DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ verschueren-2019-1 human Homo sapiens Human x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Verschueren KHG., Blanchet C., Felix J., Dansercoer A., De Vos D., Bloch Y., Van Beeumen J., Svergun D., Gutsche I., Savvides SN., Verstraete K. kenneth.verstraete@ugent.be Nature 2019 Only protein-protein interactions imex curation imex curation q75vw8_hydth ATP citrate synthase ccsA protein protein Hydrogenobacter thermophilus Hydrogenobacter thermophilus MNLYEYEAYDKIFKKYGIPTPEYMFESSVSDRLVEFVNQLGECVVKSQVLVGKRGKAGAVKVCSDPQSAIETAQALLNYPVYGEMPVGVLVARKVNILKELYASITYSTEVRAPVLTLSLEGGMDIEEVPPEKVRSWTINPLKGLYPHMVRNYLLELGFPQEYMGILRELSEVVSNMYRAFWEAEARLLEINPLAICDVNGKLKVYALDAVVTIDDDASVPPSKIYGVRTAMKRPPTEREIEASLIDRDDHRGKAGSYVEVDGDIAMMTFGGGGSTVTIETTYAIGLKPANFTDIGGNPPAEKMYKITKIILSKPGIRGVLVCGGTANNTRIDVTLGEGVANAIRDLYKEGKLNPDWIWVVRRNGPEAEKGLRMLYEAFKECKVKGEIYDSSLPLTEAPIRLKELLDICTSAQSEDRHLTEEQAKDMGI q75vw6_hydth ccsB protein protein Hydrogenobacter thermophilus Hydrogenobacter thermophilus MERRWKIGTPYLNDSTRIIVMGITGREASQVVAESEALYPGFVVAGVTPGKGGSEVAGVPVYNTVREAQERHPEINTGIVYVPPASVKDAVIELIDAGIGVIFIITEHVPIRDTVYFYHYAKERGTIIVGPTSLGCIIPKIPARIGAIGGKDPSVAYADGGLVILSKSGGLTTTTAEMFKRRGWGVYMALALGGDVISCTTFADAIENLADDPNVKGVIIQGEVGGSYEEQAAETILRLWKEGRWNKPVAAFVAGRFQESLEGVSFGHAGAIVERGKGKATDKIRAFNEVGKITGLVKVAEFYHDLVHCIEELGVPRDFEDSTPEGKVKPLYSTINEENCQFKA q9ajc4_chlli aclA protein protein Chlorobium limicola Chlorobium limicola MSILANKDTRAVIIGGVAGVNAAKRMAQFDFLVNRPLTVQAFVYPPEAGQQKEIFRGGELKNVTVYDSLAPALEEHPDINTALIYLGASRAAQAAKEALESPNIQLVSMITEGVPEKDAKRLKKLAQKLGKMLNGPSSIGIMSAGECRLGVIGGEFKNLKLCNLYRQGSFGVLTKSGGLSNEAMWLCAQNGDGITSAVAIGGDAYPGTDFVTYLEMFEKDPATKAVVMIGEVGGNLEEEAAEWLAAEPRRIKLIAAIGGTCQEVLPQGMKFGHAGAKEGKKGAGSARSKMNALRDAGAYVPDTFGGLSKEIKKVYEELIAAGEISTEIDEAVLPELPPRVQEVMKQGEVIVEPLIRTTISDDRGEEPRYAGYAASELCSKGYGIEDVIGLLWNKKLPTREESEIIKRIVMISADHGPAVSGAFGSILAACAGIDMPQAVSAGMTMIGPRFGGAVTNAGKYFKMAVEDYPNDIPGFLSWMKKNVGPVPGIGHRVKSVKNPDQRVKYLVSYIKNETSLHTPCLDYALEVEKVTTAKKGNLILNVDGTIGCILMDLDFPVHSLNGFFVLARTIGMIGHWIDQNNQNSRLIRLYDYLINYAVKPEQEVPEKK q9aqh6_chlli ATP citrate synthase aclB protein protein Chlorobium limicola Chlorobium limicola MAKILEGPAMKLFNKWGIPVPNYVVIMDPDRLAQLGEANKWLRESKLVVKAHEAIGGRFKLGLVKIGLNLEQAIEAAKEMLGAKVGTAEIGQVIIAEMLEHDAEFYVSIIGNKDGAELLISKHGGVDIEDNWDSVRRIQIELDENPTIEQLTELAKDAGFEGEIAERVGKICSRLILCFDNEDAQSIEINPLVIRKSDMRFAALDAVMNVDYDARFRHADWDFKPVSEIGRPFTEAEQQIMEIDSRIKGSVKFVEVPGGEIALLTAGGGASVFYADAVVARGGTIANYAEYSGDPADWAVEALTETICRLPNIKHIIVGGAIANFTDVKATFSGIINGFRESKSKGYLEGVKIWVRRGGPNEAQGLAAIKQLQEEGFDIHVYDRSMPMTDIVDLAMKS a0a1v4vdz9_9eury sucD A4E43_00138 protein protein Methanosaeta sp. PtaB.Bin005 Methanosaeta sp. PtaB.Bin005 