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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
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      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
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        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="24599775" refType="primary-reference" refTypeAc="MI:0358"/>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.</attribute>
            <attribute name="journal" nameAc="MI:0885">Dev. Dyn. (1058-8388)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2014</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Galli L.M., Munji R.N., Chapman S.C., Easton A., Li L., Onguka O., Ramahi J.S., Suriben R., Szabo L.A., Teng C., Tran B., Hannoush R.N., Burrus L.W.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">LBurrus@sfsu.edu</attribute>
            <attribute name="author-announcement">05-Jan-2015: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
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        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-23324" refType="imex-primary" refTypeAc="MI:0662"/>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9534">
            <names>
              <shortLabel>chlae-cos_7</shortLabel>
              <fullName>Cercopithecus aethiops simian cells transformed with SV40</fullName>
              <alias type="synonym" typeAc="MI:1041">Grivet</alias>
            </names>
            <cellType>
              <names>
                <shortLabel>cos_7</shortLabel>
                <fullName>cercopithecus aethiops, by transformation with SV40</fullName>
              </names>
              <xref>
                <primaryRef db="cabri" dbAc="MI:0246" id="ACC 60" refType="identity" refTypeAc="MI:0356"/>
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            </cellType>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>confocal microscopy</shortLabel>
            <fullName>confocal microscopy</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0663" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-933927" refType="identity" refTypeAc="MI:0356"/>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>immunocytochemistry</shortLabel>
            <fullName>immunocytochemistry</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1200" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6349984" refType="identity" refTypeAc="MI:0356"/>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Galli L.M., Munji R.N., Chapman S.C., Easton A., Li L., Onguka O., Ramahi J.S., Suriben R., Szabo L.A., Teng C., Tran B., Hannoush R.N., Burrus L.W.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">LBurrus@sfsu.edu</attribute>
          <attribute name="accepted">Accepted 2014-DEC-04 by ORCHARD</attribute>
          <attribute name="journal" nameAc="MI:0885">Dev. Dyn. (1058-8388)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2014</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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      <experimentDescription id="2">
        <names>
          <fullName>Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.</fullName>
        </names>
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            <attribute name="publication title" nameAc="MI:1091">Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.</attribute>
            <attribute name="journal" nameAc="MI:0885">Dev. Dyn. (1058-8388)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2014</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
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            <attribute name="author-announcement">05-Jan-2015: Contacted by IntAct-Help.</attribute>
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          <hostOrganism ncbiTaxId="9534">
            <names>
              <shortLabel>chlae-cos_7</shortLabel>
              <fullName>Cercopithecus aethiops simian cells transformed with SV40</fullName>
              <alias type="synonym" typeAc="MI:1041">Grivet</alias>
            </names>
            <cellType>
              <names>
                <shortLabel>cos_7</shortLabel>
                <fullName>cercopithecus aethiops, by transformation with SV40</fullName>
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        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>pla</shortLabel>
            <fullName>proximity ligation assay</fullName>
            <alias type="go synonym" typeAc="MI:0303">pELISA</alias>
            <alias type="synonym" typeAc="MI:1041">pELISA</alias>
            <alias type="synonym" typeAc="MI:1041">PLA</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0813" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="pubmed" dbAc="MI:0446" id=":17072308" refType="primary-reference" refTypeAc="MI:0358"/>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>antibody detection</shortLabel>
            <fullName>identification by antibody</fullName>
            <alias type="synonym" typeAc="MI:1041">antibody detection</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0421" refType="identity" refTypeAc="MI:0356"/>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Galli L.M., Munji R.N., Chapman S.C., Easton A., Li L., Onguka O., Ramahi J.S., Suriben R., Szabo L.A., Teng C., Tran B., Hannoush R.N., Burrus L.W.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">LBurrus@sfsu.edu</attribute>
          <attribute name="accepted">Accepted 2014-DEC-04 by ORCHARD</attribute>
          <attribute name="journal" nameAc="MI:0885">Dev. Dyn. (1058-8388)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2014</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>wnt3a_chick</shortLabel>
          <fullName>Protein Wnt-3a</fullName>
          <alias type="gene name" typeAc="MI:0301">WNT3A</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q2LMP1" version="SP_70" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9PWH1" version="SP_70" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALP00000045045" version="SP_113" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001165072.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_990006.2"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALG00000042657" version="SP_113" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALT00000054282" version="SP_113" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005109" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005125" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005640" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005783" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009953" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010831" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030182" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030509" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035108" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0040036" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042472" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045165" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045663" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045743" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048263" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050679" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060070" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060173" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060828" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061303" version="SP_113"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090263" version="SP_113"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005817" version="SP_113"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009141" version="SP_113"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018161" version="SP_113"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR043158" version="SP_113"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-201681" version="SP_113"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-3238698" version="SP_113"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-4641262" version="SP_113"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-4641263" version="SP_113"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9031">
