DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ wu-2015-14 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. DIP original experiment: DIP-268216X Science (New York, N.Y.) 2015 IMEx Structure of the voltage-gated calcium channel Cav1.1 complex. Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Only protein-protein interactions imex curation wu-2015-15 in vitro In vitro crosslink cross-linking study crosslink predetermined predetermined participant predetermined Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. DIP original experiment: DIP-268218X Science (New York, N.Y.) 2015 IMEx Structure of the voltage-gated calcium channel Cav1.1 complex. Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Only protein-protein interactions imex curation wu-2015-16 in vitro In vitro crosslink cross-linking study crosslink predetermined predetermined participant predetermined Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. DIP original experiment: DIP-268220X Science (New York, N.Y.) 2015 IMEx Structure of the voltage-gated calcium channel Cav1.1 complex. Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Only protein-protein interactions imex curation wu-2015-17 in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. DIP original experiment: DIP-268217X Science (New York, N.Y.) 2015 IMEx Structure of the voltage-gated calcium channel Cav1.1 complex. Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Only protein-protein interactions imex curation wu-2015-18 in vitro In vitro crosslink cross-linking study crosslink predetermined predetermined participant predetermined Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. DIP original experiment: DIP-268219X Science (New York, N.Y.) 2015 IMEx Structure of the voltage-gated calcium channel Cav1.1 complex. Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Only protein-protein interactions imex curation wu-2015-19 in vitro In vitro crosslink cross-linking study crosslink predetermined predetermined participant predetermined Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. DIP original experiment: DIP-268221X Science (New York, N.Y.) 2015 IMEx Structure of the voltage-gated calcium channel Cav1.1 complex. Wu J., Yan Z., Li Z., Yan C., Lu S., Dong M., Yan N. Only protein-protein interactions imex curation cac1s_rabit Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S CACH1 CACNL1A3 Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle Voltage-gated calcium channel subunit alpha Cav1.1 Dihydropyridine receptor alpha-1S subunit protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MEPSSPQDEGLRKKQPKKPLPEVLPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMDVEDLREGKLSLEEGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSRVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKTEEEKSVMAKKLEQKPKGEGIPTTAKLKVDEFESNVNEVKDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKVRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQIQAGLRTIEEEAAPEIRRTISGDLTAEEELERAMVEAAMEERIFRRTGGLFGQVDTFLERTNSLPPVMANQRPLQFAEIEMEELESPVFLEDFPQDARTNPLARANTNNANANVAYGNSNHSNNQMFSSVHCEREFPGEAETPAAGRGALSHSHRALGPHSKPCAGKLNGQLVQPGMPINQAPPAPCQQPSTDPPERGQRRTSLTGSLQDEAPQRRSSEGSTPRRPAPATALLIQEALVRGGLDTLAADAGFVTATSQALADACQMEPEEVEVAATELLKARESVQGMASVPGSLSRRSSLGSLDQVQGSQETLIPPRP mint ccg1_rabit Voltage-dependent calcium channel gamma-1 subunit CACNG1 CACNLG Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MSPTEAPKVRVTLFCILVGIVLAMTAVVSDHWAVLSPHMENHNTTCEAAHFGLWRICTKRIALGEDRSCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAISVFSLGFLIMGTICALMAFRKKRDYLLRPASMFYVFAGLCLFVSLEVMRQSVKRMIDSEDTVWIEYYYSWSFACACAAFVLLFLGGISLLLFSLPRMPQNPWESCMDAEPEH ca2d1_rabit Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 CACNL2A CCHL2A Voltage-gated calcium channel subunit alpha-2/delta-1 protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MAAGRPLAWTLTLWQAWLILIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVHQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFRRQVSYQHAAVHIPTDIYEGSTIVLNELNWTSALDDVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFLAPRDYCSDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADILQIGWWATAAAWSILQQFLLSLTFPRLLEAADMEDDDFTASMSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIIGIQFVLLWLVSGSRHCLL cacb1_rabit Voltage-dependent L-type calcium channel subunit beta-1 Calcium channel voltage-dependent subunit beta 1 CACNB1 CACNLB1 protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVEGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQSRLSSSKSGDNSSSSLGDVVTGTRRPTPPASGNEMTNLAFELEPLDLEEDEAELGEQSGSAKTSVSSVTTPPPHGTRIPFFKKTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHLFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQVQVLTSLRRNLSFWGGLETSQRGGGAVPQQQEHAM cacna1s-cacna2d1-2 3286998 N/A 3287004 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287005 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287006 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287007 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli physical association physical association false false false cacna1s-cacna2d1-3 3286999 N/A 3287004 unspecified role unspecified role unspecified role unspecified role K976 K976 xlnk-res-res crosslinked residues XLNK-Res-Res modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287006 unspecified role unspecified role unspecified role unspecified role K234 K234 xlnk-res-res crosslinked residues XLNK-Res-Res modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false rabit Oryctolagus cuniculus (Rabbit) Rabbit direct interaction direct interaction false false false cacna1s-cacnb1-1 3287000 N/A 3287004 unspecified role unspecified role unspecified role unspecified role K693 K693 xlnk-res-res crosslinked residues XLNK-Res-Res modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287007 unspecified role unspecified role unspecified role unspecified role K151 K151 xlnk-res-res crosslinked residues XLNK-Res-Res modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false rabit Oryctolagus cuniculus (Rabbit) Rabbit direct interaction direct interaction false false false cacna1s-cacna2d1-4 3287001 N/A 3287004 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287006 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287007 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3287005 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit physical association physical association false false false cacna1s-cacng1-1 3287002 N/A 3287004 unspecified role unspecified role unspecified role unspecified role K1094/1414 K1094/1414 xlnk-res-res crosslinked residues XLNK-Res-Res modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287005 unspecified role unspecified role unspecified role unspecified role M1 M1 xlnk-res-res crosslinked residues XLNK-Res-Res modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false rabit Oryctolagus cuniculus (Rabbit) Rabbit direct interaction direct interaction false false false cacna1s-cacnb1-2 3287003 N/A 3287004 unspecified role unspecified role unspecified role unspecified role K352 K352 xlnk-res-res crosslinked residues XLNK-Res-Res modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false rabit Oryctolagus cuniculus (Rabbit) Rabbit N/A 3287007 unspecified role unspecified role unspecified role unspecified role K395 K395 xlnk-res-res crosslinked residues XLNK-Res-Res modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false rabit Oryctolagus cuniculus (Rabbit) Rabbit direct interaction direct interaction false false false