DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ zhang-2012-14 yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254556X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-15 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254573X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-16 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254564X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-17 yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254557X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-18 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254581X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-19 yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254572X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-20 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254565X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-21 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254558X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-22 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254575X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-23 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254566X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-24 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254559X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-25 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254568X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-26 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254574X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-27 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254567X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-28 in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254560X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-29 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254569X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-30 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254577X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-31 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254561X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-32 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254576X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-33 in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254562X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-34 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254579X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-35 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254563X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-36 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as predetermined predetermined participant predetermined Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254580X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-37 in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254570X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-38 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254578X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation zhang-2012-39 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. DIP original experiment: DIP-254571X Nature 2012 IMEx Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Zhang L., Ding X., Cui J., Xu H., Chen J., Gong YN., Hu L., Zhou Y., Ge J., Lu Q., Liu L., Chen S., Shao F. Only protein-protein interactions imex curation tab1_human TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAB1 MAP3K7IP1 TGF-beta-activated kinase 1-binding protein 1 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 protein protein human Homo sapiens Human MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGAHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVVTAP m3k7_human Mitogen-activated protein kinase kinase kinase 7 MAP3K7 TAK1 Transforming growth factor-beta-activated kinase 1 protein protein human Homo sapiens Human MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS rnf31_human E3 ubiquitin-protein ligase RNF31 Zinc in-between-RING-finger ubiquitin-associated domain protein RNF31 ZIBRA HOIL-1-interacting protein RING finger protein 31 RING-type E3 ubiquitin transferase RNF31 protein protein human Homo sapiens Human MPGEEEERAFLVAREELASALRRDSGQAFSLEQLRPLLASSLPLAARYLQLDAARLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRGVKFNNPVFRSTVDAVQGGRDVLRLYGYTEEQPDGLSFPEGQEEPDEHQVATVTLEVLLLRTELSLLLQNTHPRQQALEQLLEDKVEDDMLQLSEFDPLLREIAPGPLTTPSVPGSTPGPCFLCGSAPGTLHCPSCKQALCPACDHLFHGHPSRAHHLRQTLPGVLQGTHLSPSLPASAQPRPQSTSLLALGDSSLSSPNPASAHLPWHCAACAMLNEPWAVLCVACDRPRGCKGLGLGTEGPQGTGGLEPDLARGRWACQSCTFENEAAAVLCSICERPRLAQPPSLVVDSRDAGICLQPLQQGDALLASAQSQVWYCIHCTFCNSSPGWVCVMCNRTSSPIPAQHAPRPYASSLEKGPPKPGPPRRLSAPLPSSCGDPEKQRQDKMREEGLQLVSMIREGEAAGACPEEIFSALQYSGTEVPLQWLRSELPYVLEMVAELAGQQDPGLGAFSCQEARRAWLDRHGNLDEAVEECVRTRRRKVQELQSLGFGPEEGSLQALFQHGGDVSRALTELQRQRLEPFRQRLWDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAELALSLLQETPRNYELGDVVEAVRHSQDRAFLRRLLAQECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHITDMVCPACGRPDLTDDTQLLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAGARAVPGGGCRVIEQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRRRK ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG tab2_human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 KIAA0733 MAP3K7IP2 TAK1-binding protein 2 Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 TGF-beta-activated kinase 1-binding protein 2 protein protein human Homo sapiens Human MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF q8n5c8-1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TAB3 MAP3K7IP3 Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 NF-kappa-B-activating protein 1 TAK1-binding protein 3 TGF-beta-activated kinase 1-binding protein 3 Tab3a protein protein human Homo sapiens Human MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPDDNRMNRNRLLHINLGIHSPSSYHPGDGAQLNGGRTLVHSSSDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIYIRQTSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQQGPPSYQKQGSHSVAYLPYTASSLSKGSMKKIEITVEPSQRPGTAINRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCTPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQSRGNFDPKAMNNFYDNIEPGPVVPPKPSKKDSSDPCTIERKARRISVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT nlee_eco27 Cysteine S-methyltransferase NleE E2348C_3232 nleE Effector protein NleE Non-LEE-encoded type III effector E protein protein eco27 Escherichia coli O127:H6 (strain E2348/69 / EPEC) MINPVTNTQGVSPINTKYAEHVVKNIYPKIKHDYFNESPNIYDKKYISGITRGVAELKQEEFVNEKARRFSYMKTMYSVCPEAFEPISRNEASTPEGSWLTVISGKRPMGQFSVDSLYNPDLHALCELPDICCKIFPKENNDFLYIVVVYRNDSPLGEQRANRFIELYNIKRDIMQELNYELPELKAVKSEMIIAREMGEIFSYMPGEIDSYMKYINNKLSKIE shrpn_human Sharpin SHARPIN SIPL1 Shank-associated RH domain-interacting protein Shank-interacting protein-like 1 PSEC0216 protein protein human Homo sapiens Human MAPPAGGAAAAASDLGSAAVLLAVHAAVRPLGAGPDAEAQLRRLQLSADPERPGRFRLELLGAGPGAVNLEWPLESVSYTIRGPTQHELQPPPGGPGTLSLHFLNPQEAQRWAVLVRGATVEGQNGSKSNSPPALGPEACPVSLPSPPEASTLKGPPPEADLPRSPGNLTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHVALQVHPHCTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGPQPAASSLPSPLQPSWSCPSCTFINAPDRPGCEMCSTQRPCTWDPLAAAST hoil1_human RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 C20orf18 RNF54 UBCE7IP3 XAP3 XAP4 Ubiquitin-conjugating enzyme 7-interacting protein 3 Hepatitis B virus X-associated protein 4 HBV-associated factor 4 RING finger protein 54 Heme-oxidized IRP2 ubiquitin ligase 1 RING-type E3 ubiquitin transferase HOIL-1 protein protein human Homo sapiens Human MDEKTKKAEEMALSLTRAVAGGDEQVAMKCAIWLAEQRVPLSVQLKPEVSPTQDIRLWVSVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLSARNTSLNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPEAYQVPASYQPDEEERARLAGEEEALRQYQQRKQQQQEGNYLQHVQLDQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCSGKLLEREIKALLTPEDYQRFLDLGISIAENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLLCKAIHEQMNCKEYQEDLALRAQNDVAARQTTEMLKVMLQQGEAMRCPQCQIVVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH vps36_yeast Vacuolar protein-sorting-associated protein 36 VPS36 GRD12 VAC3 VPL11 YLR417W ESCRT-II complex subunit VPS36 protein protein yeast Saccharomyces cerevisiae Baker's yeast MEYWHYVETTSSGQPLLREGEKDIFIDQSVGLYHGKSKILQRQRGRIFLTSQRIIYIDDAKPTQNSLGLELDDLAYVNYSSGFLTRSPRLILFFKDPSSKDELGKSAETASADVVSTWVCPICMVSNETQGEFTKDTLPTPICINCGVPADYELTKSSINCSNAIDPNANPQNQFGVNSENICPACTFANHPQIGNCEICGHRLPNASKVRSKLNRLNFHDSRVHIELEKNSLARNKSSHSALSSSSSTGSSTEFVQLSFRKSDGVLFSQATERALENILTEKNKHIFNQNVVSVNGVDMRKGASSHEYNNEVPFIETKLSRIGISSLEKSRENQLLNNDILFNNALTDLNKLMSLATSIERLYKNSNITMKTKTLNLQDESTVNEPKTRRPLLILDREKFLNKELFLDEIAREIYEFTLSEFKDLNSDTNYMIITLVDLYAMYNKSMRIGTGLISPMEMREACERFEHLGLNELKLVKVNKRILCVTSEKFDVVKEKLVDLIGDNPGSDLLRLTQILSSNNSKSNWTLGILMEVLQNCVDEGDLLIDKQLSGIYYYKNSYWPSHI 60DDD4EA3A620409 map3k7-tab1-2 3233790 N/A 3233816 unspecified role unspecified role prey prey yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast N/A 3233817 unspecified role unspecified role bait bait yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast physical association physical association false false false rnf31-ub-3 3233791 N/A 3233818 unspecified role unspecified role bait bait NZF1 domain Region 350-379 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli N/A 3233819 unspecified role unspecified role prey prey direct interaction direct interaction false false false map3k7-tab1-3 3233792 N/A 3233820 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3233816 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3233817 unspecified role unspecified role bait bait human Homo sapiens Human association association false false false b7ui22_eco27-tab3-1 3233793 n/a 3233821 unspecified role unspecified role prey prey Region 1-683 Region 1-683 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast N/A 3233822 unspecified role unspecified role bait bait yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast physical association physical association false false false b7ui22_eco27-tab2-1 3233794 N/A 3233820 enzyme target enzyme target substrate substrate unspecified role unspecified role NZF domain Region 665-693 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false metC673 metC673 mecys methylated cysteine MeCys modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3233822 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli methylation methylation reaction methylation false false false rnf31-sharpin-8 3233795 N/A 3233823 unspecified role unspecified role prey prey yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast N/A 3233818 unspecified role unspecified role bait bait yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast physical association physical association false false false b7ui22_eco27-tab3-2 3233796 N/A 3233821 enzyme target enzyme target substrate substrate unspecified role unspecified role NZF domain Region 684-712 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3233822 enzyme enzyme unspecified role unspecified role region Δ209-214 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli methylation methylation reaction methylation false false false tab3-b7ui22_eco27-1 3233797 N/A 3233821 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human N/A 3233822 unspecified role unspecified role prey prey GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false rbck1-ub-3 3233798 N/A 3233824 unspecified role unspecified role bait bait NZF domain Region 193-222 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli N/A 3233819 unspecified role unspecified role prey prey direct interaction direct interaction false false false b7ui22_eco27-tab2-2 3233799 N/A 3233820 enzyme target enzyme target substrate substrate unspecified role unspecified role NZF domain Region 665-693 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3233822 enzyme enzyme unspecified role unspecified role region Δ209-214 