<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2017-03-13Z">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
                <xref>
                    <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="2876164">
                <names>
                    <shortLabel>jelinek-2014-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="25285302" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641627" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-25661" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-fibroblast</shortLabel>
                            <fullName>Homo sapiens normal diploid fibroblasts (HDF0</fullName>
                        </names>
                        <tissue>
                            <names>
                                <shortLabel>fibroblast</shortLabel>
                                <fullName>Fibroblast</fullName>
                            </names>
                            <xref>
                                <primaryRef db="intact" dbAc="MI:0469" id="IA:0517" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-987478" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="mint" dbAc="MI:0471" id="MINT-6743481" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000452" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                            <attributeList>
                                <attribute name="definition">Resident cell of connective tissue, mesodermally derived</attribute>
                            </attributeList>
                        </tissue>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Jelinek D., Heidenreich RA., Orlando RA., Garver WS.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">wgarver@salud.unm.edu</attribute>
                    <attribute name="journal" nameAc="MI:0885">Journal of molecular biochemistry</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2014</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                </attributeList>
            </experimentDescription>
            <experimentDescription id="2876165">
                <names>
                    <shortLabel>jelinek-2014-2</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="25285302" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641646" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-25661" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-fibroblast</shortLabel>
                            <fullName>Homo sapiens normal diploid fibroblasts (HDF0</fullName>
                        </names>
                        <tissue>
                            <names>
                                <shortLabel>fibroblast</shortLabel>
                                <fullName>Fibroblast</fullName>
                            </names>
                            <xref>
                                <primaryRef db="intact" dbAc="MI:0469" id="IA:0517" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-987478" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="mint" dbAc="MI:0471" id="MINT-6743481" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000452" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                            <attributeList>
                                <attribute name="definition">Resident cell of connective tissue, mesodermally derived</attribute>
                            </attributeList>
                        </tissue>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>confocal microscopy</shortLabel>
                        <fullName>confocal microscopy</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0663" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-933927" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>immunocytochemistry</shortLabel>
                        <fullName>immunocytochemistry</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1200" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6349984" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Jelinek D., Heidenreich RA., Orlando RA., Garver WS.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">wgarver@salud.unm.edu</attribute>
                    <attribute name="journal" nameAc="MI:0885">Journal of molecular biochemistry</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2014</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="2876166">
                <names>
                    <shortLabel>cav1_human</shortLabel>
                    <fullName>Caveolin-1</fullName>
                    <alias typeAc="MI:0301" type="gene name">CAV1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CAV</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q03135" version="SP_86" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044325" secondary="transmembrane transporter binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901844" secondary="regulation of cell communication by electrical coupling involved in cardiac conduction" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046982" secondary="protein heterodimerization activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002931" secondary="response to ischemia" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000339191" version="SP_233" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098903" secondary="regulation of membrane repolarization during action potential" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030335" secondary="positive regulation of cell migration" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043407" secondary="negative regulation of MAP kinase activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010875" secondary="positive regulation of cholesterol efflux" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9009391" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006816" secondary="calcium ion transport" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005102" secondary="signaling receptor binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015031" secondary="protein transport" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006940" secondary="regulation of smooth muscle contraction" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-210991" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9696270" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003057" secondary="regulation of the force of heart contraction by chemical signal" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031410" secondary="cytoplasmic vesicle" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9035034" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070836" secondary="caveola assembly" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030193" secondary="regulation of blood coagulation" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-4641262" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030666" secondary="endocytic vesicle membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016323" secondary="basolateral plasma membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071560" secondary="cellular response to transforming growth factor beta stimulus" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032091" secondary="negative regulation of protein binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071360" secondary="cellular response to exogenous dsRNA" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031623" secondary="receptor internalization" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005901" secondary="caveola" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031397" secondary="negative regulation of protein ubiquitination" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070320" secondary="inward rectifier potassium channel inhibitor activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007595" secondary="lactation" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051001" secondary="negative regulation of nitric-oxide synthase activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903071" secondary="positive regulation of ER-associated ubiquitin-dependent protein catabolic process" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9696264" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013405" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000811" secondary="negative regulation of anoikis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006641" secondary="triglyceride metabolic process" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0052547" secondary="regulation of peptidase activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" secondary="Golgi apparatus" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043409" secondary="negative regulation of MAPK cascade" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032092" secondary="positive regulation of protein binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046426" secondary="negative regulation of receptor signaling pathway via JAK-STAT" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071455" secondary="cellular response to hyperoxia" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043085" secondary="positive regulation of catalytic activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019065" secondary="receptor-mediated endocytosis of virus by host cell" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000341049" version="SP_233" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005929" secondary="cilium" version="SP_233"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-5960N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903609" secondary="negative regulation of inward rectifier potassium channel activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034141" secondary="positive regulation of toll-like receptor 3 signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042532" secondary="negative regulation of tyrosine phosphorylation of STAT protein" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031267" secondary="small GTPase binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" secondary="positive regulation of peptidyl-serine phosphorylation" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048550" secondary="negative regulation of pinocytosis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" secondary="positive regulation of NF-kappaB transcription factor activity" version="SP_233"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001612" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9617828" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032570" secondary="response to progesterone" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002080" secondary="acrosomal membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_233"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q03135" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005783" secondary="endoplasmic reticulum" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-163560" version="SP_233"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UNG1" version="SP_86" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001744.