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    <entry>
        <source releaseDate="2020-03-13Z">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3670631">
                <names>
                    <shortLabel>schmidt-2018-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="30291362" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-25426729" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-27767" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>experimental particp</shortLabel>
                        <fullName>experimental participant identification</fullName>
                        <alias typeAc="MI:1041" type="synonym">experimental particp</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0661" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-933978" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Schmidt HR., Betz RM., Dror RO., Kruse AC.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">Andrew_Kruse@hms.harvard.edu</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature structural &amp; molecular biology</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2018</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3670632">
                <names>
                    <shortLabel>q99720-1</shortLabel>
                    <fullName>Sigma non-opioid intracellular receptor 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">SIGMAR1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">OPRS1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SRBP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Aging-associated gene 8 protein</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SR31747-binding protein</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Sigma 1-type opioid receptor</alias>
                    <alias typeAc="MI:0306" type="orf name">AAG8</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q99720-1" version="131" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000147955" version="SP_171" refType="gene"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-3248663" refType="isoform-parent" refTypeAc="MI:0243"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16203475" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000277010" version="SP_171" refType="transcript"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000277010" version="SP_171" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-27767-1" id="3670633">
                <names>
                    <shortLabel>sigmar1-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="wwpdb" dbAc="MI:0805" id="6DK0" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-27767-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="6DK1" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="6DJZ" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-25426736" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3670631</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3670634">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-25426737" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3670632</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>predetermined</shortLabel>
                                    <fullName>predetermined participant</fullName>
                                    <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>structure determination</shortLabel>
                                    <fullName>identification by structure determination</fullName>
                                    <alias typeAc="MI:1041" type="synonym">identification by structure determination</alias>
                                    <alias typeAc="MI:1041" type="synonym">structure determination</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2287" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="7877166" refType="primary-reference" refTypeAc="MI:0358"/>
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                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
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                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="7108">
                                <names>
                                    <shortLabel>spofr-sf_9</shortLabel>
                                    <fullName>Spodoptera frugiperda insect cells</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Fall armyworm</alias>
                                </names>
                                <cellType>
                                    <names>
                                        <shortLabel>sf_9</shortLabel>
                                        <fullName>insect cells</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="cabri" dbAc="MI:0246" id="ACC 125" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-86941" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-346407" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="IA:0078" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                    <attributeList>
                                        <attribute name="comment" nameAc="MI:0612">Derived from pupal ovarian tissue of the fall armyworm</attribute>
                                        <attribute name="comment" nameAc="MI:0612">Cloned from the parent cell line, IPLB-SF-21-AE (SF-21)</attribute>
                                        <attribute name="comment" nameAc="MI:0612">derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae</attribute>
                                        <attribute name="comment" nameAc="MI:0612">cells are susceptible to Baculovirus infection</attribute>
                                    </attributeList>
                                </cellType>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 3.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig 2, Tab 1</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
