<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2019-11-20Z">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
                <xref>
                    <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3582391">
                <names>
                    <shortLabel>liu-2019-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="31279174" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-21943361" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-27182" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>fluorescence spectr</shortLabel>
                        <fullName>classical fluorescence spectroscopy</fullName>
                        <alias typeAc="MI:1041" type="synonym">fluorescence spectr</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0017" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1012" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Liu H., Xu L., Huang H., Zhao P., Yang R., Zhou Q., Liu G.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Rare diseases - Interactions investigated in the context of Rare genetic disease</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">guanghualliu@yeah.net</attribute>
                    <attribute name="journal" nameAc="MI:0885">Journal of molecular graphics &amp; modelling</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2019</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3582392">
                <names>
                    <shortLabel>ghr_human</shortLabel>
                    <fullName>Growth hormone receptor</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Somatotropin receptor</alias>
                    <alias typeAc="MI:0301" type="gene name">GHR</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P10912" version="SP_102" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9HCX2" version="SP_102" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000537449" version="SP_233" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019903" secondary="protein phosphatase binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007259" secondary="receptor signaling pathway via JAK-STAT" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000615111" version="SP_233" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032355" secondary="response to estradiol" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043278" secondary="response to morphine" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042169" secondary="SH2 domain binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060396" secondary="growth hormone receptor signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019838" secondary="growth factor binding" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000478291" version="SP_233" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070555" secondary="response to interleukin-1" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-982772" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000612626" version="SP_233" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031623" secondary="receptor internalization" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019955" secondary="cytokine binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0040018" secondary="positive regulation of multicellular organism growth" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000442206" version="SP_233" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" secondary="cell surface" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004896" secondary="cytokine receptor activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070195" secondary="growth hormone receptor complex" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051384" secondary="response to glucocorticoid" version="SP_233"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229391.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_233"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1AXI" version="SP_233"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229335.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901215" secondary="negative regulation of neuron death" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_233"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5OEK" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019530" secondary="taurine metabolic process" version="SP_233"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5OHD" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042531" secondary="positive regulation of tyrosine phosphorylation of STAT protein" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0036464" secondary="cytoplasmic ribonucleoprotein granule" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006897" secondary="endocytosis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032870" secondary="cellular response to hormone stimulus" version="SP_233"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229334.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000479846" version="SP_233" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043235" secondary="receptor complex" version="SP_233"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229329.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" secondary="external side of plasma membrane" version="SP_233"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036116" version="SP_233"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003961" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000478332" version="SP_233" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-286316" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HWH" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070064" secondary="proline-rich region binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048009" secondary="insulin-like growth factor receptor signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004903" secondary="growth hormone receptor activity" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000612382" version="SP_233" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043025" secondary="neuronal cell body" version="SP_233"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003528" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045597" secondary="positive regulation of cell differentiation" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009755" secondary="hormone-mediated signaling pathway" version="SP_233"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2AEW" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042976" secondary="activation of Janus kinase activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032094" secondary="response to food" version="SP_233"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR025871" version="SP_233"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HHR" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032869" secondary="cellular response to insulin stimulus" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046898" secondary="response to cycloheximide" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="SP_233"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229330.1"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229328.1"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229333.1"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000154.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000230882" version="SP_233" refType="transcript"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015152" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042445" secondary="hormone metabolic process" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" secondary="positive regulation of peptidyl-tyrosine phosphorylation" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000112964" version="SP_233" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046427" secondary="positive regulation of receptor signaling pathway via JAK-STAT" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060351" secondary="cartilage development involved in endochondral bone morphogenesis" version="SP_233"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229332.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000482373" version="SP_233" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019221" secondary="cytokine-mediated signaling pathway" version="SP_233"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1KF9" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1170546" version="SP_233"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-630N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000618088" version="SP_233" refType="transcript"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229389.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0017046" secondary="peptide hormone binding" version="SP_233"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HWG" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0040014" secondary="regulation of multicellular organism growth" version="SP_233"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229331.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043406" secondary="positive regulation of MAP kinase activity" version="SP_233"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1A22" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000230882" version="SP_233" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP</sequence>
            </interactor>
            <interactor id="3582393">
                <names>
                    <shortLabel>soma_human</shortLabel>
                    <fullName>Somatotropin</fullName>