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli methylation methylation reaction methylation false false false tab2-b7ui22_eco27-1 3233800 N/A 3233820 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3233822 unspecified role unspecified role prey prey GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false b7ui22_eco27-tab2-3 3233801 N/A 3233820 enzyme target enzyme target substrate substrate unspecified role unspecified role human Homo sapiens Human N/A 3233822 enzyme enzyme unspecified role unspecified role region Δ209-214 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli methylation methylation reaction methylation false false false sharpin-ub-3 3233802 N/A 3233823 unspecified role unspecified role bait bait NZF domain Region 340-387 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli N/A 3233819 unspecified role unspecified role prey prey direct interaction direct interaction false false false b7ui22_eco27-tab3-3 3233803 N/A 3233821 enzyme target enzyme target substrate substrate unspecified role unspecified role human Homo sapiens Human N/A 3233822 enzyme enzyme unspecified role unspecified role region Δ209-214 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli methylation methylation reaction methylation false false false ub-tab3-1 3233804 N/A 3233819 unspecified role unspecified role bait bait SBP-tag SBP-tag sbp sbp n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal false N/A 3233821 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human physical association physical association false false false b7ui22_eco27-tab3-4 3233805 N/A 3233821 enzyme target enzyme target substrate substrate unspecified role unspecified role NZF domain Region 684-712 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q8N5C8-1:p.Cys706Ser C706S mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q8N5C8-1:p.Cys703Ser C703S mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q8N5C8-1:p.Cys689Ser C689S mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q8N5C8-1:p.Cys692Met C692M/L mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q8N5C8-1:p.Cys692Leu mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3233822 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli methylation methylation reaction methylation false false false ub-sharpin-3 3233806 N/A 3233823 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3233819 unspecified role unspecified role bait bait physical association physical association false false false ub-tab2-1 3233807 N/A 3233820 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3233819 unspecified role unspecified role bait bait SBP-tag SBP-tag sbp sbp n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal false physical association physical association false false false ub-rnf31-2 3233808 N/A 3233818 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3233819 unspecified role unspecified role bait bait physical association physical association false false false tab3-ub-1 3233809 N/A 3233819 unspecified role unspecified role prey prey N/A 3233821 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false NZF domain Region 684-712 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q8N5C8-1:p.Cys692Met C692M/L mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q8N5C8-1:p.Cys692Leu mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false b7ui22_eco27-vps36-1 3233810 N/A 3233825 enzyme target enzyme target substrate substrate unspecified role unspecified role NZF domain Region 178-206 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3233822 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli methylation methylation reaction methylation false false false tab2-ub-1 3233811 N/A 3233820 unspecified role unspecified role bait bait Q9NYJ8:p.Cys673Leu mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false NZF domain Region 665-693 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q9NYJ8:p.Cys673Met C673M/L mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3233819 unspecified role unspecified role prey prey direct interaction direct interaction false false false b7ui22_eco27-tab3-5 3233812 N/A 3233821 enzyme target enzyme target substrate substrate unspecified role unspecified role NZF domain Region 684-712 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false metC692 metC692 mecys methylated cysteine MeCys modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3233822 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli methylation methylation reaction methylation false false false b7ui22_eco27-tab2-4 3233813 N/A 3233820 enzyme target enzyme target substrate substrate unspecified role unspecified role Q9NYJ8:p.Cys673Leu mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate certain certain sequence position certain certain certain sequence position certain false NZF domain Region 665-693 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q9NYJ8:p.Cys673Met C673M/L mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9NYJ8:p.Cys687Ser C687S mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9NYJ8:p.Cys684Ser C684S mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9NYJ8:p.Cys670Ser C670S mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3233822 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli methylation methylation reaction methylation false false false ub-rbck1-3 3233814 N/A 3233824 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3233819 unspecified role unspecified role bait bait physical association physical association false false false tab3-b7ui22_eco27-2 3233815 n/a 3233821 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Region1-683 Region1-683 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3233822 unspecified role unspecified role prey prey EGFP-tag EGFP-tag egfp tag enhanced green fluorescent protein tag enhanced green fluorescent protein EGFP enhanced green fluorescent protein EGFP egfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false