IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues. In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues. Br. J. Cancer (0007-0920) 2010 imex curation Aubele M., Spears M., Ludyga N., Braselmann H., Feuchtinger A., Taylor K.J., Lindner K., Auer G., Stering K., Höfler H., Schmitt M., Bartlett J.M. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. aubele@helmholtz-muenchen.de 14-Apr-2014: Contacted by IntAct-Help. Only protein-protein interactions human-breast_cancer Homo sapiens breast cancer tissue breast_cancer Breast cancer tissue pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Aubele M., Spears M., Ludyga N., Braselmann H., Feuchtinger A., Taylor K.J., Lindner K., Auer G., Stering K., Höfler H., Schmitt M., Bartlett J.M. Cancer - Interactions investigated in the context of cancer Of Histopathological parameters used- (tumour size, lymphnode status, histological grade, oestrogen, and progesterone receptor status); only tumour size was significantly correlated (P=0.015) with the mean number of PLA signals. Significant inverse correlation of PLA signals with distant metastasis-free survival of patients was also found. aubele@helmholtz-muenchen.de Accepted 2014-APR-03 by ORCHARD Br. J. Cancer (0007-0920) 2010 Only protein-protein interactions imex curation In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues. In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues. Br. J. Cancer (0007-0920) 2010 imex curation Aubele M., Spears M., Ludyga N., Braselmann H., Feuchtinger A., Taylor K.J., Lindner K., Auer G., Stering K., Höfler H., Schmitt M., Bartlett J.M. Cancer - Interactions investigated in the context of cancer Affinomics - Interactions curated for the Affinomics consortium. aubele@helmholtz-muenchen.de 14-Apr-2014: Contacted by IntAct-Help. Only protein-protein interactions human-t47d human breast cancer tumour cell line-epithelial cells t47d Epithelial cells derived from human breast tumour pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Aubele M., Spears M., Ludyga N., Braselmann H., Feuchtinger A., Taylor K.J., Lindner K., Auer G., Stering K., Höfler H., Schmitt M., Bartlett J.M. Cancer - Interactions investigated in the context of cancer aubele@helmholtz-muenchen.de Accepted 2014-APR-03 by ORCHARD Br. J. Cancer (0007-0920) 2010 Only protein-protein interactions imex curation erbb2_human Receptor tyrosine-protein kinase erbB-2 p185erbB2 MLN19 Proto-oncogene c-ErbB-2 Tyrosine kinase-type cell surface receptor HER2 Proto-oncogene Neu ERBB2 HER2 NEU NGL Metastatic lymph node gene 19 protein protein protein human Homo sapiens Human MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV DIP protein P04626 original sequence version: 198 DIP protein P04626 original sequence version: 122 DIP protein P04626 original sequence version: 206 DIP protein P04626 original sequence version: 195 DIP protein P04626 original sequence version: 150 DIP protein P04626 original sequence version: 179 DIP protein P04626 original sequence version: 146 DIP protein P04626 original sequence version: 147 39E9DFDA04DCF962 ptk6_human Protein-tyrosine kinase 6 BRK Breast tumor kinase Tyrosine-protein kinase BRK PTK6 protein protein human Homo sapiens Human MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT DIP protein Q13882 original sequence version: 91 DIP protein Q13882-1 original sequence version: 170 DIP protein Q13882 original sequence version: 170 CDCAC0EE242E1BD7 erbb2-ptk6 2 4 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction 1A erbb2-ptk6-1 1 3 unspecified role unspecified role neutral component neutral component 4 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction Fig. 2