IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ mori-2008-5 human-macrophage Human macrophages macrophage Macrophage anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mori Y., Tsuji S., Inui M., Sakamoto Y., Endo S., Ito Y., Fujimura S., Koga T., Nakamura A., Takayanagi H., Itoi E., Takai T., Mori Y., Tsuji S., Inui M., Sakamoto Y., Endo S., Ito Y., Fujimura S., Koga T., Nakamura A., Takayanagi H., Itoi E., Takai T. Macrophages were obtained by 7 days of culture of CD14+ monocytes in medium containing M-CSF but not RANKL. tostakai@idac.tohoku.ac.jp Journal of immunology (Baltimore, Md. : 1950) 2008 imex curation Only protein-protein interactions mori-2008-6 human-osteoclast Homo sapiens osteoclast Osteoclast Large multinucleate cell formed from differentiated macrophage, responsible for breakdown of bone. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mori Y., Tsuji S., Inui M., Sakamoto Y., Endo S., Ito Y., Fujimura S., Koga T., Nakamura A., Takayanagi H., Itoi E., Takai T., Mori Y., Tsuji S., Inui M., Sakamoto Y., Endo S., Ito Y., Fujimura S., Koga T., Nakamura A., Takayanagi H., Itoi E., Takai T. "POCS":Prefusion or nonfused osteoclasts obtained by 72 h of culture in the presence of RANKL and M-CSF. tostakai@idac.tohoku.ac.jp Journal of immunology (Baltimore, Md. : 1950) 2008 imex curation Only protein-protein interactions mori-2008-7 human-osteoclast Homo sapiens osteoclast Osteoclast Large multinucleate cell formed from differentiated macrophage, responsible for breakdown of bone. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mori Y., Tsuji S., Inui M., Sakamoto Y., Endo S., Ito Y., Fujimura S., Koga T., Nakamura A., Takayanagi H., Itoi E., Takai T., Mori Y., Tsuji S., Inui M., Sakamoto Y., Endo S., Ito Y., Fujimura S., Koga T., Nakamura A., Takayanagi H., Itoi E., Takai T. "MOCS":multinucleated mature osteoclasts obtained by 7 day culture in the presence of RANKL and M-CSF. tostakai@idac.tohoku.ac.jp Journal of immunology (Baltimore, Md. : 1950) 2008 imex curation Only protein-protein interactions mori-2008-4 human-monocyte Human mononuclear cells monocyte Monocyte, mononuclear cell anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mori Y., Tsuji S., Inui M., Sakamoto Y., Endo S., Ito Y., Fujimura S., Koga T., Nakamura A., Takayanagi H., Itoi E., Takai T., Mori Y., Tsuji S., Inui M., Sakamoto Y., Endo S., Ito Y., Fujimura S., Koga T., Nakamura A., Takayanagi H., Itoi E., Takai T. tostakai@idac.tohoku.ac.jp Journal of immunology (Baltimore, Md. : 1950) 2008 imex curation Only protein-protein interactions lirb1_human Leukocyte immunoglobulin-like receptor subfamily B member 1 ILT2 LIR1 MIR7 CD85 antigen-like family member J Immunoglobulin-like transcript 2 Monocyte/macrophage immunoglobulin-like receptor 7 LILRB1 protein protein human Homo sapiens Human MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTALWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTGAYIKPTLSAQPSPVVNSGGNVILQCDSQVAFDGFSLCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEETLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKEGAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTHPSDPLELVVSGPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVILLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKHTQPEDGVEMDTRSPHDEDPQAVTYAEVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSLTLRREATEPPPSQEGPSPAVPSIYATLAIH ptn6_human Tyrosine-protein phosphatase non-receptor type 6 PTPN6 HCP Protein-tyrosine phosphatase 1C Hematopoietic cell protein-tyrosine phosphatase SH-PTP1 Protein-tyrosine phosphatase SHP-1 PTP1C protein protein human Homo sapiens Human MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK lirb3_human Leukocyte immunoglobulin-like receptor subfamily B member 3 LILRB3 ILT5 LIR3 CD85 antigen-like family member A Immunoglobulin-like transcript 5 Monocyte inhibitory receptor HL9 protein protein human Homo sapiens Human