IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ castillo_lluva-2013-2 human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Castillo-Lluva S., Tan CT., Daugaard M., Sorensen PH., Malliri A. RAC1-GST construct gifted search by Dr Francisco Sánchez-Madrid was found to be of human origin by pmids 14988412 and 8910277 amalliri@picr.man.ac.uk 2021-06-04: Serena Petracchini, Department of Microbiology, Institut Pasteur, Paris Oncogene 2013 Only protein-protein interactions imex curation imex curation castillo_lluva-2013-1 canlf-mdck_ii madin darby canine kidney cell mdck_ii Canine Cocker Spaniel kidney epithelial cell line II MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) kidney kidney [Renal] tap tandem affinity purification TAP TAP tap ms participant Identification by mass spectrometry ms participant Castillo-Lluva S., Tan CT., Daugaard M., Sorensen PH., Malliri A. RAC1-GST construct gifted search by Dr Francisco Sánchez-Madrid was found to be of human origin by pmids 14988412 and 8910277 amalliri@picr.man.ac.uk 2021-06-04: Serena Petracchini, Department of Microbiology, Institut Pasteur, Paris Oncogene 2013 Only protein-protein interactions imex curation imex curation castillo_lluva-2013-3 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Castillo-Lluva S., Tan CT., Daugaard M., Sorensen PH., Malliri A. RAC1-GST construct gifted search by Dr Francisco Sánchez-Madrid was found to be of human origin by pmids 14988412 and 8910277 amalliri@picr.man.ac.uk 2021-06-04: Serena Petracchini, Department of Microbiology, Institut Pasteur, Paris Oncogene 2013 Only protein-protein interactions imex curation imex curation castillo_lluva-2013-4 canlf-mdck_ii madin darby canine kidney cell mdck_ii Canine Cocker Spaniel kidney epithelial cell line II MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) kidney kidney [Renal] confocal microscopy confocal microscopy tag fluorescence tag visualisation by fluorescence tag fluorescence Castillo-Lluva S., Tan CT., Daugaard M., Sorensen PH., Malliri A. Cells were transfected with fluorescent HaloTag-TMR Ligand to enable visualisation of RAC1 RAC1-GST construct gifted search by Dr Francisco Sánchez-Madrid was found to be of human origin by pmids 14988412 and 8910277 amalliri@picr.man.ac.uk 2021-06-04: Serena Petracchini, Department of Microbiology, Institut Pasteur, Paris Oncogene 2013 Only protein-protein interactions imex curation imex curation castillo_lluva-2013-5 human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Castillo-Lluva S., Tan CT., Daugaard M., Sorensen PH., Malliri A. RAC1-GST construct gifted search by Dr Francisco Sánchez-Madrid was found to be of human origin by pmids 14988412 and 8910277 amalliri@picr.man.ac.uk 2021-06-04: Serena Petracchini, Department of Microbiology, Institut Pasteur, Paris Oncogene 2013 Only protein-protein interactions imex curation imex curation castillo_lluva-2013-6 in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Castillo-Lluva S., Tan CT., Daugaard M., Sorensen PH., Malliri A. RAC1-GST construct gifted search by Dr Francisco Sánchez-Madrid was found to be of human origin by pmids 14988412 and 8910277 amalliri@picr.man.ac.uk 2021-06-04: Serena