DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ chen-2008-36 in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113531X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions imex curation chen-2008-37 in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113529X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions imex curation chen-2008-38 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113534X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions imex curation chen-2008-39 ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113532X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions imex curation chen-2008-40 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113530X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions imex curation chen-2008-41 ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. DIP original experiment: DIP-113533X Nature structural & molecular biology 2008 IMEx Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Chen W., Lam SS., Srinath H., Jiang Z., Correia JJ., Schiffer CA., Fitzgerald KA., Lin K., Royer WE. Only protein-protein interactions imex curation cbp_human CREB-binding protein CREBBP CBP Histone lysine acetyltransferase CREBBP Protein-lysine acetyltransferase CREBBP protein protein human Homo sapiens Human MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL irf5_human Interferon regulatory factor 5 IRF5 protein protein human Homo sapiens Human MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ crebbp-irf5-1 3178125 N/A 3178131 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3178132 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false crebbp-irf5-2 3178126 N/A 3178131 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3178132 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false irf5-1 3178127 N/A 3178132 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false irf5-2 3178128 N/A 3178132 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false crebbp-irf5-3 3178129 N/A 3178131 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3178132 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false irf5-3 3178130 N/A 3178132 unspecified role unspecified role unspecified role unspecified role Region 222-467 Region 222-467 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false