DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ felix-2015-1 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Felix J., De Munck S., Verstraete K., Meuris L., Callewaert N., Elegheert J., Savvides SN. DIP original experiment: DIP-267224X Structure (London, England : 1993) 2015 IMEx Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Felix J., De Munck S., Verstraete K., Meuris L., Callewaert N., Elegheert J., Savvides SN. Only protein-protein interactions imex curation felix-2015-2 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Felix J., De Munck S., Verstraete K., Meuris L., Callewaert N., Elegheert J., Savvides SN. DIP original experiment: DIP-267222X Structure (London, England : 1993) 2015 IMEx Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Felix J., De Munck S., Verstraete K., Meuris L., Callewaert N., Elegheert J., Savvides SN. Only protein-protein interactions imex curation felix-2015-3 in vitro In vitro saxs x ray scattering saxs predetermined predetermined participant predetermined Felix J., De Munck S., Verstraete K., Meuris L., Callewaert N., Elegheert J., Savvides SN. DIP original experiment: DIP-267225X Structure (London, England : 1993) 2015 IMEx Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Felix J., De Munck S., Verstraete K., Meuris L., Callewaert N., Elegheert J., Savvides SN. Only protein-protein interactions imex curation felix-2015-4 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Felix J., De Munck S., Verstraete K., Meuris L., Callewaert N., Elegheert J., Savvides SN. DIP original experiment: DIP-267223X Structure (London, England : 1993) 2015 IMEx Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Felix J., De Munck S., Verstraete K., Meuris L., Callewaert N., Elegheert J., Savvides SN. Only protein-protein interactions imex curation csf1r_human Macrophage colony-stimulating factor 1 receptor CSF1R FMS Proto-oncogene c-Fms CSF-1 receptor protein protein human Homo sapiens Human MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC csf1_human Macrophage colony-stimulating factor 1 CSF1 Lanimostim protein protein human Homo sapiens Human MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPRPSVGAFNPGMEDILDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLSAQPQLSRSHSSGSVLPLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTDTGHERQSEGSFSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV csf1-csf1r-4 3281296 N/A 3281300 unspecified role unspecified role unspecified role unspecified role Region 20-296 Region 20-296 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3281301 unspecified role unspecified role unspecified role unspecified role Region 33-181 Region 33-181 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false csf1-csf1r-5 3281297 N/A 3281300 unspecified role unspecified role unspecified role unspecified role Region 20-296 Region 20-296 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3281301 unspecified role unspecified role unspecified role unspecified role Region 33-181 Region 33-181 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false csf1-csf1r-22 3281298 N/A 3281300 unspecified role unspecified role unspecified role unspecified role Region 20-503 Region 20-503 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3281301 unspecified role unspecified role unspecified role unspecified role Region 33-181 Region 33-181 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false csf1-csf1r-23 3281299 N/A 3281300 unspecified role unspecified role unspecified role unspecified role Region 20-503 Region 20-503 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3281301 unspecified role unspecified role unspecified role unspecified role Region 33-181 Region 33-181 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false