IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ kotecha-2017-1 in vitro In vitro electron microscopy electron microscopy Electron crystallography Electron cryomicroscopy Electron crystallography Electron cryomicroscopy predetermined predetermined participant predetermined Kotecha A., Wang Q., Dong X., Ilca SL., Ondiviela M., Zihe R., Seago J., Charleston B., Fry EE., Abrescia NGA., Springer TA., Huiskonen JT., Stuart DI. springer@crystal.harvard.edu Nature communications 2017 imex curation Only protein-protein interactions imex curation kotecha-2017-2 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Kotecha A., Wang Q., Dong X., Ilca SL., Ondiviela M., Zihe R., Seago J., Charleston B., Fry EE., Abrescia NGA., Springer TA., Huiskonen JT., Stuart DI. springer@crystal.harvard.edu Nature communications 2017 imex curation Only protein-protein interactions imex curation itb6_human Integrin beta-6 ITGB6 protein protein human Homo sapiens Human MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC itav_human Integrin alpha-V ITGAV VNRA Vitronectin receptor subunit alpha MSK8 Vitronectin receptor VTNR protein protein human Homo sapiens Human MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET a6y878_9pico Capsid protein VP0 Capsid protein VP1 Capsid protein VP3 Capsid protein VP4 Genome polyprotein Genome-linked protein VPg1 Genome-linked protein VPg2 Genome-linked protein VPg3 Leader protease P1A P1B P1C P1D P52 P56A Picornain 3C Protease 3C Protease P20B Protein 2A Protein 2C Protein 3A Protein 3B-1 Protein 3B-2 Protein 3B-3 RNA-directed RNA polymerase 3D-POL VP4-VP2 Virion protein 1 Virion protein 2 Virion protein 4 protein 2B Virion protein 3 protein protein Foot-and-mouth disease virus - type A Foot-and-mouth disease virus - type A MNTTDCFIALLQAFREIKTLILSRAQQKRTMEFTLHNGEKKTFFSRPNNHDNCWLNTILQLFRYVDEPFFDWVYDSPENLTLKAIQQLEEITGLELHEGGPPALVIWNIKHLLNTGIGTASRPSEVCMVDGTDMCLADFHAGIFLKGQEHAVFACVTSNGWYAIDDEDFYPWTPDPSDVLVFVPYDQEPLNGEWKAKVQKRLRGAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLGDNAISGGSNEGSLTYFPHTTNTQNNDWFSKLASSAFSGLFGALLADKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYSTGEDHVSGPNTSGLETRVVQAERFFKKYLFDWTTDKAFGHLEKLELPTEHKGVYGHLVDSFAYMRNGWDVEVTAVGNQFNGGCLLVAMVPEWKEFTPREKYQLTLFPHQFINPRTNMTGPHHGPVPWCQVGMTKYKQHKPWTLVVMVVSPLTTSSIGASQIKVYANIAPTFVHVAGELPSKEGIVPVACSDGYGGLVTTDPKTADPVYGMVYNPPRTNYPGRFTNLLDVAEACPTFLCFDDGKPYVVTRTDDQRLLAKFDVSLAAKHMSNTYLSGIAQYYTQYSGTINLHFMFTGSTESKARYMVAYIPPGMDTPPDTPEKAAHCIHAEWDTGLNSKFTFSIPYVSAADYAYTASDVAETTNVQGWVCIYQITHGKAEQDTLVVSVSAGKDFELRLPIDPRTQTTTAGESADPVTTTVENYGGETQARRRQHTDVGFIMDRFVKISPGSPTHVIDLMQTHQHALVGALLRAATYYFSDLEIVVRHDGNLTWVPNGAPVEALANTSNPTAYHKQPFTRLALPYTAPHRVLATVYNGVSKYSTTGGGRRGDLGPLAARVATQLPSSFNFGAIRATTIHELLVRMKRAELYCPRPLLTVEVLSQDRHKQKIIAPAKQLLNFDLLKLAGDVESNPGPFFFSDVRTNFSKLVDTINQMQEDMSTKHGPDFNRLVTAFEELATGVKAIRTGLDEAKPWYKLIKLLSRLSCMAAVAARSKDPVLVAIMLADTGLEILDSTFVVKKISDSLSSLFHVPAPVFSFGAPILLAGLVKVASNFFRSTPEDLERAEKQLRARDINDIFAILKNGEWLVKLILAIRDWIKAWIASEEKFVTMTDLVPGILEKQRDLNDPSKYEEAKEWLDNARQACLKSGNVHIANLCKVVAPAPSKSRPEPVVVCLRGKSGQGKSFLANVLAQAISTHFTGRTDSVWYCPPDPDHFDGYNQQTVVVMDDLGQNPDGKDFKYFAQMVSTTGFIPPMASLEDKGKPFNSKVIIATTNLYSGFTPRTMVCPDALNRRFHFDIDVSAKDGYKINNKLDIIKALEDTHTNPVAMFQYDCALLNGMAVEMKRMQQDVFKPQPPLQNVYQLVQEVIERVELHEKVSSHPIFKQISIPSQKSVLYFLIEKAQHEAAIEFFEGMVHDSIKEELRPLIQQTSFVKRAFKRLKENFEIVALCLTLLANIVIMIRETRKRQQMVDDAVNEYIEKANITTDDKTLDEAEKNPQETNSASTVGFRERTLPGHTVSNDVESEPTVPVEGQPQAEGPYAGPLERQKPLKVRAKLPQQEGPYAGPMERQKPLKVKAKAPVVKEGPYEGLVKKPVALKVKAKNLIVTESGAPPTDLQKMVMGNTKPVELILDGKTVAICCATGVFGTAYLVPRHLFAEKYDKIMLDGRAMTDSDYRVFEFEIKVKGQDMLSDAALMVLHRGNRVRDITKHFRDTARMKKGTPVVGVINNADVGRLIFSGEALTYKDIVVCMDGDTMPGLFAYRAATKAGYCGGAVLAKDGAETFIVGTHSAGGRVELDTVHVFPGPVLLKMKAHIDPEPHHEGLVIDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGVVLDEVIFSKHKGDTKMSEEDKALFRRCAADYASRLHSVLGTANAPLSIYEAIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVESALKLMEKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFCAQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYKNVWDVDYSAFDANHCSDAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGCSATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDFEALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYKPVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLFEIPSYRSLYLRWVNAVCGDA q98w00_9pico Capsid protein VP0 1D Capsid protein VP1 Capsid protein VP3 Genome polyprotein P1C P1D Virion protein 1 Virion protein 3 protein protein foot-and-mouth disease virus - type o Foot-and-mouth disease virus - type O TTSAGESADPVTATVENYGGETQVQRRQHTDVSFILDRFVKVTPKDQINVLDLMQTPAHTLVGALLRTATYYFADLEVAVKHEGNLTWVPNGAPETALDNTTNPTAYHKAPLTRLALPYTAPHRVLATVYNGNCKYGESPVTNVRGDLQVLAQKAARTLPTSFNYGAIKATRVTELLYRMKRAETYCPRPLLAIHPSEARHKQKIVAPVKQLL q6zz87_9pico Capsid protein VP0 polyprotein Capsid protein VP3 Capsid protein VP4 Genome polyprotein Genome-linked protein VPg1 Genome-linked protein VPg2 Genome-linked protein VPg3 Leader protease P1A P1B P1C P1D P52 P56A Picornain 3C Protease 3C Protease P20B Protein 2A Protein 2C Protein 3A Protein 3B-1 Protein 3B-2 Protein 3B-3 RNA-directed RNA polymerase 3D-POL Capsid protein VP1 VP4-VP2 Virion protein 1 Virion protein 2 Virion protein 3 protein 2B Virion protein 4 protein protein foot-and-mouth disease virus - type o Foot-and-mouth disease virus - type O MSTTDCFIALLYAFREIKTLFLSRAQGKMEFTLHNGEKKTFYSRPNKHDNCWLNTILQLFRYVDEPFFDWVYYSPENLTLDAIKQLEEITGLELHEGGPPALVVWNIKHLLNTGIGTASRPSEVCMVDGTDMCLADFHAGIFLKGQEHAVFACVTSNGWYAIDDEDFYPWTPDPSDVLVFVPYDQEPLNGEWKAKVQKRLRGAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLGDNAISGGSNEGSTDTTSTHTTNTQNNDWFSKLASSAFSGLFGALLADKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYATAEDFVSGPNTSGLETRVVQAERFFKTHLFDWVTSDPFGRCYLLELPTDHKGVYGSLTDSYAYMRNGWDVEVTAVGNQFNGGCLLVAMVPELCSIDKRELYQLTLFPHQFINPRTNMTAHITVPFVGVNRYDQYKVHKPWTLVVMVVAPLTVNTEGAPQIKVYANIAPTNVHVAGEFPSKEGIFPVACSDGYGGLVTTDPKTADPAYGKVFNPPRNMLPGRFTNFLDVAEACPTFLHFEGGVPYVTTKTDSDRVLAQFDLSLAAKHMSNTFLAGLAQYYTQYSGTINLHFMFTGPTDAKARYMIAYAPPGMEPPKTPEAAAHCIHAEWDTGLNSKFTFSIPYLSAADYAYTASDAAETTNVQGWVCLFQITHGKADGDALVVLASAGKDFELRLPVDARTQTTSAGESADPVTATVENYGGETQVQRRQHTDVSFILDRFVKVTPKDQINVLDLMQTPAHTLVGALLRTATYYFADLEVAVKHEGNLTWVPNGAPETALDNTTNPTAYHKAPLTRLALPYTAPHRVLATVYNGNCKYGESPVTNVRGDLQVLAQKAARTLPTSFNYGAIKATRVTELLYRMKRAETYCPRPLLAIHPSEARHKQKIVAPVKQLLNFDLLKLAGDVESNPGPFFFSDVRSNFSKLVETINQMQEDMSTKHGPDFNRLVSAFEELATGVKAIRTGLDEAKPWYKLIKLLSRLSCMAAVAARSKDPVLVAIMLADTGLEILDSTFVVKKISDSLSSLFHVPAPVFSFGAPILLAGLVKVASSFFRSTPEDLERAEKQLKARDINDIFAILKNGEWLVKLILAIRDWIKAWIASEEKFVTMTDLVPGILEKQRDLNDPSKYKEAKEWLDNARQACLKSGNIHIANLCKVVAPAPSRSRPEPVVVCLRGKSGQGKSFLANVLAQAISTHFTGRTDSVWYCPPDPDHFDGYNQQTVVVMDDLGQNPDGKDFKYFAQMVSTTGFIPPMASLEDKGKPFNSKVIIATTNLYSGFTPRTMVCPDALNRRFHFDIDVSAKDGYKINNKLDIIKALEDTHTNPVAMFQYDCALLNGMAVEMKRMQQDMFKPQPPLQNVYQLVQEVIDRVELHEKVSSHPIFKQISTPSQKAVLYFLIEKGQHEAAIEFFEGMVHDSIKEELRPLIQQTSFVKRAFKRLKENFEIVALCLTLLANIVIMIRETRKRQQMVDDAVNEYIEKANITTDDKTLDEAEKNPLETSGATTVGFREKTLPGHKAGDDVNSEPAKPVEEQPQAEGPYTGPLERQKPLKVRAKLPQQEGPYAGPMERQKPLKVKVKAPVVKEGPYEGPVKKPVALKVKAKNLIVTESGAPPTDLQKMVMGNTKPVELILDGKTVAICCATGVFGTAYLVPRHLFAEKYDKIMLDGRAMTDSDYRVFEFEIKVKGQDMLSDAALMVLHRGNRVRDITKHFRDVARMKKGTPVVGVINNADVGRLIFSGEALTYKDIVVCMDGDTMPGLFAYKAATKAGYCGGAVLAKDGAETFIVGTHSAGGNGVGYCSCVSRSMLLKMKAHIDPEPHHEGLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGVVLDEVIFSKHKGNTKMSEEDKALFRRCAADYASRLHSVLGTANTPLSTYEAIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLMEKREYKFTCQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFCAQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCSDAMNIMFEEVFNTDFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGCSATSIINTILNNIYVLYALRRHYEGVELDSYTMISYGDDIVVASDYDLDFEALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYKPVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLFEIPSYRSLYLRWVNAVCGDA q6pmw3_9pico Capsid protein VP0 Capsid protein VP1 Capsid protein VP3 Capsid protein VP4 Genome polyprotein Genome-linked protein VPg1 Genome-linked protein VPg2 Genome-linked protein VPg3 Leader protease P1A P1B P1C P1D P52 P56A Picornain 3C Protease 3C Protease P20B Protein 2A Protein 2C Protein 3A Protein 3B-1 Protein 3B-2 Protein 3B-3 RNA-directed RNA polymerase 3D-POL VP4-VP2 Virion protein 1 Virion protein 2 Virion protein 3 Virion protein 4 protein 2B protein protein foot-and-mouth disease virus - type o Foot-and-mouth disease virus - type O MNTTDCFTALLHALREIKTLFLLRTQGKMEFTLYNGEKKTFYSRPNNHDNCWLNTILQLFRYVDEPFFDWVYDSPENLTLEAIKQLEETTGLELHEGGPPALVIWNIKHLLHTGIGTASRPSEVCMVDGTDMCLADFHAGIFLKGQEHAVFACVTSNGWYAIDDEDFYPWTPDPSDVLVFVPYDQEPLNGEWKTKVQKRLKGAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLGDNATSGGSNEGSTDTTSTHTTNTQNNDWFSKLASSAFSGLFGALLADKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYATAEDFVSGPNTSGLETRVAQAERFFKTHLFDWVTSDPFGRCHLLELPTDHKGVYGSLTDSYAYMRNGWDVEVTAVGNQFNGGCLLVAMVPELCSIQKRELYQLTLFPHQFINPRTNMTAHITVPFVGVNRYDQYKVHKPWTLVVMVVAPLTVNSEGAPQIKVYANIAPTNVHVAGEFPSKEGIFPVACSDGYGGLVTTDPKTADPAYGKVFNPPRNMLPGRFTNFLDVAEACPTFLHFEGDVPYVTTKTDSDRVLAQFDLSLAAKHMSNTFLAGLAQYYTQYSGTINLHFMFTGPTDAKARYMIAYAPPGMEPPKTPEAAAHCIHAEWDTGLNSKFTFSIPYLSAADYAYTASDTAETTNVQGWVCLFQITHGKADGDALVVLASAGKDFELRLPVDARTQTTSAGESADPVTATVENYGGETQVQRRQHTDVSFILDRFVKVTPKDQINVLDLMQTPAHTLVGALLRTATYYFADLEVAVKHEGNLTWVPNGAPEAALDNTTNPTAYHKAPLTRLALPYTAPHRVLATVYNGNSKYGDGTVANVRGDLQVLAQKAARALPTSFNYGAIKATRVTELLYRMKRAETYCPRPLLAIHPDQARHKQKIVAPVKQLLNFDLLKLAGDVESNPGPFFFSDVRSNFSKLVETINQMQEDMSTKHGPDFNRLVSAFEELATGVKAIRAGLDEAKPWYKLIKLLSRLSCMAAVAARSKDPVLVAIMLADTGLEILDSTFVVKKISDSLSSLFHVPAPVFSFGAPILLAGLVKVASSFFRSTPEDLERAEKQLKARDINDIFAILKNGEWLVKLILAIRDWIKAWIASEEKFVTMTDLVPGILEKQRDLNDPSKYKEAKEWLDNARQACLKSGNVHIANLCKVVAPAPSKSRPEPVVVCLRGKSGQGKSFLANVLAQAISTHFTGRTDSVWYCPPDPDHFDGYNQQTVVVMDDLGQNPDGKDFKYFAQMVSTTGFIPPMASLEDKGKPFNSKVIIATTNLYSGFTPRTMVCPDALNRRFHFDIDVSAKDGYKVNNKLDIIKALEDTHTNPVAMFQYDCALLNGMAVEMKRMQQDMFKPQPPLQNVYQLVHEVIERVELHEKVSSHPIFKQISIPSQKSVLYFLIEKGQHEAAIEFFEGMVHDSIKEELRPLIQQTSFVKRAFKRLKENFETVALCLTLLANIVIMIRETRKRQQMVDDAVNDYIEKANITTDDKTLDEAEKNPLETSGASTIGFRERTLPGHKASDDVSTEPAKPVEDRPQAEGPYAGPLERQKPLRVKTKLPQQEGPYAGPMDRQKPLKVRARAPVVKEGPYEGPVKKPVALKVKAKNLIVTESGAPPTDLQKMVMGNTKPVELILDGKTVAICCATGVFGTAYLVPRHLFAEKYDKIMLDGRAMTDSDYRVFEFEIKVKGQDMLSDAALMVLHRGNRVRDITKHFRDTARMKKGTPVVGVINNADVGRLIFSGEALTYKDIVVCMDGDTMPGLFAYRAATKAGYCGGAVLAKDGADTFIVGTHSAGGNGVGYCSCVSRSMLLKMKAHIDPEPHHEGLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGVVLDEVIFSKHKGDTKMSEEDKALFRRCAADYASHLHSVLGTANAPLSIYEAIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLMEKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFCAQMHTNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCSDAMNIMFEEVFRTDFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGCSATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDFEALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYKPVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLFEIPSYRSLYLRWVNAVCGDA q7td07_9pico Capsid protein VP0 Protease P20B Protein 2A Protein 3A Protein 2C Protein 3B-1 Protein 3B-2 Protein 3B-3 RNA-directed RNA polymerase 3D-POL VP4-VP2 Virion protein 1 Virion protein 2 Virion protein 3 Virion protein 4 protein 2B Capsid protein VP1 Capsid protein VP3 Capsid protein VP4 Genome polyprotein Genome-linked protein VPg1 Genome-linked protein VPg2 Genome-linked protein VPg3 Leader protease P1A P1B P1C P1D P52 P56A Picornain 3C Protease 3C protein protein foot-and-mouth disease virus - type o Foot-and-mouth disease virus - type O MNTTDCLTALLYAFREIKTLFLSRAQGKMEFTLHNGEKKTFYSRPNNHDNCWLNAILQLFRYVDEPFFDWVYYSPENLTLDAIKQLEGITGLELHEGGPPALVIWNIKHLLNTGIGTASRPNEVCMVDGTDMCLADFHAGIFLKGQEHAVFACVTSNGWYAIDDEDFYPWTPDPSDVLVFVPYDQQPLNGEWKAKVQKRLRGAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLGDNAISGGSNEGSTDTTSTHTTNTQNNDWFSKLASSAFSGLFGALLADKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYATAEDFVSGPNTSGLETRVVQAERFFKTHLFDWVTSDPFGRCYLLELPTDHKGVYGSLTDSYAYMRNGWDVEVTAVGNQFNGGCLLVVMVPELCSIDKRGLYQLTLFPHQFINPQTNMTAHITVPFVGVNRYDQYKVHKPWTLVVMVVAPLTVNTEGAPQIKVYANIAPTNVHVAGELPSKEGIFPVACSDGYGGLVTTDPKTADPAYGKVFNPPRNMLPGRFTNFLDVAEACPTFLHFEGDVPYVTTKTDSDRVLAQFDLSLAAKHMSNTFLAGLAQYYTQYSGTINLHFMFTGPTDAKARYMIAYAPPGMEPPKTPEAAAHCIHAEWDTGLNSKFTFSIPYLSAADYAYTASDTAETTNVQGWVCLFQITHGKADGDALVVLASAGKDFELRLPVDARTQTTSTGESADPVTATVENYGGETQVQRRQHTDVSFILDRFVKVTPKDQINVLDLMQIPAHTLVGALLRTATYYFADLEVAVKHEGNLTWVPNGAPEAALDNTTNPTAYHKAPLTRLALPYTAPHRVLATVYNGNCKYGESPVTNLRGDLQVLTQKAARTLPTSFNYGAIKATRVTELLYRMKRAETYCPRPLLAIHPSEARHKQKIVAPVKQLLNFDLLKLAGDVEPNPGPFFFSDVRSNFSKLVETVNQMQEDMSTKHGPDFNRLVSAFEELATGVKAIRTGLDEAKPWYKLIKLLSRLSCMAAVAARSKDPLLVAIMLADTGLEILDSTFVVKKISDSLSSLFHVPAPVFSSGAPILLAGLVKVASSFFRSTPEDLERAEKQLKARDINDIFAILKNGEWPVKLILAIRDWIKAWIASEEKFVTMTDLVPGILEKQRDLNDPSKYKEAKEWLDNARQACLKSGNIHIANLCKVVAPAPSRSRPEPVVVCLRGKSGQGKSFLANVLAQAISTHFTGRTDSVWYCPPDPDHFDGYNQQTVVVMDDLGHNPDGKDFKYFAQMVSTTGFIPPMASLEDKGKPFNSKVIIATTNLYSGFTPRTMVCPDALNRRFHFDIDVSAKDGYKINNKLDIIKALEDTHPNPVAMFQYDCALLNGMAVEMKRMQQDMFKPQPPLQNVYQLVQEVIDRVELHEKVSSHPIFKQISIPSQKAVLYFLIEKGQHEAAIEFFEGMVCDSIKEELRPLIQQTSFVKRAFKRLKENFEIVALCLTLMANIVIMIRETRKRQQMVDDAVNEYTEKVNITTDDKTLDEAEKNPLETSGATTVGFREKTLPGHKTGDDVSSEPTKPVEGQPQAEGPYTGPLERQKPLKVRAKLPQQEGPYAGPMERQKPLKVKAKAPVVKEGPYEGPVKKPVALKVKAKNLIVTESGAPPTDLQKMVMGNTKPVELVLDGKTVAICCATGVFGTAYLVPRHLFAEKYDKIMLDGRAMTDSDYRVFEFEIKVKGQDMLSDAALMVLHRGNRVRDITKHFRDVARMKKGTPVVGVINNADVGRLIFSGEALTYKDIVVRMDGDTMPGLFAYKAATKAGYCGGSVLAKDGADTFIVGTHSAGGNGVGYCSCVSRSMLLKMKAHIDPEPHHEGLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKGPRLNEGVVLDEAIFSKHKGNTKMSEEDKALFRRCAADYASRLHSVLGTANAPLSIYEAIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLMEKREYKFVCQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFCAQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCSDAMNIMLEEVFNTDFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGCSATSIINTILNNIYVLYALRRHYEGVELDSYTMISYGDDIVVASDHDLDFEALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYKPVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLFEIPSYRSLYLRWVNPVCGDA 1d-a6y878_9pico-1 4078351 N/A 4078353 unspecified role unspecified role neutral component neutral component purified purified integrin beta 6 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false P18564:p.Ile287Cys mutation mutation certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. Stoichiometry: 1.0 N/A 4078354 unspecified role unspecified role neutral component neutral component purified purified integrin alpha V sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false P06756:p.Met430Cys mutation mutation certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. Stoichiometry: 1.0 N/A 4078355 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078356 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078357 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078357 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 direct interaction direct interaction false false false Figure 1A, Figure S1C, Table 1 The two PDB files given as cross-references differ in one position: the 5nem sequence contains a mutation compared to 5ner - Q98W00:p.Val129Ala. The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction. itgav-itgb6-8 4078351 N/A 4078353 unspecified role unspecified role neutral component neutral component purified purified integrin beta 6 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false P18564:p.Ile287Cys mutation mutation certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. Stoichiometry: 1.0 N/A 4078354 unspecified role unspecified role neutral component neutral component purified purified integrin alpha V sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false P06756:p.Met430Cys mutation mutation certain certain sequence position certain certain certain sequence position certain false human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. Stoichiometry: 1.0 N/A 4078358 unspecified role unspecified role neutral component neutral component purified purified VP1 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078358 unspecified role unspecified role neutral component neutral component purified purified VP3 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Q6PMW3:p.Ala672Thr mutation mutation certain certain sequence position certain certain certain sequence position certain false Q6PMW3:p.Thr678Val mutation mutation certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078358 unspecified role unspecified role neutral component neutral component purified