly increases expression at RNA level of ENSG00000271503 CHEBI:7939 indirectly decreases expression at RNA level of ENSG00000271503 snai1-cadh1_human_gene-1 2 21 unspecified role unspecified role bait bait 27 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 18 unspecified role unspecified role prey prey association association 3D-4 snai1-ajuba-3 2 21 unspecified role unspecified role bait bait 27 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 28 unspecified role unspecified role prey prey association association 3D-2 snai1-finc_human_gene-2 2 29 unspecified role unspecified role prey prey 21 unspecified role unspecified role bait bait lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain 30 unspecified role unspecified role prey prey nfkb_binding_site_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Supp 3F-3