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    <entry>
        <source releaseDate="2019-11-20Z">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
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            <xref>
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                <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3595700">
                <names>
                    <shortLabel>mcdonald-1991-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="1956407" refType="primary-reference" refTypeAc="MI:0358"/>
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                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-22016964" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-27460" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">McDonald NQ., Lapatto R., Murray-Rust J., Gunning J., Wlodawer A., Blundell TL.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">N/A</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1991</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3595701">
                <names>
                    <shortLabel>ngf_mouse</shortLabel>
                    <fullName>Beta-nerve growth factor</fullName>
                    <alias typeAc="MI:0301" type="gene name">Ngf</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Ngfb</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P01139" version="SP_138" refType="identity" refTypeAc="MI:0356"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051279" secondary="regulation of release of sequestered calcium ion into cytosol" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038177" secondary="death receptor agonist activity" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046928" secondary="regulation of neurotransmitter secretion" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051402" secondary="neuron apoptotic process" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008083" secondary="growth factor activity" version="SP_195"/>
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                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020437" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019233" secondary="sensory perception of pain" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008021" secondary="synaptic vesicle" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" secondary="positive regulation of cell population proliferation" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005788" secondary="endoplasmic reticulum lumen" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008191" secondary="metalloendopeptidase inhibitor activity" version="SP_195"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1SGF" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006919" secondary="activation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_195"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5LSD" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048672" secondary="positive regulation of collateral sprouting" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038180" secondary="nerve growth factor signaling pathway" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031904" secondary="endosome lumen" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030297" secondary="transmembrane receptor protein tyrosine kinase activator activity" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043524" secondary="negative regulation of neuron apoptotic process" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" secondary="positive regulation of ERK1 and ERK2 cascade" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007623" secondary="circadian rhythm" version="SP_195"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030307" secondary="positive regulation of cell growth" version="SP_195"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-9826976" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000648" secondary="positive regulation of stem cell proliferation" version="SP_195"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008344" secondary="adult locomotory behavior" version="SP_195"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BTG" version="SP_195"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSLDTALRRARSAPTAPIAARVTGQTRNITVDPRLFKKRRLHSPRVLFSTQPPPTSSDTLDLDFQAHGTIPFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLAEVNINNSVFRQYFFETKCRASNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDEKQAAWRFIRIDTACVCVLSRKATRRG</sequence>
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        </interactorList>
        <interactionList>
            <interaction imexId="IM-27460-1" id="3595702">
                <names>
                    <shortLabel>ngf-3</shortLabel>
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                    <primaryRef db="pdbe" dbAc="MI:0472" id="1bet" refType="identity" refTypeAc="MI:0356"/>
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                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-27460-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3595700</experimentRef>
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                <participantList>
                    <participant id="3595703">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
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                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-22016998" refType="identity" refTypeAc="MI:0356"/>
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                        <interactorRef>3595701</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
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                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
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                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="3595704">
                                <names>
                                    <shortLabel>Dimerization domain</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-22016999" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>sufficient to bind</shortLabel>
                                        <fullName>sufficient binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">sufficient to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
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                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
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                                            </xref>
                                        </startStatus>
                                        <begin position="131"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="237"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="3595705">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
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                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-22016992" refType="identity" refTypeAc="MI:0356"/>
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                        <interactorRef>3595701</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="3595706">
                                <names>
                                    <shortLabel>Dimerization domain</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-22016996" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>sufficient to bind</shortLabel>
                                        <fullName>sufficient binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">sufficient to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="131"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="237"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <inferredInteractionList>
                    <inferredInteraction>
                        <participant>
                            <participantFeatureRef>3595706</participantFeatureRef>
                        </participant>
                        <participant>
                            <participantFeatureRef>3595704</participantFeatureRef>
                        </participant>
                    </inferredInteraction>
                </inferredInteractionList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig.1a and b, Fig.2, Fig.3, Table 1</attribute>
                    <attribute name="3d-resolution" nameAc="MI:0632">2.3A</attribute>
                    <attribute name="3d-r-factors" nameAc="MI:0631">Rwork=0.22
Rfree=not available</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
