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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3293364">
                <names>
                    <shortLabel>di-1997-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="9384562" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="wwpdb" dbAc="MI:0805" id="1AN1" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16213411" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/s0969-2126(97)00296-7" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-23727" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-263251X" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Di Marco S., Priestle JP.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-263251X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1997</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Structure of the complex of leech-derived tryptase inhibitor (LDTI) with trypsin and modeling of the LDTI-tryptase system.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Di Marco S.,  Priestle JP.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3293365">
                <names>
                    <shortLabel>ldti_hirme</shortLabel>
                    <fullName>Leech-derived tryptase inhibitor C</fullName>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P80424" version="SP_57" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036058" version="SP_106"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2KMR" version="SP_106"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2KMP" version="SP_106"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-6084N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004867" secondary="serine-type endopeptidase inhibitor activity" version="SP_106"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="MINT-1526663" refType="intact-secondary"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8611877" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LDT" version="SP_106"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2KMO" version="SP_106"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2KMQ" version="SP_106"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002350" version="SP_106"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1AN1" version="SP_106"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="6421">
                    <names>
                        <shortLabel>medicinal leech</shortLabel>
                        <fullName>Hirudo medicinalis</fullName>
                    </names>
                </organism>
                <sequence>KKVCACPKILKPVCGSDGRTYANSCIARCNGVSIKSEGSCPTGILN</sequence>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                    <attribute name="function" nameAc="MI:0613">Acts as an inhibitor of human tryptase, trypsin and chymotrypsin. Probably acts to block host defense mechanisms</attribute>
                </attributeList>
            </interactor>
            <interactor id="3293366">
                <names>
                    <shortLabel>tryp_pig</shortLabel>
                    <fullName>Trypsin</fullName>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P00761" version="SP_77" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S83" version="SP_159"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018114" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4AN7" version="SP_159"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001314" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FMG" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2A32" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1TX6" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1H9H" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S84" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S6H" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1H9I" version="SP_159"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1EWU" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FNI" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1YF4" version="SP_159"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8103966" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="MINT-1512991" refType="intact-secondary"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FN6" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LT2" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S81" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1QQU" version="SP_159"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033116" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S5S" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MYW" version="SP_159"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009003" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1UHB" version="SP_159"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001254" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S82" version="SP_159"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-6083N"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S6F" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1TFX" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1MCT" version="SP_159"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004252" secondary="serine-type endopeptidase activity" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1EPT" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5XWL" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LDT" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1AKS" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1EJA" version="SP_159"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR043504" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1AN1" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1C9P" version="SP_159"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006508" secondary="proteolysis" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2A31" version="SP_159"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4DOQ" version="SP_159"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1Z7K" version="SP_159"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1D3O" version="SP_159"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9823">
                    <names>
                        <shortLabel>pig</shortLabel>
                        <fullName>Sus scrofa (Pig)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Pig</alias>
                    </names>
                </organism>
                <sequence>FPTDDDDKIVGGYTCAANSIPYQVSLNSGSHFCGGSLINSQWVVSAAHCYKSRIQVRLGEHNIDVLEGNEQFINAAKIITHPNFNGNTLDNDIMLIKLSSPATLNSRVATVSLPRSCAAAGTECLISGWGNTKSSGSSYPSLLQCLKAPVLSDSSCKSSYPGQITGNMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGYGCAQKNKPGVYTKVCNYVNWIQQTIAAN</sequence>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-23727-1" id="3293367">
                <names>
                    <shortLabel>ldti_hirme-tryp_pig-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-10966E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16213423" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-23727-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3293364</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3293368">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16213428" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3293365</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="4932">
                                <names>
                                    <shortLabel>yeasx</shortLabel>
                                    <fullName>Saccharomyces cerevisiae (Baker's yeast)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Baker's yeast</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3293369">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16213427" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3293366</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9823">
                                <names>
                                    <shortLabel>pig</shortLabel>
                                    <fullName>Sus scrofa (Pig)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Pig</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