          <names>
            <shortLabel>chick</shortLabel>
            <fullName>Gallus gallus (Chicken)</fullName>
            <alias type="synonym" typeAc="MI:1041">Chicken</alias>
          </names>
        </organism>
        <sequence>MASFGYFLFLCGLSQALSSYPIWWSLAIGHQYSSLGTQPILCGSIPGLVPKQLRFCRNYVEIMPSVAEGVKIGIQECQHQFRGRRWNCTTVNDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSATICGCDTRHKGSPGEGWKWGGCSEDVEFGSMVSREFADARENRPDARSAMNRHNNEAGRTSIIELMHLKCKCHGLSGSCEVKTCWWSQPDFRVIGDYLKDKYDSASEMVVEKHRESRGWVETLRPKYNFFKAPTEKDLVYYENSPNFCEPNPETGSFGTRDRICNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVRCQECIRVYDVHTCK</sequence>
        <attributeList>
          <attribute name="crc64">EE558AC4B2225B3A</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>fzd10_chick</shortLabel>
          <fullName>Frizzled-10</fullName>
          <alias type="gene name" typeAc="MI:0301">FZD10</alias>
          <alias type="gene name synonym" typeAc="MI:0302">FZ10</alias>
        </names>
        <xref>
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          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-9991280" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004930" version="SP_130"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_130"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_130"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0017147" version="SP_130"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042813" version="SP_130"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060070" version="SP_130"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000539"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015526"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020067"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR026549"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017981"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_989429.1"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036790"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9031">
          <names>
            <shortLabel>chick</shortLabel>
            <fullName>Gallus gallus (Chicken)</fullName>
            <alias type="synonym" typeAc="MI:1041">Chicken</alias>
          </names>
        </organism>
        <sequence>MGPAAGNLVRAVLALCWLAEHCAGISSIDIERPGDGRCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPPRGSSMLPPMFRPQRPSTGHDLQQHKDSLSRTSCENPGKFHHVEKSASCAPLCTPGVDVYWSKDDKQFAVIWIAIWSILCFFSSAFTVLTFLIDPQRFKYPERPIIFLSMCYCVYSVGYIIRLFSGAESIACDRDSGQLYVIQEGLESTGCTIVFLVLYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMRRVAGDELTGLCYVGSMDVNALTGFVLIPLACYLIIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWKIVASQQKCKMNNQTKNLDCMMNNSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVCSRRLKKRSRRKPASVITSSGIYKKPQHPQKTHLAKYESTLQPPTCV</sequence>
        <attributeList>
          <attribute name="crc64">3E2A7E747CF9EE4B</attribute>
        </attributeList>
      </interactor>
      <interactor id="5">
        <names>
          <shortLabel>wnt1_chick</shortLabel>
          <fullName>Protein Wnt-1</fullName>
          <alias type="gene name" typeAc="MI:0301">WNT1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">WNT-1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q91029" version="SP_73" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3L258" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5QEB6" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9PS91" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-9991388" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005109" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005125" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009953" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030182" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030509" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031334" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045165" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048263" version="SP_100"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060070" version="SP_100"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005817"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009139"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR043158"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018161"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_015128668.1"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9031">
          <names>
            <shortLabel>chick</shortLabel>
            <fullName>Gallus gallus (Chicken)</fullName>
            <alias type="synonym" typeAc="MI:1041">Chicken</alias>
          </names>
        </organism>
        <sequence>MRGPALLLALRALCALSALRGTARAVNNSGRWWGIINVASSTNLLTDSGSVQLVLEPGLQLLSRKQRRLIRQNPGILHSVSAGLQSAVRECQWQFRNRRWNCPTSQGPNIFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSSEKGRDLRFLMNLHNNEAGRMTVFSEMRQECKCHGMSGSCTVRTCWMRLPTFRAVGDVLKDRFDGASRVIYGNKGSNRASRVELHHLEPENPAHKPPSPHDLVYFEKSPNFCTYSGKMGTAGTAGRACNSSSPGLDGCELLCCGRGFRTRTQRVTERCNCTFHWCCHVSCLNCTNTQVLHECL</sequence>
        <attributeList>
          <attribute name="crc64">F1D7A6C5EFB44C2B</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="6" imexId="IM-23324-1">
        <names>
          <shortLabel>fzd10-wnt3a</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-9991161" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-23324-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>2</experimentRef>
        </experimentList>
        <participantList>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="8">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>proximity</shortLabel>
            <fullName>proximity</fullName>
            <alias type="synonym" typeAc="MI:1041">close-contact colocalization</alias>
            <alias type="synonym" typeAc="MI:1041">neighbourhood interaction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4/5</attribute>
          <attribute name="agonist" nameAc="MI:0625">LRP6 (a member of the low density lipoprotein receptor  family.)</attribute>
        </attributeList>
      </interaction>
      <interaction id="9" imexId="IM-23324-2">
        <names>
          <shortLabel>fzd10-wnt3a-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-9991378" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-23324-2" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>2</experimentRef>
        </experimentList>
        <participantList>
          <participant id="10">
            <interactorRef>5</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="11">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>proximity</shortLabel>
            <fullName>proximity</fullName>
            <alias type="synonym" typeAc="MI:1041">close-contact colocalization</alias>
            <alias type="synonym" typeAc="MI:1041">neighbourhood interaction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4i</attribute>
        </attributeList>
      </interaction>
      <interaction id="12" imexId="IM-23324-3">
        <names>
          <shortLabel>fzd10-wnt3a-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-9991447" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-23324-3" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="13">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="14">
            <interactorRef>5</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4i</attribute>
        </attributeList>
      </interaction>
      <interaction id="15" imexId="IM-23324-4">
        <names>
          <shortLabel>fzd10-wnt3a-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-9991449" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-23324-4" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="16">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="17">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4</attribute>
          <attribute name="agonist" nameAc="MI:0625">LRP6 (a member of the low density lipoprotein receptor  family.)</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>