IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ wenzel-2021-1 in vitro In vitro protease assay protease assay experimental particp experimental participant identification experimental particp Wenzel J., Lampe J., Müller-Fielitz H., Schuster R., Zille M., Müller K., Krohn M., Körbelin J., Zhang L., Özorhan Ü., Neve V., Wagner JUG., Bojkova D., Shumliakivska M., Jiang Y., Fähnrich A., Ott F., Sencio V., Robil C., Pfefferle S., Sauve F., Coêlho CFF., Franz J., Spiecker F., Lembrich B., Binder S., Feller N., König P., Busch H., Collin L., Villaseñor R., Jöhren O., Altmeppen HC., Pasparakis M., Dimmeler S., Cinatl J., Püschel K., Zelic M., Ofengeim D., Stadelmann C., Trottein F., Nogueiras R., Hilgenfeld R., Glatzel M., Prevot V., Schwaninger M. Virus - Publications including interactions involving viral proteins markus.schwaninger@uni-luebeck.de Nature neuroscience 2021 Only protein-protein interactions imex curation imex curation Coronavirus - Interactions investigated in the context of Coronavirus p0dtd1-pro_0000449623 3C-like proteinase nsp5 rep ORF1ab polyprotein 1a-1b protein protein SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 2019-nCoV SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 3264 3569 q9y6k9-1 NF-kappa-B essential modulator FIP-3 IkB kinase-associated protein 1 Inhibitor of nuclear factor kappa-B kinase subunit gamma NF-kappa-B essential modifier IKBKG FIP3 NEMO protein protein human Homo sapiens Human MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE nemo_mouse NF-kappa-B essential modulator NF-kappa-B essential modifier Inhibitor of nuclear factor kappa-B kinase subunit gamma IkB kinase-associated protein 1 Ikbkg Nemo protein protein mouse Mus musculus Mouse MNKHPWKNQLSEMVQPSGGPAEDQDMLGEESSLGKPAMLHLPSEQGTPETLQRCLEENQELRDAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEKLDLRSQREQALKELEQLKKCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKDRQALEGRIRAVSEQVRQLESEREVLQQQHSVQVDQLRMQNQSVEAALRMERQAASEEKRKLAQLQAAYHQLFQDYDSHIKSSKGMQLEDLRQQLQQAEEALVAKQELIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERHAREKLVEKKEYLQEQLEQLQREFNKLKVGCHESARIEDMRKRHVETPQPPLLPAPAHHSFHLALSNQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE ikbkg-rep-2 4105529 N/A 4105530 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) N/A 4105531 sequence tag sequence tag identification sequence tag western blot western blot Immuno blot Immuno blot enzyme target enzyme target substrate substrate neutral component neutral component purified purified gln83 biological feature biological feature certain certain sequence position certain certain certain sequence position certain false gln205 biological feature biological feature certain certain sequence position certain certain certain sequence position certain false gln231 biological feature biological feature certain certain sequence position certain certain certain sequence position certain false gln304 biological feature biological feature certain certain sequence position certain certain certain sequence position certain false gln313 biological feature biological feature certain certain sequence position certain certain certain sequence position certain false n-terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecoli Escherichia coli (strain K12) protein cleavage protein cleavage false false false 3 A/D/E, Supp. figure 2 ikbkg-rep-3 4105529 N/A 4105530 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) N/A 4105531 sequence tag sequence tag identification sequence tag enzyme target enzyme target substrate substrate neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gln231 biological feature biological feature certain certain sequence position certain certain certain sequence position certain false Q9Y6K9-1:p.Gln231Ala mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) protein cleavage protein cleavage false false false 4105529 3F, Supp. figure 3 ikbkg-rep-4 4105529 N/A 4105530 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) N/A 4105532 sequence tag sequence tag identification sequence tag enzyme target enzyme target substrate substrate neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gln231 biological feature biological feature certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) protein cleavage protein cleavage false false false 3F, Supp. figure 3 B/C