DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ chianale-2010-1 canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Chianale F., Rainero E., Cianflone C., Bettio V., Pighini A., Porporato PE., Filigheddu N., Serini G., Sinigaglia F., Baldanzi G., Graziani A. DIP original experiment: DIP-254204X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Chianale F., Rainero E., Cianflone C., Bettio V., Pighini A., Porporato PE., Filigheddu N., Serini G., Sinigaglia F., Baldanzi G., Graziani A. Only protein-protein interactions imex curation rac1_canlf Ras-related C3 botulinum toxin substrate 1 RAC1 p21-Rac1 Rac2 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL mint Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles f1pl93_canlf ARHGDIA protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVVVTRLTLVCSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKNDDKTDHLSWEWNLTIKKEWKD arhgdia-rac1-8 3204508 N/A 3204509 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris N/A 3204510 unspecified role unspecified role bait bait canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris physical association physical association false false false