purified VP2 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Q6PMW3:p.Ser379Tyr mutation mutation certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078358 unspecified role unspecified role neutral component neutral component purified purified VP4 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 direct interaction direct interaction false false false Figure 1B, Figure S1D, Table 1 The sequences of the viral proteins were taken from the cross-referenced PDB files. The four segments of the capsid protein quoted in PDB are actually cleaved from a viral polyprotein. The best match to the merged sequence is Q6PMW3, region 202-932 (identified using BLAST on UniProt). The mutations specified as features express the differences between this UniProt sequence and the sequences in the PDB (and are not stated in the publication). The two PDB files given as cross-references differ in one position: the 5net sequence contains a mutation compared to 5neu - Q6PMW3:p.His560Arg. 1d-polyprotein-2 4078351 N/A 4078359 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078359 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078357 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078356 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 direct interaction direct interaction false false false Fig. S1A, The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction. q6pmw3_9pico-q6pmw3_9pico-1 4078351 N/A 4078358 unspecified role unspecified role neutral component neutral component purified purified VP1 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078358 unspecified role unspecified role neutral component neutral component purified purified VP3 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Q6PMW3:p.Ala672Thr mutation mutation certain certain sequence position certain certain certain sequence position certain false Q6PMW3:p.Thr678Val mutation mutation certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078358 unspecified role unspecified role neutral component neutral component purified purified VP2 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Q6PMW3:p.Ser379Tyr mutation mutation certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078358 unspecified role unspecified role neutral component neutral component purified purified VP4 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 direct interaction direct interaction false false false Figure S1B The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction. 1d-polyprotein-1 4078352 N/A 4078359 unspecified role unspecified role neutral component neutral component purified purified VP4 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078359 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078357 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 N/A 4078356 unspecified role unspecified role neutral component neutral component purified purified Capsid protein VP0 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false mesau-bhk21 Mesocricetus auratus_BHK21 bhk-21 Cells from kidneys of five unsexed, one-day-old hamsters BHK-21/C13 cell Stoichiometry: 1.0 direct interaction direct interaction false false false Table 2 The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.