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0086098" secondary="angiotensin-activated signaling pathway involved in heart process" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013149" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013407" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903598" secondary="positive regulation of gap junction assembly" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001238" secondary="positive regulation of extrinsic apoptotic signaling pathway" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013106" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042632" secondary="cholesterol homeostasis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051480" secondary="regulation of cytosolic calcium ion concentration" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015485" secondary="cholesterol binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050998" secondary="nitric-oxide synthase binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061099" secondary="negative regulation of protein tyrosine kinase activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006874" secondary="cellular calcium ion homeostasis" version="SP_233"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018361" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045907" secondary="positive regulation of vasoconstriction" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042310" secondary="vasoconstriction" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8980692" version="SP_233"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UGP1" version="SP_86" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900027" secondary="regulation of ruffle assembly" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032507" secondary="maintenance of protein location in cell" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013409" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-203615" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044860" secondary="protein localization to plasma membrane raft" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005938" secondary="cell cortex" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071375" secondary="cellular response to peptide hormone stimulus" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051899" secondary="membrane depolarization" version="SP_233"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015504" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000535" secondary="regulation of entry of bacterium into host cell" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" secondary="negative regulation of transcription by RNA polymerase II" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901380" secondary="negative regulation of potassium ion transmembrane transport" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038016" secondary="insulin receptor internalization" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903361" secondary="protein localization to basolateral plasma membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033137" secondary="negative regulation of peptidyl-serine phosphorylation" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045019" secondary="negative regulation of nitric oxide biosynthetic process" version="SP_233"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000105974" version="SP_233" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009267" secondary="cellular response to starvation" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013026" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005113" secondary="patched binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090090" secondary="negative regulation of canonical Wnt signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002095" secondary="caveolar macromolecular signaling complex" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013423" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030512" secondary="negative regulation of transforming growth factor beta receptor signaling pathway" version="SP_233"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UQH6" version="SP_86" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090263" secondary="positive regulation of canonical Wnt signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008104" secondary="protein localization" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-203641" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013148" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016050" secondary="vesicle organization" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013404" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0120162" secondary="positive regulation of cold-induced thermogenesis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033484" secondary="nitric oxide homeostasis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005768" secondary="endosome" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009617" secondary="response to bacterium" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007519" secondary="skeletal muscle tissue development" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005789" secondary="endoplasmic reticulum membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030301" secondary="cholesterol transport" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031295" secondary="T cell costimulation" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0086091" secondary="regulation of heart rate by cardiac conduction" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098911" secondary="regulation of ventricular cardiac muscle cell action potential" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000139" secondary="Golgi membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030879" secondary="mammary gland development" version="SP_233"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-603614" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060546" secondary="negative regulation of necroptotic process" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031901" secondary="early endosome membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001570" secondary="vasculogenesis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001960" secondary="negative regulation of cytokine-mediated signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031398" secondary="positive regulation of protein ubiquitination" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051592" secondary="response to calcium ion" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071711" secondary="basement membrane organization" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" secondary="perinuclear region of cytoplasm" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013406" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010608" secondary="posttranscriptional regulation of gene expression" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030514" secondary="negative regulation of BMP signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" secondary="cell differentiation" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043627" secondary="response to estrogen" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0055074" secondary="calcium ion homeostasis" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5218920" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000286" secondary="receptor internalization involved in canonical Wnt signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016324" secondary="apical plasma membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060056" secondary="mammary gland involution" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001244" secondary="positive regulation of intrinsic apoptotic signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016504" secondary="peptidase activator activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900085" secondary="negative regulation of peptidyl-tyrosine autophosphorylation" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001666" secondary="response to hypoxia" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" secondary="focal adhesion" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005811" secondary="lipid droplet" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060355" secondary="positive regulation of cell adhesion molecule production" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013408" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030674" secondary="protein-macromolecule adaptor activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098909" secondary="regulation of cardiac muscle cell action potential involved in regulation of contraction" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010524" secondary="positive regulation of calcium ion transport into cytosol" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051117" secondary="ATPase binding" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097190" secondary="apoptotic signaling pathway" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001937" secondary="negative regulation of endothelial cell proliferation" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060090" secondary="molecular adaptor activity" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019915" secondary="lipid storage" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0072584" secondary="caveolin-mediated endocytosis" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019217" secondary="regulation of fatty acid metabolic process" version="SP_233"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030857" secondary="negative regulation of epithelial cell differentiation" version="SP_233"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9696273" version="SP_233"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI</sequence>
            </interactor>
            <interactor id="2876167">
                <names>
                    <shortLabel>npc1_human</shortLabel>
                    <fullName>NPC intracellular cholesterol transporter 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">NPC1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Niemann-Pick C1 protein</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="O15118" version="SP_91" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6W5U" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060548" secondary="negative regulation of cell death" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042632" secondary="cholesterol homeostasis" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005783" secondary="endoplasmic reticulum" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046718" secondary="viral entry into host cell" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038023" secondary="signaling receptor activity" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" secondary="perinuclear region of cytoplasm" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6W5V" version="SP_203"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000269228" version="SP_203" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001618" secondary="virus receptor activity" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007041" secondary="lysosomal transport" version="SP_203"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9P130" version="SP_91" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3GKJ" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005764" secondary="lysosome" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3GKI" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008203" secondary="cholesterol metabolic process" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031902" secondary="late endosome membrane" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004888" secondary="transmembrane signaling receptor activity" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008206" secondary="bile acid metabolic process" version="SP_203"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2368710" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030301" secondary="cholesterol transport" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3JD8" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" secondary="Golgi apparatus" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HNS" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UOX" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6W5S" version="SP_203"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003392" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6W5T" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005635" secondary="nuclear envelope" version="SP_203"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4DET3" version="SP_141" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004765" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005765" secondary="lysosomal membrane" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010467" secondary="gene expression" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015485" secondary="cholesterol binding" version="SP_203"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000141458" version="SP_203" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015248" secondary="sterol transporter activity" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090150" secondary="establishment of protein localization to membrane" version="SP_203"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032190" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5F18" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6W5R" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5U73" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JNX" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3GKH" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032367" secondary="intracellular cholesterol transport" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_203"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000262.2"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8964038" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071404" secondary="cellular response to low-density lipoprotein particle stimulus" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KWY" version="SP_203"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000269228" version="SP_203" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007628" secondary="adult walking behavior" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905103" secondary="integral component of lysosomal membrane" version="SP_203"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-53217N"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5U74" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016242" secondary="negative regulation of macroautophagy" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006486" secondary="protein glycosylation" version="SP_203"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000731" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006914" secondary="autophagy" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031579" secondary="membrane raft organization" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046686" secondary="response to cadmium ion" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006897" secondary="endocytosis" version="SP_203"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5F1B" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071383" secondary="cellular response to steroid hormone stimulus" version="SP_203"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033344" secondary="cholesterol efflux" version="SP_203"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKSCATEERYKGTERERLLNF</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-25661-1" id="2876168">
                <names>
                    <shortLabel>npc1-cav1-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641635" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-25661-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>2876164</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="2876169">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641638" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>2876166</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="2876170">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641637" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>2876167</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">2</attribute>
                    <attribute name="antagonist" nameAc="MI:0626">human LDL</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-25661-2" id="2876171">
                <names>
                    <shortLabel>npc1-cav1-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641640" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-25661-2" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>2876164</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="2876172">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641644" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>2876166</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="2876173">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641643" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>2876167</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">2-1</attribute>
                    <attribute name="antagonist" nameAc="MI:0626">human LDL</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-25661-3" id="2876174">
                <names>
                    <shortLabel>w47ys54ry-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641684" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-25661-3" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>2876165</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="2876175">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641688" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>2876166</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="2876176">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-13641687" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>2876167</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>colocalization</shortLabel>
                        <fullName>colocalization</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">3</attribute>
                    <attribute name="antagonist" nameAc="MI:0626">human LDL</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
