DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ drayman-2021-1 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction experimental particp experimental participant identification experimental particp Drayman N., DeMarco JK., Jones KA., Azizi SA., Froggatt HM., Tan K., Maltseva NI., Chen S., Nicolaescu V., Dvorkin S., Furlong K., Kathayat RS., Firpo MR., Mastrodomenico V., Bruce EA., Schmidt MM., Jedrzejczak R., Muñoz-Alía MÁ., Schuster B., Nair V., Han KY., O'Brien A., Tomatsidou A., Meyer B., Vignuzzi M., Missiakas D., Botten JW., Brooke CB., Lee H., Baker SC., Mounce BC., Heaton NS., Severson WE., Palmer KE., Dickinson BC., Joachimiak A., Randall G., Tay S. tays@uchicago.edu (S.T.); nirdra@uchicago.edu (N.D.) Science (New York, N.Y.) 2021 imex curation Only protein-protein interactions imex curation p0dtd1-pro_0000449623 3C-like proteinase nsp5 rep ORF1ab polyprotein 1a-1b protein protein SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 2019-nCoV SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 3264 3569 rep-282 4083223 N/A 4083224 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level human-a_549 Homo sapiens Caucasian lung carcinoma cell line a_549 Human Caucasian lung carcinoma Stoichiometry: 2.0 direct interaction direct interaction false false false Fig. 3d, Table S4