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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3177463">
                <names>
                    <shortLabel>kim-2008-18</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18787115" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-133368X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15728546" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-14329" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0804745105" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human</shortLabel>
                            <fullName>Homo sapiens</fullName>
                            <alias typeAc="MI:1041" type="synonym">Human</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti tag coip</shortLabel>
                        <fullName>anti tag coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti tag coip</alias>
                    </names>
                    <xref>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>anti tag western</shortLabel>
                        <fullName>anti tag western blot</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti tag western</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0705" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-967832" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Kim IM., Tilley DG., Chen J., Salazar NC., Whalen EJ., Violin JD., Rockman HA.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-133368X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Kim IM.,  Tilley DG.,  Chen J.,  Salazar NC.,  Whalen EJ.,  Violin JD.,  Rockman HA.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3177464">
                <names>
                    <shortLabel>adrb1_human</shortLabel>
                    <fullName>Beta-1 adrenergic receptor</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Beta-1 adrenoreceptor</alias>
                    <alias typeAc="MI:0301" type="gene name">ADRB1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ADRB1R</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">B1AR</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P08588" version="SP_91" refType="identity" refTypeAc="MI:0356"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001997" secondary="positive regulation of the force of heart contraction by epinephrine-norepinephrine" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7BU6" version="SP_212"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UKG8" version="SP_91" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7BU7" version="SP_212"/>
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                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-36294N"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004940" secondary="beta1-adrenergic receptor activity" version="SP_212"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-390696" version="SP_212"/>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
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                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV</sequence>
            </interactor>
            <interactor id="3177465">
                <names>
                    <shortLabel>arrb1_human</shortLabel>
                    <fullName>Beta-arrestin-1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Arrestin beta-1</alias>
                    <alias typeAc="MI:0301" type="gene name">ARRB1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ARR1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Non-visual arrestin-2</alias>
                </names>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8856828" version="SP_204"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B6V9G8" version="SP_87" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090240" secondary="positive regulation of histone H4 acetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031691" secondary="alpha-1A adrenergic receptor binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031896" secondary="V2 vasopressin receptor binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990763" secondary="arrestin family protein binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016567" secondary="protein ubiquitination" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017864" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035612" secondary="AP-2 adaptor complex binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001934" secondary="positive regulation of protein phosphorylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014752" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000137486" version="SP_204" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802948" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045746" secondary="negative regulation of Notch signaling pathway" version="SP_204"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR</sequence>
            </interactor>
            <interactor id="3177466">
                <names>
                    <shortLabel>arrb2_human</shortLabel>
                    <fullName>Beta-arrestin-2</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Arrestin beta-2</alias>
                    <alias typeAc="MI:0301" type="gene name">ARRB2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ARB2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ARR2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Non-visual arrestin-3</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P32121" version="SP_77" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6ICT3" version="SP_77" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" secondary="protein domain specific binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032695" secondary="negative regulation of interleukin-12 production" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-456926" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031701" secondary="angiotensin receptor binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005768" secondary="endosome" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043161" secondary="proteasome-mediated ubiquitin-dependent protein catabolic process" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" secondary="positive regulation of ERK1 and ERK2 cascade" version="SP_208"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014753" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" secondary="positive regulation of peptidyl-serine phosphorylation" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5635838" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-418555" version="SP_208"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011021" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005905" secondary="clathrin-coated pit" version="SP_208"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DTK2" version="SP_107" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032088" secondary="negative regulation of NF-kappaB transcription factor activity" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042699" secondary="follicle-stimulating hormone signaling pathway" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001664" secondary="G protein-coupled receptor binding" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802955" version="SP_208"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000698" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" secondary="positive regulation of peptidyl-tyrosine phosphorylation" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034122" secondary="negative regulation of toll-like receptor signaling pathway" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051897" secondary="positive regulation of protein kinase B signaling" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5674135" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060079" secondary="excitatory postsynaptic potential" version="SP_208"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000346341"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030139" secondary="endocytic vesicle" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071889" secondary="14-3-3 protein binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031826" secondary="type 2A serotonin receptor binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031748" secondary="D1 dopamine receptor binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016323" secondary="basolateral plasma membrane" version="SP_208"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000370898"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-28974065" refType="intact-secondary"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007420" secondary="brain development" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006366" secondary="transcription by RNA polymerase II" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031859" secondary="platelet activating factor receptor binding" version="SP_208"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001316993.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051019" secondary="mitogen-activated protein kinase binding" version="SP_208"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_945355.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2PP19" version="SP_77" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043422" secondary="protein kinase B binding" version="SP_208"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000403701"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001244257.