<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
      <bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
        <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="20146103" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-9301707" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-22285" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor.</attribute>
            <attribute name="journal" nameAc="MI:0885">Ann. Surg. Oncol. (1068-9265)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2010</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Hsu K.H., Tsai H.W., Lin P.W., Hsu Y.S., Shan Y.S., Lu P.J.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">ysshan@mail.ncku.edu.tw, pjlu2190@mail.ncku.edu.tw</attribute>
            <attribute name="author-announcement">22-Jan-2015: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="20146103" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-22285" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-gist_tissue</shortLabel>
              <fullName>Human Gist_tissue</fullName>
            </names>
            <tissue>
              <names>
                <shortLabel>gist</shortLabel>
                <fullName>Gastrointestinal stromal tumor tissue</fullName>
              </names>
              <xref>
                <primaryRef db="intact" dbAc="MI:0469" id="IA:2802" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0004111" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-9293646" refType="identity" refTypeAc="MI:0356"/>
              </xref>
            </tissue>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>fluorescence imaging</shortLabel>
            <fullName>fluorescence microscopy</fullName>
            <alias type="synonym" typeAc="MI:1041">fluorescence imaging</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0416" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608494" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>immunohistochemistry</shortLabel>
            <fullName>immunohistochemistry</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1198" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6349998" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="16006601" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Hsu K.H., Tsai H.W., Lin P.W., Hsu Y.S., Shan Y.S., Lu P.J.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">ysshan@mail.ncku.edu.tw, pjlu2190@mail.ncku.edu.tw</attribute>
          <attribute name="accepted">Accepted 2015-JAN-06 by PPORRAS</attribute>
          <attribute name="journal" nameAc="MI:0885">Ann. Surg. Oncol. (1068-9265)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2010</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
      <experimentDescription id="2">
        <names>
          <fullName>Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="20146103" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-9301707" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-22285" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor.</attribute>
            <attribute name="journal" nameAc="MI:0885">Ann. Surg. Oncol. (1068-9265)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2010</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Hsu K.H., Tsai H.W., Lin P.W., Hsu Y.S., Shan Y.S., Lu P.J.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">ysshan@mail.ncku.edu.tw, pjlu2190@mail.ncku.edu.tw</attribute>
            <attribute name="author-announcement">22-Jan-2015: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-22285" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="20146103" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-gist_tissue</shortLabel>
              <fullName>Human Gist_tissue</fullName>
            </names>
            <tissue>
              <names>
                <shortLabel>gist</shortLabel>
                <fullName>Gastrointestinal stromal tumor tissue</fullName>
              </names>
              <xref>
                <primaryRef db="intact" dbAc="MI:0469" id="IA:2802" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0004111" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-9293646" refType="identity" refTypeAc="MI:0356"/>
              </xref>
            </tissue>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>pla</shortLabel>
            <fullName>proximity ligation assay</fullName>
            <alias type="go synonym" typeAc="MI:0303">pELISA</alias>
            <alias type="synonym" typeAc="MI:1041">pELISA</alias>
            <alias type="synonym" typeAc="MI:1041">PLA</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0813" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218403" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="15155907" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id=":17072308" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>antibody detection</shortLabel>
            <fullName>identification by antibody</fullName>
            <alias type="synonym" typeAc="MI:1041">antibody detection</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0421" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608791" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Hsu K.H., Tsai H.W., Lin P.W., Hsu Y.S., Shan Y.S., Lu P.J.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">ysshan@mail.ncku.edu.tw, pjlu2190@mail.ncku.edu.tw</attribute>
          <attribute name="accepted">Accepted 2015-JAN-06 by PPORRAS</attribute>
          <attribute name="journal" nameAc="MI:0885">Ann. Surg. Oncol. (1068-9265)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2010</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>cd44_human</shortLabel>
          <fullName>CD44 antigen</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Epican</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CDw44</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Phagocytic glycoprotein I</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Extracellular matrix receptor III</alias>
          <alias type="gene name synonym" typeAc="MI:0302">HUTCH-I</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Phagocytic glycoprotein 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">GP90 lymphocyte homing/adhesion receptor</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Hermes antigen</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Hyaluronate receptor</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Heparan sulfate proteoglycan</alias>
          <alias type="gene name" typeAc="MI:0301">CD44</alias>
          <alias type="gene name synonym" typeAc="MI:0302">LHR</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MDU2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MDU3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MIC4</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P16070" version="SP_116" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P22511" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q04858" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13419" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13957" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13958" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13959" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13960" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13961" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13967" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13968" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13980" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15861" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q16064" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q16065" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q16066" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q16208" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q16522" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q86T72" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q86Z27" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8N694" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q92493" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96J24" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UJ36" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H5A5" version="SP_122" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A5YRN9" version="SP_124" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UC28" version="SP_127" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UC29" version="SP_127" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UC30" version="SP_127" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UCB0" version="SP_130" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DR12" version="SP_146" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DR13" version="SP_146" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B6EAT9" version="SP_159" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O95370" version="SP_160" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000398632" version="SP_245" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-490245" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000601.3"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001001389.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001001390.