UniProt UniProt http://www.uniprot.org chen-2011-3 mouse-embryo Mus musculus embryo embryo Embryo Defined as the development stage prior to the initiation of tissue differentiation. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Chen L., Fulcoli FG., Ferrentino R., Martucciello S., Illingworth EA., Baldini A. Origin of transfected Tbx1 according Ref 30 (PMID 19557177). Experiments using GST-Tbx1 omitted as Tbx1 species origin cannot be established antonio.baldini@igb.cnr.it PLoS genetics 2011 imex curation Only protein-protein interactions chen-2011-4 mouse-p19 Mus musculus embryonic teratocarcinoma cell line, epithelial-like, induced by retinoic acid p19 mouse embryonic teratocarcinoma cellline affinity chrom affinity chromatography technology Affinity purification Affinity purification affinity chrom western blot western blot Immuno blot Immuno blot Chen L., Fulcoli FG., Ferrentino R., Martucciello S., Illingworth EA., Baldini A. Origin of transfected Tbx1 according Ref 30 (PMID 19557177). Experiments using GST-Tbx1 omitted as Tbx1 species origin cannot be established antonio.baldini@igb.cnr.it PLoS genetics 2011 imex curation Only protein-protein interactions chen-2011-5 mouse-p19cl6 mouse-P19Cl6--P19 subline which differentiates into beating cardiomyocytes Mouse p19cl6 P19Cl6--P19 subline which differentiates into beating cardiomyocytes anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Chen L., Fulcoli FG., Ferrentino R., Martucciello S., Illingworth EA., Baldini A. Origin of transfected Tbx1 according Ref 30 (PMID 19557177). Experiments using GST-Tbx1 omitted as Tbx1 species origin cannot be established antonio.baldini@igb.cnr.it PLoS genetics 2011 imex curation Only protein-protein interactions smrd1_mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Smarcd1 Baf60a D15Kz1 SWI/SNF complex 60 kDa subunit 60 kDa BRG-1/Brm-associated factor subunit A BRG1-associated factor 60A Protein D15KZ1 protein protein mouse Mus musculus Mouse MAARAGFQSVAPSGGAGASGGAGVAAALGPGGTPGPPVRMGPAPGQGLYRSPMPGAAYPRPGMLPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAEDGEGTVASWELRVEGRLLEDAALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVLCDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT tbx1_mouse T-box transcription factor TBX1 Testis-specific T-box protein Tbx1 protein protein mouse Mus musculus Mouse MHFSTVTRDMEAFAASSLSGLGSPSPGADPFGPREPPPPRYDPCAAVPGAPGPPPPRAYPFAPAPGAAGSSAAESEGPGASRAAAVKAPVKKNPKVASVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGQIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLVSAFARSRNPVASPTQPNGSDKDAAEARREFDRDSGPAALGDATHPPQLLARVLSPALPGPGGLVPLPGGSGGRHSPPHADLRLEAPGASEPLHHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHGYHPHAHPHAHPHHHHHPAVNPAAAAAAAAAANVYSSAAAPPGAYDYCPR setd7_mouse Histone-lysine N-methyltransferase SETD7 Setd7 Set7 Kiaa1717 Set9 Histone H3-K4 methyltransferase SETD7 SET domain-containing protein 7 SET7/9 protein protein mouse Mus musculus Mouse MDSDDEVVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDSDGRLIFKGQYKDNNRHGVCWIHYPDGGSLVGEVNEDGEMTGEKIAYVYPDQRTALYGKFIDGEMLEGKLATLMATEEGRPHFEVTSGSSVYHFDKSTSSCISSDALLPDPYESERVYVADSLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCVYDLFVHPRFGPIKCIRTLRAVEAEEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro mint smarcd1-tbx1-1 2876069 N/A 2876072 unspecified role unspecified role bait bait N/A 2876073 unspecified role unspecified role prey prey physical association physical association false false false 9 smarcd1-tbx1-2 2876070 N/A 2876072 unspecified role unspecified role prey prey N/A 2876073 unspecified role unspecified role bait bait region protein a tag protein a tag protein A protein A undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 8A tbx1-setd7-1 2876071 N/A 2876074 unspecified role unspecified role prey prey N/A 2876072 unspecified role unspecified role prey prey N/A 2876073 unspecified role unspecified role bait bait association association false false false 8B