                    <alias typeAc="MI:0301" type="gene name">GH1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Growth hormone</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Pituitary growth hormone</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Growth hormone 1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P01241" version="SP_108" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007259" secondary="receptor signaling pathway via JAK-STAT" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032355" secondary="response to estradiol" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008083" secondary="growth factor activity" version="SP_234"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9HBZ1" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010536" secondary="positive regulation of activation of Janus kinase activity" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060396" secondary="growth hormone receptor signaling pathway" version="SP_234"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018116" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048513" secondary="animal organ development" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043568" secondary="positive regulation of insulin-like growth factor receptor signaling pathway" version="SP_234"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009079" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HHR" version="SP_234"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000312673" version="SP_234" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-982772" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070977" secondary="bone maturation" version="SP_234"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_072054.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045927" secondary="positive regulation of growth" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0040018" secondary="positive regulation of multicellular organism growth" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010828" secondary="positive regulation of glucose transmembrane transport" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070195" secondary="growth hormone receptor complex" version="SP_234"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A6NEF6" version="SP_164" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UMJ7" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014068" secondary="positive regulation of phosphatidylinositol 3-kinase signaling" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1AXI" version="SP_234"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q14405" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005148" secondary="prolactin receptor binding" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HUW" version="SP_234"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000506.2"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000259384" version="SP_234" refType="gene"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_072053.1"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1026046" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" secondary="positive regulation of peptidyl-tyrosine phosphorylation" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046427" secondary="positive regulation of receptor signaling pathway via JAK-STAT" version="SP_234"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5EB53" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031667" secondary="response to nutrient levels" version="SP_234"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001400" version="SP_234"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000323322" version="SP_234" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042531" secondary="positive regulation of tyrosine phosphorylation of STAT protein" version="SP_234"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-1022N"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q16631" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BP3" version="SP_234"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1170546" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HWG" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6QIO" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031904" secondary="endosome lumen" version="SP_234"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UNL5" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HGU" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005179" secondary="hormone activity" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005131" secondary="growth hormone receptor binding" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1A22" version="SP_234"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-422085" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043406" secondary="positive regulation of MAP kinase activity" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HWH" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1KF9" version="SP_234"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-27182-1" id="3582394">
                <names>
                    <shortLabel>gh1-ghr-4</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-21943371" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-27182-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3582391</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3582395">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-21943373" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3582392</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="3582396">
                                <names>
                                    <shortLabel>region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-21943384" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>fluorescent dye</shortLabel>
                                        <fullName>fluorescent dye label</fullName>
                                        <alias typeAc="MI:1041" type="synonym">fluorescent dye</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0857" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1372389" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="83333">
                                <names>
                                    <shortLabel>ecoli</shortLabel>
                                    <fullName>Escherichia coli (strain K12)</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 2.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="3582397">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-21943372" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3582393</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="3582398">
                                <names>
                                    <shortLabel>P01241:p.Gly146Arg</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-21943379" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation disrupting strength</shortLabel>
                                        <fullName>mutation disrupting interaction strength</fullName>
                                        <alias typeAc="MI:1041" type="synonym">mutation disrupting strength</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1128" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-5528001" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="146"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="146"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                            <feature id="3582399">
                                <names>
                                    <shortLabel>P01241:p.Glu100Lys</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-21943377" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation decreasing strength</shortLabel>
                                        <fullName>mutation decreasing interaction strength</fullName>
                                        <alias typeAc="MI:1041" type="synonym">mutation decreasing strength</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1133" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-5528801" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="100"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="100"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9606">
                                <names>
                                    <shortLabel>human-293</shortLabel>
                                    <fullName>Homo sapiens transformed primary embryonal kidney cells</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Human</alias>
                                </names>
                                <cellType>
                                    <names>
                                        <shortLabel>293</shortLabel>
                                        <fullName>Transformed human primary embryonal kidney cells.</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="mint" dbAc="MI:0471" id="MINT-1782570" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="cabri" dbAc="MI:0246" id="ACC 305" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307626" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="IA:0058" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                    <attributeList>
                                        <attribute name="comment" nameAc="MI:0612">The Cell type named 293 is synonymous with HEK-293.</attribute>
                                    </attributeList>
                                </cellType>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <parameterList>
                    <parameter uncertainty="0.179999999999999993338661852249060757458209991455078125" term="kd" termAc="MI:0646" unit="molar" unitAc="MI:0648" base="10" exponent="-9" factor="0.76">
                        <experimentRef>3582391</experimentRef>
                    </parameter>
                </parameterList>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig. 4, Table 1</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
