<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3278353">
                <names>
                    <shortLabel>radjainia-2015-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="25914057" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-265407X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24391" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2015.03.019" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16155096" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="562">
                        <names>
                            <shortLabel>ecolx</shortLabel>
                            <fullName>Escherichia coli</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>3d-em</shortLabel>
                        <fullName>3D electron microscopy</fullName>
                        <alias typeAc="MI:1041" type="synonym">3D-EM</alias>
                        <alias typeAc="MI:1041" type="synonym">electron tomog</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0410" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="12160704" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608522" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Radjainia M., Venugopal H., Desfosses A., Phillips AJ., Yewdall NA., Hampton MB., Gerrard JA., Mitra AK.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-265407X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2015</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Cryo-electron microscopy structure of human peroxiredoxin-3 filament reveals the assembly of a putative chaperone.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Radjainia M.,  Venugopal H.,  Desfosses A.,  Phillips AJ.,  Yewdall NA.,  Hampton MB.,  Gerrard JA.,  Mitra AK.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3278354">
                <names>
                    <shortLabel>prdx3_human</shortLabel>
                    <fullName>Thioredoxin-dependent peroxide reductase, mitochondrial</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Peroxiredoxin-3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Peroxiredoxin III</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Antioxidant protein 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein MER5 homolog</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">HBC189</alias>
                    <alias typeAc="MI:0301" type="gene name">PRDX3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">AOP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Thioredoxin-dependent peroxiredoxin 3</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P30048" version="SP_93" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007005" secondary="mitochondrion organization" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000298510" version="SP_236" refType="transcript"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_006784.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q0D2H1" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008379" secondary="thioredoxin peroxidase activity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045454" secondary="cell redox homeostasis" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2R7Z0" version="SP_109" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006979" secondary="response to oxidative stress" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0018171" secondary="peptidyl-cysteine oxidation" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E9PH29" version="SP_170" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" secondary="positive regulation of cell population proliferation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_236"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-748336" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019900" secondary="kinase binding" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033673" secondary="negative regulation of kinase activity" version="SP_236"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-33600N"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013766" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3299685" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005759" secondary="mitochondrial matrix" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036249" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000298510" version="SP_236" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019479" version="SP_236"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10975142" refType="intact-secondary"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008785" secondary="alkyl hydroperoxide reductase activity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008022" secondary="protein C-terminus binding" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JCG" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001289201.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P35690" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000866" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034599" secondary="cellular response to oxidative stress" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" secondary="positive regulation of NF-kappaB transcription factor activity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_236"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P30048" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UCX" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001893" secondary="maternal placenta development" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043027" secondary="cysteine-type endopeptidase inhibitor activity involved in apoptotic process" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000165672" version="SP_236" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032496" secondary="response to lipopolysaccharide" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034614" secondary="cellular response to reactive oxygen species" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13776" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5T5V2" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030099" secondary="myeloid cell differentiation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96HK4" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051881" secondary="regulation of mitochondrial membrane potential" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005769" secondary="early endosome" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042744" secondary="hydrogen peroxide catabolic process" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042542" secondary="response to hydrogen peroxide" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DRC9" version="SP_136" refType="secondary-ac" refTypeAc="MI:0360"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-24391-1" id="3278355">
                <names>
                    <shortLabel>prdx3-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-199020E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16155107" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24391-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3278353</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3278356">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16155111" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3278354</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