Petracchini, Department of Microbiology, Institut Pasteur, Paris Oncogene 2013 Only protein-protein interactions imex curation imex curation hace1_human E3 ubiquitin-protein ligase HACE1 KIAA1320 HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 HACE1 HECT-type E3 ubiquitin transferase HACE1 protein protein human Homo sapiens Human MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMKSLLRIVRMFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELMKNKRDSTEITSILLKQKGQDQDAASIPPFEPPGPGSYENLSTGTRESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA rac1_mouse Ras-related C3 botulinum toxin substrate 1 Rac1 p21-Rac1 protein protein mouse Mus musculus Mouse MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL rac1_human Ras-related C3 botulinum toxin substrate 1 RAC1 MIG5 p21-Rac1 Ras-like protein TC25 Cell migration-inducing gene 5 protein TC25 protein protein human Homo sapiens Human MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL actb_canlf Actin, cytoplasmic 1 ACTB Beta-actin protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF mint Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells f2z4p3_canlf 60S ribosomal protein L23 RPL23 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA e2r8c9_canlf MOGS protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MARGERRRRGAPVDGARTAERAARGGPARRGGEARGFAWRAALGVVVLSLALGLSGCWLLEWRRARRAVTLHSAPPSLPPDSSSPAVAPDLFWGTYRPHVYFGMKTRSPKPLLTGLMWAQQGATPGTPKLRHTCEQGDGVGPYGWEFHDGLSFGRQHIQDGALKLTTEFVKRPGGQHGGDWSWRVTVEPQASGTSALPLVSLFFYVVTDGKEVLVPEVGAKGQLKFISGHSSELGDFRFTLMAPTNPGDLAPKYSSYNVFWSSNPGLPLLTEMVKSRLNSWFQHRPPGASPERYLGLPGSLKWEDKGPSGQGQGQGQFLIQQVTLKTPFSVELVFESGSARAGRSQALEQLSGSLLTQALESHAEAFREHFEKTFQLKEKGLSLEEQALGQVALSGLLGGIGYFYGQGLVLADMGVEGSEQKVDPALFPPVPLFTAVPSRSFFPRGFLWDEGFHQLVVQRWDPRLTREVLGHWLGLLNADGWIGREQVLGDEARARVPPEFLVQKAAHANPPTLLLPVAHMLEVGDPADFAFLRRAFPRLCAWFSWLHKSQAGPVPLSYRWRGRDPVLPTLLNPKTLPSGLDDYPRASHPSVSERHLDLRCWMALGARVLLRLAEQLGEAEAAAELGPLAASLEAEENLDELHWAPELGVFADFGNHTKAVQLKPRPPQGLVRVVGRPHPRLQYVDALGYVSLFPLLLRLLDPNSPRLGPLLDVLADSRHLWSPFGLRSLAASSPFYGQRNSEHDPPYWRGAVWLNVNYLALGALYHYGHLEGPHQAQAAKLHRELRTNVVGNVWRQYQATGFLWEQYSDRDGRGMGCRPFQGWTSLVLLAMAEDY e2rqh0_canlf SH3BP4 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MAAQRIRAANSSGLPRCKSEGTLIDLSEGFSEASFNDVKVPSPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGVIDNLPDSPDEVAKELDLLGVGMDDKGPSKTYSNNPFWNGAQTNPFLNGNVTAMPSVDELMPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDELQATNRLQAEAPGKRDNPFFRSKRSYSLSELSVLQAKSDAPDSSGFFTGLKSPAPEQFQSREDFRAAWLSHRKLTRSCHDLDLLGQSPGWGQTQAVETSIACKLDSSGGAVQLPDTNISIHVPEGHVAPGETQQISMKALLDPPLELNSDRCSSVSPVLEVKLSTLEVKTYIILEMKVSAEVKNDIFSKSTVGLQCLRSDLKEGPYVPIPLTYSYGDTVQVQLDNLEPCMYLAIVAHGPNILYPSTVWDFINKKITVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPSPAPVALQLWGKHQFVLSRPQDLHVCMFSNMTNYEVKASEQAKVVRGFQMKLGKVSRLIFPIACQNPGELSDFTLRVQVKGDQEAILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFAATTKYPTFQDRPVSSLKFGKLLKTVVRQSKNHYLLEYKKGDAIALLSEEKIRLKGQLWTKEWYIGYHQGRVGLVHAKNVLVVGKARPSLLAGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRSFADALGYGNLPLTFFCRAELDSEPERVASVLEKLKEDCNNTENKDRKSFQKELMMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITKRWKHLTGTLILVNSLDILRAAAFSPVDHDDFVI j9p0d4_canlf Ig-like domain-containing protein protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MKFPSLLLGLLMLWIPGSTGEAVMTQTPLSLAVTPGELATISCRASQSLLRSDGKSYLNWYLQKPGQTPRPLIYEASKRFSGVSDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQSLHFPPTVFQLPTQTSWVSWPSCPHKLIFIHFPVSPF a0a5f4dks9_canlf KIF1C protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MTFGRKARGPGAGSLRGWLAGEGSGDASSWGKMGGGIWVAPGSLTTSSLSVLQLRRVRGSGTMAGASVKVAVRVRPFNARETSQDAKCVVSMQGSTTSIINPKQSKDAPKSFTFDYSYWSHTSAEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLFSRVNKNESAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADLQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLLAQGLSASALGGLKVDEGSPGGALPATSSPPAPVSPSHPPAHNGELEPSFSPSAEPQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGITRVGQVDVDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGRLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPEGPGDAWRAVARDVWDTVGEEEGGSSGGGGEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLTQDHEDDNEEAAEAAWAASSGSDVAAEEEAPSERAPPAPVRPQSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGAGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRESWPGAAAGEAPAAPPPPEEVAPPPAAPARRPPSPRRSHRPRRNSLDGGGRSRGGGAAQPEPQHFQPKKHNYYPQQPQPYPAQRPPGPRYPPYTTPPRMRRQRSAPDLKESGAAV f1pip0_canlf Enoyl-CoA hydratase HADHA protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MVASRAIGSLSRATASRMFRCPGYVCRNFTGSSALRSRTHINFGVKGDVAVVRLNSPNSKVNTLNKELQSEFMEVMNEIWASDQIRSAVLISTKPGCFIAGADINMLASCKTHEEVTRISQEGQRMFEKLEKSTKPIVAAISGACLGGGLELAISCQYRIATKDRKTVLGAPEVLLGILPGAGGTQRLPKMVGLPAAFDMMLTGRNIRADRAKRMGLVDQLVEPLGPGLKPPEERTIEYLEEVAVNFAKGLSDKKISIKRDKGLVEKLTSYALSIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTGIEQGNDAGYLSESQKFGELAMTKESKALMGLYHGQVLCKKNKFGAPQKEVKDLAILGAGLMGAGIAQVSVDKGLKTILKDATLTGLGRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPGHCVFASNTSALPINEIAAASKRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVLRILQEGVEPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVSEDLGKAFGERFEGGNIELLKEMVSRGFLGRKSGKGFYIYQEGVKTKNVNSDMDGILASLKVPPKYGVSSDEDIQYRLVTRFVNEAVLCLQEGILATPTEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLRKFEAAYGKQFTPCQLLIDHANSANKFYQ j9p798_canlf 40S ribosomal protein S15a RPS15A protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF a0a5f4cuj9_canlf ITPRID2 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris ASLDEQSSNTLKGVLVRNGGSFEDDLSLGAEANHLHETDTQIENCNNILAKERRLQFHQKGRSMNSTGSGKSSGTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFARGIDIKVFLSAQMQRMEVENPNYALTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTSNKETDSPPPLTRSNTANRLMKTLSKLNLCVDKTERGEGSSPSSAIEKGKIPNVSVMEESGSKNDQKSQKIVKKKDSSSMLATVKEEVSGSSATVMESAGLCDEANSDFNQKTESEQSKETQNHEMKLGEESGILESDLGNDFNTPSHSEPENGNVMKSIHVSTPEKEPCAPLTIPSIRNIMAQQKDSFEMEEVQSTEGEAPHVPAAYQLGLTKSKRDHLLRTASQHSDSSGFAEDSTDCLSLNHLQVPESLQAMGSSADSCDSETTVTSFGEELVTPTAQDQPYFNESEEESLSPLPKGRDKGREQAAPAAAKRSDSQDSPRREPAAQAGSTQSTCGAGDHTSEVTEAGQGLPPAQPADLPREASAESDVDKSSECEFAHYTTHHILKSLASIEAGHGEKGSESAPGPPSSADRVNTALQRAQMKVCSLSHQRVGRSLIKSKDLLKQRYFFAKAGYPLRRSQSLPTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEEQELGKEVAEPDGQSLVKSTIFISPSSARKEAACPSELTRLEECRPRRTPAPASQSTCSLHSVRSEWPERPLCEHTRTLSTHSVPSVSGAACSAFAAPFGCPHSHRPAAYPYRACPVNPPSAVEMQLRRVLHDIRNSLQNLSQYPMTRGSDLAAAPYSTQKSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELAMLRQQTMVYHHMTEEERYEVDQLQSLRNSVRMELQDLELQLEERLLALEEQFRVVRMPSPFRSSALMGMCGSRSADNLSCPSPLNVMEPVTELMREQSYLKSELGMGLGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSSDLVGKPKTHLVPSKKVFRASVALTPTAPSRTGSVQTPPDVESSEEVGAAEEASEFVGPKSEVEEGNGKVPLMTAAEEMHKNVEQDELQQVIREIKESIVGEIRREIVSGLLAAVSSSKASNSKQDSH