IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ zhuang-2020-1 human-ht_29 Homo sapiens HT-29 caucasian women with colon adenocarcinoma ht_29 HT-29 confirmed as human with IEF of AST, LDH established from the primary tumor of a 44-year-old Caucasian woman with colon adenocarcinoma in 1964; described to be heterotransplantable forming well-differentiated grade I tumors mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Zhuang ST., Cai YJ., Liu HP., Qin Y., Wen JF. szcaiyanjuan@163.com Molecular genetics & genomic medicine 2020 Only protein-protein interactions imex curation imex curation zhuang-2020-4 human-sw480 Human SW480 adenocarcinoma cell line sw480 SW480- human primary colorectal adenocarcinoma cell line There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution and a C -> T mutation in codon 309 resulting in a Pro -> Ser substitution. http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CCL-228&Template=cellBiology mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Zhuang ST., Cai YJ., Liu HP., Qin Y., Wen JF. szcaiyanjuan@163.com Molecular genetics & genomic medicine 2020 Only protein-protein interactions imex curation imex curation zhuang-2020-2 human-ht_29 Homo sapiens HT-29 caucasian women with colon adenocarcinoma ht_29 HT-29 confirmed as human with IEF of AST, LDH established from the primary tumor of a 44-year-old Caucasian woman with colon adenocarcinoma in 1964; described to be heterotransplantable forming well-differentiated grade I tumors rna-ip rna immunoprecipitation rna-ip qrt-pcr quantitative reverse transcription pcr QRT-PCR Zhuang ST., Cai YJ., Liu HP., Qin Y., Wen JF. szcaiyanjuan@163.com Molecular genetics & genomic medicine 2020 Only protein-protein interactions imex curation imex curation zhuang-2020-3 human-ht_29 Homo sapiens HT-29 caucasian women with colon adenocarcinoma ht_29 HT-29 confirmed as human with IEF of AST, LDH established from the primary tumor of a 44-year-old Caucasian woman with colon adenocarcinoma in 1964; described to be heterotransplantable forming well-differentiated grade I tumors pull down pull down qrt-pcr quantitative reverse transcription pcr QRT-PCR Zhuang ST., Cai YJ., Liu HP., Qin Y., Wen JF. szcaiyanjuan@163.com Molecular genetics & genomic medicine 2020 Only protein-protein interactions imex curation imex curation zhuang-2020-5 human-sw480 Human SW480 adenocarcinoma cell line sw480 SW480- human primary colorectal adenocarcinoma cell line There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution and a C -> T mutation in codon 309 resulting in a Pro -> Ser substitution. http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CCL-228&Template=cellBiology rna-ip rna immunoprecipitation rna-ip qrt-pcr quantitative reverse transcription pcr QRT-PCR Zhuang ST., Cai YJ., Liu HP., Qin Y., Wen JF. szcaiyanjuan@163.com Molecular genetics & genomic medicine 2020 Only protein-protein interactions imex curation imex curation hsa-mir-185-5p mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human UGGAGAGAAAGGCAGUUCCUGA mrna_igf2 long Homo sapiens insulin like growth factor 2 (IGF2), transcript variant 1 mrna messenger rna mRNA mrna human Homo sapiens Human GCCTGCTCTCCGGCGGAGCTGCGTGAGGCCCGGCCGGCCCCGGCCCCCCCCTTCCGGCCGCCCCCGCCTCCTGGCCCACGCCTGCCCGCGCTCTGCCCACCAGCGCCTCCATCGGGCAAGGCGGCCCCGCGTCGACGCCGCCCGCTGCCTCGCTGCTGACTCCCGTCCCGGGCGCCGTCCGCGGGGTCGCGCTCCGCCGGGCCTGCGGATTCCCCGCCGCCTCCTCTTCATCTACCTCAACTCCCCCCATCCCCGCTTCGCCCGAGGAGGCGGTTCCCCCCGCAGGCAGTCCGGCTCGCAGGCCGCCGGCGTTGTCACCCCCCCCCGCGCTCCCCCTCCAGCCCTCCCCCCGGCGCGCAGCCTCGGGCCGCTCCCCTTTCCGCGCTGCGTCCCGGAGCGGCCCCGGTGCCGCCACCGCCTGTCCCCCTCCCGAGGCCCGGGCTCGCGACGGCAGAGGGCTCCGTCGGCCCAAACCGAGCTGGGCGCCCGCGGTCCGGGTGCAGCCTCCACTCCGCCCCCCAGTCACCGCCTCCCCCGGCCCCTCGACGTGGCGCCCTTCCCTCCGCTTCTCTGTGCTCCCCGCGCCCCTCTTGGCGTCTGGCCCCGGCCCCCGCTCTTTCTCCCGCAACCTTCCCTTCGCTCCCTCCCGTCCCCCCCAGCTCCTAGCCTCCGACTCCCTCCCCCCCTCACGCCCGCCCTCTCGCCTTCGCCGAACCAAAGTGGATTAATTACACGCTTTCTGTTTCTCTCCGTGCTGTTCTCTCCCGCTGTGCGCCTGCCCGCCTCTCGCTGTCCTCTCTCCCCCTCGCCCTCTCTTCGGCCCCCCCCTTTCACGTTCACTCTGTCTCTCCCACTATCTCTGCCCCCCTCTATCCTTGATACAACAGCTGACCTCATTTCCCGATACCTTTTCCCCCCCGAAAAGTACAACATCTGGCCCGCCCCAGCCCGAAGACAGCCCGTCCTCCCTGGACAATCAGACGAATTCTCCCCCCCCCCCCAAAAAAAAGCCATCCCCCCGCTCTGCCCCGTCGCACATTCGGCCCCCGCGACTCGGCCAGAGCGGCGCTGGCAGAGGAGTGTCCGGCAGGAGGGCCAACGCCCGCTGTTCGGTTTGCGACACGCAGCAGGGAGGTGGGCGGCAGCGTCGCCGGCTTCCAGACACCAATGGGAATCCCAATGGGGAAGTCGATGCTGGTGCTTCTCACCTTCTTGGCCTTCGCCTCGTGCTGCATTGCTGCTTACCGCCCCAGTGAGACCCTGTGCGGCGGGGAGCTGGTGGACACCCTCCAGTTCGTCTGTGGGGACCGCGGCTTCTACTTCAGCAGGCCCGCAAGCCGTGTGAGCCGTCGCAGCCGTGGCATCGTTGAGGAGTGCTGTTTCCGCAGCTGTGACCTGGCCCTCCTGGAGACGTACTGTGCTACCCCCGCCAAGTCCGAGAGGGACGTGTCGACCCCTCCGACCGTGCTTCCGGACAACTTCCCCAGATACCCCGTGGGCAAGTTCTTCCAATATGACACCTGGAAGCAGTCCACCCAGCGCCTGCGCAGGGGCCTGCCTGCCCTCCTGCGTGCCCGCCGGGGTCACGTGCTCGCCAAGGAGCTCGAGGCGTTCAGGGAGGCCAAACGTCACCGTCCCCTGATTGCTCTACCCACCCAAGACCCCGCCCACGGGGGCGCCCCCCCAGAGATGGCCAGCAATCGGAAGTGAGCAAAACTGCCGCAAGTCTGCAGCCCGGCGCCACCATCCTGCAGCCTCCTCCTGACCACGGACGTTTCCATCAGGTTCCATCCCGAAAATCTCTCGGTTCCACGTCCCCCTGGGGCTTCTCCTGACCCAGTCCCCGTGCCCCGCCTCCCCGAAACAGGCTACTCTCCTCGGCCCCCTCCATCGGGCTGAGGAAGCACAGCAGCATCTTCAAACATGTACAAAATCGATTGGCTTTAAACACCCTTCACATACCCTCCCCCCAAATTATCCCCAATTATCCCCACACATAAAAAATCAAAACATTAAACTAACCCCCTTCCCCCCCCCCCACAACAACCCTCTTAAAACTAATTGGCTTTTTAGAAACACCCCACAAAAGCTCAGAAATTGGCTTTAAAAAAAACAACCACCAAAAAAAATCAATTGGCTAAAAAAAAAAAGTATTAAAAACGAATTGGCTGAGAAACAATTGGCAAAATAAAGGAATTTGGCACTCCCCACCCCCCTCTTTCTCTTCTCCCTTGGACTTTGAGTCAAATTGGCCTGGACTTGAGTCCCTGAACCAGCAAAGAGAAAAGAAGGACCCCAGAAATCACAGGTGGGCACGTCGCTGCTACCGCCATCTCCCTTCTCACGGGAATTTTCAGGGTAAACTGGCCATCCGAAAATAGCAACAACCCAGACTGGCTCCTCACTCCCTTTTCCATCACTAAAAATCACAGAGCAGTCAGAGGGACCCAGTAAGACCAAAGGAGGGGAGGACAGAGCATGAAAACCAAAATCCATGCAAATGAAATGTAATTGGCACGACCCTCACCCCCAAATCTTACATCTCAATTCCCATCCTAAAAAGCACTCATACTTTATGCATCCCCGCAGCTACACACACACAACACACAGCACACGCATGAACACAGCACACACACGAGCACAGCACACACACAAACGCACAGCACACACAGCACACAGATGAGCACACAGCACACACACAAACGCACAGCACACACACGCACACACATGCACACACAGCACACAAACGCACGGCACACACACGCACACACATGCACACACAGCACACACACAAACGCACAGCACACACAAACGCACAGCACACACGCACACACAGCACACACACGAGCACACAGCACACAAACGCACAGCACACGCACACACATGCACACACAGCACACACACTAGCACACAGCACACACACAAAGACACAGCACACACATGCACACACAGCACACACACGCGAACACAGCACACACGAACACAGCACACACAGCACACACACAAACACAGCACACACATGCACACAGCACACGCACACACAGCACACACATGAACACAGCACACAGCACACACATGCACACACAGCACACACGCATGCACAGCACACATGAACACAGCACACACACAAACACACAGCACACACATGCACACACAGCACACACACTCATGCGCAGCACATACATGAACACAGCTCACAGCACACAAACACGCAGCACACACGTTGCACACGCAAGCACCCACCTGCACACACACATGCGCACACACACGCACACCCCCACAAAATTGGATGAAAACAATAAGCATATCTAAGCAACTACGATATCTGTATGGATCAGGCCAAAGTCCCGCTAAGATTCTCCAATGTTTTCATGGTCTGAGCCCCGCTCCTGTTCCCATCTCCACTGCCCCTCGGCCCTGTCTGTGCCCTGCCTCTCAGAGGAGGGGGCTCAGATGGTGCGGCCTGAGTGTGCGGCCGGCGGCATTTGGGATACACCCGTAGGGTGGGCGGGGTGTGTCCCAGGCCTAATTCCATCTTTCCACCATGACAGAGATGCCCTTGTGAGGCTGGCCTCCTTGGCGCCTGTCCCCACGGCCCCCGCAGCGTGAGCCACGATGCTCCCCATACCCCACCCATTCCCGATACACCTTACTTACTGTGTGTTGGCCCAGCCAGAGTGAGGAAGGAGTTTGGCCACATTGGAGATGGCGGTAGCTGAGCAGACATGCCCCCACGAGTAGCCTGACTCCCTGGTGTGCTCCTGGAAGGAAGATCTTGGGGACCCCCCCACCGGAGCACACCTAGGGATCATCTTTGCCCGTCTCCTGGGGACCCCCCAAGAAATGTGGAGTCCTCGGGGGCCGTGCACTGATGCGGGGAGTGTGGGAAGTCTGGCGGTTGGAGGGGTGGGTGGGGGGCAGTGGGGGCTGGGCGGGGGGAGTTCTGGGGTAGGAAGTGGTCCCGGGAGATTTTGGATGGAAAAGTCAGGAGGATTGACAGCAGACTTGCAGAATTACATAGAGAAATTAGGAACCCCCAAATTTCATGTCAATTGATCTATTCCCCCTCTTTGTTTCTTGGGGCATTTTTCCTTTTTTTTTTTTTTTTGTTTTTTTTTTACCCCTCCTTAGCTTTATGCGCTCAGAAACCAAATTAAACCCCCCCCCCATGTAACAGGGGGGCAGTGACAAAAGCAAGAACGCACGAAGCCAGCCTGGAGACCACCACGTCCTGCCCCCCGCCATTTATCGCCCTGATTGGATTTTGTTTTTCATCTGTCCCTGTTGCTTGGGTTGAGTTGAGGGTGGAGCCTCCTGGGGGGCACTGGCCACTGAGCCCCCTTGGAGAAGTCAGAGGGGAGTGGAGAAGGCCACTGTCCGGCCTGGCTTCTGGGGACAGTGGCTGGTCCCCAGAAGTCCTGAGGGCGGAGGGGGGGGTTGGGCAGGGTCTCCTCAGGTGTCAGGAGGGTGCTCGGAGGCCACAGGAGGGGGCTCCTGGCTGGCCTGAGGCTGGCCGGAGGGGAAGGGGCTAGCAGGTGTGTAAACAGAGGGTTCCATCAGGCTGGGGCAGGGTGGCCGCCTTCCGCACACTTGAGGAACCCTCCCCTCTCCCTCGGTGACATCTTGCCCGCCCCTCAGCACCCTGCCTTGTCTCCAGGAGGTCCGAAGCTCTGTGGGACCTCTTGGGGGCAAGGTGGGGTGAGGCCGGGGAGTAGGGAGGTCAGGCGGGTCTGAGCCCACAGAGCAGGAGAGCTGCCAGGTCTGCCCATCGACCAGGTTGCTTGGGCCCCGGAGCCCACGGGTCTGGTGATGCCATAGCAGCCACCACCGCGGCGCCTAGGGCTGCGGCAGGGACTCGGCCTCTGGGAGGTTTACCTCGCCCCCACTTGTGCCCCCAGCTCAGCCCCCCTGCACGCAGCCCGACTAGCAGTCTAGAGGCCTGAGGCTTCTGGGTCCTGGTGACGGGGCTGGCATGACCCCGGGGGTCGTCCATGCCAGTCCGCCTCAGTCGCAGAGGGTCCCTCGGCAAGCGCCCTGTGAGTGGGCCATTCGGAACATTGGACAGAAGCCCAAAGAGCCAAATTGTCACAATTGTGGAACCCACATTGGCCTGAGATCCAAAACGCTTCGAGGCACCCCAAATTACCTGCCCATTCGTCAGGACACCCACCCACCCAGTGTTATATTCTGCCTCGCCGGAGTGGGTGTTCCCGGGGGCACTTGCCGACCAGCCCCTTGCGTCCCCAGGTTTGCAGCTCTCCCCTGGGCCACTAACCATCCTGGCCCGGGCTGCCTGTCTGACCTCCGTGCCTAGTCGTGGCTCTCCATCTTGTCTCCTCCCCGTGTCCCCAATGTCTTCAGTGGGGGGCCCCCTCTTGGGTCCCCTCCTCTGCCATCACCTGAAGACCCCCACGCCAAACACTGAATGTCACCTGTGCCTGCCGCCTCGGTCCACCTTGCGGCCCGTGTTTGACTCAACTCAACTCCTTTAACGCTAATATTTCCGGCAAAATCCCATGCTTGGGTTTTGTCTTTAACCTTGTAACGCTTGCAATCCCAATAAAGCATTAAAAGTCATGA