MTPALTALLCLGLSLGPRTRVQAGPFPKPTLWAEPGSVISWGSPVTIWCQGSQEAQEYRLHKEGSPEPLDRNNPLEPKNKARFSIPSMTEHHAGRYRCHYYSSAGWSEPSDPLEMVMTGAYSKPTLSALPSPVVASGGNMTLRCGSQKGYHHFVLMKEGEHQLPRTLDSQQLHSRGFQALFPVGPVTPSHRWRFTCYYYYTNTPWVWSHPSDPLEILPSGVSRKPSLLTLQGPVLAPGQSLTLQCGSDVGYNRFVLYKEGERDFLQRPGQQPQAGLSQANFTLGPVSPSNGGQYRCYGAHNLSSEWSAPSDPLNILMAGQIYDTVSLSAQPGPTVASGENVTLLCQSWWQFDTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSYSSNPHLLSHPSEPLELVVSGHSGGSSLPPTGPPSTPGLGRYLEVLIGVSVAFVLLLFLLLFLLLRRQRHSKHRTSDQRKTDFQRPAGAAETEPKDRGLLRRSSPAADVQEENLYAAVKDTQSEDRVELDSQSPHDEDPQAVTYAPVKHSSPRREMASPPSSLSGEFLDTKDRQVEEDRQMDTEAAASEASQDVTYAQLHSLTLRRKATEPPPSQEGEPPAEPSIYATLAIH lirb4_human Leukocyte immunoglobulin-like receptor subfamily B member 4 ILT3 LIR5 CD85 antigen-like family member K Immunoglobulin-like transcript 3 Leukocyte immunoglobulin-like receptor 5 Monocyte inhibitory receptor HM18 LILRB4 protein protein human Homo sapiens Human MIPTFTALLCLGLSLGPRTHMQAGPLPKPTLWAEPGSVISWGNSVTIWCQGTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYYRSPVGWSQPSDPLELVMTGAYSKPTLSALPSPLVTSGKSVTLLCQSRSPMDTFLLIKERAAHPLLHLRSEHGAQQHQAEFPMSPVTSVHGGTYRCFSSHGFSHYLLSHPSDPLELIVSGSLEDPRPSPTRSVSTAAGPEDQPLMPTGSVPHSGLRRHWEVLIGVLVVSILLLSLLLFLLLQHWRQGKHRTLAQRQADFQRPPGAAEPEPKDGGLQRRSSPAADVQGENFCAAVKNTQPEDGVEMDTRQSPHDEDPQAVTYAKVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSFTLRQKATEPPPSQEGASPAEPSVYATLAIH lirb2_human Leukocyte immunoglobulin-like receptor subfamily B member 2 LILRB2 ILT4 LIR2 MIR10 CD85 antigen-like family member D Immunoglobulin-like transcript 4 Monocyte/macrophage immunoglobulin-like receptor 10 protein protein human Homo sapiens Human MTPIVTVLICLGLSLGPRTHVQTGTIPKPTLWAEPDSVITQGSPVTLSCQGSLEAQEYRLYREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQYYSRARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGEEEHPQCLNSQPHARGSSRAIFSVGPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLVPGVSKKPSLSVQPGPVVAPGESLTLQCVSDVGYDRFVLYKEGERDLRQLPGRQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSECSAPSDPLDILITGQIRGTPFISVQPGPTVASGENVTLLCQSWRQFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHAGTYRCYGSLNSDPYLLSHPSEPLELVVSGPSMGSSPPPTGPISTPAGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVVLLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKDTQPEDGVEMDTRAAASEAPQDVTYAQLHSLTLRRKATEPPPSQEREPPAEPSIYATLAIH lilrb1-ptpn6-1 2969378 N/A 2969382 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-2 lilrb1-ptpn6-6 2969378 N/A 2969384 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-6 lilrb3-ptpn6-2 2969378 N/A 2969385 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-10 lilrb4-ptpn6-1 2969378 N/A 2969386 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-13 lilrb1-ptpn6-2 2969379 N/A 2969382 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-3 lilrb1-ptpn6-7 2969379 N/A 2969384 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-7 lilrb3-ptpn6-3 2969379 N/A 2969385 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-11 lilrb4-ptpn6-2 2969379 N/A 2969386 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-14 lilrb1-ptpn6-3 2969380 N/A 2969382 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-4 lilrb1-ptpn6-8 2969380 N/A 2969384 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-8 lilrb3-ptpn6-4 2969380 N/A 2969385 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-12 lilrb4-ptpn6-3 2969380 N/A 2969386 unspecified role unspecified role bait bait N/A 2969383 unspecified role unspecified role prey prey physical association physical association false false false 2A-15 lilrb1-ptpn6-4 2969381 N/A 2969383 unspecified role unspecified role prey prey N/A 2969382 unspecified role unspecified role bait bait physical association physical association false false false 2A-1 lilrb1-ptpn6-5 2969381 N/A 2969383 unspecified role unspecified role prey prey N/A 2969384 unspecified role unspecified role bait bait physical association physical association false false false 2A-5 lilrb3-ptpn6-1 2969381 N/A 2969383 unspecified role unspecified role prey prey N/A 2969385 unspecified role unspecified role bait bait physical association physical association false false false 2A-9 weak reaction