e2qv02_canlf CDK17 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFYSEFLRGWAYHREKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHTLPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF a0a5f4cug8_canlf LMO7 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MSFRPSSPAHTRRTAGDSEYLSPYSATLRAREGEKCEASLRPEPPRRHPAGEAGAFHLPHLEAGRSGGPPGECVCVCVGGGAGMGGARSGRCPHLPPGGPGIPRGRPRTWRRRARRARAAGEGGGAGAARHCGPRSSPGKFLGPGKVQLCAAIPVLVLEGMEEPGADCAVAFAEAQRWVEAVTEKNFETKDFRASLENGVLLCDLVNKLKPGVIKKINRLSTPIAGLDNINVFLKACEQIGLKEAQLFHPGDLQDLSNRVTVRQEETDRRVKNVLITLYWLGRKAQSNPYYNGPYLNLKAFENLLGQALTKALEDTSCLKRSGRDSGYGDIWCAERGDFPTSPGNHKREDSFESLDSLGSRSFTSCSSDITLRGGREGCESDTDSEFTSRMQDYNKDDMSYRRISAIEPKTALPFNRFLPNKSRQPSYVPAPLRKKKPDKNEDNRRSWASPVYPEADGTFPSNERRTWGTNVENCPTVQETSSSSCYLEEEREKTRTPNTIKDDLYVRKLSPIMPNPGNAFDQFLPKCWIPEDVNWKRIKRETYKPWYKEFQGFSQFLLLQALQTYSDDILASETNIKIDPTAGPRLITRRKNLSSAPGCKRDDLEMPTLDPDLENDDFFVRKTGAFHANPYVLRAFEDLRRFSEPDDSVERDIILQCREGELVLPDLEKDDMIVRRIPAQKKEVPLSGAPERYQPVPLPEPWTLPPEIQAKFLCVLERTHPSKEKRKSCGVLVPSSRKKRDDMLTRKIQSWQLGTTVPPVSFTPGPCSEADLRRWEAIREASRLRHRKRLMVERLFQKIYGENGSKSMSDVSAEDIQNLRQLRYEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSERSSKTFKEMLQDRESRNQMSTVTSRRRLHSNDDVLNEEMLSPTLTMSEASYQSERVEEKETMYSTEIPKQDSTTFVKREDAVTTDIQLPSQSPMEEQLPDSLSSQHSPSTRMQSTRVSASLPRSYQKTDTARLTSVVTPRPFGSQTRGISSLPRSYTMDDAWRYNGDVEDDKRTQNSFVSTSVQKPDTSQLASSKSSETEIAAVGEGVMGLPSPTPSFSSLSQDQAATSKATLSSSSGPDLVSELGEGRSSPQTEVSRSQDQFSDMRISINQTPGSGLDFGFTVKWAFSGIFVASVEAGSPAEFSQLQVDDEIIAINNTKFSYKDTKEWEATMANAKETGNLVMDIRRYGKSGSPETKWIDTTSGIYNSDKSSSLSITTDFSESLQHSNTESKEINGIRDESNTFESKASEPISLKNLKRRSQFFEQGSSDSVVPDLPVPTLSTPSRWAWDQEEERRRQERWQREQDRLLQEKYQREQEKLREEWQRAQQEAERENYKYLNEERMVLSSHSLSRPTREPAVATWETAWGEGSKSSDREGTRAGEEERRPQQKEDEEEDQRKRLQEQLALERERKLKEQQDQEEQERRRRQEEAQEQKPQAERERETTVKIYQYRRPIDSYDIPKREEQSSGLLPSDRNKSRSTTELDGYPANKNGGNKYSDQIGSTSSSQRSSKKEQAPSEAELERQQILQEMRKRTSLLNDNSWIRQRSSSVNKEPICLPGIMRRGESLDNLDSPRSSSWKPSPWFNQPSGVRASSSVQDFSRPPPQLVSTSNRAYMRNPSSSIPPPSSAGSVQTTTAPSPTPHSPSPSLSQSGSQLRNSVWPASVTSEAPPQEPKSESETINCTATTAISDSNLDGQLPCDVNLHTKALLQIEEEVVSADVDL e2qz61_canlf ATAD3A protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MSWLFGIKGPKGEGAGPPLSLPPAQPGAEGGGDRGGGDRPAPKDKWSNFDPTGLERAAKAARELEHSRHAKEALSLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRVQAEERRKTLSEETRQHQARAQYQDKLARQRYDDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTILESIRTAGTLFGEGFRTFVTDWDKVTATVAGLTLLALGVYSAKNATSVAGRYIEARLGKPSLVRETSRITVLEALRHPVQVSRRLLSKPQDALEGVVLSPSLEARVRDIAIATRNTMKNRSLYRNILAYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGRDGVTAMHKVFDWASTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLHRTGQHSSKFMLVLASNQPEQFDWAVNDRIDEMVRFDLPGREERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGKKCSEIAQLTEGMSGREISQLAVAWQAMAYASEDGVLTEAMMDARVQDAMQQHQQKMQWLKAEGTRPEGAQFLIPSTQAE e2qtq8_canlf SQOR protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MTPLATAVSGPRARLFACFLRLGTQQASPLQLHTGASLAAKNHYEVLVLGGGSGGITMAARMKRRVGADNVAVVEPSERHFYQPIWTLVGAGAKQLSSSGRPTASVIPSGVEWIKARVVELNPDKNCIHTDTGKEISYKYLIIALGIQLDYEKIKGLPEGFDHPKIGSNYSVKTVEKTWKALQDFKEGNAIFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGTIFGVKKYAAALQEIIRERNLTVNYKQNLIEVRADRQEAVFENLDKPGETQVISYEMLHVTPPMSSPDVLKASPVADAVGWVDVDKETLQHKKYPNVFGIGDCTNLPTSKTAAAVAAQSGILDRTISLIMKNKKPTKKYDGYTSCPLVTGYNRVILAEFDYNAQPLETFPFDQSRERLTMYLMKADLMPFLYWNMMLRGYWGGPAFLRKLFHLGMS myh9_canlf Myosin-9 Myosin heavy chain 9 Myosin heavy chain, non-muscle IIa Non-muscle myosin heavy chain IIa MYH9 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKEXYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRIAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLNDQIAELQAQIAELKMQLAKKEEELQAALARVEEEATQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEARTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLQQGKGDSEHKRKKAEAQLQELQVKFTEGERVRTELADKVTKLQVELDNVMGLLTQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQMEDEKNSFKEQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCLETAEEAKRKLQKDLEGLGQRYEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRRTASNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDEKKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCVRELDDTRASREEILAQAKENEKKMKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELVNDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRAEKKLKDVLLQVDDERRNAEQFKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRVARKGAGDCSDEEVDGKADGAEAKAAE f1py11_canlf PKP3 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris TLQAGFSSRSQGLGGDPSTFWPIAKPTYSPASWSSRSAVDLSCSRRLSSAHNGGSTLGGAGYGGPQPAAPARPVSFHERAGPGGRADYDTLSLRSLRLGAAGLDDRYSVVSEQLEPPAASAYRALAYERQAACGRMQGPDWPDASEGPPGRPIRAPAMRTLQRFQSSHRSRGTAGVAPGAALEPVARAPSVRSLSLSLADSGHLPDVRGLDSYGGHRSLQRLSSGFDDIDLPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECHGLVDALVTYINHALDVGKCEDKSVENAVCVLRNLSYRLYDEMPPSALQRLEGRGRRDVVGAPPGEVVGCFTPQSRRLRELPLTADALTFAEVSKDPKGLEWLWSPQIVGLYNRLLQRCELNPHTTEAAAGALQNITAGDRRWAGVLSRLALEQERILNPLLDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGEKCPPADVLVNIIAVLNNLVVASPIAARDLLYFDGLRKLVFIKKKRDSPDSEKSSRAASSLLANLWQYSKLHRDFRAKGYRKEDFLGP a0a5f4d968_canlf LMNA protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MGRRGGASGGRRVSHPMGTSLSPPPPFLDLPAWRFLSSSCPLPTHPHPLARPSSTQEGPSPRGQASGLDREPGAGGIQEGEAPGPAGARRQPAGPRAPTPSGLCPLRDLCPAGSPATLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLMAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVTKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLADKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGTGSITKKRKLESSESRSSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSSEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASSSGAQVGGSISSGSSASSVTVTRSYRSVGGSGGGSFGDSLVTRSYLLGSSSPRTQSPQNCSIM z4yhi2_canlf ACTG1 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWEDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKTNGEKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF cav1_human Caveolin-1 CAV1 CAV protein protein human Homo sapiens Human MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI hace1-rac1-2 4063285 N/A 4063291 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 4063292 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus tap tagged calmodulin binding