lncrn_neat1 human long Homo sapiens nuclear paraspeckle assembly transcript 1 (NEAT1) long isoform lncrna long non-coding ribonucleic acid lncRNA long non coding RNA long non coding ribonucleic acid long non-coding RNA lncrna human Homo sapiens Human GGAGTTAGCGACAGGGAGGGATGCGCGCCTGGGTGTAGTTGTGGGGGAGGAAGTGGCTAGCTCAGGGCTTCAGGGGACAGACAGGGAGAGATGACTGAGTTAGATGAGACGAGGGGGCGGGCTGGGGGTGCGAGAAGGAAGCTTGGCAAGGAGACTAGGTCTAGGGGGACCACAGTGGGGCAGGCTGCATGGAAAATATCCGCAGGGTCCCCCAGGCAGAACAGCCACGCTCCAGGCCAGGCTGTCCCTACTGCCTGGTGGAGGGGGAACTTGACCTCTGGGAGGGCGCCGCTCTTGCATAGCTGAGCGAGCCCGGGTGCGCTGGTCTGTGTGGAAGGAGGAAGGCAGGGAGAGGTAGAAGGGGTGGAGGAGTCAGGAGGAATAGGCCGCAGCAGCCCTGGAAATGATCAGGAAGGCAGGCAGTGGGTGCAGGGCTGCAGGAGGGCCGGGAGGGCTAATCTTCAACTTGTCCATGCCAGCAGCCCCTTTTTTTCCAGACCAAGGGCTGTGAACCCGCCTGGGGATGAGGCCTGGTCTTGTGGAACTGAACTTAGCTCGACGGGGCTGACCGCTCTGGCCCAGGGTGGTATGTAATTTTCGCTCGGCCTGGGACGGGGCCCAGGCCGGGCCCAGCCTGGTGGAGCGTCCAGGTCTGGGTGCGAAGCCAGGCCCCTGGGCGGAGGTGAGGGGTGGTCTGAGGAGTGATGTGGAGTTAAGGCGCCATCCTCACCGGTGACTGGTGCGGCACCTAGCATGTTTGACAGGCGGGGACTGCGAGGCACGCTGCTCGGGTGTTGGGGACAACATTGACCAACGCTTTATTTTCCAGGTGGCAGTGCTCCTTTTGGACTTTTCTCTAGGTTTGGCGCTAAACTCTTCTTGTGAGCTCACTCCACCCCTTCTTCCTCCCTTTAACTTATCCATTCACTTAAAACATTACCTGGTCATCTGGTAAGCCCGGGACAGTAAGCCGAGTGGCTGTTGGAGTCGGTATTGTTGGTAATGGTGGAGGAAGAGAGGCCTTCCCGCTGAGGCTGGGGTGGGGCGGATCGGTGTTGCTTGCCTGCAGAGAGGGTGGGGAGTGAATGTGCACCCTTGGGTGGGCCTGCAGCCATCCAGCTGAAAGTTACAAAAATGCTTCATGGACCGTGGTTTGTTACTATAGTGTTCCTCATGGCGAGCAGATGGAACCGGGAGACATGGAGTCCCTGGCCAGTGTGAGTCCTAGCATTGCAGGAGGGGAGACCCTGGAGGAGAGAGCCCGCCTCAATTGATGCCTGCAGATTGAATTTCCAGAGGCTTAGGAGGAGGAAGTTCTCCAATGTTCTGTTTCCAGGCCTTGCTCAGGAAGCCCTGTATTCAGGAGGCTACCATTTAAAGTTTGCAGATGAGCTTATGGGGGGCAATCTTAAAAAGTCCACAGCAGATGCATCCGGCTCGAGGGGCCATCAGCTTTGAATAAATGCTTGTTCCAGAGCCCATGAATGCCAGCAGGCACCCCTCCTTTCCTGGGGTAAAGGTTTTCAGATGCTGCATCTTCTAAATTGAGCCTCCGGTCATACTAGTTTTGTGCTTGGAACCTTGCTTCAAGAAGATCCCTAAGCTGTAGAACATTTTAACGTTGATGCCACAACGCAGATTGATGCCTTGTAGATGGAGCTTGCAGATGGAGCCCCGTGACCTCTCACCTACCCACCTGTTTGCCTGCCTTCTTGTGCGTTTCTCGGAGAAGTTCTTAGCCTGATGAAATAACTTGGGGCGTTGAAGAGCTGTTTAATTTTAAATGCCTTAGACTGGGGATATATTAGAGGAAGCAGATTGTCAAATTAAGGGTGTCATTGTGTTGTGCTAAACGCTGGGAGGGTACAAGTTGGTCATTCCTAAATCTGTGTGTGAGAAATGGCAGGTCTAGTTTGGGCATTGTGATTGCATTGCAGATTACTAGGAGAAGGGAATGGTGGGTACACCGGTAGTGCTCTTTTGTTCTTGCTTCGTTTTTTTAAACTTGAACTTTACTTCGTTAGATTTCATAATACTTTCTTGGCATTCTAGTAAGAGGACCCTGAGGTGGGAGTTGTGGGGGACGGGGAGAAGGGGACAGCTTGGCACCGGTCCCGTGGGCGTTGCAGTGTGGGGGATGGGGGTATGCAGCTTGGCACTGGTACTGGGAGGGATGAGGGTGAAGAAGGGGAGAGGGTTGGTTAGAGATACAGTGTGGGTGGTGGGGGTGGTAGGAAATGCAGGTTGAAGGGAATTCTCTGGGGCTTTGGGGAATTTAGTGCGTGGGTGAGCCAAGAAAATACTAATTAATAATAGTAAGTTGTTAGTGTTGGTTAAGTTGTTGCTTGGAAGTGAGAAGTTGCTTAGAAACTTTCCAAAGTGCTTAGAACTTTAAGTGCAAACAGACAAACTAACAAACAAAAATTGTTTTGCTTTGCTACAAGGTGGGGAAGACTGAAGAAGTGTTAACTGAAAACAGGTGACACAGAGTCACCAGTTTTCCGAGAACCAAAGGGAGGGGTGTGTGATGCCATCTCACAGGCAGGGGAAATGTCTTTACCAGCTTCCTCCTGGTGGCCAAGACAGCCTGTTTCAGAGGGTTGTTTTGTTTGGGGTGTGGGTGTTATCAAGTGAATTAGTCACTTGAAAGATGGGCGTCAGACTTGCATACGCAGCAGATCAGCATCCTTCGCTGCCCCTTAGCAACTTAGGTGGTTGATTTGAAACTGTGAAGGTGTGATTTTTTCAGGAGCTGGAAGTCTTAGAAAAGCCTTGTAAATGCCTATATTGTGGGCTTTTAACGTATTTAAGGGACCACTTAAGACGAGATTAGATGGGCTCTTCTGGATTTGTTCCTCATTTGTCACAGGTGTCTTGTGATTGAAAATCATGAGCGAAGTGAAATTGCATTGAATTTCAAGGGAATTTAGTATGTAAATCGTGCCTTAGAAACACATCTGTTGTCTTTTCTGTGTTTGGTCGATATTAATAATGGCAAAATTTTTGCCTATCTAGTATCTTCAAATTGTAGTCTTTGTAACAACCAAATAACCTTTTGTGGTCACTGTAAAATTAATATTTGGTAGACAGAATCCATGTACCTTTGCTAAGGTTAGAATGAATAATTTATTGTATTTTTAATTTGAATGTTTGTGCTTTTTAAATGAGCCAAGACTAGAGGGGAAACTATCACCTAAAATCAGTTTGGAAAACAAGACCTAAAAAGGGAAGGGGATGGGGATTGTGGGGAGAGAGTGGGCGAGGTGCCTTTACTACATGTGTGATCTGAAAACCCTGCTTGGTTCTGAGCTGCGTCTATTGAATTGGTAAAGTAATACCAATGGCTTTTTATCATTTCCTTCTTCCCTTTAAGTTTCACTTGAAATTTTAAAAATCATGGTTATTTTTATCGTTGGGATCTTTCTGTCTTCTGGGTTCCATTTTTTAAATGTTTAAAAATATGTTGACATGGTAGTTCAGTTCTTAACCAATGACTTGGGGATGATGCAAACAATTACTGTCGTTGGGATTTAGAGTGTATTAGTCACGCATGTATGGGGAAGTAGTCTCGGGTATGCTGTTGTGAAATTGAAACTGTAAAAGTAGATGGTTGAAAGTACTGGTATGTTGCTCTGTATGGTAAGAACTAATTCTGTTACGTCATGTACATAATTACTAATCACTTTTCTTCCCCTTTACAGCACAAATAAAGTTTGAGTTCTAAACTCATTAGAATTGTTGTATTGCTATGTTACATTTCTCGACCCCTATCACATTGCCTTCATAACGACTTTGGATGTATCTTCATATTGTAGATTTAGGTCTAGATTTGCTAGCTCCAAGTAATTAAGGCCATGTAGGAGAGCATGGTAACCACAGATAGAACTGGTATTATCCCAAGTGGTCTGCAGACTGCTGAGTGGGGATGGGATCTGCTCTCTGTTGAGAGTTGGTAATCATTGGTTTGAAATGTGATGAAACCACTCAAGCCAATGAAGGTGGGTGTGTAGGTGGGGAGTACTTTGCCATAATATTTTAAAACATTACCTGGTTAGAGTTCTAAGTGGTACTTATTTTTGTTTGGTTAGGGGAAAGCCTGAATAAAAACAGAAATGGACACATAATATGCATATTCCATAGTCTTTGGGAGGCTGGAATGTGCCTGGGATTTGGGTCTAAGTGTATGCGTAATTCTTACCTCACTAAAGAATTTGCCTTGTTTTTTTCCTTTTGGTGAGTGACTAAAACGTCTGGGCTTCCCTGTGTGCGTGCTACAGTAAGCAAGCAGAGGCTGTGCAAAGGTGTGAGCAGGATCACGTGGAATCTGGAGGATACATCTTGGCTTGCAAACTGCCTCTGTCTCCTGGGTGGGACTGTTCTGTCCTTGCACTGCTGTTCTGTGTTACCTCTTGGGGTGTAAGGTTTTGCTTACAGGAGACAAACTTTGGGCGTAGAATGGAAGCCACTGCCAGCCTCTGTGCTGAGAAGGAAGGTGCTTGTTTCAAAGGGAGCAGCAAGGGAGGCTTGTTCTACTCACCTGGGCCTGTTTGCCTGAGAAGGGGAGATAAGGGCTGAACTGGGACTAGCCAGGGGGACCAACACAAATGGTGGGGGATCATGACCTGAAGGATTCTTTCCTTCCCATGAGCTGCAGGGCTGGTTGCCGTCCTTGCAACTGTGTCTTATTTGCCTGTGCCGTTATATCTTGGTGACCCCTCCACGTGTACACTACTGACAAACGGGTGGAGTGCTGGGGAGAAGTCACTGTGCCGCCCACCTAGTAAACCTTCTGTCTGTGCTCATGGCATCTCCAAGATGGGGCACTGCTGTGTGCAGAATCCAGGGTCCTCTTTCTGCTTGCAACTCCTTTCCCTGGATGCCCCAGAAACAATCCAGGCCTCCTTTCCTATCTTACCCCTTTGCTTTGCTTTTTACCCCAGCACCTCTATAACCGCCTTCTCTTCTTTTCAGAACTCCTTGTTTCTCGTCCTGTTTTTTATGATTACAAAACTCTTGCTTCCACCCTGGAAGATAACTGCTATAGATGCCTGTATGTAAATGGTGCTGTCTCCAGCAACTGGCATGCTGAAGAAGAATTGATTCACGGGGTATAAATGTTGGGGATTGGAAGTGGGGATGAAATGGCACTTGTTGATACAGGAGCAGAGAGGTGAGGCCGACTGCTGAAGACAGCTCGCCACCCTCCTTGCCTCCACTCCAATCCAGGGGCTGGGGCCACATTCTTTGCCTTCATTTATCCTCAGATCAGGTGAGATCGACAGGAGGTGTTGATGGCAGTGCCAGCAATTATTGCTAATCCGTTTGCATCCTTATGCATAGATCTGAATTCAGACTTTGTGAATTTCCAGAGGTGTGGGTAATATAATAGAATTCAGTGAGTGGGCATGGCTGATCTTGTGCAAATTAAAAGTTATGGGGCATAAGAATAGCAAAAGTTGAACTTCTTTTAAAAAGGAAAGTACCCTGAGAGCCAGTATTGGTTGAGGCTCTTCAGTATGCCCAGGTTGGCAGCACTGAGAACCGCAGGAACGGCCTGTTGTTACAAAAAGGAGATTGACTCAGCTGCCCTTGGTGCATCTGACTGACTATGACTGCTGAGAGATTCCAAGGACCCTTAATGCCAGGGCTAACCTCTCCATGTGCAGTGAGACCTCTGGAGGAAGTGTCATCCTCTGGCTTTGTGTGGTACTCATTATGGTGCAGTGCGGGCATGAAATGAAGACACCCAAATAGGCTTACAGATACGATATGTTTTAAATGTTCGTATTTAACAAAAACATACTGACACTGTTTGGAAATGGCAACAGGAAGATAGCAAAATGAATACTAACATTACGAAAAGATGAACAGGTACATGTTCCAAGGCAGGTGGCTGTGAACTTCCTCTGAGTGAAGGCATCCCCTCCAGCACCTTTCAGCCTGCTAGTTAGGACGACCCGCCGCCACCCTCCAGGACCTCCAGCCCTGCACTGCCTTTCCTCTCTTTTAAATAATTCTTCATTGAGTTCTAATATGTAAAAAAAAAAAGTTTACTGTAAAGTTTGCAAATAAGGAAATTTTTTTTAAAAGTCCTCAGTAATCTTACCAGTAACAATTGTTATGGGCACATTTGCTTTTGGAAGATTTCTTTTGTATGCATGGGATAAGTACATTTTTAAACAAAAATGGGATTATGCCATAAATTCTATTTTGTGACTTTAATATATAGTGAACACCTTTTTTAATGATGACAGGATGTTCCCTTGCATGGCTGTATCAATTTAAACAATCTTGTTTCAATGGGCATACAGGGTATTTTCTAGTTTTTTTTTCCTCTTAGAAAATAATACTTGCGATGACTTTCCTTGTAGCTCAGACTTTTTCACGTCTGTTGTTATCTCTTTGGGAATGCTGAATACATACATTTCGAGAAGGAAATGACTGTTAAACTCTTAAGACTTCAGGTTCATATTGCTAAACTGCCCAGCAGGGAGGGATTTTTTCAATTAGTGTTCTCACTGGTGAGGCAAACCTGATGCCTTCCCCTCTTCCTCAGAACCGGCTTTATCACATTGAAAACCTTTGCTCCTCCGACGGATCGAGTCTGCTTTCCCTCTGGATGTGAGCATTGCTTTGTCTGCTGGTGACTGAACATCTCTACCTTGTGTCAATTGGCCATTTGTGGTGTGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGTGTATGATTTTCTAATTCCTAGTCATTTTTCTATTGATTGTTTTGCAAAAGCCATTTACATCTTAAGGATATTGATAATCTTTTGTTATATTTGATGCAAATATTTTTTTCCAGTTTATAGGTTGCCTTTTAATTTTGTGTTTCAGGTAGATAAAAGTTAAACGATTTTCTTAGGTTAGTTTATCACTGTGGTTTCTGAACTTGTTATGTGTAGATCTTTTCCACCCCAAGAGTACATAAATATTAATCCATACTTTCTTATGGAACTTGTATGGTTTCGTTTTTTACATTTAAACCTTCTTCCCCGTGGTGTGTGTTGTGGAATCTGTGTTTGTGTGAGGAGGGGCATGGTGCTCTCAGAACCCACCTCCTGTGGCCAGAGAGCCCTGTCCTGTGAGGGTGGTTGTCACAGTGGCAGGGTTCAATTCAGAAGACCTTGAGGGCAGGCTGATGTTTCCTGAATGGGCCCCTGGTTGTTGCTTGTCCCTGACTCTCCATTTCCCCATCTGAGTGGATTTGGACCTAATAGGGCACTGGAGCTGGTTCGAATCCTGACTGGACTACTTGGCAACTTTATGTCTGGGAGCAAGTTACTTAACCTCCCCAAGCCTGTGTCTGTGAAATGCGGGTAAATGAATGTAGATGTTTGGCAGCAGCTACTCCTTGTTGAGCTCTCACAGTGAACTCTCCTGCCTCTGCCCTCCTTCCCCGCCTCCCCTGGTGCCTAGCGTCAGGTCTAGCCACTTCCTCCTGGGCCCCTCTCCCTTTTCTGTGGCTGGCTGCCTGCCCGCCTGGCGCTGGACCTTTCATGTAACGGGAATCAGCATGTATATTCTGGTCTGGTCTGTTTCTACACTTAATTTTGTTTCCAGTAGTATTTCCCTGTACCGGCAGAGTTCACAAACACATTTGAAGAGGCTTTTTCTCAGGATTCTTAACCTTCCCAAAGGAAGTCCCATGGATGGGTTTCTAGAAGTCTATAAATGCTCTGAAATTGTATTTTTCTGTGGAAAGCATAACTTTCATCTGCTTGTTCGTGCTCAAAAAAGATCATGAATGAATGATTGCATGATTTTATGCCATTGTGCTTATACTAAAGGATATGTAGCCCATCTCTTGAGCTGTTAAACTGTTTTGACTACTTTAAATCGTGCAGCTGTGAGCATCTCTGTAAATTTAGTGTACACATGTATCCCCTGGAGTGGCATTGCCTCGGCAGTGAGCACTTATGGTTTTATAACTCTCTTCACAGACTCAAATGACTCCAGAAAGCTACACTTCCTGTTGTGAGTATATGATATCCATTTCCCTACATAGCCACTAACATCAGGTTTTTACAATTTTATTTATTTCTTGCTACTTTAAGAAATTTTTGTGGTGAAATACATATAATAGAAGTTGACTATCTGAATCATTTTTAAGTATACATTCAGTAGTGTTAAGTATGTCGCCATTGTTGTACAACCAATCTCCAGAACTTTTTCATCTTGCAAAACAAACTCTGTACCCATTAAATAACATTAAACATTCCATTCCCTCCAGCCTCAGCAACCCCATTCTACTTTCTGTTTCTGTGAGTTTGACTATTCCAAGCACTTCATATCAGTTAAATCATGAAGTATTTGTCTGTCTGTGACTGGCTTATTTCTCTGAGCACAGTGTCCTCGAGATGCGTCTATGTTGTAGCATATGTCAGAATTTCCTTCCTTTTTAAAAGATCCAAATAATATTCTTATTTTATATCTTTTTTTTATCCATTCATCCATTAGTGGACACTTGGGTTGCTTTTGGCTATTGTAAATAATGGTGCTATGTACAAATATCTATATTATTGTATTTACAAGTATAATGCTGTAATGTACACACATCTTTTTGAGATCCTACCTTCAGTTCTTTTGAGTATATAGCCAGAAGTGGTATTACTAAATCTTACGATATTTCTATTTTTAATTTATTGAGGAACCACTGTAGTTTTTCATAGCAACTGCACCATTTTACGTTCTCACCAAGAGTGCACAAGGGTTCCGAGGTTCCCACATCCTCCCCAACACTTGTTATTTTCTGCTTTTTTTAGATTGCAGCCATCATAGTGGGTGTGAGGTGACATTTCATTGTGGTTTTGATTTGCATTTCCCTAATGAGGAGTGATGCTGAGCATCTTTTCATATGCTTACTGGTCATTTGTATGTTGTCTTTGGAAAAATGTCTATTCAAGTCCTTTGACTATTTTAAAAATTGGGTTATTAGAGTTATCGTTGTTGTTGACTTGTAGGAGTTTCTTTCTATATTCTGGATATTAATCCCCTATCAGATATATGATTTGCAAATATCTTCTCTTATTCCATAAGGTTACTTTTTCACTTTGTTGATTGTGTTCTTTGATGTATAGAAGTTTTTAGTTTTGAAATAGTCTAATTTATCTGTTTTTACTTTTGTGGTCTGTGCTTTTGGTGTCATATCCAAGAAATCCTTGCCAAATCCAACGTTATAAGGTACTTTTAAGGTATTTTAGTTGTCTTAGTCTATATTTCTGTACTCACCTTTCTTTATCCACTCATCAGTTGATGGGCATGTAGGTTGGTTCCATATCTTTGCAATTCTGAATTGTGCTATGATCAGGTGTCTTTTTAGTATAATGATTTACTCTCCTTTGGGTAGATACCCAGTAGTGGGATTGCTGGATCGAATGGTTTTTATAATTTTCTATTTTACCACAGTTTCTCTCTGCATTTTTCCTCTTTGACCACTAACCATGTGAAATTCTCATATTGACCTTTATAATGATCATGAACTCTTAGTATCATTGGGAAGGCCACATTTGCCACTTATGATTGTAAACCTTATCCTCCATTTTTCCTGTTATTGTTGGTGCAAAAAGCACCTATTATACCAGGACTTTAAAAATCAGTCTGATAAGTCTTTGATAAGTCTAATAATAATAACTGATAAGTCCATTGAATTTGCTTCTGATTACTTTTTCTTTAGTAGCTAAACATGTATGTACTCCTATGATTACAATGAACACTCCTCTCCATTTAAATTAATTATTTACATTGATGAAATAGCAAAATGTTAATGACTAAATACTGTCTTGGTTTTTTCGTTCCAGGTCAGTCAATATTAACTTCTTATAATTTTCTTTTTTTTCTTTATGTGTGTGTGTGTGTGTATTTTTTTTTTTTTAATTTCAATGGCTTTTGGGGTACAAATGGCTTTTGGTCATATAGATGAATTCTACAGTAGTGAAGTCTGAGATTTTACTGCACCGGTCACCTGAGTAGTGTACATTGTACCCAATATGTGGTTTTTTATACCTTGCCCCCCTCTTACCCTCCCCACTTTGAGTCTCTAGTGTCCATTATGTCACTCTGTATACCTTTTTGTACCCATAAGTTAGCTCTCACTTATAAGTGAGAACACACAGTATTTGGTTTTCCATTCCTGAGTTGCTTCACTTAGAATAATATCCTCCAGCTCCATCCAAAATTGCTGCAAAAAAAAAAAAAACCACAAACATTATTTTGTTCTTTTTTATTGCTAAGTCATATTCCATGGTGTAGAGATACCACATTTTATTTATCCACTCACTGGTTGATGGGTTGGTTCCACATCTTTGCAATTGTGACTTGTACTGCCATCAAGTGTCTTTCTGGTATAATGACTTCTTTTCCTTTGGGTAGATACCCAGGAGTGGGATTGCTAGATCAAATGGTTCTTAACATTTTCTCTCTGGATCTATTTCTGGAAATTTTAGGCTCCAGTTTTTGTTGTTGTTGTTAATAAAATGCAATGGAATGTAATGATCATCACTTTTCATTATGCTTTAAAATCTGGTAAATGGAGGCTAGAACACTCCTGTAAGGCAAGAATATTCTCTCTGTTGGAACTCAAATACACAGAACTGGGTAAATCTCAATCTTAATCTTTGATTCAGGACACAACATGGCTCTCTTTTACTTGCTTTCTTTAATTGTTTTTTAATAATGTGGTAAGCATTTCTGAATCTCCTATCCAATACAAAAACTAGGACAATACAGACAGTAACTCCTATGGTTACAATGAACACTCCTCTCCACTTAAATTAATTATTTACACTGATGAAATTGAAATAGCAAAATTTTAATGACTAAATACTGTCTTTGATTTTTTGTTCCAGGTCTGTCAATATTAACTTCTTATAATTTTCTTTTTTTTTCTTTATGTGTGTGTGTGTGTGTGTATATATATATATTTAATTTCAATGGCTTTTGGGGTACAAATGGCTTTTGGTCATATATATGAGTTCTACAGTAGTGAAGTCTGAGATTTTACTACACCTTCCACTTATGTGGTCCCACACCACCCGCCTCCCCTGCCGCCTCCTGCCACCCCCTAGGCCAAGGTAATAATCATCCTGAATCCTGGGTTTATCTCTCACTTGCTTTCTTTTCATATAATTTTGCAAAAGAATCTGATCTAAATGTGTTTTTCAGAGTATATATTTATATTTTAGCTGTTCTTAGAGAAAATTTATTATTTTGCATGTAATCTTATGGAACATTCTCATTTAATACCATGGTAAGATTCAGCCCTTGCCCAGGGGATAGTTCATTTAGTTTGTTTACTGGATAGAGCTCATCATGTGACTATACCTCAGTTAGTTTATCAGTTCTCCCATCCATGGTGACTAGGTTGCCTCTCAGCCTCTCAACAACACTGTTTCTCAGTGTCCTTGTAGAAGTGATATGTGGGTGTTTTCTCCTTACACAGAGTTGAAAGGTGACGACAACAACGTTGGCACTACCAATCCCCCACCCTCCAGAGGGGTAACCAGTGTTACCAGTTTGCTGTGTTTCCTGCTACACCTCGCCTTATTCACTTCCATTTGTATCTGAAAAACGTGTTGCATGGTTTCTTTTCTATAGAAGTGGTAAAATGCTATTGTGTCCTGTACATTATTGATTACTTTTTTTCATTTAACAGTAGGGAGATGCCTGGGAGTACACAGAGAACTGCCCTCATTGTTTTCAACTTCTGCACTGTATGTCTGTGAGTTTAGCCATTCTGCTGTTAATGGAAATTTACAGTATTCTAATCTTTTGATATTACAAACAGTTCTGTGCGATCATCGTCATACACAACCCCTTGTGCACAATGCATGAGTGTTTCTCAGGGTAGGTACCAAGAAGTGAAATTCCTGGGTCATAGGGCGTGAGTCCGACATTTTTCTCCATTCTGCCCTGTTGCCCTCCAGAGTGGGTGTCCAGCTTTGCATACCTAAGTATGAGAGTATCTGTTGTTCATATCCTCTACGACGCTCCATATATGAAACTTAAGTTTCTGCTAGTTGCCATCTTTGATCTATCATGTATGCAGTGACCTACTAAGACTGTAATTGGTACAGTAGATTCTTGTCATCTGTGTGTGAATTTAGCATTCATGGGCTTAATGCTGACAAGGCCCCCAGGGTCCAAGACATATAATCATGTATAATTTTGTCAAGGTATAATTTTTTAAATTGCTTTTGTCATGTGTCTGCTGGTGATGCCCAACCCAGTGCTCTGCACCCAGGTCACACTGTGGCTTTGTCCTCTGCTTATGCCTGCATTGCAGCAACTGTCCTGAAGAGACCAAAATTATGCAGATTTAGGTAAGTCCATGGCTAATGTTATTATATTATGTGCTATTGTAATGGATGGGGCTGTGGAGTGTATGAATTTATAAATCACTGGTCTTGTAATTAAAATTCAAACACTATAGAAAAAGGCCATGTAGAAGATAAAAGTTCCTCTATAATCCCGGACCCCTAAGATAACTACTAATGACAACTTCATTTATATTCCTTCAGACATTTTCTGGCTGTGGATGTACTAAAATGTATCCTATTATTCTCTGCCCTAAAATGGAATCATACAAGGTGTACTGTTATTTTTATGGCTCTATAACATGTCATATTGTACGTGTTGGTATGGTCATTTTAACCATTTTTCTAGTGATGGCTTTGAGGTTATTTGCAGTTTCCTAGCCATCTCAAAGTGTGCTGCGGGGATCTCTTTTGCATCCCTCTGGGTGCAGAGCTGAGGCACCCAGAGGCAGTGTCCAGAGGAGGCAGCATCTGTAGGTGTCTTCACCTGCTCTGGCTCTTGGCACATCTGGTTGGTGACACTGTTTTGTGAGATGGGTTGAAAGCACGTGCTGCCAAAATAGAATAATGTTGGTCCTCTCCTCATGTGCCGTGGAACTGGGGTAAAACTGCGTAGTGGCTGCAGCTGCCTGTCCATACCGGAATCGAGTATAACACGGTGCCTGGCTTAGCACAAAACAGTAGTGGGTCCTGCAGGCCCCAGAGTCTAATTCCTGGTATTCTTTCCCCTACACAGATTAAATAAACCAAAAACAAACTATTCTAGGAAAGCGTCTGTGACATTTGTAAAAAGTGGTATTTAATGATCTTTTATTCACTTGTCTGTTTAGTTTGTTGAAATCTTAAGTGGCATCCTGGTCTGGGAAGGAGTGCTGTCTGCGCCTGCCCTCCGCTGGGCACAGCGTGGCTGCTTCAGGGGCTAAGCACACACTTTCTGTCTTCTAAAGGGCCGCCACATGCCAGGAGCTCAGGTGTGAGCCCGGCTCTGGCTCTTACCTCATAGGGTCACTCATAGGGGCACAGGGAGCAGAACATTGTACACAGCGAGGCACCACCCGGCTTGGCATCTGCCTCGGTGGACTTACTACCTCTAGAAGGAAATACCTGAGTTCCTCTGGCCTCAGCTCCTAGAGTGACTGGTGTGCTGTCCCTGTTACTCTTCTGTCAAGGTGACAACTGTGTGACCCATCATCTGTGTGTCAAAGCAAGGCCCTGCCTGGGCCTCTGCTCCTGTGCTGACCCCAAAGGCAAATGCTTTGCTAGTTTCCTTCCAGTTAATTTCACCTATGAATAGATGTGTGAAAACTGTTCAAAGCCATACCTGCACATGTTTGAACTTCAAACCCTGTGGGTGATTCAGTGGCATCTTTCTCTAACCCCCAGCCTCCCTTCCCACAGAGGCCACCGTCATGGCCAGTTGCTGCAGTTTCTTTCCAGAGAACCTGTGTATGTGTAAAGCTGTACAGGCGTGGGTACACCACACAGCCTGTCTTGCACTGTGGACTGTTGAGTTACTAGTACATCTAGGTAAGCACCGCATATCTGTATTCATGTCTGCCTTGGTCTTTTCAACATCTGTGTGGTAGCCGTGTTTGAATTACCCATTCCCTTTTTGGGGAACCATTAAGTTGTTTCAGCAATTTTTACTGTAGATAAGGCTATACCGCATATCTGTGTACATGGGTTTTTATGTACATGGGCAAGTATATCTGTGAGAGAAAAGTTTCCTCAGGAGGAATTCTGGGCACAGCATGTGTAAATTTCTAAATATGATGGACACCCCCAGCTTCCACCTCAAGGAGGTTGGTCCCATTGACATTTCCCCACACCTTCACCCAGGCTGTGCCCTTAAACTTGGTTATTTGTCAATGTGAGAAGTGGAAAATAGTATTTAATTGTAGTTTGGATTTGTATTTCTATTGGGTTGTATACTTACTGATTAATAATAAGAGCTCTTTACATATTAAGGAAATTAACCCTTTTCAAATACATTCCTATTTCTCACTAATCTTTAAGTTTTATTGTAATATTTTGCTCTTTAGTTTATATATATATGTATATATATATATATGTATATATATATATATACATATATATATACATATATATATACTAATTTTCTTTTATGGTTCCTGGATTTTGTGAGTAGTTTGAAAAGGCTAATCCAGCTGAAGATTTTGTTGTTGTTGTTAAACCCCATGTTTTCTCCTAACTCTTTTTATTTTTATTTTGGAGGACTCTATCTAGACTTAATTTTAGCATAACAAGTGACAGGGTTAGTTAGCCTGTTGTCCTTACACCATTTTCTGGCTAATACAGCTATTAACTATTGATCTGTCTATTCACGTGCCAGTTCCTAATGGTTTTACATAGTGTAATCTGCACTTCAAAATAGCGAAGGGAAGCCCTACCTCATTATTCTACTTTTCCAGAATTCTCCTGGCTATTCCAGGCTGCATGTTTACCTTAACCTTCCCTGTGATGTCTTCATGCCGTTGTCTTCTTATGCAAGAATAAGGTACGTCTTTCCATCCACTCACGTCTATTTAATTTGACTTTGCATTACACAGAAAGCTGGTCTTGGTCTGTCTACCTCGGCATCTAGTTGTCCTCACTGCCCCCTAGCCGACCCCACCCCATCTGACTGACTACCCCATCACAGAGTACTTTTATTTACGTTTTGCTCTGCCTAATGGTTACTTGATACTGTCACGCCGACAGTGTCCAGTTCAGTGGTCTTTGCAGTTGAAATGCTCCCGTACACACTGTCTTGTTAAAAATGCCAGTAAGTTCATACAAACCCAGCTTGCACCCAAGGTCACATTCAGAGAGCGTAGGGCTGGGATGGGTTGTTTTCCAAGCTTCTGCCACTGTGTGGCTAGCTCTTCCCACTGGGAAGTTCTGTGTACCCGGAATGTCGGAGTGGAGTCCTGTTCTAGTGTCCAGCACCTGACCCTGTGCCCAACCCCTCAACAGCCTATTCCTGCTGTCCACAGCCTGCTGGAACTTTTTACAAAATATGTTGCCATGCTGGACCCTGGGCACTGGACATAAGCCCCCTGGCAGCCTTTTTCATGTCACCCAAAGGGGTAATTGTCCTACTGGTGGTCTGTAAGATGAGTTAGGGTGACTTGCTAATAGACATTGTAAATCTTAATATTTATGTATGTATTTTATTATTACCGGTTTTCCATTTATGATGGTAATATTGTTTCTTCTAAGAATATTTATTTTTCCTTCTAAATATTGAGATAAAATTCATGCTTTTGAAATGTTCTATTCAGTGGCTTTTAGTATATTTGCTATGTTGTGCAACCATCGACACTATCCATTTCTAGAACTTTTTCGTCATCCCAAACAGACGCTCTGTATTCATAAAAAAATAACTTCCTACCTGTCTCTCCCCCTAGTCTTTGGTAACCTTTGTTATACTGGTAAACTTTGTTGTGCTCTCTGTCTGTGTGAATTTGCCTATTCTAGGGGCCTCATATAAGTGTAATCATACAGTATTTGTCTTTTTGGGTCTGTCTGATTTCACTTAGCGGGTTTTCAGGGTTCATTCATGTTGCAGCATATAACAGTACTGCGTTCCTTTTTCTGGCTGAATAATATTCCACTGTATGGATAGACCCCATTTTGTTTATTCACACATCATTTGGACATTTGGATTATTTCTGGTTTTTGGCTATTATGAACAATGGTGCTATGAACAGTTGCGTACAAGTTTTTGTGTGAACATATGTTTTCAATTCTCTCATTATATACCTAGGAGTAGAATTACTGGGTCATATGGTAACTGTATATTTTTGAGGAACTGCCAAACTATTTTCCCACGTCCATGCACCATTTCACATTCCCACCAGTAAGTAAGAGGGTTCCAATTTCTGCGCATTCTTGCCAACACTAGTTATTATCTGACTTTCTGGTTATAATCATTCTAATGAGTGTGAAGTAGCCTCTGGTGTCATTTGGATTTGCATTTCTCTGATGAGTGATGCTATCAAGCACCTTTGCTGGTGCTGTTGGCCATATGTGTATGTTCCCTGGAGAAGTGTCTGTGCTGAGCCTTGGCCCACTTTTTAATTAGGCGTTTGTCTTTTTATTACTGAGTTGTAAGAGTTCTTTATATATTCTGGATTCTAGACCCTTATCAGATACATGGTTTGCAAATATTTTCTCCCATTCTGTGGGTTGTGTTTTCACTTTATCGATAATGTCCTTAGACATATAATAAATTTGTATTTTAAAAGTGACTTGATTTGGCTGTGCAAGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGACTGAGGTGGGTGGATCATATGAGGAGGCTAGGAGTTCGAGGTCAGCCTGGCCAGCATAGCGAAAACTTGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGCACGTCTGTAATACCAGCTTCTCAGGAGGCTGAGGCACGAGGATCACTTGAACCCAGGAGGAGGAGGTTGCAGTGAGCTGAGATCATGCCAGGGCAACAGAATGAGACTTTGTTTAAAAAAAAAAAAAAGTGACTTGATTTAAGGGAAAAAATGACTGGCTATATTCAGTCAGATATGGCAAAAAGTCTCAAGGTGTTAATGTGAATGATTAAGGTCTTGGGGGGGGTGTCCCCTATCAGACTACAGGTGTTTAGAGGCACAGAAAAAGGTGCAGTTGGGTTCTTAATGTGAAATGATGAGAAGCACAACTCCAGTGTGTCTCTTTGTGTAGAATGTCAGCAGACACCCCCTGCTAGATGTGCTGGATCATGGGAAAGCATTTCCATTTGTTACTAGATTGTTCAGAAGTTTTAATTTATGATGGGTGTGGTGGCTCATGCCTGTAGTCCCAGCACTGTGGGAGGCTGAGGCAGGAGGATCATCTGAGGCCAAGAGTTCAAGATCAGCCTGGGCAACATAGTGATACCCTATCTCTTAAAAAAGAAGAAGTTTTTAAATTTGAAATAATAATAGGTACTGGATTTATGCAAATGTCTTTTCTGCGTCTTTTGAGATGAGTATCAGGTTTTTTTTTTTCCTTTTATCATCTGATGATGAACTTAATGTTTCCATTTGTATTAATGGAATACTAAGTCCCTCTGTGATTTCTGAACCAAGCTATTCCTAGGCCTGAGTTTTATTTTGTTGACACAGAAATAAATTAGAAGGCCAAGCGTGGTGGCATGTGCCTGTAGTCCTAGTTGCTGAGGTAAGAGGATTGCTTGAGCCCAGGAGTTCAAGGCTGCAGCAAGCTTTGATTGCGCCACTGCACTCCAGCCTTGGCGACAGACTAAGACGCTGTCTCAAAAAAAAACAAAAACGACAAAAAAAAAACAAAACAGAAAAAATAAACTAAGGCAATGACAGTCCCTGGCAAATGCTGGGAGGGAGGCAGCAGTGGTCAGGGAAGGTAACCCTGAAGCAGGACTTGTAAAGCAAATAAGATTGGGAGGCCAAGGTGGGTGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTTTACTAAAAATACAAAAAAATTAGCCAGGTGTGGTGGTGGGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCTCGAACCCAGGAGGCGGAGGTTACAGTCAGCTGAGACCGCACCATTGCACTCCAGCCTGGGTGACAGAGCAAGATTCCGTCTCAAAAAAAAAAAAAAAAAAAAAACCAAGAAGAAAAGGAATGAATTAGAACTTCTTCTGCTTGGACTTAAGGGCATCATCAGGCAGGTTTTGGGTAGGATAGCAGGGGAGGCAGAGACATAGTCGGGGTCAGTGGTCATGAGTGTGGCTTTGAGCCCAAAAACTTGGTTTCTGTTCCCTACTTTGCCACTCAGTAGTGCATGACTTTGGCCAAATTTCTTAAATTCATGAAGCAAGTTTCCGGGTGAATGAAATGGGGATAAAAATAGTGTTCAAACCTATCCGTTGGTTTGTGTGAAACTGAAATGAATAGTATCGTGCAGGTACTTGTGAGCAAGGGGAGCTGCTGTTTCCTGTCCCTTTATGATGGGAAATATCTAGACAAGTTCCCAACCCTCTGCACTGCAGGCTGCATGGCACGGAGGGTCTTGTAACACCAGCTGGGGCTGGCCTTCTTTTAGGAGCTTCAGTGGTTCTGAAAACTTTTATTTGTTTGTTTGTTTTAGTAGATGTGGGGTCTTTCTGTGTTGCCCGGACTGGTCTCAAACTTCTGGACTCAAGTGATCCTCCCCCGCTCAACCTCCCAAAGTGTTGGGATTACAGGTGTGAGCCACTGTGCCCAGCCTTGAAAACTTTTTCAGGTTCTTCCAGGGTTACTGGGCTATTAAATATTTCTATTTCATTATAAGTCAGTTTTTCAAAGTTATATTATCTTAATTACCTTTTTTATATGTATTAGTGTAGAGTAGCATTTTATATTTTGATATCCTCCTTATGCATAGTTTTTCACTTTTTATTCCTAGTTTTTCGTTTTTAATAAGACTTTCAAGAAATTTATTTTATTGGCCTTTTGAAAAAAGCAGCTTTAGATAAAGTAAGCAGTTCTGCTTTCATTTTATAATTTATTTCTACTTTTGTTTCATTAATCTTTTCCTCCGGCATGCCTTGGATTTTGTTGTGTTACTCTTTTTCTAGAGGCTCGCATTGTGTGTCTGGTTCACTTATGATCACGCTTGCCTACTTTTAAGAATGGAAGAGGGGAGGTGGAGGGTGGCTGCACAGTCGAGGGTGTGAGGCAGTCTTGCTCTAGCCCCACCATGCCCTCAGCCCGCTGTGGCCACGCTGGTTCCTCAATTGCTGGGGCGTGCAGTGTCTGTAAGGGAGGCTACTGATGCCATCCGAGGAAGATGTAAGGTTTCGTGTGGGCAGCGAGAGCCTAGCAGGCATGTGGGGTGCCCAGCAAAGGGTAACAGTGGACAGTTGTTGCCTCATTCCACAGAGTTTTGATTTTTTTTTTTTTTTTAATGGTCACTCCATCAACATCCCCCATGGCCAGAGCCTGAGCTGGTCCCCAGAGACACAGGCATTCAGCTGACAGCCTCGCCTTCACGCTGCTGCTGTTCTCATGGGGGACAGGCCTCAGGTGGCAATGCACAAATCATTAGTTAAGGGCAGTTGTGACAGTTACCAAGGAGTGTAGTCCCCCGCCCCCCGCCCAGTGAAAACAGCCCTAACCAGGGGTGGGGACCTTTGGGCTCTGACCCGAAGGGTAGGAGAAGCTGGAAGGACAGCATTCCTGTCTGCGAAGGCAGGAGCAAAGCTGCCAGGCTATGAAGGAAATGGCTGGAGCCTGAAGTCATGCAAGCTGGGGCTGGCAGGGACAGGGCCAACTTCCAGGCCTGGGGGCCACCATGAGGATTCAGGACGTGACCCCCAGGGCACATGAAGGCCTTCCATCTGTATTTAAGAAAAGACTTTATCAGACGAGTATGGTGGCTCACGCCTGAATCTTAGCACTTTGGGAGGCTGAGGCAGGTGGATCACGAGGTCAGGAGTTCAATACCAGCCTGGCCAATATGGTAAAACCCCATCTCTACTAAAACTACAAAAATTAGCCAGGCATGGTGGCGCACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGAAGAATCACTTGAACCCGGGAGGTGGAGGTTACAGTGAGCCAAGATCGCGCCACTACACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAACCAAAAGACTTTATCTTATTTCCTATATGTTTGTGGTTTCAGTCCTGATGTATAATTTGACCCTAGTTAGAATGGTTATCTGAGGAAGTGGCCTGTACGATTTCTGCTTTTTTAAATGTGTGGCTCCCTTTCTTCATTGATTAACGTATGATTATTTTTATAAATGTTCCATGGCAGTGGGAAGGGATTCTCTGTCACATTCCACATCTGGATCAGTTCCTCCCCATTTTGTTGGTCAAATCCGATCTGCCATATCCTGTGTAATGACAAGTGAGTTGCATTCTCACCGTCACTCCTGGGGTCTCTCCGCTTCCCCTGAGCTGGCTCAGCAGTCTGCTCCATGTGTTTTGATGCAGGGTGACCCATTGGTATTCCCGACACTAACGCCCCCGTCTGTGGACTGCTTGCTGCTTGGGCTTCACTGTGTCTGGTGTTGACAGTGCAGACCTAAAGGTGTGCACACATGTGCACACACACTCCGCTGTCTTCTTGTTTGCACTGGACTTAAATATCTATGAGGGTTATTTTCAACTGCTGAATTTGGAATGATTTTTATATCTTTTCTGCTTTCTGCCCATGTACATGTGTTTATTTTACACTGTTGTGATTGGTAGTTACTATGTGGGGACACAATTACTTGGGCTGAAATAATCCACCTGTTGTGGTTGGGGTCCTCTGGGGCATTCCAGGGTGAGAGGTTGTCACTGCCACCTGGGCCATGTGGGCCGGCACCAGCATTTTGTGGTTACGAATTCTACAGTCACAAATATCTTTGGGCAAATCCCCTTCTATACCTCAAGGCAGCTTTTGGTTTGCAACCCCACTGGCCAGAGGGAAGGGCCAGTCACTTGGCTCTCTCACTGCCCTGCGCCCCAGATGGTTCTAGGGCTGCTGTTTTCCCTTGGCCCTGCCAACACCACTGTTTTTACTTCTGCTCATTGGCTGAGTGCAGTGGTTCCTGGAAGCCAGTGGCACGTTTCCCCGCGTAGCTCGCTTATCCCACAGCACACACCCAAGGGTTCTGTTGCTAACACGCTGAATTAATTCTTTGCTCATCTTACAGAGTGTGTTTTGACTGCCCCCATTTCTGAGGCCTTGTAAGGCCAGAGCTTTGTTGCTTCATCGGCAGGTTGGGACTTAGATGGCCGTGAATGTTTCCTCTCTGCTGCTGCAGTAAGTAAGTGCCCGCACCATAGTGTGTTTGGAGGCTGAAGTTGAAGCGAGGCTGTGAGGGGAGATGGACGTGTGAGGAGGGATGATGGGGCTTGAGCAAAGTGGGGGAGGGGGCAAAGGCAGTTGGCCCAACACATTCCCCACCCCTTTGAGAGGTCTGAGGCCTGCAGACCTGGCTCGGAGCCCACCTGGTAGTCCTCAGACTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAAAAGAGAGAAGTTGTGGAGAAATGGGGGGCTGATTCTGCTCAGATTCATCAGGATGAGTAGAAGGCACCCAGCTCTCACCCTGGCCTGACATGTGTGTCCCTGAGCAGGTTACAGTCCTCTCTGAGCCTCTGCTTCCCATCTGGACCCTGCTGGGCAGGGCTTCTGAGCTCCTTAGCACTAGCAGGAGGGGCTCCAGGGGCCCTCCCTCCATGGCAGCCAGGACAGGACTCTCAAATGAGGACAGCAGAGCTCGTGGGGGGCTCCCACGGACCCGCCGTGGGCCCAGGGGAGGCAGAGCCTGAGCCAACAGCAGTGGTGCTGTGGACCGTGGATCCTGAGGGTGGCCTGGGGCAAGTACCGGCTGAGGGTCCAGGTGGGCTTTGTGTACCTTTGGGTCCTGGGGCCCTGGTGACTTGGACTCCAGGTTAGAGTCAAGTGACAGGAGAAAGGCTGGTGGGGCCCTGTGCTTCCGACTTCATTTCGAGTGATGGCAGTTCCCAGGAAGGAATCCACAGCTGACGGTGGCTGACAGATCAGAGAATGGAAGGCGAGGCAGGCGGGCGTCTGCGTGACCTCAGGTGCTTGGGGCCCAGCAGACCCAGAGAACCATTTCCACTAGGCCAGGGTGCCGGAAGTGTCCACAGGTCTTAGATTCCCTGTTCAGATGAAAAGATTTGTGCCTTTAATGATAAAAGTGATCTGCATAGAGTCAAAAATTCAAGCCATGGGTATAAAATGCAAGTAAAATCCCTGCCCTCACCTATCCCACCCTACTACACAGAGATGTCCTCTCGAGTTTCCTAGACTCACTCTGGAAATTTCTGTATACACACAGAAGCTTGTGCCTCTGCTCGTGAAGGCAGAGGGAGGGAGAGCTGAAGGGCCAGCACCTTCTCACCTGTGGGCCCCCTCAGTGCTCGGTCCCAGAGCATGCAGGACTGTGCCTCGTGTTCAGTTTGCTGGTCTGACTTCATGCTCCTTGGGCAGGATATGCATGTGCCATGCTAGGAGACATGTGGATGTGAAGCTGGGGGACAATGTCCCCTGGCTATGCCTTTACAAGGGAAGTAAGGAAGGTAGGAGGTGAGCCTGGGAGGGAGGGAGGGAGGCGCGGAGCCGCCGCAGGTGTTTCTTTTACTGAGTGCAGCCCATGGCCGCACTCAGGTTTTGCTTTTCACCTTCCCATCTGTGAAAGAGTGAGCAGGAAAAAGCAAAA I have not added the sequence because it is more than 22700 nucleotides long. should I? ago2_human Protein argonaute-2 AGO2 Argonaute RISC catalytic component 2 EIF2C2 Eukaryotic translation initiation factor 2C 2 PAZ Piwi domain protein Protein slicer protein protein human Homo sapiens Human MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA hsa_mir_185_5p-mrna_igf2_1-1 3939569 N/A 3939574 predetermined predetermined participant predetermined regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified N/A 3939575 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range false r.759_765delinsagagagg mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false FIG 4 C D down-regulates quantity by destabilization hsa_mir_185_5p-lncrn_neat1 human long-2 3939569 N/A 3939576 regulator regulator modulator regulator neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered r.20391_20397delinsagagagg mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range false N/A 3939574 predetermined predetermined participant predetermined regulator target regulator target regulator target modulator target neutral component neutral component engineered engineered purified purified physical association physical association false false false FIG 4 C D down-regulates quantity by destabilization hsa_mir_185_5p-mrna_igf2 long-1 3939570 N/A 3939574 predetermined predetermined participant predetermined regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified N/A 3939575 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range false r.759_765delinsagagagg mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false FIG 4 C D down-regulates quantity by destabilization hsa_mir_185_5p-lncrn_neat1 human long-1 3939570 N/A 3939576 regulator regulator modulator regulator neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered r.20391_20397delinsagagagg mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range false N/A 3939574 predetermined predetermined participant predetermined regulator target regulator target regulator target modulator target neutral component neutral component engineered engineered purified purified physical association physical association false false false FIG 4 C D down-regulates quantity by destabilization ago2-hsa_mir_185_5p-1 3939571 N/A 3939577 antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3939576 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3939574 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level association association false false false Fig 4 E lncrn_neat1 human long-hsa_mir_185_5p-1 3939572 N/A 3939574 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3939576 predetermined predetermined participant predetermined unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell engineered engineered tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false r.20391_20397delinsagagagg mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Fig 4 F ago2-hsa_mir_185_5p-2 3939573 N/A 3939577 antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3939576 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3939574 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level association association false false false Fig 4 E