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    <entry>
        <source releaseDate="2018-08-08+01:00">
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                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
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                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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                <attribute name="url">http://www.ebi.ac.uk/</attribute>
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            <experimentDescription id="3339160">
                <names>
                    <shortLabel>kumar-2018-1</shortLabel>
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                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-sh_sy5y</shortLabel>
                            <fullName>Homo sapiens SH-SY5Y cell line</fullName>
                        </names>
                        <cellType>
                            <names>
                                <shortLabel>sh_sy5y</shortLabel>
                                <fullName>Human neuroblastoma cells</fullName>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti tag coip</shortLabel>
                        <fullName>anti tag coimmunoprecipitation</fullName>
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                    <names>
                        <shortLabel>anti tag western</shortLabel>
                        <fullName>anti tag western blot</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti tag western</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Kumar A., Shaha C.</attribute>
                    <attribute name="data-processing" nameAc="MI:0633">The authors have stated that the  plasmids  HA-RBX1 and FLAG-SESN2 are of human origin.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">cshaha@nii.ac.in</attribute>
                    <attribute name="journal" nameAc="MI:0885">Molecular and cellular biochemistry</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2018</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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                    <shortLabel>rbx1_human</shortLabel>
                    <fullName>E3 ubiquitin-protein ligase RBX1</fullName>
                    <alias typeAc="MI:0301" type="gene name">RBX1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RNF75</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ROC1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Regulator of cullins 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RING finger protein 75</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein ZYP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RING-box protein 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">E3 ubiquitin-protein transferase RBX1</alias>
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                        <fullName>Homo sapiens</fullName>
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                <sequence>MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH</sequence>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034198" secondary="cellular response to amino acid starvation" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990253" secondary="cellular response to leucine starvation" version="SP_170"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5628897" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990316" secondary="Atg1/ULK1 kinase complex" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032868" secondary="response to insulin" version="SP_170"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P58004" version="SP_170"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5T0N" version="SP_170"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000253063" version="SP_170" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000130766" version="SP_170" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098869" secondary="cellular oxidant detoxification" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900182" secondary="positive regulation of protein localization to nucleus" version="SP_170"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5T7D0" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_170"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6N0M" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005092" secondary="GDP-dissociation inhibitor activity" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071233" secondary="cellular response to leucine" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034599" secondary="cellular response to oxidative stress" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043491" secondary="protein kinase B signaling" version="SP_170"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9639288" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032042" secondary="mitochondrial DNA metabolic process" version="SP_170"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006730" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006111" secondary="regulation of gluconeogenesis" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031932" secondary="TORC2 complex" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042149" secondary="cellular response to glucose starvation" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001932" secondary="regulation of protein phosphorylation" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042593" secondary="glucose homeostasis" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030308" secondary="negative regulation of cell growth" version="SP_170"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070728" secondary="leucine binding" version="SP_170"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000645231" version="SP_170" refType="transcript"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-26304-1" id="3339163">
                <names>
                    <shortLabel>sesn2-rbx1-3</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-16765648" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-26304-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3339160</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3339164">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16765653" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3339161</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="3339165">
                                <names>
                                    <shortLabel>n_terminus</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-16765654" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>ha tag</shortLabel>
                                        <fullName>ha tag</fullName>
                                        <alias typeAc="MI:0303" type="go synonym">YPYDVPDYA epitope tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">YPYDVPDYA epitope tag</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0520" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456513" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                    <participant id="3339166">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16765650" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3339162</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="3339167">
                                <names>
                                    <shortLabel>n_terminus</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-16765651" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>flag tag</shortLabel>
                                        <fullName>flag tag</fullName>
                                        <alias typeAc="MI:0303" type="go synonym">FLAG-tagged</alias>
                                        <alias typeAc="MI:0303" type="go synonym">FLAG</alias>
                                        <alias typeAc="MI:0303" type="go synonym">DYKDDDDKV epitope tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">DYKDDDDKV epitope tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">FLAG</alias>
                                        <alias typeAc="MI:1041" type="synonym">FLAG-tagged</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0518" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456503" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">figure 3C</attribute>
                    <attribute name="agonist" nameAc="MI:0625">CCCP -(carbonyl cyanide m-chlorophenylhydrazone), an inhibitor of oxidative phosphorylation.</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