peptide plus protein a tag CBP-ProtA tagged CBP-ProtA tagged tap tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false 1a rac1-hace1-3 4063285 N/A 4063293 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 4063291 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain range range false ankyrin repeat containing domain required to bind necessary binding region required to bind range range range range false physical association physical association false false false 1e, S1a, S1c MET receptor tyrosine kinase rac1-hace1-4 4063285 N/A 4063293 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 4063291 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false S1b rac1-actb-1 4063286 N/A 4063294 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063295 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063296 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063297 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063298 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063299 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063300 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063301 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063302 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063298 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063303 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063304 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063305 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063306 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063307 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063308 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063309 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063310 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 4063292 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus tap tagged calmodulin binding peptide plus protein a tag CBP-ProtA tagged CBP-ProtA tagged tap tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false association association false false false Supplementary Table I hepatocyte growth factor rac1-hace1-1 4063287 N/A 4063293 unspecified role unspecified role bait bait purified purified tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 4063291 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. physical association physical association false false false 1b HACE1 more efficiently binds to GTP-bound RAC1 hace1-rac1-3 4063288 N/A 4063293 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed living cell living cell halo tag tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 4063291 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed living cell living cell tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false colocalization colocalization false false false 2g hepatocyte growth factor hace1-rac1-4 4063289 N/A 4063293 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 4063311 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association false false false S3j rac1-hace1-2 4063290 N/A 4063293 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A 4063291 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection direct interaction direct interaction false false false 1c