DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ krnke-2015-1 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. DIP original experiment: DIP-265976X Nature 2015 IMEx Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. Only protein-protein interactions imex curation krnke-2015-2 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. DIP original experiment: DIP-265979X Nature 2015 IMEx Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. Only protein-protein interactions imex curation krnke-2015-3 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. DIP original experiment: DIP-265977X Nature 2015 IMEx Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. Only protein-protein interactions imex curation krnke-2015-4 human Homo sapiens Human pull down pull down predetermined predetermined participant predetermined Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. DIP original experiment: DIP-265978X Nature 2015 IMEx Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. Only protein-protein interactions imex curation ddb1_human DNA damage-binding protein 1 DDB1 Damage-specific DNA-binding protein 1 UV-damaged DNA-binding factor DDB p127 subunit DNA damage-binding protein a UV-damaged DNA-binding protein 1 Xeroderma pigmentosum group E-complementing protein XPE-binding factor HBV X-associated protein 1 XAP1 protein protein human Homo sapiens Human MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH kc1a_human Casein kinase I isoform alpha CSNK1A1 CK1 protein protein human Homo sapiens Human MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF crbn_human Protein cereblon CRBN AD-006 protein protein human Homo sapiens Human MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG crbn-csnk1a1-2 3280311 N/A 3280315 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3280316 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3280317 unspecified role unspecified role bait bait human Homo sapiens Human association association false false false crbn-csnk1a1-3 3280312 N/A 3280316 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3280317 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false crbn-ddb1-6 3280313 N/A 3280315 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3280317 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false ub-csnk1a1-1 3280314 N/A 3280318 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3280316 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false