DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ barber-2012-1 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250691X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions imex curation barber-2012-2 in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250696X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions imex curation barber-2012-3 in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250694X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions imex curation barber-2012-4 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250692X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions imex curation barber-2012-5 in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250697X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions imex curation barber-2012-6 in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250695X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions imex curation barber-2012-7 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250693X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions imex curation elk4_human ETS domain-containing protein Elk-4 ELK4 SAP1 Serum response factor accessory protein 1 protein protein human Homo sapiens Human MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQTPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT sir7_human NAD-dependent protein deacetylase sirtuin-7 NAD-dependent protein deacylase sirtuin-7 SIR2-like protein 7 SIRT7 SIR2L7 Regulatory protein SIR2 homolog 7 protein protein human Homo sapiens Human MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRGCTKRTKRKKVT h2b-2 Histone 2B peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) PEPAKSAPAPKKGSKKAVTKAQK sir1_human NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacylase sirtuin-1 SIRT1 SIR2L1 SIR2-like protein 1 Regulatory protein SIR2 homolog 1 protein protein human Homo sapiens Human MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS h3k9ac H3K9Ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ARTKQTARKSTGGKAPRKQLAK h4-2 Histone 4 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) SGRGKGGKGLGKGGAKRHRKVLR elk4-sirt7-1 3241503 N/A 3241510 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3241511 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false h2b-sirt1-1 3241504 N/A 3241512 enzyme target enzyme target substrate substrate unspecified role unspecified role K12Ac K12Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false K15Ac K15Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false K20Ac K20Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3241513 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper deacetylation deacetylation reaction deacetylation false false false h3-sirt7-1 3241505 N/A 3241514 enzyme target enzyme target substrate substrate unspecified role unspecified role K18Ac K18Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3241511 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper deacetylation deacetylation reaction deacetylation false false false elk4-sirt7-2 3241506 N/A 3241510 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3241511 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false h4-sirt1-1 3241507 N/A 3241515 enzyme target enzyme target substrate substrate unspecified role unspecified role K5Ac K5Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false K8Ac K8Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false K12Ac K12Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3241513 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper deacetylation deacetylation reaction deacetylation false false false h3-sirt1-1 3241508 N/A 3241513 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper N/A 3241514 enzyme target enzyme target substrate substrate unspecified role unspecified role K18Ac K18Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false K9Ac K9Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false in vitro In vitro deacetylation deacetylation reaction deacetylation false false false sirt7-elk4-1 3241509 N/A 3241510 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3241511 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false