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    <source releaseDate="2022-02-04">
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        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
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        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
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    <experimentList>
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        <names>
          <fullName>Central bombesin possibly induces S-nitrosylation of cyclooxygenase-1 in pre-sympathetic neurons of rat hypothalamic paraventricular nucleus.</fullName>
        </names>
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            <attribute name="publication title" nameAc="MI:1091">Central bombesin possibly induces S-nitrosylation of cyclooxygenase-1 in pre-sympathetic neurons of rat hypothalamic paraventricular nucleus.</attribute>
            <attribute name="journal" nameAc="MI:0885">Life Sci. (0024-3205)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2014</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
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            <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
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            <attribute name="author-announcement">05-Jan-2015: Contacted by IntAct-Help.</attribute>
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            <names>
              <shortLabel>rat-primary_hippocampal_neuron</shortLabel>
              <fullName>Rat primary hippocampal neuron</fullName>
            </names>
            <tissue>
              <names>
                <shortLabel>primary hippocampal neurons</shortLabel>
                <fullName>Rat primary hippocampal neurons</fullName>
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        <interactionDetectionMethod>
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            <shortLabel>pla</shortLabel>
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            <shortLabel>antibody detection</shortLabel>
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          <attribute name="exp-modification" nameAc="MI:0627">Pre-sympathetic spinally projecting neurons in the rat hypothalamic paraventricular nucleus (PVN),</attribute>
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          <attribute name="accepted">Accepted 2014-DEC-01 by ORCHARD</attribute>
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          <shortLabel>pgh1_rat</shortLabel>
          <fullName>Prostaglandin G/H synthase 1</fullName>
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          <alias type="gene name synonym" typeAc="MI:0302">Cox-1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cox1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cyclooxygenase-1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Prostaglandin H2 synthase 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Prostaglandin-endoperoxide synthase 1</alias>
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            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
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            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
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        </organism>
        <sequence>MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVITVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLAQRLLLRREFIPGPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPSTEL</sequence>
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          <attribute name="crc64">0BFAF7EBFDA0C7C2</attribute>
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      <interactor id="3">
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          <shortLabel>nos1_rat</shortLabel>
          <fullName>Nitric oxide synthase, brain</fullName>
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          <alias type="gene name synonym" typeAc="MI:0302">Bnos</alias>
          <alias type="gene name synonym" typeAc="MI:0302">BNOS</alias>
          <alias type="gene name synonym" typeAc="MI:0302">NOS type I</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Neuronal NOS</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Constitutive NOS</alias>
          <alias type="gene name synonym" typeAc="MI:0302">NC-NOS</alias>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5G0O" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5G0P" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNR" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNS" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNT" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNU" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNV" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNW" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNX" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNY" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UNZ" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UO0" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUI" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUJ" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUK" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUQ" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUR" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUS" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUT" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUU" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AUQ" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AUR" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AUS" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AUT" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AUU" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AUV" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AUW" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AUX" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGJ" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGK" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGL" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGM" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGN" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGP" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUL" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGQ" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGR" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGS" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGT" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGU" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGV" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGW" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGX" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGY" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NGZ" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NH0" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NHD" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUM" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NHE" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PMV" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PMW" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PMX" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUN" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUO" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VUP" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PMY" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PMZ" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN0" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN1" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN2" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN3" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN4" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN5" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN6" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN7" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN8" version="SP_232"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PN9" version="SP_232"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-1222556" version="SP_232"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-392154" version="SP_232"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-5578775" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005516" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005741" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005856" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006527" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006809" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006936" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006941" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007263" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007420" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007565" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007568" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008016" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009408" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001666" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001917" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002028" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009725" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004517" version="SP_232"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010181" version="SP_232"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P29476"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-33272N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAIDPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLDGKSHKAPPLGGDNDRVFNDLWGKDNVPVILNNPYSEKEQSPTSGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKPNNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSNVHKKRVSAARLLSRQNLQSPKFSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDADEVFSS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P29476 original sequence version: 172</attribute>
          <attribute name="crc64">7255C5AE165200F5</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-23317-1">
        <names>
          <shortLabel>nos1-ptgs1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-9986192" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-23317-1" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" refType="component" refTypeAc="MI:0354"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>proximity</shortLabel>
            <fullName>proximity</fullName>
            <alias type="synonym" typeAc="MI:1041">close-contact colocalization</alias>
            <alias type="synonym" typeAc="MI:1041">neighbourhood interaction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">7</attribute>
          <attribute name="agonist" nameAc="MI:0625">Bombesin (a 14-amino acid stress related neuro-peptide)</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>