DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ zheng-2010-8 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Zheng J., Taylor CA., Piasecki SK., Keatinge-Clay AT. DIP original experiment: DIP-217133X Structure (London, England : 1993) 2010 IMEx Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase. Zheng J., Taylor CA., Piasecki SK., Keatinge-Clay AT. Only protein-protein interactions imex curation zheng-2010-9 ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Zheng J., Taylor CA., Piasecki SK., Keatinge-Clay AT. DIP original experiment: DIP-217134X Structure (London, England : 1993) 2010 IMEx Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase. Zheng J., Taylor CA., Piasecki SK., Keatinge-Clay AT. Only protein-protein interactions imex curation q93nw7_9actn amphB protein protein streptomyces nodosus Streptomyces nodosus MPEPQQNQQEKVVDYLRRVTNDLRRARRRIGELESRDNEPVAIVGMSCRLPGGVSSPESLWELVESGGDAISGFPADRGWDIEALTGKGEGSSSTHEGGFLYEATDFDAGFFGISPREATAMDPQQRLLLEVSWEALERAGIAPTSLRSSATGVFVGSYHWGAPSADTATELHGHALTGTAASVLSGRLSYVYGLEGPAVTVDTACSSSLVALHMAAQSLRNGESSLALVGGVTILAEPSVFVEFSAQGGLAQDGRCKAFSDSADGTGWSEGAAVLVVERLSDARRAGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANAGLRPGDVDAVEAHGTGTPLGDPIEAQALIATYGSDRDPQQPLLLGSVKSNIGHTQSAAGVAGLVKMVMAMHNGTLPRTLHLTEPSTHVDWSLGAVRLLTEETAWPETGRVRRAAVSSFGISGTNAHAVLEQAPVPAEDAEDAGTEDAPQQPATVPGALPWLLSAHSGQALCDQAAALVTRLDADPEPRPQDIGQGLLTSRALLERRAVVVGTGRDELLTGSRALAEGQSWNGLAEGTADVDGRTVFVFPGQGSQWVGMGARLLDESPVFAERIAECAAALAEFTDWDLLDVLRGAEGAPTLERVDVVQPASFAVMVSLAAVWRAQGVEPDAVVGHSQGEIAAAVVSGALSLRDGARVVALRSQAIGRTLAGRGGMMSVALPVADVEARLEAFGGRVSVAAENGPRSCVVSGEPGALDELSELLTAEGVRVRRVPVDYASHSHHVEDLHDEILQLLAEVAPKASEVPLFSTVTGDWLDTTVMDAGYWFRSLRGRVLFADAIRGLLDTEHRAFIEVSSHPVLAMSVQDMIDDAGVVGVASGTLRRDNGGLDRFLLSAAQVFVRGVQVDWAPLFEGTGATRVDLPTYAFQHERYWNDRAVVDRSASAPMDAEFWAAVEQADVSALTEALGTDEESVAAILPGLASWRRTRGERSTVDSWRYRVVWEPLAQIPRATLDGTWLLVSAGGVDDDVAEVLEAGGAEVRRLVLDETCTDPAVLREHLTDTDGLTGIVSVLADAEEGCVRHPGLTLGLALSVSLAQALGEADVTAPLWFLTCGAFSTGPSDTVTRPLQSQIAGLGWTVAVEHPHRWGGGVDLPEALDARAAQRLVAALAGALGDDDQLAVRPAGVLARRIVRASGDTRRKARSWKPRGTTLVTGGSGTLAPGLARHLAAQGAEHLVLLSRRGADAPGAAELAAELQAAGTEVRFAACDITDPDAVAALLADLKAEGRTVRTVVHTAAVIELAALADTTVDAFADVVHAKVTGARILDELLDDEELDDFVLYSSTAGMWGSGVHAAYVAGNAYLSALAEQRRARGARATSIHWGKWPDDLERELADPHQIRRSGLEYLDPELAMTALTRVMEDDETVIGLMDIDWGTYHDVFTAGRPSHLFDRIPEVARLLADRAAPAATAVATSGLAARLQGVSAAEQDRIVLSVVREETAAVLGHASAETVPERRAFRDIGFDSVTAVDLRNRLVAATGLTLPSTMVFDHPNAVALATFLKATALGTTGTAGDRPTAAVTAGADDDLIVIVGMSCRFPGGANTPEELLRLALDGADVISEFPADRGWDAHGLYDPDPDRQGRTYSVHGGFLHEAAGFDAGFFGISPREALAMDPQQRLLLETSWEVLERAGIDPESLHSTATGAFFGASYQDYSSSVQNGTEGAEVHMMTGTAASVLSGRISYLLGLEGPAVTVDTACSSSLVAMHLACQSLRSGESSLALAGGAAVMATPHAFIGFSRQRALAENGRCKPFAEGADGMTLAEGVGVVLLEKLSDARRNGHRVLAVVRGSALNQDGASNGLTAPNGLSQQRVIRQALANAGLGTADIDVVEAHGTGTKLGDPIEAGALLATYGQGRDGGQPLLLGSVKSNIGHTQAAAGVAGVIKMVMAMHAGELPGTLHIDEPSSHVDWTSGAVTLLRERTEWPAVGDRPRRAGISSFGISGTNAHLLLEQAPPAEEPAEEPAGDIEGAPLVPWLLSARSAQALREQASRLLTATTGTDVTVEPARVGHALATTRTAFDHRAVVLGSRPEDFTRGLEAVVSSASAPGVVTGTAGPDSTGPVFVYPGQGSQWWGMGRELLAGSEVFRTAVDDCAAALAPYTDWSLHEVLAGEGDPELLERVDVVQPALFSMMVALTALWRSHGVEPAAVVGHSQGEIAAAHVAGALSLEDAALVVALRSQALPQLSGLGGMMSVSAPAARVTELLQPWGEALSIAAVNGPSSVIVSGDADALDELLETCREQNVRARKVSVDYASHGRHVEAVRDELARVLAPVSPRTPEVPFYSTVTGARLDEAAFDGTYWYTNLRQTVLMEDATRALIASGHRVFVEISPHPVLAAPIQETQESVQEELTETGAVLGTLRRDDGDRRRFLTSLAEAHTHGIAVDWTTAFDRPAYAAVDLPTYPFQRQDFWPEPKTAAPAGTADASDAAFWELVQNQDLDALAGELGIPADDGAARLGDVLPALSAWRTRSLTRSRADALRYHIEWNRVAEPGTARPAGRLLAVISPDHAGAPWVTAVLDALGPDTVRFEAKGTDRAAWAAQLAQLREDEGEFHAVVSLLAAAEALHTDHGSVPLGLAQTLLLAQALGDAGLTAPLWCLTRGGVAAGRGDVLSSPVQGALWGLGRVIGLEHPDRWGGLIDLPETVDTRAAARLTGLLADAGGEDQLAIRGSGVLARRLAHAAPAVPGSGKRPPVHGSVLVTGGTGGIGGRVARRLAEQGAAHLVLTSRRGADAPGAAELRAELEQLGVRVTIAACDAADREALAALLAELPEDAPLTAVFHSAGVAHDDAPVADLTLGQLDALMRAKLTAARHLHELTADLDLDAFVLFSSGAAVWGSGGQPGYAAANAYLDALAEHRRSLGLTASSVAWGTWGEVGMATDPEVHDRLVRQGVLAMEPEHALGALDQMLENDDTAAAITLMDWEMFAPAFTANRPSALLSTVPEAVSALSDEGPADGGADAAVPPLRARLDGLPTAERARALVEAVRAEASATLGHDSPDAVPASRAFRDVGFDSVTAVELRNRLRAALGLPLPAALVFDYPTPTALAQHIGSLLYGTAPDEADTGRADDPDARIREALATVPIGRLRKAGLLDMVLKLAESDDTEDSATATDDAADALDLDDMDAEALLRLAAENSAN amphb-1 3212267 N/A 3212269 unspecified role unspecified role unspecified role unspecified role Ketoreductase domain Region 2489-3003 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false amphb-2 3212268 N/A 3212269 unspecified role unspecified role unspecified role unspecified role Ketoreductase domain Region 2529-3003 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false