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050965" secondary="detection of temperature stimulus involved in sensory perception of pain" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031762" secondary="follicle-stimulating hormone receptor binding" version="SP_208"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B7WPL3" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_208"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q0Z8D3" version="SP_77" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9649948" version="SP_208"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-40089N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000141480" version="SP_208" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002031" secondary="G protein-coupled receptor internalization" version="SP_208"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-714559" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000269260" version="SP_208" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007628" secondary="adult walking behavior" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051898" secondary="negative regulation of protein kinase B signaling" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_208"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000381488"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001244258.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="H0Y688" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004304.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002092" secondary="positive regulation of receptor internalization" version="SP_208"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4DLW0" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032226" secondary="positive regulation of synaptic transmission, dopaminergic" version="SP_208"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001244259.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034392" secondary="negative regulation of smooth muscle cell apoptotic process" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002032" secondary="desensitization of G protein-coupled receptor signaling pathway by arrestin" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045211" secondary="postsynaptic membrane" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045953" secondary="negative regulation of natural killer cell mediated cytotoxicity" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5689880" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031397" secondary="negative regulation of protein ubiquitination" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007212" secondary="dopamine receptor signaling pathway" version="SP_208"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011022" version="SP_208"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014756" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014069" secondary="postsynaptic density" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8856825" version="SP_208"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000269260"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032691" secondary="negative regulation of interleukin-1 beta production" version="SP_208"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UEQ6" version="SP_77" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043197" secondary="dendritic spine" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" secondary="transforming growth factor beta receptor signaling pathway" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032715" secondary="negative regulation of interleukin-6 production" version="SP_208"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B5B0C0" version="SP_97" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031410" secondary="cytoplasmic vesicle" version="SP_208"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000269260" version="SP_208" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005102" secondary="signaling receptor binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000727" secondary="positive regulation of cardiac muscle cell differentiation" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2122948" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043524" secondary="negative regulation of neuron apoptotic process" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8856828" version="SP_208"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001244260.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015031" secondary="protein transport" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031692" secondary="alpha-1B adrenergic receptor binding" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802952" version="SP_208"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8N7Y2" version="SP_77" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090201" secondary="negative regulation of release of cytochrome c from mitochondria" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990763" secondary="arrestin family protein binding" version="SP_208"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000341895"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031691" secondary="alpha-1A adrenergic receptor binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051928" secondary="positive regulation of calcium ion transport" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001933" secondary="negative regulation of protein phosphorylation" version="SP_208"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017864" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802946" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031623" secondary="receptor internalization" version="SP_208"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000412477"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032720" secondary="negative regulation of tumor necrosis factor production" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016567" secondary="protein ubiquitination" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034260" secondary="negative regulation of GTPase activity" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904037" secondary="positive regulation of epithelial cell apoptotic process" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032967" secondary="positive regulation of collagen biosynthetic process" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031702" secondary="type 1 angiotensin receptor binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000573" secondary="positive regulation of DNA biosynthetic process" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060326" secondary="cell chemotaxis" version="SP_208"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P32121" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043154" secondary="negative regulation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9656223" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802948" version="SP_208"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014752" version="SP_208"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5099900" version="SP_208"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-14329-1" id="3177467">
                <names>
                    <shortLabel>adrb1-arrb1-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-103249E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-14329-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15728557" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3177463</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3177468">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15728563" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3177464</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="3177469">
                                <names>
                                    <shortLabel>Flag tag</shortLabel>
                                    <fullName>Flag tag</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15728564" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>flag tag</shortLabel>
                                        <fullName>flag tag</fullName>
                                        <alias typeAc="MI:0303" type="go synonym">FLAG-tagged</alias>
                                        <alias typeAc="MI:0303" type="go synonym">FLAG</alias>
                                        <alias typeAc="MI:0303" type="go synonym">DYKDDDDKV epitope tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">DYKDDDDKV epitope tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">FLAG</alias>
                                        <alias typeAc="MI:1041" type="synonym">FLAG-tagged</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0518" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456503" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>predetermined featur</shortLabel>
                                        <fullName>predetermined feature</fullName>
                                        <alias typeAc="MI:1041" type="synonym">predetermined featur</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0823" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218592" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9606">
                                <names>
                                    <shortLabel>human</shortLabel>
                                    <fullName>Homo sapiens</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Human</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3177470">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15728562" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3177465</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9606">
                                <names>
                                    <shortLabel>human</shortLabel>
                                    <fullName>Homo sapiens</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Human</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3177471">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15728561" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3177466</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9606">
                                <names>
                                    <shortLabel>human</shortLabel>
                                    <fullName>Homo sapiens</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Human</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
