DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ zheng-2012-6 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250595X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-7 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250598X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-8 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250600X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-9 human Homo sapiens Human pull down pull down anti tag western anti tag western blot anti tag western Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250603X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-10 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250596X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-11 human Homo sapiens Human pull down pull down anti tag western anti tag western blot anti tag western Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250605X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-12 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250602X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-13 human Homo sapiens Human pull down pull down anti tag western anti tag western blot anti tag western Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250597X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-14 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250601X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-15 human Homo sapiens Human pull down pull down anti tag western anti tag western blot anti tag western Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250604X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation zheng-2012-16 human Homo sapiens Human pull down pull down western blot western blot Immuno blot Immuno blot Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. DIP original experiment: DIP-250599X Nature 2012 IMEx Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Zheng J., Umikawa M., Cui C., Li J., Chen X., Zhang C., Huynh H., Kang X., Silvany R., Wan X., Ye J., Cantó AP., Chen SH., Wang HY., Ward ES., Zhang CC. Only protein-protein interactions imex curation ptn6_mouse Tyrosine-protein phosphatase non-receptor type 6 Ptpn6 Hcp Hcph Ptp1C Protein-tyrosine phosphatase 1C Hematopoietic cell protein-tyrosine phosphatase 70Z-SHP SH-PTP1 PTPTY-42 protein protein mouse Mus musculus Mouse MVRWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHISGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNSREHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQKGQESEYGNITYPPAVRSAHAKASRTSSKHKEEVYENVHSKSKKEEKVKKQRSADKEKNKGSLKRK lirb3_mouse Leukocyte immunoglobulin-like receptor subfamily B member 3 Lilrb3 Pirb Cell-surface glycoprotein p91 Paired immunoglobulin-like receptor B protein protein mouse Mus musculus Mouse MSCTFTALLRLGLTLSLWIPVLTGSLPKPILRVQPDSVVSRRTKVTFLCEETIGANEYRLYKDGKLYKTVTKNKQKPENKAEFSFSNVDLSNAGQYRCSYSTQYKSSGYSDLLELVVTGHYWTPSLLAQASPVVTSGGYVTLQCESWHNDHKFILTVEGPQKLSWTQDSQYNYSTRKYHALFSVGPVTPNQRWICRCYSYDRNRPYVWSPPSESVELLVSGNLQKPTIKAEPGSVITSKRAMTIWCQGNLDAEVYFLHNEKSQKTQSTQTLQEPGNKGKFFIPSVTLQHAGQYRCYCYGSAGWSQPSDTLELVVTGIYEYYEPRLSVLPSPVVTAGGNMTLHCASDFPYDKFILTKEDKKFGNSLDTEHISSSGQYRALFIIGPTTPTHTGAFRCYGYYKNAPQLWSVPSALQQILISGLSKKPSLLTHQGHILDPGMTLTLQCFSDINYDRFALHKVGGADIMQHSSQQTDTGFSVANFTLGYVSSSTGGQYRCYGAHNLSSEWSASSEPLDILITGQLPLTPSLSVQPNHTVHSGETVSLLCWSMDSVDTFILSKEGSAQQPLRLKSKSHDQQSQAEFSMSAVTSHLSGTYRCYGAQDSSFYLLSSASAPVELTVSGPIETSTPPPTMSMPLGGLHMYLKALIGVSVAFILFLFIFIFILLRRRHRGKFRKDVQKEKDLQLSSGAEEPITRKGELQKRPNPAAATQEESLYASVEDMQTEDGVELNSWTPPEEDPQGETYAQVKPSRLRKAGHVSPSVMSREQLNTEYEQAEEGQGANNQAAESGESQDVTYAQLCSRTLRQGAAASPLSQAGEAPEEPSVYATLAAARPEAVPKDMEQ lirb2_human Leukocyte immunoglobulin-like receptor subfamily B member 2 LILRB2 ILT4 LIR2 MIR10 CD85 antigen-like family member D Immunoglobulin-like transcript 4 Monocyte/macrophage immunoglobulin-like receptor 10 protein protein human Homo sapiens Human MTPIVTVLICLGLSLGPRTHVQTGTIPKPTLWAEPDSVITQGSPVTLSCQGSLEAQEYRLYREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQYYSRARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGEEEHPQCLNSQPHARGSSRAIFSVGPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLVPGVSKKPSLSVQPGPVVAPGESLTLQCVSDVGYDRFVLYKEGERDLRQLPGRQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSECSAPSDPLDILITGQIRGTPFISVQPGPTVASGENVTLLCQSWRQFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHAGTYRCYGSLNSDPYLLSHPSEPLELVVSGPSMGSSPPPTGPISTPAGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVVLLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKDTQPEDGVEMDTRAAASEAPQDVTYAQLHSLTLRRKATEPPPSQEREPPAEPSIYATLAIH