MSRKDYVLFDINTKAFVYGYQTNAIQRMLDFDYVCKRSSPSISAIINPSRAGIHKAFWGTKEIILPMYKTIPLAALAYPEADVMVNFASHRSAFETTMEALKEDTIRIVAVIAEGVPERQSRVMAATARKLDKIVIGPATVGGMTAGAFRIGNTAGTIENIIASKLYRPGCVGFVSKSGGMLNEAFNIISRNSDGIYEGVAIGGDRYPGSNMLDHILRYERNPAIKMIACLGELGGEDEYMIIQALKEKKITKPLVAWVTGTCSPYLPASVQFGHAGAKANTEKETAQAKNDAFRQAGAYVPRSFDDYGEMVRQVYDMLLTRGIVQKFDEPEVPRIPTDYSKALATGDIRKPTTFICTISDDSGEELLYAGKKLSDVLDRKMGIGGVIGLLWFKKELPEYAAHFIELVIQIVADHGPAVSGAHNAIVASCAGKDLISSLCSGLLTIGPRFGGAIDDAAREFKRAQETGLAPEQFVGEMKKKGINIPGIGHKIKSVKNPDKRVQLLISYARANFPSTELLNYALQVEELTTAKKGNLILNVDGCIGILFIDLMSSCGAFSKEEIDEVVRLGYLNGLFALGRSIGLIGHILDQKRLGSRLYRHPAEDIAYMMPSEEEIQCKRDR a0a0w8fb26_9zzzz ATP citrate synthase ASZ90_012237 protein protein hydrocarbon metagenome hydrocarbon metagenome MAQRGIREYDAKNLLARYLPEYLDDFSYKGNLALVGPETDIEGLEAENPWLKTTRLVVKPDQLFGKRGKLGLVLLDADWEEAKEYLNEKMGLEVTIGGITGRLSYFLIEPFTPHKEEYYVAISSDYEGDNIFFSMDGGVGVEENWEKVISIHVDSLEGIDALDVGSKLPAELGDKRALVEEFITALWRFYSDTGFAYVEINPFTFSGRGIVPLDMVAKLDDAEEYWQKKRWSELAFPEPFGRTPSKEELFIKEIDSKTGASLKLTILNPEGRVWTMVAGGGASVIYADTICDLGHADEMANYGEYSGDPNTEETYHYTCTILDLMTRSKNPNGKVLLIGGAIANFTDVAKTFKGVVMALEEYQQKLQEADIEIYVRRGGPNYEQGLKLMRDLGKRLGVPIQVHGPETHMTRIVPLALEENQ p53396-2 ATP-citrate synthase ATP-citrate (pro-S-)-lyase Citrate cleavage enzyme ACLY protein protein human Homo sapiens Human MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM q75vx1_hydth Citrate synthase (unknown stereospecificity) ccl protein protein Hydrogenobacter thermophilus Hydrogenobacter thermophilus MERIWKTGITQHIGHETYIRGYRLLDLVGNLSFAQAIYLILKGELPTERESRMMEAMLVSVIDHGIAPPSAIAARSVASGGNSLNVGVAAGVLAFGSAHGGALEDAMRFIQEGVSSKRSVEDIVKEYLETKKPIPGYGHRYYKDFDPRTKRLMDIARVLEFYGEHCKFAEDVAEEIGRQKGKKLVLNVDGAIAAIASEMGFDWRLGKGFFIIGRVPGLVAHVYEELTTEKPFSKRLDEERDVEYTGSPPRELPQELKKI ccsa-ccsb-1 3651882 N/A 3651883 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 2.0 N/A 3651884 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 2.0 direct interaction direct interaction false false false Extended Data Fig 1, Extended Data Table 1 acla-aclb-1 3651882 N/A 3651885 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 4.0 N/A 3651886 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 4.0 direct interaction direct interaction false false false Extended Data Fig 1, Extended Data Table 1 a0a0w8fb26_9zzzz-sucd-1 3651882 N/A 3651887 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 4.0 N/A 3651888 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 4.0 direct interaction direct interaction false false false Extended Data Fig 1, Extended Data Table 1 acly-2 3651882 N/A 3651889 structure determination identification by structure determination identification by structure determination structure determination unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 4.0 direct interaction direct interaction false false false Extended Data Fig 1, Extended Data Table 1 acla-1 3651882 N/A 3651885 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 4.0 direct interaction direct interaction false false false Extended Data Fig 1, Extended Data Table 1 ccl-1 3651882 N/A 3651890 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 4.0 direct interaction direct interaction false false false Extended Data Fig 1, Extended Data Table 1