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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3245197">
                <names>
                    <shortLabel>koehn-2012-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="23019356" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="wwpdb" dbAc="MI:0805" id="4GTA" refType="identity" refTypeAc="MI:0356"/>
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                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="4GTD" refType="identity" refTypeAc="MI:0356"/>
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                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="4GTB" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-251794X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-20713" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="562">
                        <names>
                            <shortLabel>ecolx</shortLabel>
                            <fullName>Escherichia coli</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Koehn EM., Perissinotti LL., Moghram S., Prabhakar A., Lesley SA., Mathews II., Kohen A.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-251794X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2012</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Folate binding site of flavin-dependent thymidylate synthase.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Koehn EM.,  Perissinotti LL.,  Moghram S.,  Prabhakar A.,  Lesley SA.,  Mathews II.,  Kohen A.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3245198">
                <names>
                    <shortLabel>thyx_thema</shortLabel>
                    <fullName>Flavin-dependent thymidylate synthase</fullName>
                    <alias typeAc="MI:0301" type="gene name">thyX</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">thy1</alias>
                    <alias typeAc="MI:0305" type="locus name">TM_0449</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">FAD-dependent thymidylate synthase</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Thymidylate synthase ThyX</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9WYT0" version="86" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004799" secondary="thymidylate synthase activity" version="SP_141"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003669" version="SP_141"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="WP_004081517.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GTE" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JFE" version="SP_141"/>
                    <secondaryRef db="ensemblbacteria" id="TM_0449" version="SP_141" refType="gene"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5IOQ" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1O27" version="SP_141"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GTF" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1O25" version="SP_141"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006231" secondary="dTMP biosynthetic process" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1O28" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1KQ4" version="SP_141"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-60076N"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5CHP" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3N0B" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1O2A" version="SP_141"/>
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                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036098" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1O24" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GTB" version="SP_141"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5IOT" version="SP_141"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4KAR" version="SP_141"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032259" secondary="methylation" version="SP_141"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5IOR" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GTD" version="SP_141"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050660" secondary="flavin adenine dinucleotide binding" version="SP_141"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="243274">
                    <names>
                        <shortLabel>thema</shortLabel>
                        <fullName>Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)</fullName>
                    </names>
                </organism>
                <sequence>MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-20713-1" id="3245199">
                <names>
                    <shortLabel>thyx-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-190365E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-20713-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16014573" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3245197</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3245200">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16014577" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3245198</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
