IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ rosa-2021-3 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P., Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P. Virus - Publications including interactions involving viral proteins peter.cherepanov@crick.ac.uk, katie.doores@ kcl.ac.uk, l.mccoy@ucl.ac.uk, george.kassiotis@crick.ac.uk Science advances 2021 Only protein-protein interactions imex curation imex curation Coronavirus - Interactions investigated in the context of Coronavirus rosa-2021-5 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P., Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P. Virus - Publications including interactions involving viral proteins peter.cherepanov@crick.ac.uk, katie.doores@ kcl.ac.uk, l.mccoy@ucl.ac.uk, george.kassiotis@crick.ac.uk Science advances 2021 Only protein-protein interactions imex curation imex curation Coronavirus - Interactions investigated in the context of Coronavirus rosa-2021-1 in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog structure determination identification by structure determination identification by structure determination structure determination Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P., Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P. Virus - Publications including interactions involving viral proteins peter.cherepanov@crick.ac.uk, katie.doores@ kcl.ac.uk, l.mccoy@ucl.ac.uk, george.kassiotis@crick.ac.uk Science advances 2021 Only protein-protein interactions imex curation imex curation Coronavirus - Interactions investigated in the context of Coronavirus rosa-2021-2 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P., Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P. Virus - Publications including interactions involving viral proteins peter.cherepanov@crick.ac.uk, katie.doores@ kcl.ac.uk, l.mccoy@ucl.ac.uk, george.kassiotis@crick.ac.uk Science advances 2021 Only protein-protein interactions imex curation imex curation Coronavirus - Interactions investigated in the context of Coronavirus rosa-2021-4 in vitro In vitro thermal shift thermal shift binding thermal shift predetermined predetermined participant predetermined Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P., Rosa A., Pye VE., Graham C., Muir L., Seow J., Ng KW., Cook NJ., Rees-Spear C., Parker E., Dos Santos MS., Rosadas C., Susana A., Rhys H., Nans A., Masino L., Roustan C., Christodoulou E., Ulferts R., Wrobel AG., Short CE., Fertleman M., Sanders RW., Heaney J., Spyer M., Kjær S., Riddell A., Malim MH., Beale R., MacRae JI., Taylor GP., Nastouli E., van Gils MJ., Rosenthal PB., Pizzato M., McClure MO., Tedder RS., Kassiotis G., McCoy LE., Doores KJ., Cherepanov P. Virus - Publications including interactions involving viral proteins Changes in intrinsic fluorescence were monitored over a range of temperatures. peter.cherepanov@crick.ac.uk, katie.doores@ kcl.ac.uk, l.mccoy@ucl.ac.uk, george.kassiotis@crick.ac.uk Science advances 2021 Only protein-protein interactions imex curation imex curation Coronavirus - Interactions investigated in the context of Coronavirus biliverdin biliverdin 8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbilin-1(19)(21H,24H)-dione Biliverdin Biliverdin IX alpha Biliverdin IXalpha Biliverdine BILIVERDINE IX ALPHA biliverdin small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) spike_sars2 Spike glycoprotein S E2 Peplomer protein 2 protein protein SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 2019-nCoV MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT hemin-1 hemin chloro(protoporphyrinato)iron(III) chloro[3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(III) chlorohemin chloroprotoferrihem ferriprotoporphyrin IX chloride Haemin hemin Hemin hemin chloride hemin IX Hemine hemine Panhematin protohemin protohemin IX chlorido(protoporphyrinato)iron(III) small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) spike_sars Spike glycoprotein S E2 Peplomer protein 2 protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MFIFLLFLTLTSGSDLDRCTTFDDVQAPNYTQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHTINHTFGNPVIPFKDGIYFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGTQTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAILTAFSPAQDIWGTSAAAYFVGYLKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTVSLLRSTSQKSIVAYTMSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLCCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT bilirubin ixalpha bilirubin IXalpha 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid 2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid 8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione Bilirubin bilirubin(Z,Z) 3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid bilirubin bilirubin-IXalpha small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) s-biliverdin-1 4084246 N/A 4084251 unspecified role unspecified role prey prey N/A 4084252 unspecified role unspecified role bait bait purified purified C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. direct interaction direct interaction false false false 4084246 Supp. figure 3. Table S1 s-biliverdin-2 4084246 N/A 4084251 unspecified role unspecified role prey prey N/A 4084252 unspecified role unspecified role bait bait purified purified C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. direct interaction direct interaction false false false 4084246 Supp. figure 3. Table S1 s-biliverdin-3 4084246 N/A 4084252 unspecified role unspecified role bait bait purified purified C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. N/A 4084251 unspecified role unspecified role prey prey direct interaction direct interaction false false false 4084246 Supp. figure 3. Table S1 s-biliverdin-4 4084246 N/A 4084252 unspecified role unspecified role bait bait purified purified C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. N/A 4084251 unspecified role unspecified role prey prey direct interaction direct interaction false false false 4084246 Supp. figure 3. Table S1 s-biliverdin-8 4084246 N/A 4084252 unspecified role unspecified role bait bait purified purified C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. N/A 4084251 unspecified role unspecified role prey prey direct interaction direct interaction false false false 4084246 Supp. figure 3. Table S1 s-hemin_1-1 4084247 N/A 4084253 unspecified role unspecified role prey prey N/A 4084252 unspecified role unspecified role bait bait purified purified C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. direct interaction direct interaction false false false 4084247 Supp. figure 3. Table S1 s-biliverdin-6 4084247 N/A 4084251 unspecified role unspecified role prey prey N/A 4084254 unspecified role unspecified role bait bait purified purified C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. direct interaction direct interaction false false false 4084247 Supp. figure 3. Table S1 s-biliverdin-7 4084247 N/A 4084251 unspecified role unspecified role prey prey N/A 4084252 unspecified role unspecified role bait bait purified purified C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false P0DTC2:p.Arg190Lys mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false P0DTC2:p.Asn121Gln mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. direct interaction direct interaction false false false 4084247 Supp. figure 3. Table S1 s-bilirubin ixalpha-1 4084247 N/A 4084255 unspecified role unspecified role prey prey N/A 4084252 unspecified role unspecified role bait bait purified purified P0DTC2:p.Asn121Gln mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false C-terminus strep tag strep tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false S1 region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. direct interaction direct interaction false false false 4084247 Supp. figure 3. Table S1 biliverdin-s-1 4084248 N/A 4084252 unspecified role unspecified role neutral component neutral component purified purified foldon trimerisation tag tag tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false TEV-cleavage site tag tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false P0DTC2:p.Lys986_Val987delinsProPro mutation mutation certain certain sequence position certain certain certain sequence position certain false mu-phosphatase secretion leader sequence tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false C-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. Stoichiometry: 3.0 N/A 4084251 unspecified role unspecified role neutral component neutral component Stoichiometry: 3.0 direct interaction direct interaction false false false Table S2 biliverdin-s-2 4084249 N/A 4084252 unspecified role unspecified role neutral component neutral component purified purified N-terminal region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. Stoichiometry: 1.0 N/A 4084251 unspecified role unspecified role neutral component neutral component Stoichiometry: 1.0 direct interaction direct interaction false false false Table S3 biliverdin-s-3 4084250 N/A 4084252 unspecified role unspecified role neutral component neutral component purified purified N-terminal region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. N/A 4084251 unspecified role unspecified role neutral component neutral component direct interaction direct interaction false false false Figure S3K The melting point of isolated NTD increased by over 8 degrees C in the presence of biliverdin.