angl5_human Angiopoietin-related protein 5 ANGPTL5 UNQ5795/PRO19600 Angiopoietin-like protein 5 protein protein human Homo sapiens Human MMSPSQASLLFLNVCIFICGEAVQGNCVHHSTDSSVVNIVEDGSNAKDESKSNDTVCKEDCEESCDVKTKITREEKHFMCRNLQNSIVSYTRSTKKLLRNMMDEQQASLDYLSNQVNELMNRVLLLTTEVFRKQLDPFPHRPVQSHGLDCTDIKDTIGSVTKTPSGLYIIHPEGSSYPFEVMCDMDYRGGGRTVIQKRIDGIIDFQRLWCDYLDGFGDLLGEFWLGLKKIFYIVNQKNTSFMLYVALESEDDTLAYASYDNFWLEDETRFFKMHLGRYSGNAGDAFRGLKKEDNQNAMPFSTSDVDNDGCRPACLVNGQSVKSCSHLHNKTGWWFNECGLANLNGIHHFSGKLLATGIQWGTWTKNNSPVKIKSVSMKIRRMYNPYFK angl2_human Angiopoietin-related protein 2 ANGPTL2 ARP2 UNQ170/PRO196 Angiopoietin-like protein 2 protein protein human Homo sapiens Human MRPLCVTCWWLGLLAAMGAVAGQEDGFEGTEEGSPREFIYLNRYKRAGESQDKCTYTFIVPQQRVTGAICVNSKEPEVLLENRVHKQELELLNNELLKQKRQIETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKDLEHKYQHLATLAHNQSEIIAQLEEHCQRVPSARPVPQPPPAAPPRVYQPPTYNRIINQISTNEIQSDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWRDCLQALEDGHDTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH ptn11_mouse Tyrosine-protein phosphatase non-receptor type 11 Ptpn11 Protein-tyrosine phosphatase SYP SH-PTP2 protein protein mouse Mus musculus Mouse MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLVDQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQRSFR lilrb3-ptpn6-5 3240939 N/A 3240950 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3240951 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association false false false lilrb2-angptl5-1 3240940 N/A 3240952 unspecified role unspecified role bait bait Extracellular domain Region 22-461 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3240953 unspecified role unspecified role prey prey GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false in vitro In vitro direct interaction direct interaction false false false lilrb2-angptl5-2 3240941 N/A 3240952 unspecified role unspecified role bait bait Extracellular domain Region 22-461 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3240953 unspecified role unspecified role prey prey GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false in vitro In vitro direct interaction direct interaction false false false lilrb2-angptl2-1 3240942 N/A 3240954 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3240952 unspecified role unspecified role bait bait Extracellular domain Region 22-461 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human physical association physical association false false false ptpn11-lilrb3-1 3240943 N/A 3240955 unspecified role unspecified role bait bait mouse Mus musculus Mouse N/A 3240951 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association false false false lilrb3-angptl2-1 3240944 N/A 3240954 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3240951 unspecified role unspecified role bait bait Extracellular domain Region 25-642 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human physical association physical association false false false lilrb2-angptl2-4 3240945 N/A 3240954 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false ecolx Escherichia coli N/A 3240952 unspecified role unspecified role bait bait Extracellular domain Region 22-461 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human direct interaction direct interaction false false false lilrb3-angptl5-1 3240946 N/A 3240951 unspecified role unspecified role bait bait Extracellular domain Region 25-642 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3240953 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false lilrb2-angptl5-3 3240947 N/A 3240952 unspecified role unspecified role bait bait Extracellular domain Region 22-461 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3240953 unspecified role unspecified role prey prey GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false in vitro In vitro direct interaction direct interaction false false false lilrb2-angptl5-4 3240948 N/A 3240952 unspecified role unspecified role bait bait Extracellular domain Region 22-461 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3240953 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false lilrb2-angptl2-5 3240949 N/A 3240954 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3240952 unspecified role unspecified role bait bait Extracellular domain Region 22-461 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human physical association physical association false false false