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001001391.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001001392.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001189484.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001189485.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001189486.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011518790.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000026508" version="SP_245" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000428726" version="SP_245" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004888" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005518" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005540" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005902" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006954" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007155" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007160" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016323" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016324" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016477" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019221" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030214" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030667" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031258" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034116" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035692" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042110" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042995" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043154" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043518" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044319" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044344" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051216" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070487" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098609" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1900625" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902166" version="SP_245"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000392" version="SP_245"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000538" version="SP_245"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001231" version="SP_245"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016186" version="SP_245"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016187" version="SP_245"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR043210" version="SP_245"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1POZ" version="SP_245"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1UUH" version="SP_245"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2I83" version="SP_245"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4PZ3" version="SP_245"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4PZ4" version="SP_245"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6TXS" version="SP_245"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1474228" version="SP_245"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202733" version="SP_245"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-216083" version="SP_245"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2160916" version="SP_245"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6798695" version="SP_245"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-877300" version="SP_245"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-1121N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P16070 original sequence version: 142</attribute>
          <attribute name="remark-internal">DIP protein P16070 original sequence version: 157</attribute>
          <attribute name="crc64">BB9B66B19B970349</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>ostp_human</shortLabel>
          <fullName>Osteopontin</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Bone sialoprotein 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Secreted phosphoprotein 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Urinary stone protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Nephropontin</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Uropontin</alias>
          <alias type="gene name" typeAc="MI:0301">SPP1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">OPN</alias>
          <alias type="orf name" typeAc="MI:0306">PSEC0156</alias>
          <alias type="gene name synonym" typeAc="MI:0302">BNSP</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P10451" version="SP_94" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000378517" version="SP_224" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000477824" version="SP_224" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15681" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15682" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15683" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8NBK2" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96IZ1" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2RDA1" version="SP_145" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q4W597" version="SP_145" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q567T5" version="SP_147" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-723648" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000573.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001035147.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000118785" version="SP_224" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000395080" version="SP_224" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000614857" version="SP_224" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001649" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005125" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005178" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005788" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006710" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006954" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007155" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007566" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031214" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033280" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042995" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045780" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048545" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048685" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050840" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071394" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000866" version="SP_224"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002038" version="SP_224"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019841" version="SP_224"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P10451" version="SP_224"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3CXD" version="SP_224"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3DSF" version="SP_224"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1474228" version="SP_224"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-186797" version="SP_224"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-216083" version="SP_224"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-381426" version="SP_224"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8949275" version="SP_224"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8957275" version="SP_224"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046697" version="SP_224"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001035149.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001238758.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001238759.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-49933N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN</sequence>
        <attributeList>
          <attribute name="crc64">4996429EC4752B86</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5" imexId="IM-22285-1">
        <names>
          <shortLabel>cd44-spp1-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-9301728" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-22285-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>colocalization</shortLabel>
            <fullName>colocalization</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4B</attribute>
        </attributeList>
      </interaction>
      <interaction id="8" imexId="IM-22285-2">
        <names>
          <shortLabel>cd44-spp1-3</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-9301740" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-22285-2" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>2</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="10">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>proximity</shortLabel>
            <fullName>proximity</fullName>
            <alias type="synonym" typeAc="MI:1041">close-contact colocalization</alias>
            <alias type="synonym" typeAc="MI:1041">neighbourhood interaction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4C</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>